Plasma Free Amino Acid and Carnitine Levels in Pregnant Women with Hydatidiform Mole: A Case-Controlled Study

Yıl 2024, , 131 - 137, 29.04.2024

Hacer Uyanikoglu , İsmail Koyuncu , Sibel Sak , Mehmet Emin Tasduzen , Ataman Gönel , Muhammet Erdal Sak , Mert Ulaş Barut

https://doi.org/10.35440/hutfd.1381095

Öz

Background: To determine plasma free amino acid (FAA) and carnitine levels in pregnant women with hydatidiform mole (HM).
Materials and Methods: Twenty-three pregnant women with HM, and 24 healthy pregnant wo-men as controls were enrolled in the study. FAA and carnitine concentrations were measured in plasma using liquid chromatography/tandem mass spectrometry (LC-MS).
Results: The levels of alanine, arginine, and valine from the 14 amino acids examined were signif-icantly lower in the HM group than in the healthy group (p = 0.019, p = 0.009, and p = 0.03, respec-tively). In addition, several carnitines, C8DC, C16:1, and C18, of the 27 carnitines examined were significantly higher in the HM group than in the control group (p = 0.021, p = 0.03, and p = 0.021, respectively).
Conclusions: This study demonstrated that a decrease in some plasma FAAs and an increase in some plasma carnitine levels might be effective in the pathogenesis of HM.

Anahtar Kelimeler

carnitine, free amino acid, hydatidiform mole, pregnancy

Hidatidiform Mol Gebeliği olan Kadınlarda Plazma Serbest Amino Asit ve Karnitin Düzeyleri: Vaka Kontrol Çalışması

Öz

Amaç: Hidatidiform mol (HM)'li gebe kadınlarda plazma serbest amino asit (FAA) ve karnitin düzeylerini belirlemek.
Materyal ve metod: Çalışmaya 23 HM'li gebe ve kontrol grubu olarak 24 sağlıklı gebe dahil edildi. FAA ve karnitin konsantrasyonları, sıvı kromatografisi/tandem kütle spektrometrisi (LC-MS) kullanılarak plazmada ölçüldü.
Bulgular: İncelenen 14 amino asitten alanin, arginin ve valin düzeyleri HM grubunda sağlıklı gruba göre anlamlı derecede düşüktü (sırasıyla p = 0,019, p = 0,009 ve p = 0,03). Ek olarak, incelenen 27 karnitinden birkaç karnitin, C8DC, C16:1 ve C18, HM grubunda kontrol grubuna göre önemli ölçüde daha yüksekti (sırasıyla p = 0,021, p = 0,03 ve p = 0,021).
Sonuç: Bu çalışma, bazı FAA'lerin plazma seviyesindeki azalmanın ve bazı karnitinlerin de plazma düzeylerindeki artışın HM patogenezinde etkili olabileceğini ortaya koydu.

Anahtar Kelimeler

karnitin, serbest amino asit, gebelik, hidatidiform mol

Etik Beyan

Kurumumuzun 09.11.2017 tarih ve 11 nolu oturumunun 03 sayılı kararı ile etik onay verilmiştir.

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