Diyagonal kulak memesi kırışması artmış ortalama trombosit hacmi ile ilişkilidir

Yıl 2018, Cilt: 15 Sayı: 3, 134 - 139, 12.12.2018

Selim Kul , Muhammet Raşit Sayın , İhsan Dursun , Sinan Şahin , Doğuş Hemşinli Cihan Aydın , Ahmet Hakan Ateş

Öz

Giriş: Diagonal Kulak Memesi Kırışıklığı (KMK), aterosklerozun bir işareti olarak kabul edilir. Trombositler aterosklerotik lezyonların başlamasında ve sonrasında oluşan komplikasyonlarda önemli rol oynarlar. Ortalama trombosit hacmi (OTH), trombosit aktivasyonunun bir göstergesidir. Bu çalışmada KMK’lı bireylerde OTH’nin değerlendirilmesi amaçlandı.

Materyal ve Metod: Çalışmaya KMK olan 75 hasta (28K; ort. yaş: 59±10 yıl) ve KMK olmayan 54 hasta (23 K; yaş: 56±11 yıl) alındı. Klinik ve demografik özellikler, OTH, lökosit sayısı, hemoglobin düzeyi, trombosit sayısı ve plateletkrit düzeyi gruplar arasında karşılaştırıldı.

Sonuç: Klinik ve demografik özellikler her iki grupta benzer bulundu. Hemoglobin (13,7±1,3 g/dL vs 13,8±1,40 g/dL; p=0,782), lökosit (7,01±1,57 x103mm-3 vs 7,26±1,63 x103mm-3; p=0,429), trombosit (240±57 x103mm-3 vs 246±59 x103mm-3; p=0,617) ve plateletkrit (0,207±0,048 % vs 0,196±0,046 %; p=0,258) değerleri arasında iki grup arasında istatistiksel olarak anlamlı fark saptanmadı. KMK olan grupta OTH; KMK olmayan gruba göre istatistiksel olarak anlamlı derecede daha yüksek bulundu (8,69±0,95 fL vs 7,96±0,75 fL; p<0,0001). Yapılan korelasyon analizinde KMK ile OTH arasında anlamlı ancak orta düzeyde bir ilişki saptandı (p<0,001; r = 0,356).

Tartışma: KMK olan grupta OTH artmış olarak izlendi. Sonuçlarımız, artan trombosit aktivitesinin KMK olanlarda, KMK olmayanlara göre daha fazla görülen koroner arter hastalığının patofizyolojisinde rol oynayabileceğini düşündürmektedir.

Anahtar Kelimeler

Kulak memesi kırışıklığı, Subklinik ateroskleroz, Trombosit hacmi

Diagonal earlobe crease is associated with increased mean platelet volume

Öz

Background: Diagonal earlobe crease (DEL) is considered a sign of atherosclerosis. Platelets play an important role in the onset and subsequent complications of atherosclerotic lesions. Mean platelet volume (MPV) is an indicator of platelet activation. In this study, we aimed to evaluate MPV in DEL individuals.

Material and Methods: Seventy-five patients with DEL (28F; mean age: 59±10 years) and 54 patients without DEL (23F; mean age: 56±11 years) were included in this study. Clinical and demographic characteristics, MPV, leukocyte counts, hemoglobin levels, platelet counts and plateletcrit levels were compared between the two groups.

Results: Clinical and demographic characteristics were similar between the two groups. Hemoglobin levels (13.7±1.3 g/dL vs. 13.8±1.40 g/dL; p=0.782), leukocyte counts (7.01±1.57 x103mm-3 vs. 7.26±1.63 x103mm-3; p=0.429), platelet counts (240±57 x103mm-3 vs. 246±59 x103mm-3; p=0.617) and plateletcrit levels (0.207±0.048 % vs. 0.196±0.046%; p=0.258) were comparable between the two groups. MPV was significantly higher in the DEL group compared to non-DEL group (8.69±0.95 fL vs 7.96±0.75 fL; p<0.0001). Correlation analysis showed a significant but moderate correlation between DEL and MPV (p<0.0001; r = 0.356).

Conclusion: MPV is elevated in patients with DEL. Considering the effects of platelets on atherosclerosis as well as their close relation to other risk factors, MPV may be an important predisposing factor for atherosclerosis in patients with DEL.

Anahtar Kelimeler

Diagonal earlobe crease, Platelet volume, Subclinical atherosclerosis

Kaynakça

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