A Flavonoid has Neuroprotective Effect: Nobiletin

Yıl 2017, Cilt: 6 Sayı: 1, 102 - 107, 30.06.2017

Gül Fatma Yarım Metin Çenesiz Murat Yarım Filiz Kazak

https://doi.org/10.31196/huvfd.325789

Cited By: 3

Öz

The use of
flavonoids promises new approach for the treatment of neurodegenerative
diseases. Nobiletine is a polymethoxy flavonoid found in the citrus peel. The
neuroprotective effect of nobiletin has been demonstrated in vivo and in vitro.
Nobiletine affects the signaling cascades associated with learning and memory,
alleviates neurodegeneration by modulating inflammatory mediators, inhibits
motor and cognitive dysfunction by increasing dopamine release and enhances
memory and recognition of emotions and innovations. Recent studies suggest that
nobiletine has the potential to be a new drug for the treatment of
neurodegenerative diseases. In this review, the neuroprotective effects of
nobiletin was emphasized and the results obtained from the literature were
summarized.

Anahtar Kelimeler

Flavonoid, Nobiletin, Neuroprotective

Nöroprotektif Etkili Bir Flavonoid: Nobiletin

Öz

Nörodejeneratif hastalıkların
tedavisinde flavonoidlerin kullanımı yeni umutlar vaad etmektedir. Nobiletin,
narenciye kabuklarında bulunan bir polimetoksi flavonoiddir. Nobiletinin nöroprotektif etkiye sahip olduğu pek çok in vivo ve in vitro araştırma ile ortaya konulmuştur. Nobiletin,
öğrenme ve hafıza ile ilişkili sinyalizasyon kaskadlarını etkilemekte, enflamasyon mediyatörlerini modüle ederek
nörodejenerasyonu hafifletmekte, dopamin salınımını artırarak motor ve
bilişsel işlev bozukluğunu engellemekte, duygusal ve yenilikleri tanıma
belleğini geliştirmektedir. Güncel çalışmalar, nobiletinin nörodejeneratif
hastalıkların tedavisi için yeni bir ilaç olma potansiyeline sahip olduğunu
desteklemektedir. Bu derlemede, nobiletinin nöroprotektif etkileri üzerinde
durularak, literatürden elde edilen sonuçlar özetlenmiştir.

Anahtar Kelimeler

Flavonoid, Nobiletin, Nöroprotektif

Kaynakça

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