Boy uzunluğu ve kanser ilişkisi

Yıl 2018, Cilt: 4 Sayı: 3, 149 - 153, 14.10.2018

Aslıhan İleri Zeynep Akbaş Beyza Yıldırım Oytun Erbaş

Öz

İnsülin benzeri büyüme faktörü (IGF) sistemi, IGF-1, IGF-2 ligandları, membran reseptörleri ve bağlanma proteinlerinden (IGFBP) oluşan önemli biyolojik mekanizmalardan biridir. İnsülin benzeri büyüme faktörü sistemi, birçok spesifik hücrede büyümeyi sağlar. Büyüme hormonunun (GH) biyolojik etkileri olan postnatal gelişim ve longitudinal büyüme, GH stimülasyonu ile karaciğerden sentezlenen IGF-1 üzerinden gerçekleşir. IGF-1, kemik ve iskelet kasında da sentezlenen bir peptiddir. Bu etkisiyle boy uzamasında rol oynar. İnsülin benzeri büyüme faktörü sistemi aynı zamanda hücresel döngüde hücre proliferasyonunu ilerletir, regüle eder ve apoptozisi inhibe eder. Tüm bu etkiler hücresel döngüde mutasyona uğramış hücrelerin devamlı bölünmesine olanak sağlayarak kanser oluşumuna yol açar. Genom çapındaki bu bağlantılar boy ve kanser arasındaki ilişkinin ortaya çıkmasına olanak sağlamıştır. Yapılan bazı araştırmalarda birçok kanser türü ile boy uzunluğu arasında anlamlı pozitif ilişki görülür iken, bazı çalışmalarda ise bu sonuç elde edilememiştir.

Anahtar Kelimeler

Apoptoz, kanser riski, hücre bölünmesi, boy uzunluğu, insülin benzeri büyüme faktörü

Kaynakça

• 1. Samani AA, Yakar S, LeRoith D, Brodt P. The role of the IGF system in cancer growth and metastasis: overview and recent insights. Endocr Rev 2007;28:20-47. 2. Rotwein P, Bichell DP, Kikuchi K. Multifactorial regulation of IGF‐I gene expression. Wiley Online Library 1993;35:358-64. 3. Gunnell D, Okasha M, Smith GD, Oliver SE, Sandhu J, Holly JM. Height, leg length, and cancer risk: a systematic review. Epidemiol Rev 2001;23:313-42. 4. Crowe FL, Key TJ, Allen NE, Appleby PN, Overvad K, Grønbæk H, et al. A cross-sectional analysis of the associations between adult height, BMI and serum concentrations of IGF-I and IGFBP-1 -2 and -3 in the European Prospective Investigation into Cancer and Nutrition (EPIC).Ann Hum Biol 2011;38:194-202. 5. Elis S, Courtland HW, Wu Y, Rosen CJ, Sun H, Jepsen KJ, et al. Elevated serum levels of IGF-1 are sufficient to establish normal body size and skeletal properties even in the absence of tissue IGF-1. J Bone Miner Res 2010;25:1257-66. 6. Yakar S, Rosen CJ, Beamer WG, Ackert-Bicknell CL, Wu Y, Liu JL, et al. Circulating levels of IGF-1 directly regulate bone growth and density. J Clin Invest 2002;110:771-81. 7. Rietveld I, Janssen JA, van Rossum EF, Houwing-Duistermaat JJ, Rivadeneira F, Hofman A, et al. A polymorphic CA repeat in the IGF-I gene is associated with gender-specific differences in body height, but has no effect on the secular trend in body height. Clin Endocrinol (Oxf) 2004;61:195-203. 8. Jones JI, Clemmons DR. Insulin-like growth factors and their binding proteins: biological actions. Endocr Rev 1995;16:3-34. 9. Renehan AG, Zwahlen M, Minder C, O'Dwyer ST, Shalet SM, Egger M. Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis. Lancet 2004;363:1346-53. 10. Bale LK, Conover CA. Regulation of insulin-like growth factor binding protein-3 messenger ribonucleic acid expression by insulin-like growth factor I. Endocrinology 1992;131:608-14. 11. Cohick WS, Wang B, Verma P, Boisclair YR. Insulin-Like growth factor I (IGF-I) and cyclic adenosine 3',5'-monophosphate regulate IGF-binding protein-3 gene expression by transcriptional and posttranscriptional mechanisms in mammary epithelial cells. Endocrinology 2000;141:4583-91. 12. Ma J, Giovannucci E, Pollak M, Stampfer M. RESPONSE: Re: Prospective Study of Colorectal Cancer Risk in Men and Plasma Levels of Insulin-Like Growth Factor (IGF)-I and IGF-Binding Protein-3. J Natl Cancer Inst 1999;91:2052. 13. Toniolo P, Bruning PF, Akhmedkhanov A, Bonfrer JM, Koenig KL, Lukanova A, et al. Serum insulin-like growth factor-I and breast cancer. Int J Cancer 2000;88:828-32. 14. Baserga R, Peruzzi F, Reiss K. The IGF-1 receptor in cancer biology. Int J Cancer 2003;107:873-7. 15. Jiang Y, Wang L, Gong W, Wei D, Le X, Yao J, et al. A high expression level of insulin-like growth factor I receptor is associated with increased expression of transcription factor Sp1 and regional lymph node metastasis of human gastric cancer. Clin Exp Metastasis 2004;21:755-64. 16. McSkane M, Stintzing S, Heinemann V, Puccini A, Naseem M, Cao S, et al. Association Between Height and Clinical Outcome in Metastatic Colorectal Cancer Patients Enrolled Onto a Randomized Phase 3 Clinical Trial: Data From the FIRE-3 Study. Clin Colorectal Cancer 2018;17:215-22. 17. Rinaldi S, Cleveland R, Norat T, Biessy C, Rohrmann S, Linseisen J, et al. Serum levels of IGF-I, IGFBP-3 and colorectal cancer risk: results from the EPIC cohort, plus a meta-analysis of prospective studies. Int J Cancer 2010;126:1702-15. 18. Pollak M. Insulin and insulin-like growth factor signalling in neoplasia. Nat Rev Cancer 2008;8:915-28. 19. Pollak MN, Schernhammer ES, Hankinson SE. Insulin-like growth factors and neoplasia. Nat Rev Cancer 2004;4:505-18. 20. Wang L, Huang M, Ding H, Jin G, Chen L, Chen F, et al. Genetically determined height was associated with lung cancer risk in East Asian population. Cancer Med 2018. [Epub ahead of print] 21. Sung J, Song YM, Lawlor DA, Smith GD, Ebrahim S. Height and site-specific cancer risk: A cohort study of a korean adult population. Am J Epidemiol 2009;170:53-64. 22. Green J, Cairns BJ, Casabonne D, Wright FL, Reeves G, Beral V. Height and cancer incidence in the Million Women Study: prospective cohort, and meta-analysis of prospective studies of height and total cancer risk. Lancet Oncol 2011;12:785-94. 23. Engeland A, Tretli S, Hansen S, Bjørge T. Height and body mass index and risk of lymphohematopoietic malignancies in two million Norwegian men and women. Am J Epidemiol 2007;165:44-52. 24. Kabat GC, Anderson ML, Heo M, Hosgood HD, Kamensky V, Bea JW, et al. Adult stature and risk of cancer at different anatomic sites in a cohort of postmenopausal women. Cancer Epidemiol Biomarkers Prev 2013;22:1353-63. 25. Kabat GC, Heo M, Kamensky V, Miller AB, Rohan TE. Adult height in relation to risk of cancer in a cohort of Canadian women. Int J Cancer 2013;132:1125-32. 26. Meyle KD, Gamborg M, Hölmich LR, Baker JL. Associations between childhood height and morphologically different variants of melanoma in adulthood. Eur J Cancer 2016;67:99-105. 27. Zhang B, Shu XO, Delahanty RJ, Zeng C, Michailidou K, Bolla MK, et al. Height and Breast Cancer Risk: Evidence From Prospective Studies and Mendelian Randomization. J Natl Cancer Inst 2015;107. pii: djv219. 28. Murphy N, Ward HA, Jenab M, Rothwell JA, Boutron-Ruault MC, Carbonnel F, et al. Heterogeneity of Colorectal Cancer Risk Factors by Anatomical Subsite in 10 European Countries: A Multinational Cohort Study. Clin Gastroenterol Hepatol 2018 Jul 26. pii: S1542-3565(18)30756-0. 29. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 2015;136:359-86. 30. Travis RC, Appleby PN, Martin RM, Holly JMP, Albanes D, Black A, et al. A Meta-analysis of Individual Participant Data Reveals an Association between Circulating Levels of IGF-I and Prostate Cancer Risk. Cancer Res 2016;76:2288-300. 31. Rowlands MA, Holly JM, Hamdy F, Phillips J, Goodwin L, Marsden G, et al. Serum insulin-like growth factors and mortality in localised and advanced clinically detected prostate cancer. Cancer Causes Control 2012;23:347-54. 32. Möller E, Wilson KM, Batista JL, Mucci LA, Bälter K, Giovannucci E. Body size across the life course and prostate cancer in the Health Professionals Follow-up Study. Int J Cancer 2016;138:853-65. 33. MacInnis RJ, English DR. Body size and composition and prostate cancer risk: systematic review and meta-regression analysis. Cancer Causes Control 2006;17:989-1003. 34. World Cancer Research Continuous Update Project Report: Diet, Nutrition, Physical Activity, and Prostate Cancer. WCRF/AICR; 2014. 35. Zuccolo L, Harris R, Gunnell D, Oliver S, Lane JA, Davis M, et al. Height and prostate cancer risk: a large nested case-control study (ProtecT) and meta-analysis. Cancer Epidemiol Biomarkers Prev 2008;17:2325-36. 36. Sutcliffe S, Colditz GA. Prostate cancer: is it time to expand the research focus to early-life exposures? Nat Rev Cancer 2013;13:208-518. 37. Batty GD, Kivimäki M, Clarke R, Davey Smith G, Shipley MJ. Modifiable risk factors for prostate cancer mortality in London: forty years of follow-up in the Whitehall study. Cancer Causes Control 2011;22:311-8. 38. Rodriguez C, Patel AV, Calle EE, Jacobs EJ, Chao A, Thun MJ. Body mass index, height, and prostate cancer mortality in two large cohorts of adult men in the United States. Cancer Epidemiol Biomarkers Prev 2001;10:345-53. 39. Hernandez BY, Park SY, Wilkens LR, Henderson BE, Kolonel LN. Relationship of body mass, height, and weight gain to prostate cancer risk in the multiethnic cohort. Cancer Epidemiol Biomarkers Prev 2009;18:2413-21. 40. Gong Z, Neuhouser ML, Goodman PJ, Albanes D, Chi C, Hsing AW, et al. Obesity, diabetes, and risk of prostate cancer: results from the prostate cancer prevention trial. Cancer Epidemiol Biomarkers Prev 2006;15:1977-83. 41. Perez-Cornago A, Appleby PN, Pischon T, Tsilidis KK, Tjønneland A, Olsen A, et al. Tall height and obesity are associated with an increased risk of aggressive prostate cancer: results from the EPIC cohort study. BMC Med 2017;15:115. 42. Green J, Cairns BJ, Casabonne D, Wright FL, Reeves G, Beral V. Height and cancer incidence in the Million Women Study: prospective cohort, and meta-analysis of prospective studies of height and total cancer risk. Lancet Oncol 2011;12:785-94. 43. Sung J, Song YM, Lawlor DA, Smith GD, Ebrahim S. Height and site-specific cancer risk: A cohort study of a korean adult population. Am J Epidemiol 2009;170:53-64. 44. Khankari NK, Shu XO, Wen W, Kraft P, Lindström S, Peters U, et al. Association between Adult Height and Risk of Colorectal, Lung, and Prostate Cancer: Results from Meta-analyses of Prospective Studies and Mendelian Randomization Analyses. PLoS Med 2016;13:1002118. 45. Albanes D, Winick M. Are cell number and cell proliferation risk factors for cancer? J Natl Cancer Inst 1988;80:772-4.