Investigation of the effects of levetiracetam on sympathetic skin response

Yıl 2018, Cilt: 15 Sayı: 2, 80 - 84, 14.08.2018

Halil Ay

Öz

Background: It has been aimed to investigate the effects of levetiracetam on sympathetic skin response.

Material and Methods: Thirty-seven patients those admitted to neurology policlinic and electroencephalography laboratory of Harran University Medical Faculty or neurology policlinics of the other area hospitals and using levetiracetam regularly as monotherapy or polytherapy with the diagnosis of epilepsy and 26 non- taking medicine healthy people were involved to the study. Sympathetic skin responses of the patient and healthy groups were measured from the right-hand region by the electromyoneurography device. Nine male and 14 female patients were taking monotherapy. Their ages were between 16 and 63 with a mean of 26.73 ± 10.62. 7 male and 7 female patients were taking polytherapy. Their ages were between 16 and 38 with a mean of 24.21 ± 6.32. Healthy people of the control group were 21 males and 5 females. Their ages were between 20 and 45 with a mean of 29.69 ± 5.77.

Results: Mean of sympathetic skin response latencies in monotherapy taking patient group was shorter compared to the control group and a statistically significant difference was detected (p≤0.05). There has been no statistically significant difference between monotherapy taking patient group and control group in terms of mean sympathetic skin response amplitude levels. There has been no statistically significant difference between polytherapy taking patient group and control group in terms of mean sympathetic skin response amplitudes and latencies.

Conclusion: These results point out that levetiracetam treatment may partly cause hyperactivity in sympathetic skin reactions.

Anahtar Kelimeler

Levetiracetam, sympathetic skin response, epilepsy

Levetirasetam’ın sempatik deri yanıtları üzerine etkilerinin araştırılması

Öz

Levetirasetamın sempatik deri yanıtları üzerine etkilerinin
araştırılması amaçlandı. Harran Üniversitesi Tıp Fakültesi nöroloji
polikliniğine, elektroensefalografi laboratuvarına, çevre hastanelerin nöroloji
polikliniklerine başvuran epilepsi tanısı almış, monoterapi ya da politerapi
şeklinde Levetirasetam daha önceden reçete edilmiş ve düzenli kullanan 37 hasta
ile, ilaç kullanmayan sağlıklı 26 kişi çalışmaya dahil edildi. Hasta ve
sağlıklı gruplara elektomyo-nörografi cihazı ile sağ el bölgesinde sempatik
deri yanıtlarına bakıldı.Monoterapi alan hasta grup 14 bayan ve 9 erkekten
oluşmaktadır. Yaşları 16-63 arasındaydı ve yaş ortalaması 26,73 ± 10,62 idi.
Politerapi alan hasta grup 7 bayan ve 7 erkek hastadan oluşmaktaydı. Yaşları
16-38 arası olup, yaş ortalaması 24,21 ± 6,35 idi. Kontrol grubu olan sağlıklı
bireyler 5 bayan ve 21 erkekten oluşmaktaydı. Yaşları 20 - 45 yaş arası olup,
yaş ortalaması 29,69 ± 5,77 idi. Monoterapi alan hasta grubundaki sempatik deri
yanıtı latans ortalaması kontrol grubu ile kıyaslandığında kısa olup,
istatistiksel olarak anlamlı fark saptandı (p≤0,05). Monoterapi alan hasta
grubundaki sempatik deri yanıtı amplitüd değerleri, kontrol grubu ile kıyaslandığında
istatistiksel olarak anlamlı fark saptanmadı. Politerapi alan hasta grubundaki
sempatik deri yanıtı latans ve amplitüdlerin ortalamaları, kontrol grubu ile
kıyaslandığında istatistiksel olarak anlamlı fark saptanmadı. Bulgular, levetirasetam tedavisinin sempatik deri
yanıtlarında kısmen de olsa hiperaktiviteye sebep olduğunu göstermektedir

Anahtar Kelimeler

Levetirasetam, sempatik deri yanıtları, epilepsi

Kaynakça

• References
• 1- Allan H.Ropper Robert H.Brown, Ed: Murat Emre, Adams and Victor’s principles of neurology, 8.Basım, Öncü Basımevi, 2006, s.87-88,271-274
• 2- Öge E. Istanbul University, Istanbul Faculty of Medicine Basic and Clinical Sciences Neurology Lesson Book, Ed: Öge E. 19.Print, 2004, S.279-285 ( Epilepsy)
• 3- Snell SR. Clinical neuroanatomy Türkçe çeviri editörü: Mehmet Yıldırım Lıppıncott Williams 2000:342-380.
• 4- Drake, M.E. Clinical neurophysiology of the autonomic nervoussystem. Clinical EEG. 1995; 26: 133-134.
• 5- Mıles E. Drake Jr, Jodıe M. Andrews & Chrıstına M. Castleberry. Division of Epilepsy and Clinical Neurophysiology, 1998; 7:91-96
• 6- Braune HJ. Autonomic dysfunction in Parkinson’s disease assessed by sympathetic skin response: a prospective clinical and neurophysiological trial on 50 patients. Acta Neurol Scand 1987; 95 (5): 293-7.
• 7- Fusina S, Conte S, Bertolasi L, Fincati E, Nardelli E, Bongiovanni LG. Sympathetic skin esponse asymmetry in early stage idiopathic Parkinson’s disease. Clin Neurophysiol 1999; 110 (2) 358-366.
• 8- Zakrzewska-Pniewska B, Jamrozik Z. Are electrophysiological autonomic tests useful in the assessment of dysautonomia in Parkinson’s disease? Parkinsonism Rel D 2003;9(3):179-83.
• 9- Orrin Devisky. Effects of seizures on autonomic and cardiovascular function. Epilepsy Currents 2004; 4 (2): 43-6.
• 10- Gleizer MA, Karlov VA. Autonomic dysfunction in patients withtemporal lobe epilepsy. Zh Nevropatol Psikhiatr Im S S Korsakova 1988; 88 (6):11–5.
• 11- Wannamaker BB. Autonomic nervous system and epilepsy. Epilepsia 1985;26 (1):31-9.
• 12- Isojarvi JI, Ansakorpi H, Suominen K, Tolonen U, Repo M, Myllyla VV. Interictal cardiovascular autonomic responses in patients with epilepsy. Epilepsia 1998; 39 (4):420-6.
• 13- Ansokorpi H, Korpelainen JT, Suominen K, Tolonen U, Myllyla VV, Isojarvi JI. Interictal cardiovascular autonomic responses in patients with temporal lobe epilepsy. Epilepsia 2000; 41 (1):42–7.
• 14- Faustmann PM, Ganz RE. Central cardio-autonomic disorganization in interictal states of epilepsy detected by phase space analysis. Int J Neurosci 1994; 78 (1-2):43–7.
• 15- Eretekin C, Santral ve periferik EMG, anatomi, fizyoloji, klinik, 2006, 890-891
• 16- Drory VE, Korezyn A.D. Sympathetic Skin Response: Age effect. Neurology 1993:43 (9):1818-20
• 17- M. Said Berilgen, Tacim Sari, Serpil Bulut, and Bulent Mungen,Effects of epilepsy on autonomic nervous system and respiratory function test, Epilepsy and Behavior, 2004, 5(4) 513-516
• 18- Devinsky O, Perrine K, Theodore WH. Interictal autonomic nervous system function in patients with epilepsy. Epilepsia, 1994; 35 (1):199–204.