Trivalent Cr III and Hexavalent Cr VI Chromium Affect Morphology and Diversity of Hematopoietic Outcome in Japanese Quail Coturnix Japonica

Yıl 2017, Cilt: 45 Sayı: 2, 263 - 268, 01.06.2017

Andi Alijagi Damir Suljevi Muhamed Focak

Öz

Chromium is a naturally occurring heavy metal found commonly in the environment in trivalent Cr III and hexavalent Cr VI forms. Cr VI compounds are rated as potential carcinogens. The study covered an analysis of the effect of Cr III as CrCl3 chromium chloride and Cr VI as CrO3 chromium oxide on hematolo- gical parameters of Japanese quail Coturnix japonica . Chromium was added to food and water ad libitium and the experiment lasted 20 days. Significant differences in values of heterophils and lymphocytes were obtained with the tendency of reducing the number of these blood cells. The surface of erythrocytes, thrombocytes and heterophils was significantly reduced p

Anahtar Kelimeler

Toxicity, chromium, quails, hematology

Trivalent Cr III ve Hekzavalent Cr VI Krom iyonlarının Japon Bıldırcınının Coturnix Japonica Morfolojisi ve Hematopoietik Sonuçları Üzerine Etkisi

Öz

K rom, üç değerlikli Cr III ve altı değerlikli Cr VI formlarında yaygın olarak bulunan, doğal olarak oluşan bir ağır metaldir. Cr VI bileşikleri potansiyel kanserojenler olarak sınıflandırılmıştır. Çalışma, Japon bıldırcınlarının Coturnix japonica hematolojik parametrelerinde Cr III ’ün CrCl3 krom klorür ve Cr VI ’nın CrO3 krom oksit olarak etkisinin analizini kapsamaktadır. Krom yiyeceklere ve içeceklere ilave edilmiş ve deneyler 20 gün boyunca sürdürülmüştür. Kan hücrelerinin sayısında azalma eğilimi ile heterofiller ve lenfosit değerlerinde belirgin farklılıklar elde edilmiştir. Eritrositlerin, trombositlerin ve heterofillerin yüzeyi önemli derecede küçülmüştür p

Anahtar Kelimeler

Toksisite, krom, bıldırcın, hematoloji

Kaynakça

• A. Yildiz, S. Parlat, O. Yazgan, The effects of organic chromium supplementation on production traits and some serum parameters of laying, Quails. Rev. Med. Vet., 155 (2004) 642.
• N. Kleefstra, H. Bilo, S. Bakker, S. Houweling, Chroom en insulineresistentie, Ned. Tijdschr. Geneeskd., 148 (2004) 217.
• J. Vincent, Recent advances in the nutritional biochemistry of trivalent chromium, Proc.Nutr. Soc., 63 (2004) 41.
• R. Anderson, M. Polansky, N. Bryden, K. Patterson, C. Veillon, W. Glinsmann, Effects of chromium supplementation on urinary Cr excretion of human subjects and correlation of Cr excretion with selected clinical parameters, J. Nutr., 113 (1983) 276.
• P. Sakas, Essentials of Avian Medicine: A Practitioner’s Guide 2nd Edition, AAHA Press., (2002).
• E. Hernawan, S. Wahyuni, H. Suprapti, The levels of blood glucose, trygliceride, final body weight and abdominal fat percentage of broiler under sex- separated and straight run rearing system, Lucrări Ştiinăifice-Seria Zootehnie, 57 (2012) 28.
• S. Ukashatu, A. Bello, M. Umaru, J. Onu, A. Shehu, A. Mahmuda, B. Saidu, A study of some serum biochemical values of Japanese quails (Coturnix coturnix japonica) fed graded levels of energy diets in Northwestern Nigeria, Sci. J. Micro., 3 (2014) 1.
• R. Sokoll, M. Gesek, M. Ras-Norynska, M. Michalczyk, S. Koziatek, Biochemical parameters in Japanese quails Coturnix coturnix japonica infected with coccidia and treated with Toltrazuril, Pol. J. Vet. Sci., 18 (2015) 79.
• T. Ozawa, A. Hanaki, Spin-trapping studies on the reactions of Cr(III) with hydrogen peroxide in the presence of biological reductants: is Cr(III) non-toxic?, Int. J. Biochem., 22 (1990) 343.
• I. Kat, J. Vogelman, V. Dilman, J. Karkoszka, K. Frenkel, N. Durr, P. Toniolo, Effect of supplementation with chromium picolinate on antibody titers to 5— hydroxymethyl uracil, Eur. J. Epidemiol., 14 (1998) 621
• N. Tonks, PTP1B: From the sidelines to the front lines FEBS, Letters, 546 (2003) 140.
• A. Dayan, A. Paine, Mechanisms of chromium toxicity, carcinogenicity and allerginicity: Review of the literature from 1985 to 2000, Hum. Exp. Toxicol., 20 (2001) 439.
• G. De Mattia, M.C. Bravi, O. Laurenti, O. De Luca, A. Palmeri, A. Sabatucci, G. Mendico, A. Ghiselli, Impairment of cell and plasma redox state in subjects professionally exposed to chromium, Am. J. Ind. Med., 46 (2004) 120.
• K. Sugden, D. Stearns, The role of chromium (V) in the mechanism of chromate-induced oxidative DNA damage and cancer, J. Environ. Pathol. Toxicol. Oncol., 19 (1999) 215.
• B.K. Sharma, P.C. Singhal, K.S. Chugh, Intravascular haemolysis and acute renal failure following potassium dichromate poisoning, Postgrad. Med. J., 54 (1978) 414
• Y. Loubieres, A. de Lassence, M. Bernier, A. Vieillard- Baron, J. M. Schmitt, B. Page, F. Jardin, Acute, fatal, oral chromic acid poisoning, J. Toxicol. Clin. Toxicol., 37 (1999) 333.
• M. Myslak, K. Kosmider, Kinetics of cell division in peripheral blood lymphocytes of stainless steel welders, Medycyna Pracy, 48 (1997) 261.
• S. Richa, R.K. Upreti, P.K. Seth, U.C. Chaturvedi, Effects of chromium on the immune system, FEMS Immunol. Med. Microbiol., 34 (2002) 1.
• P. Borella, S. Manni, A. Giardino, Cadmium, nickel, chromium and lead accumulate in human lymphocytes and interfere with PHA-induced proliferation. Journal of trace elements and electrolytes in health and disease, J. Trace. Elem. Electrolytes. Health. Dis. 4 (1990) 87.
• C. Faleiro, I. Godinho, U. Reus, M. de Sousa, Cobalt- chromium-molybdenum but not titanium-6aluminium- 4vanadium al-loy discs inhibit human T cell activation in vitro, Biometals, 9 (1996) 321.
• J.Y. Wang, B.H. Wicklund, R.B. Gustilo, D.T. Tsukayama, Prosthetic metals impair murine immune response and cytokine release in vivo and in vitro, J. Orthop. Res., 15 (1997) 688.
• B. Yucesoy, S. Mirshahidi, C. Yucesoy, A. Karakaya, In vitro effects of various metals on natural killer cell activity in cultured human lymphocytes. Immunopharmacol. Immunotoxicol., 21 (1999) 599.