Synthesis, Characterization, and Evaluation Of Antibacterial 4H-1,2,4-triazole-5- 4-Bromophenoxymethyl -3- 4-substituted Benzyl sulfide

Yıl 2017, Cilt: 45 Sayı: 2, 251 - 255, 01.06.2017

Mazin N. Mousa

Öz

Aseries of 4H-1,2,4-triazole-5- 4-Bromophenoxymethyl - 3- 4-substitutedBenzyl sulfide derivative 6a-6g were designed and prepared. The structures have been confirmed using FT-IR spectroscopy, elemental analysis and 1H NMR.Antibacterial study was done using gram+ve Staphylococcus aureus, and Bacillus cereus and gram+ve microorganisms E. coli, and Pseudomonas aeruginosa and disc diffusion method for evaluation of antibacterial activity. Compound 6d showed the highest effect, while compound 6a showed the lowest. All of the prepared compound has antibacterial activity, but none of them has higher effect than the standard Cefuroxime.

Anahtar Kelimeler

1, 2, 4-triazole, antibacterial, sulfide

4H-1,2,4-triazol-5- 4-Bromofenoksimetil -3- 4-Substitue Benzil Sülfidin Sentezi, Karakterizasyonu ve Antibakteriyel Aktivitesinin Değerlendirilmesi

Öz

H-1, 2,4-triazol-5- 4-Bromofenoksimetil -3- 4-substitue benzil sülfid türevli serisi 6a-6g tasarlanmış ve hazırlanmıştır. Yapılar, FT-IR spektroskopisi, elemental analiz ve 1H NMR kullanılarak doğrulanmıştır. Antibakteriyel çalışmalar, gram+ve Staphylococcus aureus ve Bacillus cereus ve gram mikro mikroorganizmalar Escherichia coli ve Pseudomonas aeruginosa kullanılmış ve disk difüzyon yöntemi ile antibakteriyel aktivitenin değerlendirilmesiyle gerçekleştirilmiştir. Bileşik 6a en düşük etkiyi gösterirken, bileşik 6d en yüksek etkiyi göstermiştir. Hazırlanan bileşiklerin hepsi antibakteriyel etkiye sahiptir. Fakat bunların hiçbiri standart Sefuroksime göre daha yüksek etkiye sahip değildir

Anahtar Kelimeler

1, 2, 4-triazol, antibakteriyel, sülfid

Kaynakça

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