D VİTAMİNİ EKSİKLİĞİ NEDENİYLE TEDAVİ ALAN POLİKİSTİK OVER SENDROMLU HASTALARIN KLİNİK, METABOLİK VE ULTRASONOGRAFİK PARAMETRELERİNİN DEĞERLENDİRİLMESİ

Yıl 2022, Cilt: 8 Sayı: 2, 1 - 20, 03.09.2022

Ufuk Atlıhan

Öz

Amaç: Bu çalışmada, D vitamini eksikliği nedeniyle tedavi alan polikistik over sendromlu hastaların klinik, metabolik, ultrasonografik parametrelerinin değerlendirilmesi amaçlanmıştır.
Materyal-Metod: Dokuz Eylül Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Doğum Anabilim Dalı, Üreme Endokrinolojisi ve İnfertilite Bilim Dalı Polikliniği’ne 01/12/2013-01/12/2014 tarihleri arasında başvuran polikistik over sendromu tanısı konulan toplam 95 hasta çalışmaya alınmıştır. D vitamini eksikliği nedeniyle tedavi alan polikistik over sendromlu hastaların 3 aylık tedavi sonrasındaki klinik, metabolik, ultrasonografik parametreleri retrospektif olarak değerlendirilmiştir.
Bulgular: Vitamin D3 kullanımı sonrasında 0.ay ve 3.ay arasında kilo,bel çevresi,kalça çevresi,bel/kalça oranı, LH, FSH, estradiol, total testosteron, PRL, TSH, OGTT düzeyi, insülin, 17-OH progesteron, HDL, LDL, trigliserit, total kolesterol, açlık kan şekeri düzeyi, ortalama arteriyal kan basıncı, androstenedion, SHBG, VKİ, HOMA-IR, total over volümü değerleri arasında anlamlı farklılık izlenmedi. Ferriman gallwey skoru, adet düzeni, 25-OH D vitamini düzeyi, DHEAS düzeyi, free testosteron, LH/FSH oranı, total antral folikül sayısı, free androjen indeks düzeyinde istatistiksel olarak anlamlı azalma saptandı. 25-OH D vitamin düzeyi artışı ile LH/FSH oranı düzeyi, total antral folikül sayısı, serbest androjen indeksi düzeyi, DHEAS düzeyi azalması korelasyonu, pearson korelasyon analizi ile değerlendirildi ve istatistiksel olarak anlamlı farklılık saptanmadı[(p<0,05),(r: ±1)]. 25-OH D vitamin düzeyi artışı ile Ferriman Gallwey skoru azalması arasında anlamlı korelasyon saptandı (p<0.024, r:-0,232).
Sonuç: Polikistik over sendromlu hastalarda vitamin D3 kullanımı sonrasında lipid parametreleri ve insülin rezistansında anlamlı bir azalma saptanmamıştır. Hiperandrojenizmin biyokimyasal parametrelerinde tedavi sonrası dönemde anlamlı azalma saptanmıştır. Hastaların menstrual sikluslarında tedavi sonrası anlamlı düzelme saptanmıştır. Hastaların tedavi sonrası yapılan ultrasonografisinde, tedavi öncesi döneme göre total antral folikül sayısında anlamlı azalma saptanmıştır.

Anahtar Kelimeler

Polikistik over sendromu, 25-OH D Vitamini, tedavi

Kaynakça

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