Variation of oxidative stress parameters in patients with lung, breast and colon cancer

Yıl 2019, , 235 - 240, 29.08.2019

Ömer Faruk Özer , Eray Metin Güler , Şahabettin Selek , Ganime Çoban , Hacı Mehmet Türk Abdurrahim Koçyiğit

https://doi.org/10.35440/hutfd.576016

Cited By: 4

Öz

Background: Cancer is a very common deadly disease in the world. In the cancer
formation oxidative stress on the cellular level is thought to be effective for
many reasons. The aim of this study was to investigate the changes in oxidative
status in cancer types in lung, breast and colon cancers.

Methods:
Forty four lung cancer patients, 37 breast cancer patients and 20 colon cancer
patients in the medical oncology department were included in the study. All
patients were histopathologically diagnosed. Total Antioxidant Levels (TAS),
Total Oxidant Levels (TOS) and Catalase (CAT) and Myeloperoxidase (MPO) enzyme
activities were measured by photometric method in autoanalyser and compared
with 43 healthy volunteers.

Results:
TOS was significantly higher in all cancer types than control group, but not
statistically significant, but significantly higher in breast cancer
(p<0.002). Oxidative Stress Index (OSI) were found to be significantly lower
in all three types of cancer than in the control group (p<0.001). TAS, CAT
and MPO values were significantly higher in all three types of cancer than in
the control group (p<0.001).

Conclusion: In the study, it was concluded that oxidative stress increased in
cancer, but increased oxidative stress may decrease OSI level due to induction
of antioxidant defense system.

 

Keywords:
Oxidative stress, Lung cancer, Breast cancer, Colon cancer

Anahtar Kelimeler

Oxidative stress, Lung cancer, Breast cancer, Colon cancer

Akciğer, meme ve kolon kanserli hastalarda oksidatif stres parametrelerinin değişimi

Öz

Amaç: Kanser dünyada çok yaygın ölümcül bir hastalıktır. Kanser oluşumunda
birçok nedenden dolayı hücresel düzeyde meydana gelen oksidatif stresin etkili
olduğu düşünülmektedir. Bu çalışmada akciğer, meme ve kolon kanserlerinde
oksidatif durumun kanser türlerindeki değişiminin araştırılması amaçlandı.

Materyal ve
Metot: Medikal Onkoloji
bölümünde tedavileri süren 44 akciğer kanseri, 37 meme kanseri, 20 kolon
kanseri hastası çalışmaya dahil edildi. Çalışmaya katılan hastaların tamamı
histopatolojik olarak tanısı kesinleştirilirmiş hastalardı. Hastaların Total
Antioksidan Seviye (TAS), Total Oksidan Seviye (TOS) ile Katalaz (CAT) ve
Myeloperoksidaz (MPO) enzim aktiviteleri otoanalizörde fotometrik yöntemle
ölçülüp, 43 sağlıklı gönüllü ile karşılaştırıldı.

Bulgular: TOS seviyeleri kontrol grubuna göre meme kanserinde anlamlı olarak
yüksek bulunurken (p<0.002), diğer kanser gruplarında yüksek olmakla
birlikte anlamlı fark bulunmadı. 
Oksidatif Stres İndeksi (OSİ) ise her üç kanser türünde de kontrol
grubuna göre anlamlı derecede düşük bulundu (p<0.001). TAS, CAT ve
MPO aktiviteleri her üç kanser tipinde de kontrol grubuna göre anlamlı derecede
yüksek idi. (p<0.001).

Sonuç: Çalışmada, kanserde oksidatif stresin arttığı ancak, artmış oksidatif
stresin antioksidan savunma sistemini indüklemesi nedeni ile OSI seviyesini
düşürmüş olabileceği sonucuna varıldı.

 

Anahtar Kelimeler: Oksidatif stres, Akciğer kanseri, Meme kanseri, Kolon kanseri

Anahtar Kelimeler

Oksidatif stres, Akciğer kanseri, Meme kanseri, Kolon kanseri

Kaynakça

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