Amoxicillin Loaded Magnetic Nanoparticles Developed For Treatment of Osteomyelitis

Yıl 2020, Cilt: 48 Sayı: 2, 137 - 145, 19.04.2020

Güliz Ak , Tülay Yılmaz Şengel Şenay Hamarat Şanlıer

https://doi.org/10.15671/hjbc.519916

Cited By: 2

Öz

Osteomyelitis is a bone infection caused by
microorganisms. Localized efficient drug delivery for treatment osteomyelitis
is an important topic. Amoxicillin is one the antibiotics used for
osteomyelitis therapy. Magnetic nanoparticles could achieve localized targeted
treatment with the help of magnetic field. Starch is biodegradable and
biocompatible biopolymer and can be used for carrier material for drug delivery.
The aim of this study is to develope amoxicillin loaded magnetic nanoparticles
for the use of treatment of osteomyelitis. Here, magnetite nanostructures were
coated with starch and characterized with FTIR, TGA and SEM. It was seen that
nanoparticles were spherical and had a size of 14-36 nm. Amoxicillin loading
onto magnetic nanoparticles was performed by adsorption method using various
concentrations of drug and 0.483 mg amoxicillin was adsorbed on per mg of
nanoparticles. In addition, in vitro
drug release at pH 7.4 was obtained as in a controlled manner. As a conclusion,
it can be suggested that amoxicillin loaded these nanoparticles could have a
potential for drug delivery to osteomyelitis. 

Anahtar Kelimeler

magnetic nanoparticles, amoxicillin, drug delivery, osteomyelitis

Kaynakça

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