Prognostic Value of Systemic Immune-Inflammation Index (SII), Platelet-Lymphocyte Ratio (PLR) and Neutrophil-Lymphocyte Ratio (NLR) in Predicting Mortality in Pneumosepsis Patients in Intensive Care Unit

Öz

Background: This study aims to evaluate the prognostic value of Systemic Immune-Inflammation Index (SII), Platelet-Lymphocyte Ratio (PLR) and Neutrophil-Lymphocyte Ratio (NLR) to predict mortality in patients with pneumosepsis in the intensive care unit (ICU). Materials and Methods: The study was conducted retrospectively and clinical data of patients diag-nosed with pneumosepsis were analyzed. Age, gender, comorbidities, length of stay (LOS) in the ICU, Sequential Organ Failure Assessment (SOFA) score, Acute Physiology and Chronic Health Evaluation II (APACHE II) score, SII, PLR, NLR values and prognoses were obtained from patient files and hospital records system. Results: A total of 68 patients were included in the study. 60.3% of the patients were male and 39.7% were female. The mean age of deceased patients was statistically significantly higher than that of discharged patients (p = 0.016). In the study, 22 patients were discharged and 46 patients died. While the mean SII value was 464.05±107.31 in the discharged group, this value was 845.53±111.04 in those who died (p<0.001). Similarly, the PLR value was 88.14 ± 10.66 in those discharged and 114.89±12.97 in those who died (p<0.001). The NLR value was 3.5 ± 0.86 in the discharged group and 6.73±0.84 in the deceased group (p<0.001). Conclusions: This study reveals that SII, NLR and PLR indices are important and reliable indicators for predicting mortality in pneumosepsis patients in the ICU.

Anahtar Kelimeler

• Systemic immune-inflammation index
• Platelet/lymphocyte ratio
• Neutrophil/lymphocyte ratio
• Pneumosepsis
• Intensive care unit

Etik Beyan

Approval was obtained from the Ethics Committee of Health Sciences University Diyarbakır Gazi Yaşargil Training and Research Hospital (Approval no: 187 ). The study was conducted in accordance with the Declaration of Helsinki.

Yoğun Bakım Ünitesinde Pnömosepsis Hastalarında Mortaliteyi Öngörmede Sistemik İmmün-İnflamasyon İndeksi (SII), Trombosit-Lenfosit Oranı (PLR) ve Nötrofil-Lenfosit Oranının (NLR) Prognostik Değeri

Öz

Amaç: Bu çalışma, pnömosepsis tanısı almış hastalarda yoğun bakım ünitesinde mortaliteyi öngörmek amacıyla Sistemik İmmün-İnflamasyon İndeksi (SII), Trombosit-Lenfosit Oranı (PLR) ve Nötrofil-Lenfosit Oranı'nın (NLR) prognostik değerini değerlendirmeyi amaçlamaktadır. Materyal ve Metod: Çalışma retrospektif olarak gerçekleştirilmiş ve pnömosepsis tanısı almış hastaların klinik verileri analiz edilmiştir. Hastaların yaşı, cinsiyeti, eşlik eden hastalıkları, yoğun bakımda kalış süresi, Sıralı Organ Yetmezliği Değerlendirmesi (SOFA) skoru, Akut Fizyoloji ve Kronik Sağlık Değerlen-dirmesi II (APACHE II) skoru, SII, PLR, NLR değerleri ve prognozları hasta dosyaları ve hastane kayıt sisteminden elde edilerek kaydedilmiştir. Bulgular: Çalışmaya toplam 68 hasta dahil edilmiştir. Hastaların %60,3’ü erkek, %39,7’si kadındır. Hayatını kaybeden hastaların yaş ortalaması, taburcu edilen hastalara kıyasla istatistiksel olarak anlamlı şekilde daha yüksek bulunmuştur (p = 0,016). Çalışmada 22 hasta taburcu edilirken, 46 hasta hayatını kaybetmiştir. Taburcu edilen grupta ortalama SII değeri 464,05±107,31 iken, hayatını kaybedenlerde bu değer 845,53±111,04 olarak tespit edilmiştir (p<0.001). Benzer şekilde PLR değeri taburcu edilen-lerde 88,14 ± 10,66, hayatını kaybedenlerde ise 114,89±12,97’dir (p<0.001). NLR değeri ise taburcu edilen grupta 3,5±0,86 hayatını kaybeden grupta 6,73±0,84 olarak bulunmuştur (p<0.001). Sonuç: Bu çalışma, yoğun bakım ünitesindeki pnömosepsis hastalarında SII, NLR ve PLR indekslerinin mortaliteyi öngörmede önemli ve güvenilir göstergeler olduğunu ortaya koymaktadır.

Anahtar Kelimeler

• Sistemik immün-inflamasyon indeks
• Trombosit/lenfosit oranı
• Nötrofil/lenfosit oranı
• Pnömosepsis
• Yoğun bakım ünitesi

Kaynakça

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