Kardiyak Arrest Sonrası Yoğun Bakım Hastalarında Amantadin Tedavisinin Nörolojik ve Laboratuvar Sonuçlar Üzerine Etkisi: Retrospektif Bir Analiz

Yıl 2026, Sayı: Advanced Online Publication, 09.03.2026

Mizgin Duz Taymur , Başak Pehlivan , Veli Fahri Pehlivan , Erdoğan Duran

https://izlik.org/JA93FJ52DE

Öz

Amaç: Kardiyopulmoner arrest (KPA), yüksek mortalite ve ciddi nörolojik hasar riski nedeniyle önemli bir halk sağlığı sorunudur. Bu retrospektif çalışma, KPA sonrası spontan dolaşımın geri dönüşünü (ROSC) sağlayan ve yoğun bakım ünitesine (YBÜ) yatırılan hastalarda amantadin’in nörolojik iyileşme, mortalite ve inflamatuar biyomarkerlar üzerindeki etkisini araştırmıştır. Materyal ve metod: Bu retrospektif gözlemsel çalışma, 1 Ocak 2016 ile 31 Aralık 2020 tarihleri arasında ROSC sonra yoğun bakım ünitesine yatırılan ve en az altı gün kalan 18-85 yaş arası hastaları içermiştir. Hastalar iki gruba ayrılmıştır: amantadin grubu (Grup A, n=31) ve kontrol grubu (Grup C, n=47). Demografik bilgiler, GCS, CPC ve laboratuvar parametreleri (laktat, nötrofil, lenfosit, NLR) 1., 2., 4. ve 6. günlerde kaydedilmiştir. İstatistiksel analiz SPSS 22.0 kullanılarak yapılmıştır.

Bulgular: Gruplar arasında yaş, cinsiyet veya KPR süresi açısından anlamlı bir fark bulunmadı. Hedeflenen sıcaklık yönetimi A grubunda daha yaygındı. GKS, CPC ve inflamatuar belirteçler gruplar arasında anlamlı farklılık göstermezken, 6. günde laktat seviyeleri hayatta kalanlarda anlamlı derecede daha düşüktü. Hayatta kalamayanlarda ise 2. gün nötrofil seviyeleri ve 4. gün NLR anlamlı derecede daha düşüktü.

Sonuç: Amantadin nöroprotektif faydalar sağlayabilir, ancak istatistiksel anlamlılığa ulaşılamamıştır. Daha büyük prospektif çalışmalara ihtiyaç vardır. Laktat, nötrofil ve NLO, KPA sonrası hastalarda değerli prognostik göstergeler olabilir.

Anahtar Kelimeler

Amantadin , Kardiyopulmoner resüsitasyon (CPR) , Glasgow Koma Skalası (GKS) , Nötrofil/lenfosit oranı (NLR) , Serebral performans kategorisi (SPK) , Nöroproteksiyon

Etik Beyan

This retrospective observational study was approved by the Interventional Clinical Research Ethics Committee of Harran University (approval no: HRU/21.13.13, date: July 05, 2021).

Effect of Amantadine Therapy on Neurological and Laboratory Outcomes in Post-Cardiac Arrest Intensive Care Patients: A Retrospective Analysis

https://izlik.org/JA93FJ52DE

Öz

Background: Cardiopulmonary arrest (CPA) is a major public health issue due to its high mortality and risk of severe neurological impairment. This retrospective study investigated the impact of amantadine on neurological recovery, mortality, and inflammatory biomarkers in patients who achieved return of spontaneous circulation (ROSC) after CPA and were admitted to the intensive care unit (ICU).

Materials and Methods: This retrospective observational study included patients aged 18-85 years who were admitted to the ICU after ROSC and stayed for at least six days between January 1, 2016, and December 31, 2020. Patients were divided into two groups: amantadine group (Group A, n=31) and control group (Group C, n=47). Demographics, GCS, CPC, and laboratory parameters (lactate, neutrophil, lymphocyte, NLR) were recorded on days 1, 2, 4, and 6. Statistical analysis was performed using SPSS 22.0.

Results: No significant differences were found between the groups in terms of age, sex, or CPR duration. Targeted temperature management was more common in Group A. While GCS, CPC, and inflammatory markers did not significantly differ between groups, lactate levels on day 6 were significantly lower in survivors. In non-survivors, day 2 neutrophil levels and day 4 NLR were significantly lower.

Conclusions: Amantadine may offer neuroprotective benefits, though statistical significance was not reached. Larger prospective studies are needed. Lactate, neutrophil, and NLR may be valuable prognostic indicators in post-CPA patients.

Anahtar Kelimeler

Amantadine , Cardiopulmonary resuscitation (CPR) , Glasgow Coma Scale (GCS) , Neutrophil/lymphocyte ratio (NLR) , Cerebral Performance Category (CPC) , Neuroprotection

Etik Beyan

This retrospective observational study was approved by the Interventional Clinical Research Ethics Committee of Harran University (approval no: HRU/21.13.13, date: July 05, 2021).

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