Reproducibility of choroidal thickness measurements in hemodialysis patients: A spectral domain optical coherence tomography study

Mehmet Murat Uzel; Özgür Eroğul; Leyla Eryiğit Eroğul; Ayşe Güzin Taşlıpınar Uzel; Avşin İbiş; Hamidu Hamisi Gobeka

Reproducibility of choroidal thickness measurements in hemodialysis patients: A spectral domain optical coherence tomography study

Öz

Aside from general body fluid fluctuation, hemodialysis (HD) may cause changes in ocular fluid balance, resulting in changes in subfoveal choroidal thickness (SFCT) and other ocular parameters. As a result, the purpose of this study was to investigate the effects of hemodialysis on the reproducibility of SFCT measured by spectral domain-optical coherence tomography (SD-OCT). Twenty-six HD (26 eyes) patients had their pre- and post-HD SFCT measured, and the results were compared for reproducibility. Following a thorough ophthalmic examination, SD-OCT was performed three times in a row during a single session. The same physician measured SFCT after automatically identifying choroid with a software caliper. Reproducibility parameters, including intra-class correlation coefficients (ICCs), coefficients of variation (COV), and test-retest variability (TRTV) were then calculated. Males made up 53.85% of the 26 HD patients. There was a significant IOP difference between pre-HD (16.42±3.14 mmHg) and post-HD (14.21±2.78 mmHg) (P<0.001). SFCT decreased significantly from pre-HD 243.50±10.23 μm to post-HD 234.29±9.41 μm (P<0.001). ICC value increased significantly after HD, rising from 0.948 to 0.989 (P<0.001, for all). Pre- and post-HD COV values were 1.6% and 0.65%, respectively. Also, pre- and post-HD TRTV values were 7.864±1.996 μm and 3.074±1.536 μm, respectively. In this study, the reproducibility of SFCT as measured by OCT was lower during pre-HD compared to post-HD. Post-HD SD-OCT assessment appears to improve the reliability of clinical outcomes in the diagnosis and monitoring of HD patients.

Anahtar Kelimeler

Kaynakça

1. Chelala E, Dirani A, Fadlallah A, Slim E, Abdelmassih Y, Fakhoury H, et al. Effect of hemodialysis on visual acuity, intraocular pressure, and macular thickness in patients with chronic kidney disease. Clin Ophthalmol. 2015;9:109-14. doi: 10.2147/OPTH.S74481.
2. Mullaem G, Rosner MH. Ocular problems in the patient with end-stage renal disease. Semin Dial. 2012;25(4):403-7. doi: 10.1111/j.1525-139X.2012.01098.x.
3. Jung JW, Yoon MH, Lee SW, Chin HS. Effect of hemodialysis (HD) on intraocular pressure, ocular surface, and macular change in patients with chronic renal failure. Effect of hemodialysis on the ophthalmologic findings. Graefes Arch Clin Exp Ophthalmol. 2013;251(1):153-62. doi: 10.1007/s00417-012-2032-6.
4. Jung JW, Chin HS, Lee DH, Yoon MH, Kim NR. Changes in subfoveal choroidal thickness and choroidal extravascular density by spectral domain optical coherence tomography after haemodialysis: A pilot study. Br J Ophthalmol. 2014;98(2):207-12. doi: 10.1136/bjophthalmol-2013-303645.
5. Spaide RF. Disease expression in nonexudative age-related macular degeneration varies with choroidal thickness. Retina. 2018;38(4):708-16.doi: 10.1097/IAE.0000000000001689.
6. Huang X, Zhang P, Zou X, Xu Y, Zhu J, He J, et al. Thinner average choroidal thickness is a risk factor for the onset of diabetic retinopathy. Ophthalmic Res. 2020;63(3):259-70. doi: 10.1159/000504756.
7. Ahn SJ, Park KH, Woo SJ. Subfoveal choroidal thickness changes following anti-vascular endothelial growth factor therapy in myopic choroidal neovascularization. Invest Ophthalmol Vis Sci. 2015;56(10):5794-800. doi: 10.1167/iovs.14-16006.
8. Okamoto M, Matsuura T, Ogata N. Effects of panretinal photocoagulation on choroidal thickness and choroidal blood flow in patients with severe nonproliferative diabetic retinopathy. Retina. 2016;36(4):805-11. doi: 10.1097/IAE.0000000000000800.

9. Kim KH, Lee DH, Lee JJ, Park SW, Byon IS, Lee JE. Regional choroidal thickness changes in branch retinal vein occlusion with macular edema. Ophthalmologica. 2015;234(2):109-18. doi: 10.1159/000437276.
10. Abadía B, Calvo P, Bartol-Puyal F, Verdes G, Suñén I, Ferreras A. Repeatability of choroidal thickness measurements assessed with swept-source optical coherence tomography in healthy and diabetic individuals. Retina. 2019;39(4):786-93. doi: 10.1097/IAE.0000000000002022.
11. Wong SS, Vuong VS, Cunefare D, Farsiu S, Moshiri A, Yiu G. Macular fluid reduces reproducibility of choroidal thickness measurements on enhanced depth optical coherence tomography. Am J Ophthalmol. 2017;184:108-14. doi: 10.1016/j.ajo.2017.10.005.
12. Cho AR, Choi YJ, Kim YT; Medscape. Influence of choroidal thickness on subfoveal choroidal thickness measurement repeatability using enhanced depth imaging optical coherence tomography. Eye (Lond). 2014;28(10):1151-60. doi: 10.1038/eye.2014.197.
13. Sala-Puigdollers A, Figueras-Roca M, Hereu M, Hernández T, Morató M, Adán A, et al. Repeatability and reproducibility of retinal and choroidal thickness measurements in diabetic macular edema using swept-source optical coherence tomography. PLoS One. 2018;13(7):0200819. doi: 10.1371/journal.pone.0200819.
14. Hanumunthadu D, Ilginis T, Restori M, Sagoo MS, Tufail A, Balaggan KS, et al. Repeatability of swept-source optical coherence tomography retinal and choroidal thickness measurements in neovascular age-related macular degeneration. Br J Ophthalmol. 2017;101(5):603-8. doi: 10.1136/bjophthalmol-2016-308999.
15. Farias LB, Lavinsky D, Benfica CZ, da Silva MO, Lavisnky J, Canani LH. Changes in choroidal thickness and volume are related to urinary albumin excretion in type 2 diabetic patients without retinopathy. Clin Ophthalmol. 2018;12:1405-11. doi: 10.2147/OPTH.S164195.
16. Rayess N, Rahimy E, Ying GS, Bagheri N, Ho AC, Regillo CD, et al. Baseline choroidal thickness as a predictor for response to anti-vascular endothelial growth factor therapy in diabetic macular edema. Am J Ophthalmol. 2015;159(1):85-91.e1-3. doi: 10.1016/j.ajo.2014.09.033.
17. Ikuno Y, Kawaguchi K, Nouchi T, Yasuno Y. Choroidal thickness in healthy Japanese subjects. Invest Ophthalmol Vis Sci. 2010;51(4):2173-6. doi: 10.1167/iovs.09-4383.
18. Yilmaz I, Ozkaya A, Kocamaz M, Ahmet S, Ozkaya HM, Yasa D, et al. Correlation of choroidal thickness and body mass index. Retina. 2015;35(10):2085-90.doi: 10.1097/IAE.0000000000000582.
19. Tan CS, Ouyang Y, Ruiz H, Sadda SR. Diurnal variation of choroidal thickness in normal, healthy subjects measured by spectral domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2012;53(1):261-6. doi: 10.1167/iovs.11-8782
20. Usui S, Ikuno Y, Akiba M, Maruko I, Sekiryu T, Nishida K, et al. Circadian changes in subfoveal choroidal thickness and the relationship with 44circulatory factors in healthy subjects. Invest Ophthalmol Vis Sci. 2012;53(4):2300-7. doi: 10.1167/iovs.11-8383.
21. Yang SJ, Han YH, Song GI, Lee CH, Sohn SW. Changes of choroidal thickness, intraocular pressure and other optical coherence tomographic parameters after haemodialysis. Clin Exp Optom. 2013;96(5):494-9. doi: 10.1111/cxo.12056.
22. Ulas F, Dogan U, Keles A, Ertilav M, Tekce H, Celebi S. Evaluation of choroidal and retinal thickness measurements using optical coherence tomography in non-diabetic haemodialysis patients. Int Ophthalmol. 2013;33(5):533-9. doi: 10.1007/s10792-013-9740-8.
23. Chang IB, Lee JH, Kim JS. Changes in choroidal thickness in and outside the macula after hemodialysis in patients with end-stage renal disease. Retina. 2017;37(5):896-905. doi: 10.1097/IAE.0000000000001262.
24. Hwang H, Chae JB, Kim JY, Moon BG, Kim DY. Changes in optical coherence tomography findings in patients with chronic renal failure undergoing dialysis for the first time. Retina. 2019;39(12):2360-8. doi: 10.1097/IAE.0000000000002312.
25. Zhang Y, Weng H, Li Q, Wang Z. Changes in retina and choroid after haemodialysis assessed using optical coherence tomography angiography. Clin Exp Optom. 2018;101(5):674-9. doi: 10.1111/cxo.12660.
26. Jung JW, Chin HS, Lee DH, Yoon MH, Kim NR. Changes in subfoveal choroidal thickness and choroidal extravascular density by spectral domain optical coherence tomography after haemodialysis: A pilot study. Br J Ophthalmol. 2014;98(2):207-12. doi: 10.1136/bjophthalmol-2013-303645.
27. Karaca EE, Ozdek S, Yalcin NG, Ekici F. Reproducibility of choroidal thickness measurements in healthy Turkish subjects. Eur J Ophthalmol. 2014;24(2):202-8. doi: 10.5301/ejo.5000351.
28. Ikuno Y, Maruko I, Yasuno Y, Miura M, Sekiryu T, Nishida K, et al. Reproducibility of retinal and choroidal thickness measurements in enhanced depth imaging and high-penetration optical coherence tomography. Invest Ophthalmol Vis Sci. 2011;52(8):5536-40. doi: 10.1167/iovs.10-6811.
29. Vuong VS, Moisseiev E, Cunefare D, Farsiu S, Moshiri A, Yiu G. Repeatability of choroidal thickness measurements on enhanced depth imaging optical coherence tomography using different posterior boundaries. Am J Ophthalmol. 2016;169:104-12. doi: 10.1016/j.ajo.2016.06.023.

Ayrıntılar

Birincil Dil

İngilizce

Konular

Sağlık Kurumları Yönetimi

Bölüm

Araştırma Makalesi

Yazarlar

Mehmet Murat Uzel Bu kişi benim
0000-0002-7420-8934
Türkiye

Özgür Eroğul Bu kişi benim
0000-0002-0875-1517
Türkiye

Leyla Eryiğit Eroğul Bu kişi benim
0000-0003-3622-2089
Türkiye

Ayşe Güzin Taşlıpınar Uzel Bu kişi benim
0000-0002-0079-5179
Türkiye

Avşin İbiş Bu kişi benim
0000-0003-2050-0953
Türkiye

Hamidu Hamisi Gobeka Bu kişi benim
0000-0002-7656-3155
Türkiye

Yayımlanma Tarihi

27 Ocak 2022

Gönderilme Tarihi

9 Ekim 2021

Kabul Tarihi

29 Kasım 2021

Yayımlandığı Sayı

Yıl 2022 Cilt: 2 Sayı: 1

IZ

https://izlik.org/JA62DX82YR

Kaynak Göster

RIS / Bibtex

APA

Uzel, M. M., Eroğul, Ö., Eryiğit Eroğul, L., Taşlıpınar Uzel, A. G., İbiş, A., & Gobeka, H. H. (2022). Reproducibility of choroidal thickness measurements in hemodialysis patients: A spectral domain optical coherence tomography study. Health Sciences Quarterly, 2(1), 39-44. https://izlik.org/JA62DX82YR

AMA

1.Uzel MM, Eroğul Ö, Eryiğit Eroğul L, Taşlıpınar Uzel AG, İbiş A, Gobeka HH. Reproducibility of choroidal thickness measurements in hemodialysis patients: A spectral domain optical coherence tomography study. Health Sci. Q. 2022;2(1):39-44. https://izlik.org/JA62DX82YR

Chicago

Uzel, Mehmet Murat, Özgür Eroğul, Leyla Eryiğit Eroğul, Ayşe Güzin Taşlıpınar Uzel, Avşin İbiş, ve Hamidu Hamisi Gobeka. 2022. “Reproducibility of choroidal thickness measurements in hemodialysis patients: A spectral domain optical coherence tomography study”. Health Sciences Quarterly 2 (1): 39-44. https://izlik.org/JA62DX82YR.

EndNote

Uzel MM, Eroğul Ö, Eryiğit Eroğul L, Taşlıpınar Uzel AG, İbiş A, Gobeka HH (01 Ocak 2022) Reproducibility of choroidal thickness measurements in hemodialysis patients: A spectral domain optical coherence tomography study. Health Sciences Quarterly 2 1 39–44.

IEEE

[1]M. M. Uzel, Ö. Eroğul, L. Eryiğit Eroğul, A. G. Taşlıpınar Uzel, A. İbiş, ve H. H. Gobeka, “Reproducibility of choroidal thickness measurements in hemodialysis patients: A spectral domain optical coherence tomography study”, Health Sci. Q., c. 2, sy 1, ss. 39–44, Oca. 2022, [çevrimiçi]. Erişim adresi: https://izlik.org/JA62DX82YR

ISNAD

Uzel, Mehmet Murat - Eroğul, Özgür - Eryiğit Eroğul, Leyla - Taşlıpınar Uzel, Ayşe Güzin - İbiş, Avşin - Gobeka, Hamidu Hamisi. “Reproducibility of choroidal thickness measurements in hemodialysis patients: A spectral domain optical coherence tomography study”. Health Sciences Quarterly 2/1 (01 Ocak 2022): 39-44. https://izlik.org/JA62DX82YR.

JAMA

1.Uzel MM, Eroğul Ö, Eryiğit Eroğul L, Taşlıpınar Uzel AG, İbiş A, Gobeka HH. Reproducibility of choroidal thickness measurements in hemodialysis patients: A spectral domain optical coherence tomography study. Health Sci. Q. 2022;2:39–44.

MLA

Uzel, Mehmet Murat, vd. “Reproducibility of choroidal thickness measurements in hemodialysis patients: A spectral domain optical coherence tomography study”. Health Sciences Quarterly, c. 2, sy 1, Ocak 2022, ss. 39-44, https://izlik.org/JA62DX82YR.

Vancouver

1.Mehmet Murat Uzel, Özgür Eroğul, Leyla Eryiğit Eroğul, Ayşe Güzin Taşlıpınar Uzel, Avşin İbiş, Hamidu Hamisi Gobeka. Reproducibility of choroidal thickness measurements in hemodialysis patients: A spectral domain optical coherence tomography study. Health Sci. Q. [Internet]. 01 Ocak 2022;2(1):39-44. Erişim adresi: https://izlik.org/JA62DX82YR