Intoxication Cases and Evaluation of Liver Toxicity of Sanliurfa Region

Yıl 2021, Cilt: 18 Sayı: 3, 456 - 459, 29.12.2021

Süleyman Sari , Ahmet Uyanıkoğlu

https://doi.org/10.35440/hutfd.931668

Öz

Abstract

Background: In this study, it was aimed to investigate the demographic, etiological and prognostic character-istics of the cases who applied to the emergency department due to intoxication and how much of the intoxication cases the liver was affected.
Materials and Methods: The files of the patients who appliedto the emergency service of Harran University Medical Faculty Hospital between January 2018 and September 2019 were retrospectively scanned. Age, gender, anamnesis features and blood tests were examined.
Results: 137 of the 211 cases (64.9%) were female, the meanage was 30.3 ± 13.12, the agerange was between 18-72. Of the cases, 108 (51.2%) were drug, 39 (18.5%) were scorpion bites, 23 (10.9%) were food, 14 (6.6%) were insect-mice, 12 (5.7%) were snake bites, 9 (4.3%) were corrosive substances, canna-bis-ecstasy in 4 cases and alcohol and carbon monoxide intoxication in 1 case each. Transaminases (ALT, AST) were found to be elevated in 11 patients, cholestasis enzymes (ALP, GGT) or bilirubin in 16 patients. By evaluating the recommendation and clinical conditions of the Poison Counseling Center, 136 (64.5%) cases were followed in the intensive care unit (ICU) and 44 (20.8%) Cases were followed in the service. One of the cases followed up due to drug intoxication died due to organ failure during follow-up in the ICU, and liver enzymes of this patient were high.
Conclusions: The most common cause of intoxication applications to the emergency department of ourhos-pital is medication, followed by scorpion-snake bites and food poisoning. Intoxication is mostly seen in younger ages and in female patients. The liver is affected in about ten percent of patients, elevated liver enzymes may indicate a poor prognosis.

Keywords: Intoxication, Drug, Liver

Şanlıurfa Yöresi İntoksikasyon Olguları ve Karaciğer Toksisitesinin Değerlendirilmesi

Öz

Amaç: Bu çalışmada intoksikasyon nedeni ile acil servise başvuran olguların demografik, etyolojik, prognostik özellikleri ve intoksikasyon olgularının ne kadarında karaciğerin etkilendiğinin araştırılması amaçlanmıştır.
Materyal - Metod: Ocak 2018 – Eylül 2019 tarihleri arasında Harran Üniversitesi Tıp Fakültesi Hastanesi acil servisine başvuran hastaların dosyaları retrospektif olarak tarandı. Yaş, cinsiyet, anamnez özellikleri ve kan tahlilleri incelendi.
Bulgular: 211 vakanın 137`si (%64.9) kadın, yaş ortalaması 30.3± 13.12, yaş dağılımı 18-72 yaş aralığında idi. Olguların 108`i (%51.2) ilaç, 39`u (%18.5) akrep ısırması, 23`ü (%10.9) gıda, 14`ü (%6.6) böcek-fare, 12`si (%5.7) yılan ısırması, 9`u (%4.3) koroziv madde 4 olguda esrar-ekstazi ve 1`er olguda da alkol ve karbon monoksit intoksikasyonu tespit edildi. Olguların 11`inde transaminazlarda (ALT, AST), 16`sında kolestaz enzimlerinde (ALP, GGT) veya bilirubin değerlerinde yükseklik saptandı. Zehir Danışma Merkezinin önerisi ve klinik durumları değerlendirilerek 136 (%64.5) olgu yoğun bakım ünitesinde (YBÜ), 44 (%20.8) olgu da serviste takip edildi. İlaç intoksikasyonu nedeniyle takip edilen olgulardan 1`i YBÜ’nde takip esnasında, organ yetmezliği nedeniyle ex oldu, bu hastanın karaciğer enzimleri yüksekti.
Sonuç: Hastanemiz acil servisine intoksikasyon nedenli başvurularda en sık neden ilaç, onu takiben akrep-yılan ısırması ve gıda zehirlenmesidir. İntoksikasyon daha çok genç yaşlarda ve kadın hastalarda görülmektedir. Hastaların yaklaşık yüzde on kadarında karaciğer etkilenmektedir, karaciğer enzim yükselmesi kötü prognoz göstergesi olabilir.
Anahtar Kelimeler: intoksikasyon, ilaç, karaciğer
Objective: In this study, it was aimed to investigate the demographic, etiological and prognostic characteristics of the cases who applied to the emergency department due to intoxication and how much of the intoxication cases the liver was affected.
Material-Method: The files of the patients who applied to the emergency service of Harran University Medical Faculty Hospital between January 2018 and September 2019 were retrospectively scanned. Age, gender, anamnesis features and blood tests were examined.
Results: 137 of the 211 cases (64.9%) were female, the mean age was 30.3 ± 13.12, the age range was between 18-72. Of the cases, 108 (51.2%) were drug, 39 (18.5%) were scorpion bites, 23 (10.9%) were food, 14 (6.6%) were insect-mice, 12 (5.7%) were snake bites, 9 (4.3%) were corrosive substances, cannabis-ecstasy in 4 cases and alcohol and carbon monoxide intoxication in 1 case each. Transaminases (ALT, AST) were found to be elevated in 11 patients, cholestasis enzymes (ALP, GGT) or bilirubin in 16 patients. By evaluating the recommendation and clinical conditions of the Poison Counseling Center, 136 (64.5%) cases were followed in the intensive care unit (ICU) and 44 (20.8%)
cases were followed in the service. One of the cases followed up due to drug intoxication died due to organ failure during follow-up in the ICU, and liver enzymes of this patient were high.
Conclusion: The most common cause of intoxication applications to the emergency department of our hospital is medication, followed by scorpion-snake bites and food poisoning. Intoxication is mostly seen in younger ages and in female patients. The liver is affected in about ten percent of patients, elevated liver enzymes may indicate a poor prognosis.
Key Words: intoxication, drug, liver

Anahtar Kelimeler

intoksikasyon, ilaç, karaciğer

Kaynakça

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