Metabolik Sendromda Adiponektin

Yıl 2007, Cilt: 4 Sayı: 2, 61 - 68, 01.08.2007

Aşkın Hekimoğlu

Öz

Derlememizde insülin direnci, diyabet ve metabolik sendromda adiponektin ve adiponektin reseptörlerinin patofizyolojisi tanımlanmaktadır. Adiposit biyolojisindeki son gelişmeler adipositlerin enerji depolayan hücreler olmaktan öte çeşitli hormonlar sitokinler, growth faktörler ve diğer biyoaktif maddeleri salgıladığını göstermektedir. Adiponektin adipöz dokudan büyük miktarlarda salgılanan ve vücudu insüline duyarlılaştıran bir adipokindir. Bu adipositokin antidiyabetik, antiaterosklerotik ve antiinflamatuvar fonksiyonlara sahiptir. Adiponektin reseptörleri, AdipoR1 ve AdipoR2 adiponektinin metabolik etkilerine aracılık etmektedir. Bu nedenle adiponektin ve adiponektin reseptörleri insülin direnci ile karakterize obezite ile ilişkili hastalıklar ile mücadele için çok yönlü potansiyel terapötik hedeflerdir

Anahtar Kelimeler

Adiponektin, İnsülin Direnci, Metabolik Sendrom, Diabet

Adıponectın In Metabolıc Syndrome

Öz

This review describes the pathophysiology of adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. Recent progress in adipocyte biology shows thatadipocytes are not merely energy-storing cells but that theysecrete a variety of hormones cytokines, growth factors, andother bioactive substances. Adiponectin is an adipokine that is abundantly expressed in adipose tissue and directly sensitizes the body to insulin. This adipocytokine has various biofunctions,such as antidiabetic, antiatherosclerotic, and antiinflammatoryfunctions. The adiponectin receptors, AdipoR1 and AdipoR2, mediate the metabolic actions of adiponectin. Therefore, adiponectin and adiponectin receptors represent potential therapeutic targets to combat obesity-linked diseases characterized by insulin resistance

Anahtar Kelimeler

Adiponectin, Insuline Resistance, Metabolic Syndrome, Diabetes

Kaynakça

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