The impact of type 2 diabetes mellitus on plasma fibrinogen level

Öz

Background: To assess type 2 diabetes mellitus (DM) impact on plasma fibrinogen levels

Material and Methods: Our study group consisted of 50 patients with type diabetes and 50 healthy control groups who applied to the Internal Medicine Specialist Policlinic of Lütfi Kırdar Kartal Training and Research Hospital between 1998- and 1999. Intergroup analysis was performed by age-related correlation analysis, fibrinogen levels by Student-T, ANOVA test, and other variables by chi-square test.

Results: Plasma fibrinogen level correlated positively with age (p = 0,005) but DM presence did not affect this condition. Mean plasma fibrinogen level was measured as 372,21±69,2 mg/dl in type 2 DM and 336,86 ± 59,92 mg/dl in the control group. This statistical significance was significant (p=0.005).

Conclusion: Elevated plasma fibrinogen level is an independent risk factor for coronary artery disease (CAD). Type 2 DM has an increased risk of CAD. Plasma fibrinogen levels also contribute to hemostatic abnormalities in this increased risk.

Anahtar Kelimeler

• Coronary artery disease,Type 2 DM,Fibrinogen

Tip 2 diyabetes mellitusun plazma fibrinojen düzeyine etkisi

Öz

Amaç: Tip 2 diyabetes mellitus (DM)’un plazma fibrinojen düzeylerine etkisini değerlendirmek.

Materyal ve Metod: Çalışma grubumuz 1998-1999 yılları arasında Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi iç hastalıkları uzman polikliniğine başvuran 50 tip 2 DM hasta ve 50 sağlıklı kontrol grubu üzerinde gerçekleştirilmiştir. Gruplar arası değerlendirmede yaş değişkeninde korelasyon analizi, fibrinojen düzeylerinde Student-T ve ANOVA test, diğer değişkenlerde ki-kare testi ile uygulanmıştır.

Bulgular: Plazma fibrinojen düzeyinin yaşla pozitif korelasyon gösterdiği (p=0,005) fakat DM varlığının bu duruma etki etmediği gözlendi. Tip 2 DM varlığında ortalama plazma fibrinojen düzeyi 372,21±69,2 mg/dl, kontrol grubunda ise 336,86 ± 59,92 mg/dl olarak ölçüldü. Bu durum istatistiksel açıdan anlamlıydı (p=0,005).

Sonuç: Plazma fibrinojen düzeyi yüksekliği koroner arter hastalığı (KAH) için bağımsız risk faktörüdür. Tip 2 DM’de artmış KAH riski vardır. Bu risk artışına hemostatik bozukluk olarak plazma fibrinojen düzeyi de katkı sunmaktadır.

Anahtar Kelimeler

• koroner arter hastalığı,tip 2 DM,fibrinojen

Kaynakça

1. 1- Foster WD. Diabetes mellitus. Principle of internal medicine, Harrison 1988;14th ed. p:2060-2080
2. 2- Colwell JA, Winocour PD, Lopes-Virella M, Halushka PV. New concepts about the pathogenesis of atherosclerosis in diabetes mellitus. NEJM 1988;75:67-80
3. 3- Christe M, Fritschi J, Lämmle B, Tran TH, Marbet GA, Berger W, Duckert F. Fifteen coagulation and fibrinolysis parameters in diabetes mellitus and in patients with vasculopathy. Thromb Haemost 1984 Oct 31;52(2):138-43.
4. 4- Dalsguard-nielsen J, Madsbad S, Hşsted J. Changes in platelet function, blood coagulation and fibrinolysis during insulin induced hypoglycemia in juvenile diabetes and normal subjects. Thrombosis and Haemostasis 1982;47:254-258
5. 5- Barkenstein M, Muntean W. Elevated factor VIII activity and factor VIII related antigen in diabetic children without vascular disease Diabetes 1982;31:1006-1009
6. 6- Heinrich J, Assmann G. Fibrinogen and cardiovascular risk. J Cardiovasc Risk 1995; Jun;2(3):197-205.
7. 7- Kannel WB, Wolf PA, Castelli WP, D'Agostino RB. Fibrinogen and risk of cardiovascular disease. The Framingham Study. JAMA 1987 Sep 4;258(9):1183-6.
8. 8- Válek J, Válková L, Vlasáková Z, Topinka V. Increased fibrinogen levels in the offspring of hypertensive men. Relation with hyperinsulinemia and the metabolic syndrome. Arterioscler Thromb Vasc Biol 1995 Dec;15(12):2229-33.

9. 9- Hu J, Wei W, Din G, Yuan L, Liu Z. Variations and clinical significance of coagulation and fibrinolysis parameters in patients with diabetes mellitus. J Tongji Med Univ 1998;18(4):233-5.
10. 10- Kannel WB, D'Agostino RB, Belanger AJ. Update on fibrinogen as a cardiovascular risk factor. Ann Epidemiol 1992 Jul;2(4):457-66.
11. 11- Bembde AS. A study of plasma fibrinogen level in type-2 diabetes mellitus and its relation to glycemic control. Indian J Hematol Blood Transfus 2012 Jun;28(2):105-8.
12. 12- Fuller JH, Keen H, Jarrett RJ, Omer T, Meade TW, Chakrabarti R, North WR, Stirling Y. Haemostatic variables associated with diabetes and its complications. Br Med J. 1979 Oct 20;2(6196):964-6.
13. 13- Balleisen L, Assmann G, Bailey J, Epping PH, Schulte H, van de Loo J. Epidemiological study on factor VII, factor VIII and fibrinogen in an industrial population--II. Baseline data on the relation to blood pressure, blood glucose, uric acid, and lipid fractions. Thromb Haemost 1985 Oct 30;54(3):721-3.