Araştırma Makalesi
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Yıl 2020, , 42 - 48, 25.06.2020
https://doi.org/10.31196/huvfd.691353

Öz

Proje Numarası

The study was carried out according to the protocol approved by the Experimental Animal Ethics Committee of Fırat University (Protocol 2019/07).

Kaynakça

  • References Ahangar N, Naderi M, Noroozi A, Ghasemi M, Zamani E, Shaki F, 2017: Zinc deficiency and oxidative stress involved in valproic acid induced hepatotoxicity: Protection by zinc and selenium supplementation. Biol Trace Elem Res, 179(1), 102–9. Beydilli H, Yilmaz N, Cetin ES, Topal Y, Celik OI, Sahin C, Topal H, Cigerci IH, Sozen H, 2015: Evaluation of the protective effect of silibinin against diazinon induced hepatotoxicity and free-radical damage in rat liver. Iran Red Crescent Med J, 17(4), 1–7. Casini AF, Ferrali M, Pompella A, Maellaro E, Comporti M, 1986: Lipid peroxidation and cellular damage in extrahepatic tissues of bromobenzene-intoxicated mice. Am J Pathol, 123(3), 520–31. Chaudhary S, Ganjoo P, Raiusddin S, Parvez S, 2015: Nephroprotective activities of quercetin with potential relevance to oxidative stress induced by valproic acid. Protoplasma, 252(1), 209–17. Crowley LV, 1967: The Reitman-Frankel colorimetric transaminase procedure in suspected myocardial infarction. Clin Chem, 13(6), 1–7. de Avelar CR, Pereira EM, de Farias Costa PR, de Jesus RP, de Oliveira LPM, 2017: Effect of silymarin on biochemical indicators in patients with liver disease: Systematic review with meta-analysis. World J Gastroenterol, 23(27), 5004–17. Dökmeci İ, Dökmeci AH, 2016: Sağlık Yüksek Okulları İçin Farmakoloji. 2. Baskı, İstanbul Tıp Kitapevi, İstanbul, Türkiye. Emekli-Alturfan E, Alev B, Tunali S, Oktay S, Tunali-Akbay T, Ozturk LK, Yanardag R, Yarat A, 2015: Effects of edaravone on cardiac damage in valproic acid induced toxicity. Ann Clin Lab Sci, 45(2), 166–72. Goli F, Karimi J, Khodadadi I, Tayebinia H, Kheiripour N, Hashemnia M, Rahimi R, 2019: Silymarin attenuates ELMO-1 and KIM-1 expression and oxidative stress in the kidney of rats with type 2 diabetes. Indian J Clin Biochem, 34(2), 172–9. Graf W, Oleinik O, Glauser T, Maertens P, Eder D, Pippenger C, 1998: Altered antioxidant enzyme activities in children with a serious adverse experience related to valproic acid therapy. Neuropediatrics, 29(04), 195–201. Guzel S, Sahinogullari ZU, Canacankatan N, Antmen SE, Kibar D, Coskun Yilmaz B, 2019: Potential renoprotective effects of silymarin against vancomycin-induced nephrotoxicity in rats. Drug Chem Toxicol, 1–7. Hassan SMS, Youakim MF, Rizk AAE, Thomann C, Ahmad Z, 2017a: Does silybin protect against toxicity induced by polymyxin E in rat kidney? Neurourol Urodyn, 36(5), 1278–87. Hassan SS, Thomann C, Ettarh R, Ahmad Z, 2017b: Possible protective role of silybin against polymyxin E-induced toxic effect in rat kidneys: A biochemical approach. Neurourol Urodyn, 36(8), 2003–10. Heidari R, Jafari F, Khodaei F, Shirazi Yeganeh B, Niknahad H, 2018: Mechanism of valproic acid-induced fanconi syndrome involves mitochondrial dysfunction and oxidative stress in rat kidney. Nephrology, 23(4), 351–61. Kandimalla R, Dash S, Bhowal AC, Kalita S, Talukdar NC, Kundu S, Kotoky J, 2017: Glycogen-gold nanohybrid escalates the potency of silymarin. Int J Nanomedicine, 12, 7025–38. Kudin AP, Mawasi H, Eisenkraft A, Elger CE, Bialer M, Kunz WS, 2017: Mitochondrial liver toxicity of valproic acid and its acid derivatives is related to inhibition of α-lipoamide dehydrogenase. Int J Mol Sci, 18(9), 1–11. Kyriakopoulos G, Tsaroucha AK, Valsami G, Lambropoulou M, Kostomitsopoulos N, Christodoulou E, Kakazanis Z, Anagnostopoulos C, Tsalikidis C, Simopoulos CE, 2018: Silibinin improves TNF-α and M30 expression and histological parameters in rat kidneys after hepatic ischemia/reperfusion. J Investig Surg, 31(3), 201–9. Li Y, Ye Z, Lai W, Rao J, Huang W, Zhang X, Yao Z, Lou T, 2017: Activation of sirtuin 3 by silybin attenuates mitochondrial dysfunction in cisplatin-induced acute kidney injury. Front Pharmacol, 8, 1–12. Nerdy N, Ritarwan K, 2019: Hepatoprotective activity and nephroprotective activity of peel extract from three varieties of the passion fruit (Passiflora Sp.) in the albino rat. Open access Maced J Med Sci, 7(4), 536–42. Placer ZA, Cushman LL, Johnson BC, 1966: Estimation of product of lipid peroxidation (malonyl dialdehyde) in biochemical systems. Anal Biochem, 16(2), 359–64. Rafieian-Kopaie M, Nasri H, 2012: Silymarin and diabetic nephropathy. J Renal Inj Prev, 1(1), 3–5. Refaiy A, Muhammad E, ElGanainy EO, 2011: Semiquantitative smoothelin expression in detection of muscle invasion in transurethral resection and cystectomy specimens in cases of urinary bladder carcinoma. African J Urol, 17(1), 6–10. Sedlak J, Lindsay RH, 1968: Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman’s reagent. Anal Biochem, 25(1), 192–205. Semmler A, Frisch C, Bleul C, Smith D, Bigler L, Prost JC, Blom H, Linnebank M, 2017: Intrauterine valproate exposure is associated with alterations in hippocampal cell numbers and folate metabolism in a rat model of valproate teratogenicity. Seizure, 46, 7–12. Speir RW, Stallings JD, Andrews JM, Gelnett MS, Brand TC, Salgar SK, 2015: Effects of valproic acid and dexamethasone administration on early bio-markers and gene expression profile in acute kidney ischemia-reperfusion injury in the rat. PLoS One, 10(5), 1–24. Tong V, Teng XW, Chang TKH, Abbott FS, 2005: Valproic acid I: Time course of lipid peroxidation biomarkers, liver toxicity, and valproic acid metabolite levels in rats. Toxicol Sci, 86(2), 427–35. Zheng Q, Liu W, Liu Z, Zhao H, Han X, Zhao M, 2014: Valproic acid protects septic mice from renal injury by reducing the inflammatory response. J Surg Res, 192(1), 163–9.

Investigation of the effects of silymarin on valproic acid-induced kidney damage in rats

Yıl 2020, , 42 - 48, 25.06.2020
https://doi.org/10.31196/huvfd.691353

Öz

In this study; we aimed to investigate the protective effects of silymarin (SLY) against kidney damage on valproic acid (VPA)-induced rats using histological and biochemical evaluations. Experimental procedures were performed on 21 male Sprague Dawley rats. Rats were divided randomly into three groups: group 1, control; group 2, VPA; group 3, VPA+SLY. The control group was given 1 mL 0.9 % NaCl orally for 14 days. The VPA group was given 500 mg/kg/day VPA per os for 14 days. The VPA+SLY group was given 500 mg/kg/day VPA and 100 mg/kg/day SLY per os for 14 days. SLY treatment decreased the levels of creatinine (Cr) and blood urea nitrogen (BUN) levels significantly (p < 0.05). In addition, increased amount of thiobarbitüric acid reactive substance (TBARS) and decreased levels of glutathione (GSH) with VPA were significantly suppressed by SLY in kidney tissue (p < 0.05). Histologically, the extent of kidney damage was remarkably lower in the VPA+SLY group (p < 0.005). In addition, VPA+SLY group had decreased oxidative stress, increased antioxidant activity and decreased histopathological changes compared to VPA group. This study revealed that the kidney damage induced by VPA was attenuated with SLY administration. SLY can protect rat kidney against VPA induced damage via anti-oxidative effect and might be useful for reducing the severity of kidney injuries.

Proje Numarası

The study was carried out according to the protocol approved by the Experimental Animal Ethics Committee of Fırat University (Protocol 2019/07).

Kaynakça

  • References Ahangar N, Naderi M, Noroozi A, Ghasemi M, Zamani E, Shaki F, 2017: Zinc deficiency and oxidative stress involved in valproic acid induced hepatotoxicity: Protection by zinc and selenium supplementation. Biol Trace Elem Res, 179(1), 102–9. Beydilli H, Yilmaz N, Cetin ES, Topal Y, Celik OI, Sahin C, Topal H, Cigerci IH, Sozen H, 2015: Evaluation of the protective effect of silibinin against diazinon induced hepatotoxicity and free-radical damage in rat liver. Iran Red Crescent Med J, 17(4), 1–7. Casini AF, Ferrali M, Pompella A, Maellaro E, Comporti M, 1986: Lipid peroxidation and cellular damage in extrahepatic tissues of bromobenzene-intoxicated mice. Am J Pathol, 123(3), 520–31. Chaudhary S, Ganjoo P, Raiusddin S, Parvez S, 2015: Nephroprotective activities of quercetin with potential relevance to oxidative stress induced by valproic acid. Protoplasma, 252(1), 209–17. Crowley LV, 1967: The Reitman-Frankel colorimetric transaminase procedure in suspected myocardial infarction. Clin Chem, 13(6), 1–7. de Avelar CR, Pereira EM, de Farias Costa PR, de Jesus RP, de Oliveira LPM, 2017: Effect of silymarin on biochemical indicators in patients with liver disease: Systematic review with meta-analysis. World J Gastroenterol, 23(27), 5004–17. Dökmeci İ, Dökmeci AH, 2016: Sağlık Yüksek Okulları İçin Farmakoloji. 2. Baskı, İstanbul Tıp Kitapevi, İstanbul, Türkiye. Emekli-Alturfan E, Alev B, Tunali S, Oktay S, Tunali-Akbay T, Ozturk LK, Yanardag R, Yarat A, 2015: Effects of edaravone on cardiac damage in valproic acid induced toxicity. Ann Clin Lab Sci, 45(2), 166–72. Goli F, Karimi J, Khodadadi I, Tayebinia H, Kheiripour N, Hashemnia M, Rahimi R, 2019: Silymarin attenuates ELMO-1 and KIM-1 expression and oxidative stress in the kidney of rats with type 2 diabetes. Indian J Clin Biochem, 34(2), 172–9. Graf W, Oleinik O, Glauser T, Maertens P, Eder D, Pippenger C, 1998: Altered antioxidant enzyme activities in children with a serious adverse experience related to valproic acid therapy. Neuropediatrics, 29(04), 195–201. Guzel S, Sahinogullari ZU, Canacankatan N, Antmen SE, Kibar D, Coskun Yilmaz B, 2019: Potential renoprotective effects of silymarin against vancomycin-induced nephrotoxicity in rats. Drug Chem Toxicol, 1–7. Hassan SMS, Youakim MF, Rizk AAE, Thomann C, Ahmad Z, 2017a: Does silybin protect against toxicity induced by polymyxin E in rat kidney? Neurourol Urodyn, 36(5), 1278–87. Hassan SS, Thomann C, Ettarh R, Ahmad Z, 2017b: Possible protective role of silybin against polymyxin E-induced toxic effect in rat kidneys: A biochemical approach. Neurourol Urodyn, 36(8), 2003–10. Heidari R, Jafari F, Khodaei F, Shirazi Yeganeh B, Niknahad H, 2018: Mechanism of valproic acid-induced fanconi syndrome involves mitochondrial dysfunction and oxidative stress in rat kidney. Nephrology, 23(4), 351–61. Kandimalla R, Dash S, Bhowal AC, Kalita S, Talukdar NC, Kundu S, Kotoky J, 2017: Glycogen-gold nanohybrid escalates the potency of silymarin. Int J Nanomedicine, 12, 7025–38. Kudin AP, Mawasi H, Eisenkraft A, Elger CE, Bialer M, Kunz WS, 2017: Mitochondrial liver toxicity of valproic acid and its acid derivatives is related to inhibition of α-lipoamide dehydrogenase. Int J Mol Sci, 18(9), 1–11. Kyriakopoulos G, Tsaroucha AK, Valsami G, Lambropoulou M, Kostomitsopoulos N, Christodoulou E, Kakazanis Z, Anagnostopoulos C, Tsalikidis C, Simopoulos CE, 2018: Silibinin improves TNF-α and M30 expression and histological parameters in rat kidneys after hepatic ischemia/reperfusion. J Investig Surg, 31(3), 201–9. Li Y, Ye Z, Lai W, Rao J, Huang W, Zhang X, Yao Z, Lou T, 2017: Activation of sirtuin 3 by silybin attenuates mitochondrial dysfunction in cisplatin-induced acute kidney injury. Front Pharmacol, 8, 1–12. Nerdy N, Ritarwan K, 2019: Hepatoprotective activity and nephroprotective activity of peel extract from three varieties of the passion fruit (Passiflora Sp.) in the albino rat. Open access Maced J Med Sci, 7(4), 536–42. Placer ZA, Cushman LL, Johnson BC, 1966: Estimation of product of lipid peroxidation (malonyl dialdehyde) in biochemical systems. Anal Biochem, 16(2), 359–64. Rafieian-Kopaie M, Nasri H, 2012: Silymarin and diabetic nephropathy. J Renal Inj Prev, 1(1), 3–5. Refaiy A, Muhammad E, ElGanainy EO, 2011: Semiquantitative smoothelin expression in detection of muscle invasion in transurethral resection and cystectomy specimens in cases of urinary bladder carcinoma. African J Urol, 17(1), 6–10. Sedlak J, Lindsay RH, 1968: Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman’s reagent. Anal Biochem, 25(1), 192–205. Semmler A, Frisch C, Bleul C, Smith D, Bigler L, Prost JC, Blom H, Linnebank M, 2017: Intrauterine valproate exposure is associated with alterations in hippocampal cell numbers and folate metabolism in a rat model of valproate teratogenicity. Seizure, 46, 7–12. Speir RW, Stallings JD, Andrews JM, Gelnett MS, Brand TC, Salgar SK, 2015: Effects of valproic acid and dexamethasone administration on early bio-markers and gene expression profile in acute kidney ischemia-reperfusion injury in the rat. PLoS One, 10(5), 1–24. Tong V, Teng XW, Chang TKH, Abbott FS, 2005: Valproic acid I: Time course of lipid peroxidation biomarkers, liver toxicity, and valproic acid metabolite levels in rats. Toxicol Sci, 86(2), 427–35. Zheng Q, Liu W, Liu Z, Zhao H, Han X, Zhao M, 2014: Valproic acid protects septic mice from renal injury by reducing the inflammatory response. J Surg Res, 192(1), 163–9.
Toplam 1 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Veteriner Cerrahi
Bölüm Makaleler
Yazarlar

İbrahim Aktaş 0000-0002-0956-8204

Dilek Bayram 0000-0003-3568-2673

Proje Numarası The study was carried out according to the protocol approved by the Experimental Animal Ethics Committee of Fırat University (Protocol 2019/07).
Yayımlanma Tarihi 25 Haziran 2020
Gönderilme Tarihi 19 Şubat 2020
Kabul Tarihi 17 Haziran 2020
Yayımlandığı Sayı Yıl 2020

Kaynak Göster

APA Aktaş, İ., & Bayram, D. (2020). Investigation of the effects of silymarin on valproic acid-induced kidney damage in rats. Harran Üniversitesi Veteriner Fakültesi Dergisi, 9(1), 42-48. https://doi.org/10.31196/huvfd.691353
AMA Aktaş İ, Bayram D. Investigation of the effects of silymarin on valproic acid-induced kidney damage in rats. Harran Univ Vet Fak Derg. Haziran 2020;9(1):42-48. doi:10.31196/huvfd.691353
Chicago Aktaş, İbrahim, ve Dilek Bayram. “Investigation of the Effects of Silymarin on Valproic Acid-Induced Kidney Damage in Rats”. Harran Üniversitesi Veteriner Fakültesi Dergisi 9, sy. 1 (Haziran 2020): 42-48. https://doi.org/10.31196/huvfd.691353.
EndNote Aktaş İ, Bayram D (01 Haziran 2020) Investigation of the effects of silymarin on valproic acid-induced kidney damage in rats. Harran Üniversitesi Veteriner Fakültesi Dergisi 9 1 42–48.
IEEE İ. Aktaş ve D. Bayram, “Investigation of the effects of silymarin on valproic acid-induced kidney damage in rats”, Harran Univ Vet Fak Derg, c. 9, sy. 1, ss. 42–48, 2020, doi: 10.31196/huvfd.691353.
ISNAD Aktaş, İbrahim - Bayram, Dilek. “Investigation of the Effects of Silymarin on Valproic Acid-Induced Kidney Damage in Rats”. Harran Üniversitesi Veteriner Fakültesi Dergisi 9/1 (Haziran 2020), 42-48. https://doi.org/10.31196/huvfd.691353.
JAMA Aktaş İ, Bayram D. Investigation of the effects of silymarin on valproic acid-induced kidney damage in rats. Harran Univ Vet Fak Derg. 2020;9:42–48.
MLA Aktaş, İbrahim ve Dilek Bayram. “Investigation of the Effects of Silymarin on Valproic Acid-Induced Kidney Damage in Rats”. Harran Üniversitesi Veteriner Fakültesi Dergisi, c. 9, sy. 1, 2020, ss. 42-48, doi:10.31196/huvfd.691353.
Vancouver Aktaş İ, Bayram D. Investigation of the effects of silymarin on valproic acid-induced kidney damage in rats. Harran Univ Vet Fak Derg. 2020;9(1):42-8.