Flavonoidlerin Beyin Fonksiyonu Üzerindeki Potansiyellerini Keşfetmek: Üç Fenolik Bileşiğin Beyin Elektriksel Aktivitesi Üzerindeki Etkileri

Yıl 2023, , 525 - 532, 31.12.2023

Hilal Öztürk , Harun Başoğlu , Selcen Abidin , İsmail Abidin

https://doi.org/10.35440/hutfd.1328652

Öz

Amaç: Organizma tarafından besin zinciri yoluyla alınan en yaygın polifenolik bileşikler flavonoidlerdir. Kan-beyin bariyerini geçtiği bilinen 7,8-DHF, L-theanine ve Fisetin'in nörodejeneratif hastalıklar için terapötik potansiyellerinin yanı sıra nöronal etkilerinin de olduğu bildirilmiştir. Bununla birlikte, nöronal fonksiyon üzerindeki akut etkileri hakkında çok az şey bilinmektedir. Bu çalışma, söz konusu flavonoidlerin sağlıklı farelerin toplam ECoG aktiviteleri ve bant analizleri üzerindeki etkilerini açıklamayı amaçlamaktadır. Materyal ve metod: Bu amaçla her bir flavonoid uygulaması için 7 hayvandan oluşan 3 farklı grup oluşturulmuştur. Bazal elektrofizyolojik kayıtların ardından flavonoid uygulaması yapılmış ve akut etkiler belirlenmiştir. Bulgular: 7.8-DHF, toplam ECoG gücünü düşürürken teta, alfa ve beta bant aktivitelerini artırdı. L-theanine ve Fisetin, toplam ECoG aktivitesini önemli ölçüde değiştirmedi. Bununla birlikte, L-theanine teta, alfa ve beta bant aktivitelerini istatistiksel olarak arttırdı. Sonuç: Sonuç olarak, verilerimiz flavonoidlerin akut ECoG yanıtlarını banda özgü bir şekilde modüle edebildiğini gösterdi. Merkezi sinir sistemi bozuklukları için ilaç keşif çalışmalarında aday moleküller olarak kabul edilebilirler.

Anahtar Kelimeler

Flavanoidler, Elektrokortikografi, Bant aktiviteleri

Exploring the Potentials of Flavonoids on Brain Function: Effects of Three Phenolic Compounds on Brain Electrical Activity

Öz

Background: The most common polyphenolic compounds taken up by the organism through the food chain are flavonoids. Known to cross the blood-brain barrier, 7,8-DHF, L-theanine and Fisetin are re-ported to have neuronal effects as well as therapeutic potential for neurodegenerative diseases. How-ever, little is known on their acute effects of neuronal function. This study aims to describe the effects of the mentioned flavonoids on the total ECoG activities and band analyzes of healthy mice.
Materials and Methods: For this purpose, 3 different groups consisting of 7 subjects were created for each flavonoid administration. After the baseline electrophysiological recordings, flavonoid administra-tion was performed and acute effects were determined.
Results: 7.8-DHF increased the theta, alpha and beta band activities while decreasing the total ECoG power. L-theanine and Fisetin did not significantly alter the total ECoG activity. However, L-theanine statistically increased theta, alpha and beta band activities.
Conclusions: In conclusion, our data showed that flavonoids could acutely modulate the ECoG respons-es in a band specific manner. They can be considered as candidate molecules for drug discovery studies for central nervous system disorders.

Anahtar Kelimeler

Flavonoids, Electrocorticography, band activities

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