The Effects of Body Mass Index and Blood Group on Immune Thrombocytopenia Therapy

Yıl 2023, , 298 - 304, 31.08.2023

Murat Kaçmaz , Yavuz Katırcılar

https://doi.org/10.35440/hutfd.1321714

Öz

Background: The effects of body mass index (BMI) and blood groups on immune thrombocytopenia (ITP) are not clearly known. This study aims to investigate the effect of BMI and blood groups on the treatment of ITP.
Materials and Methods: All cases included in this study were primary ITP patients. Body measure-ments, treatment history, demographic, and laboratory data were recorded. The data obtained were analyzed after the patients were divided into groups based on BMI and blood groups.
Results: The study included 68 (100%) cases, 53 of which were female (77.9%). The median age of the cases was 44 years (min: 18, max: 87). The median BMI was 28.05 (min: 17.6, max: 51.4), and patients with normal weight, overweight, and obesity were found in 24 (35.3%), 20 (29.4%), and 24 (35.3%) cases, respectively. According to blood groups, 29 (42.6%), 20 (29.4%), 11 (16.2%), and 8 (11.8%) cases had blood groups A, O, B, and AB, respectively. The analysis of BMI and blood groups together with demographic and laboratory variables revealed that patients with obesity had a higher mean age (p=0.049) and lactate dehydrogenase levels (p<0.001) than other BMI groups. In the analysis of treat-ment responses, it was found that using eltrombopag in the second-line treatment in the patients with normal weight group was associated with a better response than other BMI groups (p=0.025).
Conclusions: This is the first study to look investigate the relationship between BMI and ITP therapy. According to the results of our study, we believe that BMI should be considered in the selection of second-line therapy for ITP.

Anahtar Kelimeler

Blood Group Antigens, eltrombopag, Obesity, Overweight

Vücut Kitle İndeksi ve Kan Gruplarının İmmün Trombositopeni Tedavisine Etkisi

Öz

Amaç: Vücut kitle indeksi (VKİ) ve kan gruplarının immün trombositopeni (ITP) üzerindeki etkileri net olarak bilinmemektedir. Bu çalışmada VKİ ve kan gruplarının ITP tedavisindeki etkisinin araştırılması amaçlanmaktadır.
Materyal ve Metod: Bu çalışmaya dahil edilen tüm vakalar primer ITP hastalarından oluşmaktadır. Vücut ölçütleri, tedavi geçmişleri, demografik ve laboratuvar verileri kayıt altına alınmıştır. Hastalar VKİ ve kan gruplarına göre gruplara ayrıldıktan sonra elde edilen veriler analiz edilmiştir.
Bulgular: Çalışmaya 53’ü kadın (%77,9) toplamda 68 (%100) vaka dahil edilmiştir. Vakaların ortanca yaşı 44 yıl (min:18, max:87) saptanmıştır. Ortanca VKİ 28,05 (min:17,6, max:51,4) olup sırasıyla 24 (%35,3), 20 (%29,4) ve 24 (%35.3) vaka normal kilolu, aşırı kilolu ve obeziteli olarak saptandı. Kan grup-larına göre sırasıyla 29 (%42,6), 20 (%29,4), 11 (%16,2) ve 8 (%11,8) vaka A, O, B ve AB kan grubuna sahipti. VKİ ve kan gruplarının demografik ve laboratuvar değişkenleri ile analizinde obeziteli hastaların diğer VKİ gruplarına göre yaş ortalamalarının (p=0.049) ve laktat dehidrogenaz düzeylerinin daha yük-sek olduğu (p<0.001) saptanmıştır. Tedavi yanıtlarının analizinde ise normal kilolu grupta ikinci sıra tedavide eltrombopag kullanımının diğer VKİ gruplarına göre daha iyi yanıtla ilişkisi saptanmıştır (p=0.025).
Sonuç: Bu çalışma VKİ ve kan gruplarının ITP tedavisindeki etkisini araştıran ilk çalışmadır. Çalışma sonuçlarımıza göre ITP’nin ikinci basamak tedavi seçiminde VKİ’ninde göz önünde bulundurulması gerektiği görüşündeyiz.

Anahtar Kelimeler

Kan grubu antijenleri, eltrombopag, obesite, aşırı kilo.

Kaynakça

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