The Effect of Interval Training Program on Nuclear Factor Erythroid-Derived 2-like 2 (NFE2L2/Nrf2) Gene Expression in Women

Abstract

Purpose in this work, to investigate whether interval training program has an effect on Nuclear factor erythroid-derived 2-like 2 (NFE2L2/Nrf2) gene expression in women.The research was made on 12 women. Participants were given a medium-term interval training program for 8 weeks, 3 days a week. The  blood samples of the participants were collected before and after the 8 weeks of training. RNA isolation was performed using TRIzol Reagent from peripheral blood mononuclear cells. NFE2L2 gene expression was determined by Biomark Real-Time PCR (RT-PCR). The participants  was a significant increase in heart rate and maximal oxygen use capacity (VO₂ max ) after the exercise (p <0.001). There was a significant decrease in the body weight and body mass index of women after the exercise (p <0.001). There was a decrease in NFE2L2 gene expressions after 8 weeks of the training program (p <0.05,). It shows that interval exercise reduces NFE2L2 gene expression in women. 

Keywords

• Exercise,gene expression,NFE2L2 gene,interval training

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