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Akut Perikardit Tanısı Konulmuş Hastalarda Frontal QRS-T Açısının İncelenmesi

Yıl 2025, Cilt: 22 Sayı: 4, 739 - 746, 25.12.2025
https://doi.org/10.35440/hutfd.1707098

Öz

Amaç: Akut perikardit acil servise başvuran hastaların yaklaşık %5’inde gözlemlenen, tanısı konulduğunda tedaviye iyi yanıt alınan bir inflamatuar hastalıktır. Akut perikarditin diğer kardiyovasküler hastalıklar ile karıştırılması tanıda zorluklar yaşanmasına ve hastalığın ilerlemesine sebep olmaktadır. Bu sebeple çalışma kapsamında akut perikardit tanısına yardımcı olabilecek parametrelerin incelenmesi amaçlandı.
Mayertal ve metod: Çalışma kapsamında 30 sağlıklı katılımcı ve 29 akut perikardit kesin tanısı almış hastaların demografik, klinik, laboratuvar testleri, elektrokardiyografi (EKG) ölçümleri retrospektif olarak değerlendirildi. EKG değerlendirilmesinde akut perikarditte görülme sıklığından dolayı PR segmenti, ST elevasyonu, düşük voltaj kriterlerine ek olarak interval ve süre değerleri ile frontal QRS-T açıları değerlendirildi.
Bulgular: Sağlıklı katılımcılar ile akut perikardit hastalarının demografik özelliklerinde herhangi bir farklılık gözlenmezken akut perikardit hastalarının komorbid özellikleri, C-reaktif protein, eritrosit sedimantasyon hızı gibi laboratuvar değerleri beklendiği üzere daha yüksekti. Frontal QRS-T açısının sağlıklı katılımcılar ile akut perikardit hastaları arasında kıyaslandığında belirgin olarak arttığı (p<0,05) gözlemlendi. Ek olarak frontal QRS-T açısının perikardit tanısını belirlemedeki başarısının %89, duyarlılığının %93, özgüllüğünün %86 olduğu gözlemlendi.
Sonuç: Çalışmadan elde edilen sonuçlar akut perikardit tanısında frontal QRS-T açısının bir biyobelirteç adayı olma potansiyeline sahip olduğunu göstermektedir.

Etik Beyan

Bu çalışma, Akdeniz Üniversitesi Tıbbi Bilimsel Araştırmalar Etik Kurulu tarafından onaylanmıştır (karar no: TBAEK-246, tarih: 06.03.2025).

Kaynakça

  • 1. Troughton R, Asher C, Klein A. Pericarditis. Lancet. 2004;363(9410):717-727.
  • 2. Doctor N, Shah A, Coplan N, Kronzon I. Acute Pericarditis. Prog Cardiovasc Dis. 2017;59(4):349-359. 3. Lazarou E, Tsioufis P, Vlachopoulos C, Tsioufis C, Lazaros G. Acute Pericarditis: Update. Curr Cardiol Rep. 2022;24(8):905-913.
  • 4. Rey F, Delhumeau-Cartier C, Meyer P, Genne D. Is acute idiopathic pericarditis associated with recent upper respiratory tract infection or gastroenteritis? A case-control study. BMJ Open. 2015;5(11):e009141.
  • 5. Imazio M, Gaita F, LeWinter M. Evaluation and Treatment of Pericarditis: A Systematic Review. JAMA. 2015;314(14):1498-1506.
  • 6. Adler Y, Charron P, Imazio M, Badano L, Barón-Esquivias G, Bogaert J, et al. 2015 ESC Guidelines for the diagnosis and management of pericardial diseases: The Task Force for the Diagnosis and Management of Pericardial Diseases of the European Society of Cardiology (ESC)Endorsed by: The European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J. 2015;36(42):2921-2964.
  • 7. Liu L, Lin C, Cheng C, Lin C. A deep learning algorithm for detecting acute pericarditis by electrocardiogram. J Pers Med. 2022;12(7):1150.
  • 8. Bhardwaj R, Berzingi C, Miller C, Hobbs G, Gharib W, Beto R, et al. Differential diagnosis of acute pericarditis from normal variant early repolarization and left ventricular hypertrophy with early repolarization: an electrocardiographic study. Am J Med Sci. 2013;345(1):28-32.
  • 9. Ginzton L, Laks M. The differential diagnosis of acute pericarditis from the normal variant: new electrocardiographic criteria. Circulation. 1982;65(5):1004-1009.
  • 10. Uslu S, Ozturk N, Kucukseymen S, Ozdemir S. Left atrial overload detection in ECG using frequency domain features with machine learning and deep learning algorithms. Biomed Signal Process Control. 2023;85:104981.
  • 11. Gotsman I, Keren A, Hellman Y, Banker J, Lotan C, Zwas D. Usefulness of electrocardiographic frontal QRS-T angle to predict increased morbidity and mortality in patients with chronic heart failure. Am J Cardiol. 2013;111(10):1452-1459.
  • 12. Chen S, Hoss S, Zeniou V, Shauer A, Admon D, Zwas D, et al. Electrocardiographic Predictors of Morbidity and Mortality in Patients With Acute Myocarditis: The Importance of QRS-T Angle. J Card Fail. 2018;24(1):3-8.
  • 13. Gungor M, Celik M, Yalcinkaya E, Polat A, Yuksel U, Yildirim E, et al. The Value of Frontal Planar QRS-T Angle in Patients without Angiographically Apparent Atherosclerosis. Med Princ Pract. 2017;26(2):125-131.
  • 14. Kaya E, Karabacak K, Kadan M, Gurses K, Kocyigit D, Doganci S, et al. Preoperative frontal QRS-T angle is an independent correlate of hospital length of stay and predictor of haemodynamic support requirement following off-pump coronary artery bypass graft surgery. Interact Cardiovasc Thorac Surg. 2015;21(1):96-101.
  • 15. Kuyumcu M, Özbay M, Özen Y, Yayla Ç. Evaluation of frontal plane QRS-T angle in patients with slow coronary flow. Scand Cardiovasc J. 2020;54(1):20-25.
  • 16. Medvedovsky A, Pollak A, Shuvy M, Gotsman I. Prognostic significance of the frontal QRS-T angle in patients with AL cardiac amyloidosis. J Electrocardiol. 2020;59:122-125.
  • 17. Surawicz B, Knilans T. Chou's electrocardiography in clinical practice: adult and pediatric. Elsevier Health Sciences; 2008.
  • 18. Lampejo T, Durkin S, Bhatt N, Guttmann O. Acute myocarditis: aetiology, diagnosis and management. Clin Med (Lond). 2021;21(5):e505-e510.
  • 19. Birnbaum Y, Perez Riera A, Nikus K. PR depression with multi lead ST elevation and ST depression in aVR: Is it always acute pericarditis? J Electrocardiol. 2019;54:13-17.
  • 20. de Bliek E. ST elevation: Differential diagnosis and caveats. A comprehensive review to help distinguish ST elevation myocardial infarction from nonischemic etiologies of ST elevation. Turk J Emerg Med. 2018;18(1):1-10.
  • 21. Kuş G, Çağırcı G. The relationship between frontal QRS-T angle and premature ventricular contraction burden in ambulatory 24-hour Holter. Acta Med Alanya. 2022;6(2):200-206.
  • 22. Gürbak İ, Güler A, Panç C, Güner A, Erturk M. The Status of Frontal QRS-T Angle in Hypertensive Patients with Different Left Ventricular Geometry. Sakarya Med J. 2021;11(4):843-849.

Investigation of the Frontal QRS-T Angle in Patients with Acute Pericarditis

Yıl 2025, Cilt: 22 Sayı: 4, 739 - 746, 25.12.2025
https://doi.org/10.35440/hutfd.1707098

Öz

Background: Acute pericarditis is an inflammatory disease observed in approximately 5% of patients presenting to the emergency department and responds well to treatment when early diagnosed. Misdiagnoses of acute pericarditis with other cardiovascular diseases lead to the progression of the disease. Therefore, the study aims to examine electrocardiographic markers that may assist in diagnosis of acute pericarditis.
Materials and Method: The study retrospectively evaluated the demographic, clinical, laboratory tests, and electrocardiogram (ECG) measurements of 30 healthy participants and 29 patients with a definitive diagnosis of acute pericarditis. Due to the frequency of occurrence in acute pericarditis, the ECG evaluation included the PR segment, ST elevation, low voltage criteria, interval and duration values, and frontal QRS-T angles.
Results: While no difference was observed in the demographic characteristics of healthy participants and acute pericarditis patients, comorbid characteristics, laboratory values such as C-reactive protein and erythrocyte sedimentation rate were higherin acute pericarditis patients as expected. It was noted that thefrontal QRS-T angle showed a significant increase when comparinghealthy participants to patients with acute pericarditis (p<0.05).Moreover, the frontal QRS-T angle showed 89% diagnosticaccuracy, with a sensitivity of 93% and a specificity of 86% for thediagnosis of pericarditis.
Conclusions: The findings of the study suggest that the frontalQRS-T angle may serve as a potential biomarker for diagnosingacute pericarditis.

Kaynakça

  • 1. Troughton R, Asher C, Klein A. Pericarditis. Lancet. 2004;363(9410):717-727.
  • 2. Doctor N, Shah A, Coplan N, Kronzon I. Acute Pericarditis. Prog Cardiovasc Dis. 2017;59(4):349-359. 3. Lazarou E, Tsioufis P, Vlachopoulos C, Tsioufis C, Lazaros G. Acute Pericarditis: Update. Curr Cardiol Rep. 2022;24(8):905-913.
  • 4. Rey F, Delhumeau-Cartier C, Meyer P, Genne D. Is acute idiopathic pericarditis associated with recent upper respiratory tract infection or gastroenteritis? A case-control study. BMJ Open. 2015;5(11):e009141.
  • 5. Imazio M, Gaita F, LeWinter M. Evaluation and Treatment of Pericarditis: A Systematic Review. JAMA. 2015;314(14):1498-1506.
  • 6. Adler Y, Charron P, Imazio M, Badano L, Barón-Esquivias G, Bogaert J, et al. 2015 ESC Guidelines for the diagnosis and management of pericardial diseases: The Task Force for the Diagnosis and Management of Pericardial Diseases of the European Society of Cardiology (ESC)Endorsed by: The European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J. 2015;36(42):2921-2964.
  • 7. Liu L, Lin C, Cheng C, Lin C. A deep learning algorithm for detecting acute pericarditis by electrocardiogram. J Pers Med. 2022;12(7):1150.
  • 8. Bhardwaj R, Berzingi C, Miller C, Hobbs G, Gharib W, Beto R, et al. Differential diagnosis of acute pericarditis from normal variant early repolarization and left ventricular hypertrophy with early repolarization: an electrocardiographic study. Am J Med Sci. 2013;345(1):28-32.
  • 9. Ginzton L, Laks M. The differential diagnosis of acute pericarditis from the normal variant: new electrocardiographic criteria. Circulation. 1982;65(5):1004-1009.
  • 10. Uslu S, Ozturk N, Kucukseymen S, Ozdemir S. Left atrial overload detection in ECG using frequency domain features with machine learning and deep learning algorithms. Biomed Signal Process Control. 2023;85:104981.
  • 11. Gotsman I, Keren A, Hellman Y, Banker J, Lotan C, Zwas D. Usefulness of electrocardiographic frontal QRS-T angle to predict increased morbidity and mortality in patients with chronic heart failure. Am J Cardiol. 2013;111(10):1452-1459.
  • 12. Chen S, Hoss S, Zeniou V, Shauer A, Admon D, Zwas D, et al. Electrocardiographic Predictors of Morbidity and Mortality in Patients With Acute Myocarditis: The Importance of QRS-T Angle. J Card Fail. 2018;24(1):3-8.
  • 13. Gungor M, Celik M, Yalcinkaya E, Polat A, Yuksel U, Yildirim E, et al. The Value of Frontal Planar QRS-T Angle in Patients without Angiographically Apparent Atherosclerosis. Med Princ Pract. 2017;26(2):125-131.
  • 14. Kaya E, Karabacak K, Kadan M, Gurses K, Kocyigit D, Doganci S, et al. Preoperative frontal QRS-T angle is an independent correlate of hospital length of stay and predictor of haemodynamic support requirement following off-pump coronary artery bypass graft surgery. Interact Cardiovasc Thorac Surg. 2015;21(1):96-101.
  • 15. Kuyumcu M, Özbay M, Özen Y, Yayla Ç. Evaluation of frontal plane QRS-T angle in patients with slow coronary flow. Scand Cardiovasc J. 2020;54(1):20-25.
  • 16. Medvedovsky A, Pollak A, Shuvy M, Gotsman I. Prognostic significance of the frontal QRS-T angle in patients with AL cardiac amyloidosis. J Electrocardiol. 2020;59:122-125.
  • 17. Surawicz B, Knilans T. Chou's electrocardiography in clinical practice: adult and pediatric. Elsevier Health Sciences; 2008.
  • 18. Lampejo T, Durkin S, Bhatt N, Guttmann O. Acute myocarditis: aetiology, diagnosis and management. Clin Med (Lond). 2021;21(5):e505-e510.
  • 19. Birnbaum Y, Perez Riera A, Nikus K. PR depression with multi lead ST elevation and ST depression in aVR: Is it always acute pericarditis? J Electrocardiol. 2019;54:13-17.
  • 20. de Bliek E. ST elevation: Differential diagnosis and caveats. A comprehensive review to help distinguish ST elevation myocardial infarction from nonischemic etiologies of ST elevation. Turk J Emerg Med. 2018;18(1):1-10.
  • 21. Kuş G, Çağırcı G. The relationship between frontal QRS-T angle and premature ventricular contraction burden in ambulatory 24-hour Holter. Acta Med Alanya. 2022;6(2):200-206.
  • 22. Gürbak İ, Güler A, Panç C, Güner A, Erturk M. The Status of Frontal QRS-T Angle in Hypertensive Patients with Different Left Ventricular Geometry. Sakarya Med J. 2021;11(4):843-849.
Toplam 21 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular İnsan Biyofiziği
Bölüm Araştırma Makalesi
Yazarlar

Serkan Uslu 0000-0002-0875-5905

Murathan Küçük 0000-0003-0320-2890

Semir Özdemir 0000-0002-4807-7344

Gönderilme Tarihi 27 Mayıs 2025
Kabul Tarihi 22 Ekim 2025
Erken Görünüm Tarihi 15 Aralık 2025
Yayımlanma Tarihi 25 Aralık 2025
Yayımlandığı Sayı Yıl 2025 Cilt: 22 Sayı: 4

Kaynak Göster

Vancouver Uslu S, Küçük M, Özdemir S. Akut Perikardit Tanısı Konulmuş Hastalarda Frontal QRS-T Açısının İncelenmesi. Harran Üniversitesi Tıp Fakültesi Dergisi. 2025;22(4):739-46.

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