Domuzlarda deneysel karotis bileşke anevrizma modeli ve literatür araştırması

Öz

Amaç: Deneysel anevrizma modeli intrakranial anevrizmaların tedavisini değerlendirmek için üç ayrı nedenle kullanılmıştır. Bunlar; deneysel anevrizma oluşturulurken kazanılan pratik ve tecrübeler, karşılaştırılmalı çalışmaların ve yeni prosedürlerin yapılabilmesi ve yeni tedavi yöntemlerinin geliştirilmesidir. Bu çalışmada domuzlarda deneysel karotis bileşke anevrizması oluşturulmuş ve bu konudaki literatür çalışmalarının sunulması amaçlanmıştır. Gereç ve Yöntem: Domuzlar üzerinde boyun bölgesinde karotis arter ve bileşkedeki dalları geçici anevrizma klipleri ile kapatılıp oval arter kesisi yapıldıktan sonra venöz damar grefti ile anastomoz yapılıp anevrizma oluşturuldu. Sonuçlar: Karotis arter bileşkesinde 10 adet anevrizma oluşturuldu. Anevrizmaların büyüklüğü en az 4 mm olup, boyun genişliği en az 2 mm ölçüldü. Oluşturulan anevrizmaların sadece bir tanesi tromboze oldu. Tartışma: Bu çalışmada deneysel arteriel bileşke anevrizması oluşturulurken bu modelin ve ayrıntılı literatür araştırmamızın endovasküler tekniklere ve anevrizma hemodinamiği için yapılan yeni çalışmalara ışık tutacağına ümit ediyoruz

Anahtar Kelimeler

• Deneysel sakküler anevrizma,anjiografi,hayvan modeli

Experimental carotid bifurcation aneurysm model in the pig and review of the literature

Öz

Objective: Experimentally constructed aneurysms have been used in three ways in the evaluation of therapeutic methods for intracranial aneurysms: they may be used simply for the acquisition of skill through repeated practice of certain therapeutic procedures; in comparative studies of new and/or established procedures, and in the investigation, development, and refinement of new therapies. In this article a carotid artery bifurcation saccular aneurysm model is described in the pig and also we review the experimental applications of the aneurysms in the laboratory animals. Methods: The cervical carotid and both bifurcation branches are occluded with temporary aneurysm clips for performance of an elliptical arteriotomy and anastomosis of the vein graft in the suscrofa pigs. Results: 10 aneurysms were created at the carotid bifurcation of the pig. The lower limit on the size of the aneurysm in our study was 4 mm the lower limit of the size of the arteriotomy orifice was 2 mm. Only one aneurysm had thrombosed. Conclusion: The surgical steps in the construction of this model are detailed and such a model is useful in studying aneurysm hemodynamics with various therapeutic modalities, and evaluating interventional techniques for the treatment of aneurysm

Anahtar Kelimeler

• Experimental saccular aneurysm,angiography,animal model

Kaynakça

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