Akut Koroner Sendromlu Hastalarda Plazma von Willebrand Faktör Düzeyi ile Koroner Arter Hastalığı Ciddiyeti Arasındaki İlişkisi

Öz

Amaç: Koroner arter hastalığının yaygınlığını ve ciddiyetini değerlendirmek için anjiyografik bir skorlama sistemi olan Gensini skoru kullanılmaktadır. Yüksek Gensini skoru ve vonWillebrand faktör düzeyi akut koroner sendromlu hastalarda kötü kardiyak olaylar ile ilişkilidir. Bu çalışmada akut koroner sendromlu hastalarda Gensini skoru ile vonWillebrand faktör düzeyi arasındaki ilişkiyi araştırmayı planladık.

Materyal ve Metot: Çalışmaya akut koroner sendrom tanısıyla koroner anjiyografi yapılan 141 hasta dahil edildi. Gensini skoru <32 olan hastalar grup 1, gensini skoru ≥ 32 olan hastalar ise grup 2 olarak tanımlandı. Her iki grup, anjiyografik özellikler ve plazma vonWillebrand faktör düzeyleri açısından karşılaştırıldı

Bulgular: Grup 1 hastalar ile karşılaştırıldıklarında, grup 2 hastalarda vonWillebrand faktör düzeyi anlamlı olarak daha yüksek idi (140 IU [101-149]’e karşın 120 IU [100-134], P=0.010). Korelasyon analizinde gensini skoru ile vWF arasında pozitif bir korelasyon mevcuttu (r = 0.228, p = 0.007). Çok değişkenli lojistik regresyon analizinde, vWF yüksek Gensini skorunun bağımsız bir öngördürücüsü olarak tespit edildi (odds oranı, 1.013; % 95 güven aralığı, 1.002 - 1.026, P <0.027). vonWillebrand faktör sınır değerinin  ≥ 128 IU alınması, % 59 duyarlılık ve % 63 özgüllük ile yüksek gensini skorunu öngördü.

Sonuç: Akut koroner sendromlu hastalarda yüksek von Willebrand faktör seviyesi bağımsız olarak yüksek gensini skoru ile ilişkilidir.

Anahtar Kelimeler

• Akut koroner sendrom,Gensin skoru,von Willebrand faktör

The Relationship between Plasma von Willebrand Factor Level and Severity of Coronary Artery Disease in Patients with Acute Coronary Syndrome

Öz

Background: Gensini score, an angiographic scoring system, is used to evaluate the extent and severity of coronary artery disease. High Gensini score and von Willebrand factor level are associated with poor cardiac events in patients with acute coronary syndrome. In this study, we aimed to investigate the relationship between Gensini score and von Willebrand factor level in patients with acute coronary syndrome

Materials and Methods: The study included 141 patients with acute coronary syndrome who underwent coronary angiography. Patients with gensini score <32 were defined as group 1, while patients with gensini score ≥32 were defined as group 2. Angiographic characteristics and plasma von Willebrand factor level were compared between two groups.

Results: When compared to group 1 patients, group 2 patients had significantly higher levels of von Willebrand factor (140 IU [101-149] vs. 120 IU [100-134], P = 0.010). In correlation analysis, Gensini score and von Willebrand factor level was positively correlated (r = 0.228, p = 0.007). Multivariate logistic regression analysis demonstrated that Willebrand factor was an independent predictor of high gensini score (odds ratio, 1.013; 95% confidence interval, 1.002 - 1.026, P <0.027]. von Willebrand factor level ≥ 128 IU predicted high gensini score with a sensitivity of 59% and specificity of 63%.

Conclusion: High von Willebrand factor level is independently associated with high gensini score in patients with acute coronary syndrome.

Kaynakça

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