Endometrial Polip Tanısı Konulan Olgularda Ghrelin'in Serum ve Doku Düzeyi Seviyelerinin Araştırılması

Öz

Amaç: Endometrial polipler infertiliteye neden olabilen endometriumun iyi huylu lezyonlarıdır. Bu çalışmada ghrelin miktarının endometrial polip gelişimindeki etkisi değerlendirildi. Materyal ve metod: Endometrial polip tanısı konulan 9'u proliferasyon, 6'sı sekretuvar fazda 15 olgunun doku ghrelin miktarı immünohistokimyasal metod, Enzim İmmunoassay (EIA) ve ELİSA ile değerlendirildi. Bulgular: Ghrelin konsantrasyonu sekretuvar fazda proliferatif faza göre daha yüksekti. Ghrelin konsantrasyonu endometrial polipte endometrium grubuna göre daha düşüktü. Sonuç: Endometrial polip oluşumunda ghrelin salınımı önemli bir rol oynamaktadır. 

Anahtar Kelimeler

• Ghrelin,Endometriyum,Polip

Investigation of Plasma and Tissue Ghrelin Levels in Diagnosed Endometrial Polyps

Öz

Background: Endometrial polyps, which are benign growths of the endometrium, may be a factor in female subfertility. We aimed to evaluate the ghrelin expressions for the development of endometrial polyps. Methods: Tissue ghrelin expressions of a total of 15 cases endometrial polyps, whom 9 had in the proliferation phase, 6 had in the sekretuar phase were examined using immunohistochemical method, Enzim İmmunoassay (EIA) and ELİSA. Results: Ghrelin concentrations in the secretuar phase group were higher compared to the proliferative phase. Ghrelin concentrations were lower in the endometrial polyps group as compared to the endometrium group in the secretuar phase. Conclusions: We think that ghrelin expression can be important in endometrial polyps formation.

Anahtar Kelimeler

• Ghrelin,Endometrium,Polyp

Kaynakça

1. 1. Reslova T, Tosner J, Resl M, Kugler R, Vavrova I. Endometrial polyps. A clinical study of 245 cases. Arch Gynecol Obstet 1999;262:133-139. 2. Varras M, Akrivis Ch. Large endometrial polyp with sarcomatous stromal components following longterm tamoxifen treatment for breast cancer: a case report and review of the literature. Eur J Gynaecol Oncol. 2003;24:565-568. 3. Mittal K, Schwartz L, Goswami S, Demopoulos R: Estrogen and progesterone receptor expression in endometrial polyps. Int J Gynecol Pathol 1996;15:345- 348. 4. Barreiro, M.L, Tena-Sempere, M, Ghrelin and reproduction: a novel signal linking energy status and fertility?,Molecular and Cellular Endocrinology 2004,226,1-2,1-9. 5. Peterson WF, Novak. Endometrial polyps Obstet Gynecol. 1956; 8: 40-49. 6. Van Bogaert LJ. Clinicopathologic findings in endometrial polyps. Obstet Gynecol. 1988;71:771-773 7. Shalev J,Meizner I. Predictive value of transvaginal sonography performed routine diagnostic hysteroscopy for evaluation of infertility. Fertil Steril 2000;73:412- 417. 8. Kojima, M, Hosoda, H, Date, Y, Nakazato, M, Matsuo, H, Kangawa, K, 1999, Ghrelin is growth-hormonereleasing acylated peptide from stomach, Nature 402, 656-660. 9. Wang, G, Lee, H.M, Englander, E, Greeley, H.G, 2002, Ghrelin—not just another stomach hormone, Regulatory Peptides 105,75–81. 10. Tena-Sempere, M, Aguilar, E; Fernandez-Fernandez, R, Pinilla, L., 2004, Ghrelin inhibits prolactin secretion in prepubertal rats, Neuroendocrinology 79, 133–141. 11. Katergari SA, Milousis A, Pagonopoulou O, Asimakopoulos B, Nikolettos NK. Laboratory of Physiology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece. Endocrine Journal 2008;55:439-453. 12. Cassoni P, Ghé C, Marrocco T, Tarabra E, Allia E, Catapano F, Deghenghi R, Ghigo E, Papotti M, Muccioli G.,Expression of ghrelin and biological activity of specific receptors for ghrelin and desacyl ghrelin in human prostate neoplasms and related cell lines. Eur J Endocrinol. 2004; 150: 173-184. 13. Cassoni P, Papotti M, Ghè C, et al. Identification, characterization, and biological activity of specific receptors for natural (ghrelin) and synthetic growth hormone secretagogues and analogs in human breast carcinomas and cell lines. J Clin Endocrinol Metab. 2001;86:1738-1745. 14. Jeffery PL, Herington AC, Chopin LK. The potential autocrine/paracrine roles of ghrelin and its receptor in hormone-dependent cancer. Cytokine Growth Factor Rev. 2003;14:113-122. 15. Jeffery PL, Murray RE, Yeh AH, et al. Expression and function of the ghrelin axis, including a novel preproghrelin isoform, in human breast cancer tissues and cell lines. Endocr Relat Cancer. 2005;12:839-850. 16. Korbonits M, Bustin SA, Kojima M, Jordan S, Adams EF, Lowe DG, Kangawa K, Grossman AB. The expression of the growth hormone secretagogue receptor ligand ghrelin in normal and abnormal human pituitary and other neuroendocrine tumors. J Clin Endocrinol Metab 2001;86:881-887. 17. Molecular Human Reproduction 2007;13:483-489 18. Tanaka et al. Ghrelin and Decidualization of Stromal Cells The Journal of Clinical Endocrinology & Metabolism 2003;88:2335-2340.