Ischemia Modified Albumin as A Marker of Silent Cerebral Ischemia Before and after Carotid Artery Stenting

Yıl 2024, Cilt: 21 Sayı: 3, 496 - 501

Zeynal Tunç , Emrah Aytaç

https://doi.org/10.35440/hutfd.1518649

Öz

Background: Stroke is the second most common cause of mortality after ischemic heart disease. The aim of this study was to investigate the presence of silent ischemia in carotid stenosis wit-hout acute clinical symptoms by checking ischemia-modified albumin (IMA) level before and 14 days after stenting.
Materials and Methods: Thirty-two patients who applied to our clinic and did not have acute ischemic stroke findings were included in the study. Patients with diseases that caused an increa-se in ischemia-modified albumin levels were excluded. Samples taken from the patients before and after stenting were centrifuged and stored. All samples were studied on the same day.
Results: Thirty-two patients were included in the study. The mean age of the patients was 66.96±11.27 years. No significant difference was found in IMA levels between patients over 70 and under 70 years of age (p>0.05). It was found that the IMA level before carotid stenting (43.94±20.18) was significantly higher than the IMA level after stenting (22.00±11.34) (p<0.05).
Conclusions: This study suggests that there is a silent ischemic process in carotid stenosis even in the absence of clinical findings and that IMA can be used as a non-invasive marker of silent cereb-ral ischemia.

Keywords: Silent cerebral ischemia, carotid stenosis, carotid artery stenting, ischemia modified albumin

Anahtar Kelimeler

Silent cerebral ischemia, carotid stenosis, carotid artery stenting, ischemia modified albumin

Sessiz Serebral İskemi Belirteci Olarak Karotis Arter Stenleme Öncesi Ve Sonrası Bakılan İskemi Modifiye Albümin

Öz

Amaç: İnme, iskemik kalp hastalıklarından sonra mortalitenin ikinci en sık nedenidir. Bu çalışmada akut klinik bulgu vermeyen karotis darlığında stentlemeden önce ve 14 gün sonra iskemi modifiye albümin (İMA) düzeyi bakılarak sessiz iskemi varlığının araştırılması amaçlanmıştır.
Materyal ve metod: Çalışmaya kliniğimize başvuran akut iskemik inme bulguları olmayan 32 hasta alındı. İskemi modifiye albumin düzeyinde yüksekliğe yol açan hastalığı olan hastalar çalışmadan dışlandı. Çalışmaya alınan hastalardan stentlemeden önce ve sonra alınan numuneler santrifüj edilerek saklandı. Tüm numuneler aynı gün çalışıldı.
Bulgular: Çalışmaya 32 hasta alındı. Hastaların ortalama yaşı 66,96±11,27 idi. 70 yaş üzeri ve 70 yaş altı hastalar arasında İMA düzeyleri açısından anlamlı fark saptanmadı (p>0.05). Karotis stent-lemeden önce bakılan İMA düzeyinin (43,94±20,18), stentlemeden sonra bakılan İMA düzeyine (22,00±11,34) göre belirgin şekilde yüksek olduğu saptandı (p<0.05).
Sonuç: Bu çalışma karotis darlığında klinik bulgu olmadığında bile sessiz bir iskemik sürecin oldu-ğunu, İMA’nın sessiz serebral iskeminin non invaziv bir belirteci olarak kullanılabileceğini düşün-dürmektedir.

Anahtar Kelimeler

Sessiz serebral iskemi, karotis darlığı, karotis arter stentleme, iskemi modifiye albümin

Destekleyen Kurum

FIRAT ÜNİVERSİTESİ BAP

Teşekkür

Prof. Dr. Dilara Kaman' a teşekkür ederim.

Kaynakça

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