Klinik Araştırma
BibTex RIS Kaynak Göster

Arrhythmia Incidence and Risk Factors in Adult Critically Ill Patients in Intensive Care Unit

Yıl 2025, Cilt: 5 Sayı: 2, 59 - 67, 29.08.2025

Öz

Introduction: Cardiac arrhythmias may be observed at critically ill patients during intensive care unit (ICU) stay, and this condition may negatively affect the prognosis. In our study, we aimed to evaluate the incidence and risk factors of arrhythmias occurring in critically ill patients being treated in the ICU.
Materials and Methods: The study included critically ill patients over the age of 18, who were receiving mechanical ventilation (MV), had at least one organ failure, but had no history of valvular hearth disease, cardiac surgery within the past 6 months, or myocardial infarction (MI). Demographic, hemodynamic and laboratory parameters, acute physiology and chronic health evaluation (APACHE) II score, ICU practices and treatments (tracheostomy, central venous catheter, inotrophic and vasoactive drugs. etc), diagnoses of sepsis, AKI (acute kidney injury), MI, and ventilator-associated pneumonia (VAP) during ICU stay, duration of ICU and hospital stay, and outcome of ICU treatment were recorded. In patients who developed arrhythmia, an electrocardiography was performed. During arrhythmia episode, hemodynamic and laboratory parameters, the use of inotropic and vasoactive drug, the presence of diagnosis such as sepsis, AKI, MI and pneumonia as well as treatments applied for arrhythmia and their outcome were recorded.
Results: The study included 214 patients, among whom 56 (26.1%) developed arrhythmia. Arrytmia incidence in females (55.5%) were higher than male patients (44.6%) (p=0.045). Arrhythmic patients were older (p<0.001), had higher APACHE II scores (p=0.001), and were more frequently admitted to the ICU with a diagnosis of CVE (cerebrovascular event) and trauma (p=0.021, p=0.032, respectively) compared to non-arrhythmic patients. Furthermore, a higher incidence of arrhythmia was observed in patients who developed VAP and sepsis during ICU stay (p<0.001, p<0.001 respectively). The most frequently observed type of arrhythmia was atrial fibrillation (53%).
Conclusion: Older age, higher APACHE II score, CVE, trauma, VAP and sepsis increases arrhytmia risk in adult critically ill patients.

Kaynakça

  • Gordon P, Kerton M. Cardiac arrhythmias in the critically ill. Anaesthesia & Intensive Care Medicine. 2021; 22(5), 301-12.
  • Goodman S, Shirov T, Weissman C. Supraventricular arrhythmias in intensive care unit patients: short and long-term consequences. Anesth Analg. 2007;104(4):880-6.
  • ​Yong-li Z, Feng H, Yan-zong Y. Clinical characteristics and mortality of patients in the intensive care unit with and without new-arrhythmias. Signa Vitae. 2017; 13(2): 20-4.
  • Perry TW, Pugh MJ, Waterer GW, Nakashima B, Orihuela CJ, Copeland LA, et al. Incidence of cardiovascular events after hospital admission for pneumonia. Am J Med. 2011;124(3):244-51.
  • Seguin P, Laviolle B, Maurice A, Leclercq C, Malledant Y. Atrial fibrillation in trauma patients requiring intensive care. Care Med. 2006;32(3):398-404.
  • Yoshida T, Fujii T, Uchino S, Takinami M. Epidemiology, prevention, and treatment of new-onset atrial fibrillation in critically ill: a systematic review. J Intensive Care. 2015;3(1):19.
  • Valderrabano RJ, Blanco A, Santiago-Rodriguez EJ, Miranda C, Rivera-Del Rio Del Rio J, Ruiz J, et al. Risk factors and clinical outcomes of arrhythmias in the medical intensive care unit. J Intensive Care. 2016;4:9.
  • Kanji S, Williamson DR, Yaghchi BM, Albert M, McIntyre L. Epidemiology and management of atrial fibrillation in medical and noncardiac surgical adult intensive care unit patients. J Crit Care. 2012;27(3):326.e1-8.
  • Schwartz A, Brotfain E, Koyfman L, Klein M. Cardiac arrhythmias in a septic ICU population: A review. J Crit Care Med (Targu Mures). 2015;1(4):140-6.
  • Wetterslev M, Hylander Møller M, Granholm A, Hassager C, Haase N, Lange T, et al; AFIB-ICU Collaborators. Atrial fibrillation (AFIB) in the ICU: Incidence, risk factors, and outcomes: The International AFIB-ICU Cohort Study. Crit Care Med. 2023;51(9):1124-37.
  • Bedford JP, Harford M, Petrinic T, Young JD, Watkinson PJ. Risk factors for new-onset atrial fibrillation on the general adult ICU: A systematic review. J Crit Care. 2019;53:169-75.
  • Rottmann FA, Abraham H, Welte T, Westermann L, Bemtgen X, Gauchel N. Atrial fibrillation and survival on a medical intensive care unit. Int J Cardiol. 2024;399:131673.
  • Chen AY, Sokol SS, Kress JP, Lat I. New-onset atrial fibrillation is an independent predictor of mortality in medical intensive care unit patients. Ann Pharmacother. 2015;49(5):523-7.
  • Wu Z, Fang J, Wang Y, Chen F. Prevalence, outcomes, and risk factors of new-onset atrial fibrillation in critically ill patients. Int Heart J. 2020;61(3):476-85.
  • Bosch NA, Cimini J, Walkey AJ. Atrial fibrillation in the ICU. Chest. 2018;154(6):1424-34.
  • Dernellis J, Panaretou M. Effects of C-reactive protein and the third and fourth components of complement (C3 and C4) on incidence of atrial fibrillation. Am J Cardiol. 2006;97(2):245-8.
  • Buckley BJR, Harrison SL, Hill A, Underhill P, Lane DA, Lip GYH. Stroke-Heart Syndrome: Incidence and clinical outcomes of cardiac complications following stroke. Stroke. 2022;53(5):1759-63.
  • Long B, Brady WJ, Gottlieb M. Emergency medicine updates: Atrial fibrillation with rapid ventricular response. Am J Emerg Med. 2023;74:57-64.
  • Seiffge DJ, Cancelloni V, Räber L, Paciaroni M, Metzner A, Kirchhof P, et al. Secondary stroke prevention in people with atrial fibrillation: treatments and trials. Lancet Neurol. 2024;23(4):404-17.
  • Elsheikh S, Hill A, Irving G, Lip GYH, Abdul-Rahim AH. Atrial fibrillation and stroke: State-of-the-art and future directions. Curr Probl Cardiol. 2024;49(1 Pt C):102181.
  • Buiten MS, de Bie MK, Rotmans JI, Gabreels BA, van Dorp W, Wolterbeek R, et al. The dialysis procedure as a trigger for atrial fibrillation: new insights in the development of atrial fibrillation in dialysis patients. Heart. 2014;100(9):685-90.
  • Tapoi L, Ureche C, Sascau R, Badarau S, Covic A. Atrial fibrillation and chronic kidney disease conundrum: an update. J Nephrol. 2019;32(6):909-17.
  • Tanaka A, Inaguma D, Shinjo H, Takeda A. Incidence rate of atrial fibrillation after dialysis initiation and its relationship with cardiovascular events. Acta Cardiol. 2019;74(6):527-535.
  • Joglar JA, Chung MK, Armbruster AL, Benjamin EJ, Chyou JY, Cronin EM, et al: Peer Review Committee Members. 2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Fibrillation: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2024;149(1):e1-e156.
  • Drikite L, Bedford JP, O'Bryan L, Petrinic T, Rajappan K, Doidge J, et al. Treatment strategies for new onset atrial fibrillation in patients treated on an intensive care unit: a systematic scoping review. Crit Care. 2021;25(1):257.
  • Johnston BW, Chean CS, Duarte R, Hill R, Blackwood B, McAuley DF, Welters ID. Management of new onset atrial fibrillation in critically unwell adult patients: a systematic review and narrative synthesis. Br J Anaesth. 2022;128(5):759-71.
  • Chyou JY, Barkoudah E, Dukes JW, Goldstein LB, Joglar JA, Lee AM, et al. Atrial fibrillation occurring during acute hospitalization: A scientific statemenfrom the American Heart Association. Circulation. 2023;147(15):e676-e698.

Yoğun Bakım Ünitesinde Yetişkin Kritik Hastalarda Aritmi İnsidansı ve Risk Faktörleri

Yıl 2025, Cilt: 5 Sayı: 2, 59 - 67, 29.08.2025

Öz

Amaç: Kritik hastalarda yoğun bakımda (YB) yatışları döneminde kardiyak aritmiler gözlenebilmekte ve bu durum prognozu olumsuz etkileyebilmektedir. Çalışmamızda YB’de tedavi edilmekte olan kritik hastalarda aritmi insidansını ve risk faktörlerini araştırmayı amaçladık.
Gereç ve Yöntemler: Çalışmaya mekanik ventilasyon (MV) uygulanan, en az bir organ yetmezliği olan 18 yaş üzeri, kalp kapak hastalığı ve 6 ay içinde geçirilmiş kardiyak cerrahi ya da miyokard infarktüsü (MI) öyküsü bulunmayan kritik hastalar dahil edildi. Demografik, hemodinamik ve laboratuvar parametreleri, akut fizyoloji ve kronik sağlık değerlendirmesi (APACHE) II skorları, YB’deki tıbbi uygulamalar-tedaviler (trakeostomi, santral venöz kateter, inotropik ve vazoaktif ilaç vs.), YB tedavi döneminde gelişen tanılar (sepsis, AKI: akut böbrek hasarı, MI ve ventilatörle ilişkili pnömoni: VAP), YB ve hastanede yatış süreleri ile YB tedavi sonucu kayıt edildi. Kardiyak aritmi gelişen hastalardan aritmi sırasında EKG çekildi. Aritmi geliştiği andaki hemodinamik parametreler, laboratuar verileri, inotropik ve vazoaktif ilaç kullanımları, sepsis, ARY, MI ve pnömoni tanılarının varlığı, aritmi için uygulanan tedaviler ve sonuçları kayıt edildi.
Bulgular: Çalışmaya 214 hasta dahil edildi. Hastaların 56'sında (%26,1) aritmi gelişti. Kadınlarda aritmi insidansı (%55.4), erkeklerden (%44.6) yüksekti (p=0.045). Aritmili hastalar, olmayanlara göre daha yaşlı (p<0,001), APACHE II skorları daha yüksek (p=0,001), serebrovasküler olay (SVO) (p=0,021) ve travma (p=0,032) tanısı ile YB yatış daha fazla idi. Ayrıca YB’de tedavi sırasında VAP (p<0,001) ve sepsis gelişenlerde (p<0,001) daha fazla aritmi saptanmıştı. Atriyal fibrilasyon en sık görülen aritmi türüydü (%53).
Sonuç: İleri yaş, yüksek APACHE II skoru, SVO, travma, VAP ve sepsis erişkin kritik hastalarda aritmi riskini artırmaktadır.

Kaynakça

  • Gordon P, Kerton M. Cardiac arrhythmias in the critically ill. Anaesthesia & Intensive Care Medicine. 2021; 22(5), 301-12.
  • Goodman S, Shirov T, Weissman C. Supraventricular arrhythmias in intensive care unit patients: short and long-term consequences. Anesth Analg. 2007;104(4):880-6.
  • ​Yong-li Z, Feng H, Yan-zong Y. Clinical characteristics and mortality of patients in the intensive care unit with and without new-arrhythmias. Signa Vitae. 2017; 13(2): 20-4.
  • Perry TW, Pugh MJ, Waterer GW, Nakashima B, Orihuela CJ, Copeland LA, et al. Incidence of cardiovascular events after hospital admission for pneumonia. Am J Med. 2011;124(3):244-51.
  • Seguin P, Laviolle B, Maurice A, Leclercq C, Malledant Y. Atrial fibrillation in trauma patients requiring intensive care. Care Med. 2006;32(3):398-404.
  • Yoshida T, Fujii T, Uchino S, Takinami M. Epidemiology, prevention, and treatment of new-onset atrial fibrillation in critically ill: a systematic review. J Intensive Care. 2015;3(1):19.
  • Valderrabano RJ, Blanco A, Santiago-Rodriguez EJ, Miranda C, Rivera-Del Rio Del Rio J, Ruiz J, et al. Risk factors and clinical outcomes of arrhythmias in the medical intensive care unit. J Intensive Care. 2016;4:9.
  • Kanji S, Williamson DR, Yaghchi BM, Albert M, McIntyre L. Epidemiology and management of atrial fibrillation in medical and noncardiac surgical adult intensive care unit patients. J Crit Care. 2012;27(3):326.e1-8.
  • Schwartz A, Brotfain E, Koyfman L, Klein M. Cardiac arrhythmias in a septic ICU population: A review. J Crit Care Med (Targu Mures). 2015;1(4):140-6.
  • Wetterslev M, Hylander Møller M, Granholm A, Hassager C, Haase N, Lange T, et al; AFIB-ICU Collaborators. Atrial fibrillation (AFIB) in the ICU: Incidence, risk factors, and outcomes: The International AFIB-ICU Cohort Study. Crit Care Med. 2023;51(9):1124-37.
  • Bedford JP, Harford M, Petrinic T, Young JD, Watkinson PJ. Risk factors for new-onset atrial fibrillation on the general adult ICU: A systematic review. J Crit Care. 2019;53:169-75.
  • Rottmann FA, Abraham H, Welte T, Westermann L, Bemtgen X, Gauchel N. Atrial fibrillation and survival on a medical intensive care unit. Int J Cardiol. 2024;399:131673.
  • Chen AY, Sokol SS, Kress JP, Lat I. New-onset atrial fibrillation is an independent predictor of mortality in medical intensive care unit patients. Ann Pharmacother. 2015;49(5):523-7.
  • Wu Z, Fang J, Wang Y, Chen F. Prevalence, outcomes, and risk factors of new-onset atrial fibrillation in critically ill patients. Int Heart J. 2020;61(3):476-85.
  • Bosch NA, Cimini J, Walkey AJ. Atrial fibrillation in the ICU. Chest. 2018;154(6):1424-34.
  • Dernellis J, Panaretou M. Effects of C-reactive protein and the third and fourth components of complement (C3 and C4) on incidence of atrial fibrillation. Am J Cardiol. 2006;97(2):245-8.
  • Buckley BJR, Harrison SL, Hill A, Underhill P, Lane DA, Lip GYH. Stroke-Heart Syndrome: Incidence and clinical outcomes of cardiac complications following stroke. Stroke. 2022;53(5):1759-63.
  • Long B, Brady WJ, Gottlieb M. Emergency medicine updates: Atrial fibrillation with rapid ventricular response. Am J Emerg Med. 2023;74:57-64.
  • Seiffge DJ, Cancelloni V, Räber L, Paciaroni M, Metzner A, Kirchhof P, et al. Secondary stroke prevention in people with atrial fibrillation: treatments and trials. Lancet Neurol. 2024;23(4):404-17.
  • Elsheikh S, Hill A, Irving G, Lip GYH, Abdul-Rahim AH. Atrial fibrillation and stroke: State-of-the-art and future directions. Curr Probl Cardiol. 2024;49(1 Pt C):102181.
  • Buiten MS, de Bie MK, Rotmans JI, Gabreels BA, van Dorp W, Wolterbeek R, et al. The dialysis procedure as a trigger for atrial fibrillation: new insights in the development of atrial fibrillation in dialysis patients. Heart. 2014;100(9):685-90.
  • Tapoi L, Ureche C, Sascau R, Badarau S, Covic A. Atrial fibrillation and chronic kidney disease conundrum: an update. J Nephrol. 2019;32(6):909-17.
  • Tanaka A, Inaguma D, Shinjo H, Takeda A. Incidence rate of atrial fibrillation after dialysis initiation and its relationship with cardiovascular events. Acta Cardiol. 2019;74(6):527-535.
  • Joglar JA, Chung MK, Armbruster AL, Benjamin EJ, Chyou JY, Cronin EM, et al: Peer Review Committee Members. 2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Fibrillation: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2024;149(1):e1-e156.
  • Drikite L, Bedford JP, O'Bryan L, Petrinic T, Rajappan K, Doidge J, et al. Treatment strategies for new onset atrial fibrillation in patients treated on an intensive care unit: a systematic scoping review. Crit Care. 2021;25(1):257.
  • Johnston BW, Chean CS, Duarte R, Hill R, Blackwood B, McAuley DF, Welters ID. Management of new onset atrial fibrillation in critically unwell adult patients: a systematic review and narrative synthesis. Br J Anaesth. 2022;128(5):759-71.
  • Chyou JY, Barkoudah E, Dukes JW, Goldstein LB, Joglar JA, Lee AM, et al. Atrial fibrillation occurring during acute hospitalization: A scientific statemenfrom the American Heart Association. Circulation. 2023;147(15):e676-e698.
Toplam 27 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Yoğun Bakım
Bölüm Araştırma Makaleleri
Yazarlar

Gülnihal Aykut 0000-0001-5280-9843

Elif Ayşe Çizmeci 0000-0003-4910-7602

Nermin Kelebek Girgin 0000-0002-5882-1632

Aysel Kaderli Aydın 0009-0007-7215-5777

Remzi Iscimen 0000-0001-8111-5958

Ferda Şöhret Kahveci 0000-0003-4820-2288

Ali Aydınlar 0000-0002-8974-8837

Yayımlanma Tarihi 29 Ağustos 2025
Gönderilme Tarihi 21 Haziran 2025
Kabul Tarihi 22 Temmuz 2025
Yayımlandığı Sayı Yıl 2025 Cilt: 5 Sayı: 2

Kaynak Göster

Vancouver Aykut G, Çizmeci EA, Kelebek Girgin N, Kaderli Aydın A, Iscimen R, Kahveci FŞ, vd. Arrhythmia Incidence and Risk Factors in Adult Critically Ill Patients in Intensive Care Unit. HTD / HMJ. 2025;5(2):59-67.

e-ISSN: 2791-9935