May Recovered COVID-19 Patients Have Impaired Myocardial Work?

Öz

Background: The aim of this study was to investigate whether there are sequelae in left ventricular (LV) systolic function by comparing LV function in fully recovered COVID-19 patients with pulmonary involvement and healthy controls without COVID-19 by conventional echocardiography and myocardial work. Materials and Methods: 55 healthy volunteers and 61 patients hospitalized with COVID-19 with pulmonary in-volvement were included. Patients did not need non-invasive or invasive mechanical ventilation support during hospitalization. Patients were included in the study if they were asymptomatic for at least six months after recov-ery from COVID-19. Transthoracic echocardiography (TTE) was performed. Demographic and clinical characteris-tics and laboratory test results were collected. Clinical characteristics, blood tests, TTE, speckle-tracking echocar-diography (STE) and myocardial work results were compared. Results: No statistically significant differences were found in the longitudinal strain parameters of the LV among the study groups. The patient group exhibited notably reduced levels of global work index (GWI), global con-structed work (GCW), and global work efficiency (GWE). The patient group exhibited a notably elevated global wasted work (GWW). Conclusions: The group of fully recovered asymptomatic COVID-19 patients with pulmonary involvement showed significantly lower values for GWI, GCW, and GWE, while GWW showed a significantly higher value. Myocardial work parameters may be useful in determining myocardial sequelae.

Anahtar Kelimeler

• COVID-19
• Myocardial Work
• Longitudinal strain
• Speckle-tracking echocardiography

İyileşen COVID-19 Hastalarında Miyokard Çalışması Bozulmuş Olabilir mi?

Öz

Amaç: Bu çalışmanın amacı tamamen iyileşmiş akciğer tutulumlu COVID-19 hastalarında sol ventrikül (LV) sistolik fonksiyonunda sekel olup olmadığını, COVID-19 geçirmemiş sağlıklı kontrol grubundaki kişilerle geleneksel ekokardiyografi ve miyokard çalışması ile karşılaştırarak incelemektir. Materyal ve Metod: 55 sağlıklı gönüllü ve akciğer tutulumlu COVID-19 nedeniyle hastaneye yatışı yapılan 61 hasta dahil edildi. Hastaların hastanede yatışları sırasında non-invaziv veya invaziv mekanik ventilasyon desteğine ih-tiyaçları olmadı. Hastalar COVID-19'dan iyileştikten sonra en az altı ay süreyle semptomsuzlarsa çalışmaya dahil edildi. Transtorasik ekokardiyografi (TTE) yapıldı. Demografik ve klinik özellikler ile laboratuvar test sonuçları top-landı. Klinik özellikler, kan testleri, TTE, STE ve miyokardiyal çalışma sonuçları karşılaştırıldı. Bulgular: Çalışma grupları arasında LV’nin strain parametrelerinde istatistiksel olarak anlamlı bir fark bulunmadı. Hasta grubunda global çalışma indeksi (GWI), global yapılandırılmış çalışma (GCW) ve global çalışma verimliliği (GWE) düzeylerinde belirgin derecede azalma izlendi. (tüm p değerleri < 0.001) Hasta grubunda anlamlı derecede yüksek global boşa giden çalışma (GWW) düzeyi izlendi. (p=0.009) Sonuç: Tamamen iyileşmiş, semptomsuz akciğer tutulumlu COVID-19 hastalarında GWI, GCW ve GWE anlamlı olarak düşük değerler gösterirken, GWW anlamlı olarak daha yüksek değerler gösterdi. Miyokardiyal çalışma pa-rametreleri miyokardiyal sekelleri belirlemede yararlı olabilir.

Anahtar Kelimeler

• COVID-19
• Miyokardial iş
• Uzunlamasına zorlanma
• Benek izleme ekokardiyografi

Kaynakça

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