Systemic Lupus Erythematosus Developed Under The Brucellosis Therapy

Öz

Drug-induced lupus erythematosus is a disorder which is temporally related to continuous drug exposure and clinical findings resolve upon discontinuation of the offending drug. Its clinical and laboratory findings are similar to systemic lupus erythematosus (SLE). SLE induced by doxycycline, rifampicin or streptomycin are extremely rare. We present the case of a patient who developed arthralgia, leucopenia, lymphopenia and pleural effusion due to the doxycycline, rifampicin or streptomycin drugs treatment. 

Anahtar Kelimeler

• Brucellosis,Doxycycline,Rifampicin,Streptomycin

Bruselloz Tedavisi Altında Gelişen Sistemik Lupus Eritematozus

Öz

İlaca bağlı lupus eritematozus, ilaç kullanımına bağlı ortaya çıkan ve ilacın kesilmesi sonrasında klinik bulguların gerilemesi ile karakterize bir bozukluktur. İlaç kaynaklı lupus eritematozusun klinik ve laboratuar bulguları sistemik lupus eritematozusun (SLE) bulguları ile benzerdir. Doksisiklin, rifampisin veya streptomisin ile tetiklenen SLE son derece nadirdir. Bu yazıda doksisiklin, rifampisin veya streptomisin tedavisine bağlı artralji, lökopeni, lenfopeni ve plevral efüzyon gelişen bir olgu sunulmuştur.

Anahtar Kelimeler

• Bruselloz,Doksisiklin,Rifampisin,Streptomisin

Kaynakça

1. 1. Atwater BD, Ai Z, Wolff MR. Fulminant myopericarditis from phenytoin-induced systemic lupus erythematosus. WMJ 2008;107(6):298-300. 2. Weigert O, von Spee C, Undeutsch R, Kloke L, Humrich JY, Riemekasten G. CD4+Foxp3+ regulatory T cells prolong drug-induced disease remission in (NZBxNZW) F1 lupus mice. Arthritis Res Ther 2013;15(1):R35. 3. Dalle Vedove C, Simon JC, Girolomoni G. Druginduced lupus erythematosus with emphasis on skin manifestations and the role of anti-TNFα agents. J Dtsch Dermatol Ges 2012;10(12):889-97. 4. Williams EL, Gadola S, Edwards CJ. Anti-TNFinduced lupus. Rheumatology (Oxford) 2009; 48(7):716- 720. 5. Liakou AI, Brunner M, Theodorakis MJ, Makrantonaki E, Zouboulis CC. Recurrent subacute cutaneous lupus erythematosus following exposure to different drugs. Acta Derm Venereol 2011; 91(5):586-7. 6. Vedove CD, Del Giglio M, Schena D, Girolomoni G. Drug induced lupus erythematosus. Arch Dermatol Res 2009;301(1):99-105. 7. Fritzler MJ. Drugs recently associated with lupus syndromes. Lupus 1994;3(6):455-9. 8. Marzano AV, Vezzoli P, Crosti C. Drug–induced lupus: an update on its dermatolojic aspects. Lupus 2009;18(11):935- 40. 9. Lewis-Jones MS, Evans S, Thompson CM. Erythema multiforme occuring in association with lupus erythematosus during therapy with doxycycline. Clin Exp Dermatol 1988;13(4):245-7. 10. Patel GK, Anstey AV. Rifampicin-induced lupus erythematosus. Clin Exp Dermatol 2001;26(3):260-2.