Cerrahi Erken Menopoz Geçiren Hastalarda Damar Sertliği Artar mı?

Öz

Amaç: Cerrahi erken menopoz, doğal yaşlanma sürecinden ziyade tıbbi nedenlerle meydana gelen erken menopozdur. Nabız dalga hızı (NDH) ve büyütme indeksi (Augmentasyon indeksi, AIx), arteryel sertliğin değerlendirilmesi için basit ve invazif olmayan parametrelerdir. Bu çalışmanın amacı, cerrahi erken menopoz hastalarında arteryel sertliği araştırmaktır. Materyal ve Metod: Çalışmaya cerrahi erken menopozlu 40 hasta ve 40 sağlıklı kontrol dahil edildi. Hastaların arter sertliği ve hemodinamik parametreleri, Mobil-O-Graph NG (IEM GmbH, Stolberg, Almanya) 24 saatlik ambulatuvar kan basıncı monitör arteriyografisi ile ölçüldü. Bulgular: Başlangıç demografik, laboratuvar ve ekokardiyografik parametrelerde gruplar arasında fark yoktu. Cerrahi erken menopozlu hastalarda (n=40) etiyoloji değerlendirildiğinde 27 hastada (% 67.5) malignite, 11 hastada (%27.5) miyom ve 2 hastada (%5) kanama idi. Nabız dalga hızı (NDH), erken menopoz grubunda (6.5 m/s, (4,7-8,2) 5.6 m/s'ye (4,5-9,0 m/s) karşı anlamlı olarak daha yüksekti; P<0,001), ancak Alx'te istatistiksel olarak anlamlı bir fark yoktu (%28.3±10.9'a karşı %27.4±9.0; P=0.69). Ayrıca kardiyak hemodinamik parametreler ve santral aort basınçları açısından istatistiksel olarak anlamlı bir fark yoktu. Sonuç: Cerrahi erken menopoz hastalarında arteryel sertlik, diğer risk faktörlerinden bağımsız olarak sağlıklı bireylerle karşılaştırıldığında önemli ölçüde artmıştır.

Anahtar Kelimeler

• Arteryel sertlik
• Nabız dalga hızı
• Cerrahi erken menopoz

Does Arterial Stiffness Increase in Patients with Surgical Early Menopause?

Öz

Background Surgical early menopause is early menopause due to medical reasons rather than the natural aging process. Pulse wave velocity (PWV) and augmentation index (AIx) are simple and non-invasive parameters for assessment of arterial stiffness. The aim of this study investigated the arterial stiffness in the surgical early menopause patients. Material and Method We included 40 patients with surgical early menopause and 40 healthy controls for the study. The patients’ arterial stiffness and hemodynamic parameters were measured with Mobil-O-Graph NG (IEM GmbH, Stolberg, Germany) 24-hour ambulatory blood pressure monitor arteriography. Result There was no difference between the groups in baseline demographic, laboratory, and echocardiographic parameters. In patients with surgical early menopause (n=40), the etiology was malignancy in 27 (67.5%), myoma in 11 (27.5%) and bleeding in 2 (5%) patients. PWV was significantly higher in the early menopause group (6.5 m/s, (4.7-8.2) versus 5.6 m/s, (4.5-9.0 m/s); P<0.001), but there was no statistically significant difference in Alx (28.3±10.9% versus 27.4±9.0%; P=0.69). Also, there was no statistically significant difference in terms of cardiac hemodynamic parameters and central aortic pressures. Conclusion Arterial stiffness is significantly increased in surgical early menopause patients compared with healthy subjects independent of other risk factors.

Anahtar Kelimeler

• Arterial stiffness
• pulse-wave velocity (PWV)
• surgical early menopause

Kaynakça

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