Klinik Araştırma
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BİR ARAŞTIRMA HASTANESİNDE GÖRÜLEN TRANSFÜZYON REAKSİYONLARININ DEĞERLENDİRİLMESİ

Yıl 2025, Cilt: 5 Sayı: 3, 83 - 88, 25.12.2025
https://doi.org/10.58961/hmj.1757128

Öz

Amaç: Çalışmanın amacı, hemovijilans kapsamında kan/kan bileşeni transfüzyonu yapılan hastalarda transfüzyona bağlı advers reaksiyonların sıklığını ve tiplerini belirlemek ve bunların pandemi sırasındaki dağılımı hakkında veri elde etmektir.
Gereç ve Yöntemler: Hemovijilans sistemi kapsamında izlenen kan/kan ürünü transfüzyonlarına ilişkin veriler retrospektif olarak incelendi Çalışmada, transfüzyona bağlı advers reaksiyon gelişen hastaların sosyodemografik özellikleri, transfüzyon sırasında advers reaksiyon gelişen kan ve kan bileşenleri, transfüzyona bağlı advers reaksiyonlar ve bunların ilişki ve şiddet dereceleri değerlendirildi.
Bulgular: Transfüzyon merkezinde 17533 kan ve kan bileşeni transfüzyonunda 73 (420/100000) transfüzyona bağlı advers reaksiyon tespit edildi. Reaksiyonlar en sık göğüs hastalıkları uzmanları tarafından uygulanan transfüzyonlarda ve yataklı tedavi ünitelerinde görülürken, reaksiyonların %17,8'i acil servis transfüzyon uygulamaları sırasında gözlendi. Tespit edilen transfüzyon reaksiyonlarının ilişki derecesi 1-3 aralığında, reaksiyon şiddeti derecesi ise 1-2 aralığındaydı. Transfüzyonla ilişkili tüm advers reaksiyonlar akuttu. En sık görülen transfüzyon reaksiyonu trombosit transfüzyonları sırasında gözlendi.
Sonuç: Covid -19 pandemisi istenmeyen transfüzyon reaksiyonlarının hemovijilansı verileri, transfüzyon güvenlik önlemlerinin planlanmasında hasta güvenliği uygulamaları için bir rehber olarak kullanılabilecek katkılar sağlayacaktır.

Kaynakça

  • Turkish Society of Hematology, Effects of SARS-CoV-2 pandemic on competence and reliability in blood transfusion blood banking, transfusion medicine and hemapheresis BAK. [Internet]. Turkish society of hematology; 2020 [cited 2023 Apr 20]. Available from:https://www.thd.org.tr/thdData/userfiles/file/SARS-COV-2%20PANDEMI%CC%87SI%CC%87NI%CC%87N%20KAN%20TRANSFU%CC%88ZYONUNDA%20YETERLI%CC%87LI%CC%87K%20VE%20GU%CC%88VENI%CC%87RLI%CC%87K%20U%CC%88ZERI%CC%87NE%20ETKI%CC%87LERI%CC%87%20-%20SON.pdf
  • Hernández-Maraver D, Viejo A, Kerguelén AE, Jiménez-Yuste V. Transfusion medicine during COVID-19 outbreak in the hotspot of Spain. Transfusion. 2020;60(11):2762-4. doi: 10.1111/trf.16038
  • Ertuğrul Örüç E, Yenicesu I, Öztürk A, et al. National hemovigilance guide. [Internet]. T.C. Sağlık Bakanlığı; 2020 [cited 2023 Dec 20]. Available from: https://dosyamerkez.saglik.gov.tr/Eklenti/37016/0/ulusal-hemovijilans-rehberi-versiyon-2pdf.pdf
  • Ackfeld T, Schmutz T, Guechi Y, Le Terrier C. Blood transfusion reactions: A comprehensive review of the literature including a Swiss perspective. J clin med. 2022; 11(10):2859. Published 2022 May 19. doi:10.3390/jcm11102859
  • Suddock JT, Crookston KP. Transfusion reactions. [Internet]. National library of medicine; 2020 [cited 2023 Apr 20]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482202/
  • Carson JL, Guyatt G, Heddle NM, Grossman BJ, Cohn CS, Fung MK, et al. Clinical practice guidelines from the aabb: red blood cell transfusion thresholds and storage. JAMA. 2016;316(19):2025-35. doi:10.1001/jama.2016.9185
  • Gürbüz H, Zengin Y, Gündüz E, Durgun HM, Dursun R, İçer M et al. Evaluation of blood and blood product transfusions performed in the emergency department of dicle university faculty of medicine research hospital. EJSSH 2021;8(16):36–48. doi:10.38065/euroasiaorg.578
  • Kar YD, Yıldırgan DO, Aygun B, Erdoğmus D, Altınkaynak K. Retrospective evaluation of acute transfusion reactions in a tertiary hospital in Erzurum, Turkey. North Clin Istanb. 2021;8(3):261-8. Published 2021 May 24. doi:10.14744/nci.2020.76258
  • Bulter R, Doğan N, Haemovigilance annual report. [Internet]. Swissmedic; 2020 [cited 2023 Apr 20]. Available from: https://www.swissmedic.ch/swissmedic/fr/home/humanarzneimittel/marktueberwachung/haemovigilance/haemovigilance-publications-events/haemovigilance-report-2020.html
  • Harvey AR, Basavaraju SV, Chung KW, Kuenert MJ. Transfusion-related adverse reactions reported to the national healthcare safety network hemovigilance module, united states, 2010 to 2012. Transfusion. 2015; 55(4):709-18. doi:10.1111/trf.12918
  • Kracalik I, Mowla S, Basavaraju SV, Sapiano MRP. Transfusion-related adverse reactions: data from the national healthcare safety network hemovigilance module - united states, 2013-2018. Transfusion. 2021;61(5):1424-34. doi:10.1111/trf.16362
  • Bloch EM, Shoham S, Casadevall A, Sachais BS, Shaz B, Winters JL, et al. Deployment of convalescent plasma for the prevention and treatment of covid-19. J Clin Invest. 2020;130(6):2757-65. doi:10.1172/JCI138745
  • Hırçın Cenger D, Yenice Aktaş S, İleri Fikri B, Kutbay H, Albayrak MD, Altın S. Evaluation of patients who were administered immune plasma due to covid-19 infection in an educational and research hospital. Med J SDU. 2022; 29(2): 229-36. doi:10.17343/sdutfd.1006069
  • 18 eme rapport national d’hémovigilance. [Internet]. Agence nationale de sécurité du médicament et des produits de santé; 2021 [cited 2023 Apr 20]. Available from: https://ansm.sante.fr/uploads/2021/12/08/20211208-rapport-hemovigilance-2020-vf.pdf;
  • Atik B, Atik TK, Duran H, Baykan O, Ersal T, Avci E, et al. Erythrocyte autoantibody positivity in serological cross-matching. J coll physicians surg pak. 2020;30(5):485-9. doi:10.29271/jcpsp.2020.05.485
  • Barriteau CM, Bochey P, Lindholm PF, Hartman K, Sumugod R, Ramsey G. Blood transfusion utilization in hospitalized COVID-19 patients. transfusion. 2020;60(9):1919-23. doi:10.1111/trf.15947
  • Pagano MB, Hess JR, Tsang HC, Staley E, Gernsheimer T, Sen N, et al. Prepare to adapt: blood supply and transfusion support during the first 2 weeks of the 2019 novel coronavirus (COVID-19) pandemic affecting Washington State. Transfusion. 2020;60(5):908-11. doi:10.1111/trf.15789

EVALUATION OF TRANSFUSION REACTIONS OBSERVED IN A RESEARCH HOSPITAL

Yıl 2025, Cilt: 5 Sayı: 3, 83 - 88, 25.12.2025
https://doi.org/10.58961/hmj.1757128

Öz

Objective: The aim of the study was to determine the frequency and types of transfusion-related adverse reactions in patients receiving blood/blood component transfusions as part of hemovigilance and to obtain data on their distribution during the pandemic.
Materials and Methods: Data on blood/blood component transfusions monitored within the hemovigilance system were retrospectively analyzed to evaluate the sociodemographic characteristics of patients with transfusion-related adverse reactions, blood and blood components that developed adverse reactions during transfusion, transfusion-related adverse reactions and their association and severity ratings.
Results: At the transfusion center, 73 (420/100000) transfusion-related adverse reactions were detected in 17533 blood and blood component transfusions. Reactions were most frequent in transfusions administered by pulmonologists and in inpatient units, but 17.8% of the reactions were observed in emergency room transfusion practices. The degree of association of the transfusion reactions observed ranged from 1 to 3, and the degree of severity ranged from 1 to 2. All transfusion-related adverse events were acute. The most common transfusion reaction was observed with platelet transfusions.
Conclusions: Covid-19 pandemic hemovigilance of adverse transfusion reactions data can be used as a guide for patient safety practice for planning transfusion safety measures will contribute.

Etik Beyan

Ethics committee approval of the study was obtained from the Ethics Committee of Istanbul Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital on 10/02/2022 with decision number 2022-190.

Destekleyen Kurum

There is no.

Kaynakça

  • Turkish Society of Hematology, Effects of SARS-CoV-2 pandemic on competence and reliability in blood transfusion blood banking, transfusion medicine and hemapheresis BAK. [Internet]. Turkish society of hematology; 2020 [cited 2023 Apr 20]. Available from:https://www.thd.org.tr/thdData/userfiles/file/SARS-COV-2%20PANDEMI%CC%87SI%CC%87NI%CC%87N%20KAN%20TRANSFU%CC%88ZYONUNDA%20YETERLI%CC%87LI%CC%87K%20VE%20GU%CC%88VENI%CC%87RLI%CC%87K%20U%CC%88ZERI%CC%87NE%20ETKI%CC%87LERI%CC%87%20-%20SON.pdf
  • Hernández-Maraver D, Viejo A, Kerguelén AE, Jiménez-Yuste V. Transfusion medicine during COVID-19 outbreak in the hotspot of Spain. Transfusion. 2020;60(11):2762-4. doi: 10.1111/trf.16038
  • Ertuğrul Örüç E, Yenicesu I, Öztürk A, et al. National hemovigilance guide. [Internet]. T.C. Sağlık Bakanlığı; 2020 [cited 2023 Dec 20]. Available from: https://dosyamerkez.saglik.gov.tr/Eklenti/37016/0/ulusal-hemovijilans-rehberi-versiyon-2pdf.pdf
  • Ackfeld T, Schmutz T, Guechi Y, Le Terrier C. Blood transfusion reactions: A comprehensive review of the literature including a Swiss perspective. J clin med. 2022; 11(10):2859. Published 2022 May 19. doi:10.3390/jcm11102859
  • Suddock JT, Crookston KP. Transfusion reactions. [Internet]. National library of medicine; 2020 [cited 2023 Apr 20]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482202/
  • Carson JL, Guyatt G, Heddle NM, Grossman BJ, Cohn CS, Fung MK, et al. Clinical practice guidelines from the aabb: red blood cell transfusion thresholds and storage. JAMA. 2016;316(19):2025-35. doi:10.1001/jama.2016.9185
  • Gürbüz H, Zengin Y, Gündüz E, Durgun HM, Dursun R, İçer M et al. Evaluation of blood and blood product transfusions performed in the emergency department of dicle university faculty of medicine research hospital. EJSSH 2021;8(16):36–48. doi:10.38065/euroasiaorg.578
  • Kar YD, Yıldırgan DO, Aygun B, Erdoğmus D, Altınkaynak K. Retrospective evaluation of acute transfusion reactions in a tertiary hospital in Erzurum, Turkey. North Clin Istanb. 2021;8(3):261-8. Published 2021 May 24. doi:10.14744/nci.2020.76258
  • Bulter R, Doğan N, Haemovigilance annual report. [Internet]. Swissmedic; 2020 [cited 2023 Apr 20]. Available from: https://www.swissmedic.ch/swissmedic/fr/home/humanarzneimittel/marktueberwachung/haemovigilance/haemovigilance-publications-events/haemovigilance-report-2020.html
  • Harvey AR, Basavaraju SV, Chung KW, Kuenert MJ. Transfusion-related adverse reactions reported to the national healthcare safety network hemovigilance module, united states, 2010 to 2012. Transfusion. 2015; 55(4):709-18. doi:10.1111/trf.12918
  • Kracalik I, Mowla S, Basavaraju SV, Sapiano MRP. Transfusion-related adverse reactions: data from the national healthcare safety network hemovigilance module - united states, 2013-2018. Transfusion. 2021;61(5):1424-34. doi:10.1111/trf.16362
  • Bloch EM, Shoham S, Casadevall A, Sachais BS, Shaz B, Winters JL, et al. Deployment of convalescent plasma for the prevention and treatment of covid-19. J Clin Invest. 2020;130(6):2757-65. doi:10.1172/JCI138745
  • Hırçın Cenger D, Yenice Aktaş S, İleri Fikri B, Kutbay H, Albayrak MD, Altın S. Evaluation of patients who were administered immune plasma due to covid-19 infection in an educational and research hospital. Med J SDU. 2022; 29(2): 229-36. doi:10.17343/sdutfd.1006069
  • 18 eme rapport national d’hémovigilance. [Internet]. Agence nationale de sécurité du médicament et des produits de santé; 2021 [cited 2023 Apr 20]. Available from: https://ansm.sante.fr/uploads/2021/12/08/20211208-rapport-hemovigilance-2020-vf.pdf;
  • Atik B, Atik TK, Duran H, Baykan O, Ersal T, Avci E, et al. Erythrocyte autoantibody positivity in serological cross-matching. J coll physicians surg pak. 2020;30(5):485-9. doi:10.29271/jcpsp.2020.05.485
  • Barriteau CM, Bochey P, Lindholm PF, Hartman K, Sumugod R, Ramsey G. Blood transfusion utilization in hospitalized COVID-19 patients. transfusion. 2020;60(9):1919-23. doi:10.1111/trf.15947
  • Pagano MB, Hess JR, Tsang HC, Staley E, Gernsheimer T, Sen N, et al. Prepare to adapt: blood supply and transfusion support during the first 2 weeks of the 2019 novel coronavirus (COVID-19) pandemic affecting Washington State. Transfusion. 2020;60(5):908-11. doi:10.1111/trf.15789
Toplam 17 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri (Diğer)
Bölüm Klinik Araştırma
Yazarlar

Derya Hırçın Cenger 0000-0003-1470-1783

Sevinç Yenice Aktaş 0000-0003-0877-9162

Gönderilme Tarihi 2 Ağustos 2025
Kabul Tarihi 8 Eylül 2025
Yayımlanma Tarihi 25 Aralık 2025
Yayımlandığı Sayı Yıl 2025 Cilt: 5 Sayı: 3

Kaynak Göster

Vancouver Hırçın Cenger D, Yenice Aktaş S. EVALUATION OF TRANSFUSION REACTIONS OBSERVED IN A RESEARCH HOSPITAL. HTD / HMJ. 2025;5(3):83-8.

e-ISSN: 2791-9935