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Boronic Acid Functionalized Adsorbents for Antibody Removal

Yıl 2008, Cilt: 36 Sayı: 1, 47 - 60, 01.01.2008

Başak Şaşmaz Gözde Baydemir Nilay Bereli Serap Şenel Handan Yavuz

Öz

In this study a novel approach was developed to obtain an efficient separation of human-IgG from human plasma. 4- Vinylphenylboronic acid VPBA and 2-hydroxyethylmethacrylate HEMA were chosen as monomers. Spherical microbeads with an average size of 100-140 µm were obtained by the radical suspension polymerization of VPBA and HEMA conducted in an aqueous dispersion medium. VPBA monomer was characterized by FTIR. p HEMA-VPBA beads were characterized by swelling studies, FTIR and SEM. The pHEMA and p HEMA-VPBA microbeads were contacted with blood in in-vitro systems. Loss of the blood cells and the clotting times were also followed. Good blood compatibility properties of both pHEMA and p HEMA-VPBA were clearly observed with blood coagulation experiments. Loss of cells in the blood contacting with pHEMA and p HEMA-VPBA microbeads were nearly the same. These VPBA containing p HEMA-VPBA microbeads with a swelling ratio of 57 % were used in the adsorption/desorption of human-IgG from aqueous solutions and human plasma. The maximum human-IgG adsorption 139 mg/g polymer was observed at pH 8.5 for HEPES buffer. IgG adsorption from human plasma was 38.75 mg/g. It was also observed that human-IgG could be repeatedly adsorbed and desorbed with p HEMA-VPBA microbeads without significant loss in the adsorption capacity.

Anahtar Kelimeler

Boronic Acid Antibody Removal Boranate affinity

Kaynakça

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  • 2. Goding, J.W., Monoclonal Antibodies: Principles and Practice, New York 1995.
  • 3. Serpaa, G., Augusto, E.F.P., Tamashiroc, W., Riberiora, M.B., Mirandaa, E.A., Buenoa, S.M.A., Journal of Chromatography B, , 2005, 816, 259.
  • 4. Riske, F., Smith, M., Menon, M., Goetschalck, S., Goidsenhoven, I.V., Krul, A., Pimpaneau, V., Renaers, I., Van Tichelt, N., Van Houdt, K., Hayes, M., Lawrence, C., Bigelow, R., Schroeder, J., Journal of Chromatography B, 2007, 848, 108.
  • 5. Ishihara, T., Kadoya, T., Journal of Chromatography A, , 2007, 1176, 149.
  • 6. Galina A.P., Tatiana B.T., Journal of Chromatography A, , 2005, 1065, 19.
  • 7. Zimmerman, T., Frère, C.P., Satzger, M., Raba, M., Weisbach, M., Journal of Immunological Methods , 2006, 314, 67.
  • 8. Roque, A.C.A., Silva, C.S.O., Taipa, M.A., Döhn, K., Popp, A., Donzeau, M., Journal of Chromatography A, , 2007, 1160, 44.
  • 9. Denizli, A., Arıca, M.Y., J. Biomater. Sci. Polym. Ed. 11, , 2000, 367.
  • 10. Hober, S., Nord, K., Linhult, M., Journal of Chromatography B, , 2007, 848, 40.
  • 11. McCue, J.T., Kemp, G., Low, D., Quinones-Garcia, I., J. Chromatogr. A , 2003, 989, 139.
  • 12. Jungbauer, A., Hahn, R., Curr. Opion. Drug Dis. Dev. 7, 2004, 248.
  • 13. Hahn, R., Schlegel, R., Jungbauer, A., J. Chromatogr. B , 2003, 790, 25.
  • 14. Reis, K.J., Boyle, M.D.P., Ayoub, E.M., J. Clin. Lab. Immunol. , 1984, 13, 75.
  • 15. Fahrner, R.L., Whitney, D.H., Vanderlaan, M., Blank, G.S., Biotechnol. Appl. Biochem., 1999, 30, 121.
  • 16. Hahn, R., Shimahara, K., Steindl, F., Jungbauer, A., J. Chromatogr. A,, 2006, 1102, 224.
  • 17. Bak, H., Thomas, O.R.T, Journal of Biotechnology, 2007, 131S, S130.
  • 18. Zhou, J.X. Dermawan, S., Solamo, F., Flynn, G., Stenson, R., Tressel, T., Guhan, S., Journal of Chromatography A, , 2007, 1175, 69.
  • 19. Rena, D., Pipes, G.D., Hambly, D.M., Bondarenko, P.V., Treuheit, M.J., Bremsa, D.N., Gadgil, H.S., Journal of Chromatography A, 2007, 1175, 63.
  • 20. Temperature-Triggered Purification of Antibodies, Kim, J.Y., Mulchandani, A., Chen, W., Biotechnol. Bioeng., 2005, Vol. 90, No. 3, May 5, 373.
  • 21. Roque, A.C., Taipa, M.A., Lowe, C.R., Journal of Chromatography A,, 2005, 1064, 157.
  • 22. Roque, A.C., Taipa, M.A., Lowe, C.R., J. Mol. Recognit., 2004, 262.
  • 23. Verdoliva, A., Marasco, D., De Capua, A., Saporito, A., Bellofiore, P., Manfredi, V., Fattorusso, R., Pedone, C., Ruvo, M., ChemBioChem, 2005, 6, 1242.
  • 24. Özkara, S., Yavuz, H., Patır, S., Arıca, M.Y., Denizli, A., Separation Science and Technology, 2002, 37, 717.
  • 25. Coffinier, Y., Legallais, C., Vijayalakshmi, M.A., J. Membr. Sci., 2002, 208, 13.
  • 26. Yang, L., Chen, P., J. Membr. Sci., 2002, 205, 141.
  • 27. Kalaycioğlu, E., Patir, S., Piskin, E., Langmuir, 2003, 19, 9538.
  • 28. Bueno, S.M.A., Haupt, K., Vijayalakshmi, M.A., J. Chromatogr. B, 1995, 667, 57.
  • 29. Özkara, S., Akgöl, S., Çanak, Y., Denizli, A., Biotechnol. Prog. 20, 2004, 1169.
  • 30. Çanak, Y., Özkara, S., Akgöl, S., Denizli, A., React. Funct. Polym., 2004, 61, 369.
  • 31. Xiao-Chuan, L., Chin J Chromatogr, , 2006, 24 (1) 73.
  • 32. Weith, H.L, Wiebers, J.L., Gilham, P.T., Biochemistry, 1970, 9, 4396.
  • 33. Singh, N., Willson, R.C., Journal of Chromatography A, , 1999, 840, 205.
  • 35. Elmas, B., Onur, M.A., Senel, S., Tuncel, A., Colloids and Surfaces A: Physicochem. Eng. Aspects , 2004, 232, 253.
  • 36. Özdemir, A., Tuncel, A., Journal of Applied Polymer Science, Vol. , 2000, 78, 268.
  • 37. Lei, Y., Liu, Z., Liu, Q., Wu, X., Reactive & Functional Polymers, 2001, 48, 159.
  • 38. Ivanov, A.E., Galaev, I.Y., Mattiasson, B., J. Mol. Recognit. , 2006, 19, 322.
  • 39. Palanisamy, U.D., Hussain, A., Iqbal, S., Sproule, K., Lowe, C.R., J. Mol. Recognit., , 1999, 12, 57.
  • 40. Li, Y., Jeppsson, J.O., Karlsson, M.J., Larsson, E.L., Jungvida, H., Galaev, I.Y., Mattiasson, B., Journal of Chromatography B, , 2002, 776, 149.
  • 41. Tanaka, T., Matsunaga, T., Biosens. Bioelectron., 2001, 16, 1089.
  • 42. Cannizzo, C., Gerbier, A.S., Larpent, C., Polymer, 2005, 46, 1269.
  • 43. Kanayama, N., Kitano, H., Langmuir, , 2000, 16, 577.
  • 44. Sanz, V.C., Mena, M.L., Cortes, A.G., Sedeno, P.Y., Pingarron, J.M., Analytica Chimica Acta , 2005, 528, 1.
  • 45. Matsumoto, A., Ikeda, S., Harada, A., Kataoka, H., Biomacromolecules, 2003, 4, 1410.
  • 46. Denizli, A., Pişkin, E., J. Chromatogr. B,, 1995, 666, 215.
  • 47. Denizli, A., Pişkin, E., J. Chromatogr. B, , 1995, 670, 157.
  • 48. Lagergren, H., Olsson, P., Swedenborg, J., Surgery,, 1974, 75, 643.
  • 49. Doumas, B.R., Biggs, H., Standart methods of Clin. Chem., , 1972, Vol 7.
  • 50. Peppas, N., Hydrogels, in Biomaterials Science, Hoffmann, A. Ed., Academic Pres, New York, 1996, 60-64.
  • 51. Denizli, A., J. Appl. Polym. Sci., , 1999, 74, 655.
  • 52. Brash, J.L., Modern Aspects of Protein Adsorption on Biomaterials, Missirlis, Y.F., Lemm, W. Eds., Kluwer Academic Publishers, 1991, 39-47.
  • 53. Haupt, K., Bueno, S.M.A. and Vijayalakshmi, M.A., Journal of Chromatography B,, 1995, 674, 13.

Yıl 2008, Cilt: 36 Sayı: 1, 47 - 60, 01.01.2008

Başak Şaşmaz Gözde Baydemir Nilay Bereli Serap Şenel Handan Yavuz

Öz

Kaynakça

  • 1. Huse K., Böhme H.J., Scholz G.H., J. Biochem Biophys. Methods, 2002, 51, 217.
  • 2. Goding, J.W., Monoclonal Antibodies: Principles and Practice, New York 1995.
  • 3. Serpaa, G., Augusto, E.F.P., Tamashiroc, W., Riberiora, M.B., Mirandaa, E.A., Buenoa, S.M.A., Journal of Chromatography B, , 2005, 816, 259.
  • 4. Riske, F., Smith, M., Menon, M., Goetschalck, S., Goidsenhoven, I.V., Krul, A., Pimpaneau, V., Renaers, I., Van Tichelt, N., Van Houdt, K., Hayes, M., Lawrence, C., Bigelow, R., Schroeder, J., Journal of Chromatography B, 2007, 848, 108.
  • 5. Ishihara, T., Kadoya, T., Journal of Chromatography A, , 2007, 1176, 149.
  • 6. Galina A.P., Tatiana B.T., Journal of Chromatography A, , 2005, 1065, 19.
  • 7. Zimmerman, T., Frère, C.P., Satzger, M., Raba, M., Weisbach, M., Journal of Immunological Methods , 2006, 314, 67.
  • 8. Roque, A.C.A., Silva, C.S.O., Taipa, M.A., Döhn, K., Popp, A., Donzeau, M., Journal of Chromatography A, , 2007, 1160, 44.
  • 9. Denizli, A., Arıca, M.Y., J. Biomater. Sci. Polym. Ed. 11, , 2000, 367.
  • 10. Hober, S., Nord, K., Linhult, M., Journal of Chromatography B, , 2007, 848, 40.
  • 11. McCue, J.T., Kemp, G., Low, D., Quinones-Garcia, I., J. Chromatogr. A , 2003, 989, 139.
  • 12. Jungbauer, A., Hahn, R., Curr. Opion. Drug Dis. Dev. 7, 2004, 248.
  • 13. Hahn, R., Schlegel, R., Jungbauer, A., J. Chromatogr. B , 2003, 790, 25.
  • 14. Reis, K.J., Boyle, M.D.P., Ayoub, E.M., J. Clin. Lab. Immunol. , 1984, 13, 75.
  • 15. Fahrner, R.L., Whitney, D.H., Vanderlaan, M., Blank, G.S., Biotechnol. Appl. Biochem., 1999, 30, 121.
  • 16. Hahn, R., Shimahara, K., Steindl, F., Jungbauer, A., J. Chromatogr. A,, 2006, 1102, 224.
  • 17. Bak, H., Thomas, O.R.T, Journal of Biotechnology, 2007, 131S, S130.
  • 18. Zhou, J.X. Dermawan, S., Solamo, F., Flynn, G., Stenson, R., Tressel, T., Guhan, S., Journal of Chromatography A, , 2007, 1175, 69.
  • 19. Rena, D., Pipes, G.D., Hambly, D.M., Bondarenko, P.V., Treuheit, M.J., Bremsa, D.N., Gadgil, H.S., Journal of Chromatography A, 2007, 1175, 63.
  • 20. Temperature-Triggered Purification of Antibodies, Kim, J.Y., Mulchandani, A., Chen, W., Biotechnol. Bioeng., 2005, Vol. 90, No. 3, May 5, 373.
  • 21. Roque, A.C., Taipa, M.A., Lowe, C.R., Journal of Chromatography A,, 2005, 1064, 157.
  • 22. Roque, A.C., Taipa, M.A., Lowe, C.R., J. Mol. Recognit., 2004, 262.
  • 23. Verdoliva, A., Marasco, D., De Capua, A., Saporito, A., Bellofiore, P., Manfredi, V., Fattorusso, R., Pedone, C., Ruvo, M., ChemBioChem, 2005, 6, 1242.
  • 24. Özkara, S., Yavuz, H., Patır, S., Arıca, M.Y., Denizli, A., Separation Science and Technology, 2002, 37, 717.
  • 25. Coffinier, Y., Legallais, C., Vijayalakshmi, M.A., J. Membr. Sci., 2002, 208, 13.
  • 26. Yang, L., Chen, P., J. Membr. Sci., 2002, 205, 141.
  • 27. Kalaycioğlu, E., Patir, S., Piskin, E., Langmuir, 2003, 19, 9538.
  • 28. Bueno, S.M.A., Haupt, K., Vijayalakshmi, M.A., J. Chromatogr. B, 1995, 667, 57.
  • 29. Özkara, S., Akgöl, S., Çanak, Y., Denizli, A., Biotechnol. Prog. 20, 2004, 1169.
  • 30. Çanak, Y., Özkara, S., Akgöl, S., Denizli, A., React. Funct. Polym., 2004, 61, 369.
  • 31. Xiao-Chuan, L., Chin J Chromatogr, , 2006, 24 (1) 73.
  • 32. Weith, H.L, Wiebers, J.L., Gilham, P.T., Biochemistry, 1970, 9, 4396.
  • 33. Singh, N., Willson, R.C., Journal of Chromatography A, , 1999, 840, 205.
  • 35. Elmas, B., Onur, M.A., Senel, S., Tuncel, A., Colloids and Surfaces A: Physicochem. Eng. Aspects , 2004, 232, 253.
  • 36. Özdemir, A., Tuncel, A., Journal of Applied Polymer Science, Vol. , 2000, 78, 268.
  • 37. Lei, Y., Liu, Z., Liu, Q., Wu, X., Reactive & Functional Polymers, 2001, 48, 159.
  • 38. Ivanov, A.E., Galaev, I.Y., Mattiasson, B., J. Mol. Recognit. , 2006, 19, 322.
  • 39. Palanisamy, U.D., Hussain, A., Iqbal, S., Sproule, K., Lowe, C.R., J. Mol. Recognit., , 1999, 12, 57.
  • 40. Li, Y., Jeppsson, J.O., Karlsson, M.J., Larsson, E.L., Jungvida, H., Galaev, I.Y., Mattiasson, B., Journal of Chromatography B, , 2002, 776, 149.
  • 41. Tanaka, T., Matsunaga, T., Biosens. Bioelectron., 2001, 16, 1089.
  • 42. Cannizzo, C., Gerbier, A.S., Larpent, C., Polymer, 2005, 46, 1269.
  • 43. Kanayama, N., Kitano, H., Langmuir, , 2000, 16, 577.
  • 44. Sanz, V.C., Mena, M.L., Cortes, A.G., Sedeno, P.Y., Pingarron, J.M., Analytica Chimica Acta , 2005, 528, 1.
  • 45. Matsumoto, A., Ikeda, S., Harada, A., Kataoka, H., Biomacromolecules, 2003, 4, 1410.
  • 46. Denizli, A., Pişkin, E., J. Chromatogr. B,, 1995, 666, 215.
  • 47. Denizli, A., Pişkin, E., J. Chromatogr. B, , 1995, 670, 157.
  • 48. Lagergren, H., Olsson, P., Swedenborg, J., Surgery,, 1974, 75, 643.
  • 49. Doumas, B.R., Biggs, H., Standart methods of Clin. Chem., , 1972, Vol 7.
  • 50. Peppas, N., Hydrogels, in Biomaterials Science, Hoffmann, A. Ed., Academic Pres, New York, 1996, 60-64.
  • 51. Denizli, A., J. Appl. Polym. Sci., , 1999, 74, 655.
  • 52. Brash, J.L., Modern Aspects of Protein Adsorption on Biomaterials, Missirlis, Y.F., Lemm, W. Eds., Kluwer Academic Publishers, 1991, 39-47.
  • 53. Haupt, K., Bueno, S.M.A. and Vijayalakshmi, M.A., Journal of Chromatography B,, 1995, 674, 13.
Toplam 52 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Research Article
Yazarlar

Başak Şaşmaz Bu kişi benim

Gözde Baydemir Bu kişi benim

Nilay Bereli Bu kişi benim

Serap Şenel Bu kişi benim

Handan Yavuz Bu kişi benim

Yayımlanma Tarihi 1 Ocak 2008
Yayımlandığı Sayı Yıl 2008 Cilt: 36 Sayı: 1

Kaynak Göster

APA Şaşmaz, B., Baydemir, G., Bereli, N., Şenel, S., vd. (2008). Boronic Acid Functionalized Adsorbents for Antibody Removal. Hacettepe Journal of Biology and Chemistry, 36(1), 47-60.
AMA Şaşmaz B, Baydemir G, Bereli N, Şenel S, Yavuz H. Boronic Acid Functionalized Adsorbents for Antibody Removal. HJBC. Ocak 2008;36(1):47-60.
Chicago Şaşmaz, Başak, Gözde Baydemir, Nilay Bereli, Serap Şenel, ve Handan Yavuz. “Boronic Acid Functionalized Adsorbents for Antibody Removal”. Hacettepe Journal of Biology and Chemistry 36, sy. 1 (Ocak 2008): 47-60.
EndNote Şaşmaz B, Baydemir G, Bereli N, Şenel S, Yavuz H (01 Ocak 2008) Boronic Acid Functionalized Adsorbents for Antibody Removal. Hacettepe Journal of Biology and Chemistry 36 1 47–60.
IEEE B. Şaşmaz, G. Baydemir, N. Bereli, S. Şenel, ve H. Yavuz, “Boronic Acid Functionalized Adsorbents for Antibody Removal”, HJBC, c. 36, sy. 1, ss. 47–60, 2008.
ISNAD Şaşmaz, Başak vd. “Boronic Acid Functionalized Adsorbents for Antibody Removal”. Hacettepe Journal of Biology and Chemistry 36/1 (Ocak 2008), 47-60.
JAMA Şaşmaz B, Baydemir G, Bereli N, Şenel S, Yavuz H. Boronic Acid Functionalized Adsorbents for Antibody Removal. HJBC. 2008;36:47–60.
MLA Şaşmaz, Başak vd. “Boronic Acid Functionalized Adsorbents for Antibody Removal”. Hacettepe Journal of Biology and Chemistry, c. 36, sy. 1, 2008, ss. 47-60.
Vancouver Şaşmaz B, Baydemir G, Bereli N, Şenel S, Yavuz H. Boronic Acid Functionalized Adsorbents for Antibody Removal. HJBC. 2008;36(1):47-60.

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