Diyabetik Anne Bebeklerinde Serum Paraoksonaz Aktivitesi ve Total Oksidan ve Antioksidan Kapasitenin Değerlendirilmesi

Öz

Amaç: Bu çalışmada diyabetik anne bebeklerinde (DAB), ateroskleroz oluşma riskini gösteren Paraoksonaz (PON) aktivitesi ile total oksidan (TOS) ve antioksidan kapasitelerinin (TAS) değerlendirilmesi amaçlanmaktadır. Materyal ve metod: Çalışmaya, prospektif olarak 01.03.2012-25.09.2012 tarihleri arasında, pregestasyonel veya gestasyonel diyabet nedeniyle izlenen 58 anneden doğan ve postnatal ilk 3 gün içinde olan yenidoğan bebekler dahil edilmiştir. Maternal risk faktörü olmayan sağlıklı bebekler kontrol grubu olarak alınmıştır. Hastaların PON, TOS ve TAS düzeyleri karşılaştırılmıştır. Bulgular: DAB’de PON1 aktivitesi, TOS seviyeleri ve oksidatif stres indeksi kontrol grubuna göre anlamlı derecede yüksek bulunmuştur (sırasıyla; p<0,01, p<0,01, p<0,01). Serum TAS seviyelerinde ise kontrol grubuna göre anlamlı fark saptanmamıştır (p=0,446). Sonuç: İntrauterin programlama ile diyabetik annelerin glisemik kontrolünün sağlanması, DAB’nin daha az hiperglisemiye maruz kalması durumunda oksidatif stresin azalabileceği düşündürmektedir.

Anahtar Kelimeler

• Diyabetik anne bebeği
• Serum paraoksonaz aktivitesi
• Oksidan-antioksidan sistem

Evaluation of Serum Paraoxonase Activity and Total Oxidant and Antioxidant Capacity in Infants of Diabetic Mothers

Öz

Background: This study aims to evaluate the paraoxonase (PON) activity, total oxidant (TOS) levels, and antioxidant capacities (TAS) in infants of diabetic mothers (IDM), to assess the risk of atherosclerosis formation. Materials and Methods: A total of 58 infants born to mothers with pregestational or gestational diabetes who were followed up prospectively between 01.03.2012 and 25.09.2012 and were within the first 3 postnatal days were included in the study. Healthy infants without maternal risk factors were selected as the control group. The levels of PON, TOS, and TAS were compared between the groups. Results: PON1 activity, TOS levels, and oxidative stress index were found to be significantly higher in IDM compared to the control group (p<0.01, p<0.01, p<0.01, respectively). However, no significant difference was found in serum TAS levels between the IDM and the control group (p=0.446). Conclusions: Achieving glycemic control in diabetic mothers through intrauterine programming may reduce oxidative stress and the risk of atherosclerosis development by reducing the exposure of infants to hyperglycemia.

Anahtar Kelimeler

• Infant of diabetic mother
• Serum paraoxonase activity
• Oxidant-antioxidant system

Kaynakça

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