Comparison of Laboratory Findings And Mortalıty Rates of Varıant ALPHA and SARS-COV-2 Infected Patients

Yıl 2021, Cilt: 7 Sayı: 3, 79 - 88, 30.12.2021

Adem Keskin Recai Aci Mehmet Hakan Taşkın Mukadder Erdem Melek Bilgin Murat Arı

Öz

In our study, the common laboratuvary findings affecting SARS-CoV-2 patient outcomes were designed on the levels detected in Variant Alpha patients. 115 Variant Alpha inpatients, 115 SARS-CoV-2 inpatients and 111 healthy individuals were included in this study. Variant Alpha White Blood Cell (WBC), Platelet, Neutrophil, Lymphocyte, Monocyte count, Neutrophil Lymphocyte Ratio(NLR), Monocyte Lymphocyte Ratio (MLR), Hemoglobin, Procalcitonin, C-reactive protein (CRP), Ferritin, Prothrombin Time (PT), activated Partial Thromboplastin Time (aPTT), International Normalized Ratio(INR), D-dimer levels and SARS-CoV-2 patients levels were compared. This comparison also includes comparison with the levels of healthy individuals. WBC, Neutrophil, MLR, NLR, PCT (p=0.037), Ferritin, CRP, aPTT, D-dimer levels of the Variant Alpha group were higher than the levels of SARS-CoV-2 group, and Lymphocyte (p=0.001), PT, INR levels of the Variant Alpha group were lower than the levels of SARS-CoV-2 group (p<0.001). There was no difference between the mortality rates observed in the Variant Alpha group and the SARS-CoV-2 group (p>0.05). In terms of laboratory findings, Variant Alpha patients experience more severe disease than SARS-CoV-2 patients. The reason that there was no difference in mortality rate between the groups may be the higher PT and INR values of the SARS-CoV-2 group.

Anahtar Kelimeler

Variant Alpha, SARS-CoV-2, Mortality Rate, D-dimer, Prothrombin Time, C-reactive protein

Varyant ALFA VE SARS-COV-2 Enfekte Hastaların Laboratuvar Bulgularının ve Mortalite Oranlarının Karşılaştırılması

Öz

Çalışmamız, SARS-CoV-2 hasta sonuçlarını etkileyen yaygın laboratuvar bulgularının, Varyant Alfa hastalarında tespit edilen düzeyleri üzerine tasarlanmıştır. Bu çalışmaya 115 Varyant Alfa yatan hasta, 115 SARS-CoV-2 yatan hasta ve 111 sağlıklı birey dahil edildi. Varyant Alfa hastaların Beyaz Kan Hücresi (WBC), Trombosit, Nötrofil, Lenfosit, Monosit sayısı, Monosit Lenfosit Oranı (MLR), Nötrofil Lenfosit Oranı (NLR), Hemoglobin, Prokalsitonin, C-reaktif protein (CRP), Ferritin, Protrombin Zamanı (PT), Aktive Parsiyel Tromboplastin Zamanı (aPTT), D-dimer, International Normalized Ratio (INR) seviyeleri SARS-CoV-2 hasta seviyeleri karşılaştırıldı. Bu karşılaştırma aynı zamanda sağlıklı bireylerin seviyeleri ile karşılaştırmayı da içerir. Varyant Alfa grubunun WBC, Nötrofil, MLR, NLR, PCT (p=0.037), Ferritin, CRP, aPTT, D-dimer seviyeleri SARS-CoV-2 grubunun seviyelerinden önemli ölçüde yüksekti (p=0.001). Ayrıca, Varyant Alfa grubunun Lenfosit, PT, INR seviyeleri SARS-CoV-2 grubunun seviyelerinden anlamlı derecede düşüktü (p<0.001). Varyant Alfa grubunda ve SARS-CoV-2 grubunda gözlemlenen ölüm oranları arasında anlamlı bir fark yoktu. Laboratuvar bulguları açısından Varyant Alfa hastaları SARS-CoV-2 hastalarına göre daha şiddetli hastalık yaşamaktadır. Gruplar arasında ölüm oranı farkı olmamasının nedeni, SARS-CoV-2 grubunun PT ve INR değerlerinin yüksek olması olabilir.

Anahtar Kelimeler

Varyant Alfa, SARS-CoV-2, Ölüm Oranı, D-dimer, Protrombin Zamanı, C-reaktif protein

Kaynakça

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