Variation of oxidative stress parameters in patients with lung, breast and colon cancer

Öz

Background: Cancer is a very common deadly disease in the world. In the cancer formation oxidative stress on the cellular level is thought to be effective for many reasons. The aim of this study was to investigate the changes in oxidative status in cancer types in lung, breast and colon cancers.

Methods: Forty four lung cancer patients, 37 breast cancer patients and 20 colon cancer patients in the medical oncology department were included in the study. All patients were histopathologically diagnosed. Total Antioxidant Levels (TAS), Total Oxidant Levels (TOS) and Catalase (CAT) and Myeloperoxidase (MPO) enzyme activities were measured by photometric method in autoanalyser and compared with 43 healthy volunteers.

Results: TOS was significantly higher in all cancer types than control group, but not statistically significant, but significantly higher in breast cancer (p<0.002). Oxidative Stress Index (OSI) were found to be significantly lower in all three types of cancer than in the control group (p<0.001). TAS, CAT and MPO values were significantly higher in all three types of cancer than in the control group (p<0.001).

Conclusion: In the study, it was concluded that oxidative stress increased in cancer, but increased oxidative stress may decrease OSI level due to induction of antioxidant defense system.

 

Keywords: Oxidative stress, Lung cancer, Breast cancer, Colon cancer

Anahtar Kelimeler

• Oxidative stress,Lung cancer,Breast cancer,Colon cancer

Akciğer, meme ve kolon kanserli hastalarda oksidatif stres parametrelerinin değişimi

Öz

Amaç: Kanser dünyada çok yaygın ölümcül bir hastalıktır. Kanser oluşumunda birçok nedenden dolayı hücresel düzeyde meydana gelen oksidatif stresin etkili olduğu düşünülmektedir. Bu çalışmada akciğer, meme ve kolon kanserlerinde oksidatif durumun kanser türlerindeki değişiminin araştırılması amaçlandı.

Materyal ve Metot: Medikal Onkoloji bölümünde tedavileri süren 44 akciğer kanseri, 37 meme kanseri, 20 kolon kanseri hastası çalışmaya dahil edildi. Çalışmaya katılan hastaların tamamı histopatolojik olarak tanısı kesinleştirilirmiş hastalardı. Hastaların Total Antioksidan Seviye (TAS), Total Oksidan Seviye (TOS) ile Katalaz (CAT) ve Myeloperoksidaz (MPO) enzim aktiviteleri otoanalizörde fotometrik yöntemle ölçülüp, 43 sağlıklı gönüllü ile karşılaştırıldı.

Bulgular: TOS seviyeleri kontrol grubuna göre meme kanserinde anlamlı olarak yüksek bulunurken (p<0.002), diğer kanser gruplarında yüksek olmakla birlikte anlamlı fark bulunmadı.  Oksidatif Stres İndeksi (OSİ) ise her üç kanser türünde de kontrol grubuna göre anlamlı derecede düşük bulundu (p<0.001). TAS, CAT ve MPO aktiviteleri her üç kanser tipinde de kontrol grubuna göre anlamlı derecede yüksek idi. (p<0.001).

Sonuç: Çalışmada, kanserde oksidatif stresin arttığı ancak, artmış oksidatif stresin antioksidan savunma sistemini indüklemesi nedeni ile OSI seviyesini düşürmüş olabileceği sonucuna varıldı.

 

Anahtar Kelimeler: Oksidatif stres, Akciğer kanseri, Meme kanseri, Kolon kanseri

Anahtar Kelimeler

• Oksidatif stres,Akciğer kanseri,Meme kanseri,Kolon kanseri

Kaynakça

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