Endometrial Polip Tanısı Konulan Olgularda Ghrelin'in Serum ve Doku Düzeyi Seviyelerinin Araştırılması

Yıl 2015, Cilt: 12 Sayı: 1, 90 - 97, 15.04.2015

Ömer Faruk Doğan

Öz

Amaç: Endometrial polipler infertiliteye neden olabilen endometriumun iyi huylu lezyonlarıdır. Bu
çalışmada ghrelin miktarının endometrial polip gelişimindeki etkisi değerlendirildi.
Materyal ve metod: Endometrial polip tanısı konulan 9'u proliferasyon, 6'sı sekretuvar fazda 15 olgunun
doku ghrelin miktarı immünohistokimyasal metod, Enzim İmmunoassay (EIA) ve ELİSA ile
değerlendirildi.
Bulgular: Ghrelin konsantrasyonu sekretuvar fazda proliferatif faza göre daha yüksekti. Ghrelin
konsantrasyonu endometrial polipte endometrium grubuna göre daha düşüktü.
Sonuç: Endometrial polip oluşumunda ghrelin salınımı önemli bir rol oynamaktadır. 

Anahtar Kelimeler

Ghrelin, Endometriyum, Polip

Investigation of Plasma and Tissue Ghrelin Levels in Diagnosed Endometrial Polyps

Öz

Background: Endometrial polyps, which are benign growths of the endometrium, may be a factor in female
subfertility. We aimed to evaluate the ghrelin expressions for the development of endometrial polyps.
Methods: Tissue ghrelin expressions of a total of 15 cases endometrial polyps, whom 9 had in the
proliferation phase, 6 had in the sekretuar phase were examined using immunohistochemical method, Enzim
İmmunoassay (EIA) and ELİSA.
Results: Ghrelin concentrations in the secretuar phase group were higher compared to the proliferative
phase. Ghrelin concentrations were lower in the endometrial polyps group as compared to the endometrium
group in the secretuar phase.
Conclusions: We think that ghrelin expression can be important in endometrial polyps formation.

Anahtar Kelimeler

Ghrelin, Endometrium, Polyp

Kaynakça

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