Hematolojik Maligniteli Olgularda C Vitamini Seviyesi

Yıl 2024, Cilt: 21 Sayı: 3, 359 - 365

Gülden Sincan , Fuat Erdem , Ahmet Kızıltunç

https://doi.org/10.35440/hutfd.1458028

Öz

Amaç: Oksidatif stres, hematolojik malignitelerin patogenezinde önemli bir rol oynamaktadır. Anti-oksidan özellikleri ile bilinen C vitamini, bu bağlamda dikkat çekmektedir. Bu nedenle, çalışmamız hematolojik malignitelerde C vitamini seviyelerini araştırmayı ve C vitamini düzeyi ile tedaviye yanıt arasındaki ilişkiyi değerlendirmeyi amaçlamıştır.
Materyal ve Metod: Çalışmamızda 150 hematolojik malignite vakası ve 30 sağlıklı vaka incelendi. Hematolojik malignite vakalarının C vitamini seviyeleri, sağlıklı grup ile karşılaştırıldı.
Bulgular: Akut miyeloblastik lösemi (n=30) (p<0.001), akut lenfoblastik lösemi (n=30) (p<0.001), Hodgkin lenfoma (n=30) (p<0.001), diffüz büyük B-hücreli lenfoma (n=30) (p<0.001) ve multipl miye-lom (n=30) (p<0.001) vakalarında C vitamini seviyeleri, sağlıklı bireylerle karşılaştırıldığında anlamlı derecede düşüktü. Akut miyeloblastik lösemi, akut lenfoblastik lösemi, Hodgkin lenfoma, diffüz büyük B-hücreli lenfoma ve multipl miyeloma vakalarında C vitamini seviyeleri ile kemoterapiye yanıt arasında anlamlı bir ilişki bulundu (sırasıyla p=0.020, p=0.020, p=0.040, p<0.001, p<0.001). Hodgkin lenfoma ve non-Hodgkin lenfoma vakalarında, C vitamini seviyeleri ile laktat dehidrogenaz ve beta-2 mikroglobulin seviyeleri arasında negatif bir korelasyon bulundu (sırasıyla r=-0.59, p=0.001; r=-0.47, p=0.008; r=-0.43, p=0.017; r=-0.42, p=0.019).
Sonuç: Çalışmamız, hematolojik malignitelerde sağlıklı bireylerle karşılaştırıldığında C vitamini sevi-yelerinin daha düşük olduğunu vurgulamaktadır. Ayrıca, bulgular, C vitamini seviyelerinin bu vakalar-da kemoterapiye yanıtı öngörmek için potansiyel bir biyobelirteç olarak hizmet edebileceğini öner-mektedir.

Anahtar Kelimeler

: Hematolojik maligniteler, C vitamini, Oksidatif stres

Proje Numarası

TSA-2022-11098

The Vitamin C Level in Cases with Hematological Malignancies

Öz

Background: Oxidative stress plays a significant role in the pathogenesis of hematological malignan-cies. Vitamin C, known for its antioxidant properties, has garnered attention in this context. There-fore, we investigated vitamin C levels in patients with hematological malignancies and evaluated the relationship between vitamin C levels and response to treatment.
Materials and Methods: Our study examined 150 cases of hematological malignancies and 30 he-althy cases. The vitamin C levels of patients with hematological malignancies were compared with those of the healthy group.
Results: Vitamin C levels in cases of acute myeloblastic leukemia (n=30) (p<0.001), acute lympho-blastic leukemia (n=30) (p<0.001), Hodgkin lymphoma (n=30) (p<0.001), diffuse large B-cell lympho-ma (n=30) (p<0.001), and multiple myeloma (n=30) (p<0.001) were significantly lower compared to healthy individuals. There was a significant relationship between vitamin C levels and the response to treatment in cases with acute myeloblastic leukemia, acute lymphoblastic leukemia, Hodgkin lymphoma, diffuse large B-cell lymphoma, and multiple myeloma (p=0.020, p=0.020, p=0.040, p<0.001, p<0.001, respectively). In Hodgkin and non-Hodgkin lymphoma cases, a negative correla-tion was found between vitamin C levels and LDH and beta-2 microglobulin levels (p=0.001; p=0.008; p=0.017; p=0.019, respectively).
Conclusions: Our study underscores the lower levels of vitamin C in patients with hematological malignancies compared to healthy individuals. Furthermore, the findings suggest that vitamin C levels could serve as a potential biomarker for predicting the response to treatment in these cases.

Anahtar Kelimeler

Hematological malignancies, Vitamin C, Oxidative stress

Etik Beyan

Approval was obtained from the Ethics Committee of Atatürk University (date: 02.06.2022, approval no: B.30.2.ATA.0.01.00/460).

Destekleyen Kurum

BAP- Atatütk University

Proje Numarası

TSA-2022-11098

Kaynakça

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