Öz
Yaygın bilinenin aksine, genetik olarak aktarılan özelliklerimiz sadece fiziksel olanlar değildir. Ruh halimizi belirleyen özelliklerimizin de genetik ifadesi vardır. VMAT2 proteini olumlu düşünmeye yatkınlığa GOD geni aracılığıyla etki eder. Benzer şekilde, monoamin oksidaz A proteini de amigdala ve hipokampüste bolca bulunan monoamin yıkımından sorumlu olarak ruh haline etki eder. Kadınlarda daha yaygın bulunan Kappa opioid reseptörü ve erkeklerde daha yaygın bulunan Mü opioid reseptörünün madde arama davranışı ve bağımlılık üzerinde belirleyici etkileri vardır. Dolayısıyla, aşağı regülasyon/yukarı regülasyon mekanizmasına göre, bağımlılık davranışı tamamen çevresel etkenlere bağlı olmayıp genetik etkenlere de bağlıdır.
Anahtar Kelimeler
Mutluluk kalıtım kappa opiat reseptör mono amino oksidaz geni mü opiat reseptör zevk veziküler monoamin transporter 2
Kaynakça
- 1. Hawkes CH. Endorphins: the basis of pleasure? J Neurol Neurosurg Psychiatry 1992;55:247-50. 2. Dfarhud D, Malmir M, Khanahmadi M. Happiness & health: the biological factors- systematic review article. Iran J Public Health 2014;43:1468-77. 3. Bartels M, Saviouk V, de Moor MH, Willemsen G, van Beijsterveldt TC, Hottenga JJ, et al. Heritability and genome-wide linkage scan of subjective happiness.Twin Res Hum Genet 2010;13:135-42. 4. Lykken D, Tellegen A. Happiness is a stochastic phenommon. Psychoogical Science 1996;7:186-9. 5. Blum K, Chen ALC, Chen TJH, Bowirat A, Downs BW, Waite RL, et al. Genes and Happiness. Gene Therapy & Molecular Biology 2009;13:91-129. 6. Schwab SG, Franke PE, Hoefgen B, Guttenthaler V, Lichtermann D, Trixler M, et al. Association of DNA polymorphisms in the synaptic vesicular amine transporter gene (SLC18A2) with alcohol and nicotine dependence. Neuropsychopharmacology 2005;30:2263-8. 7. Vaas R. Gods, gains, and genes. In: Voland E, Schiefenhövel W, editors. The biological evolution of religious mind and behavior. 1st ed. Berlin: Springer-Verlag Berlin Heidelberg; 2009. p. 25-49. 8. Shih JC, Chen K, Ridd MJ. Role of MAO A and B in neurotransmitter metabolism and behavior. Pol J Pharmacol 1999;51:25-9. 9. Brunner HG, Nelen M, Breakefield XO, Ropers HH, van Oost BA. Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A. Science 1993;262:578-80. 10. Lalanne L, Ayranci G, Kieffer BL, Lutz PE. The kappa opioid receptor: from addiction to depression, and back. Front Psychiatry 2014;5:170. 11. Di Chiara G, Imperato A. Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proc Natl Acad Sci U S A 1988;85:5274-8. 12. Zaliauskiene L, Kang S, Brouillette CG, Lebowitz J, Arani RB, Collawn JF. Down-regulation of cell surface receptors is modulated by polar residues within the transmembrane domain. Mol Biol Cell 2000;11:2643-55. 13. Nestler EJ. Epigenetic mechanisms of drug addiction. Neuropharmacology 2014;76:259-68.
Öz
Kaynakça
- 1. Hawkes CH. Endorphins: the basis of pleasure? J Neurol Neurosurg Psychiatry 1992;55:247-50. 2. Dfarhud D, Malmir M, Khanahmadi M. Happiness & health: the biological factors- systematic review article. Iran J Public Health 2014;43:1468-77. 3. Bartels M, Saviouk V, de Moor MH, Willemsen G, van Beijsterveldt TC, Hottenga JJ, et al. Heritability and genome-wide linkage scan of subjective happiness.Twin Res Hum Genet 2010;13:135-42. 4. Lykken D, Tellegen A. Happiness is a stochastic phenommon. Psychoogical Science 1996;7:186-9. 5. Blum K, Chen ALC, Chen TJH, Bowirat A, Downs BW, Waite RL, et al. Genes and Happiness. Gene Therapy & Molecular Biology 2009;13:91-129. 6. Schwab SG, Franke PE, Hoefgen B, Guttenthaler V, Lichtermann D, Trixler M, et al. Association of DNA polymorphisms in the synaptic vesicular amine transporter gene (SLC18A2) with alcohol and nicotine dependence. Neuropsychopharmacology 2005;30:2263-8. 7. Vaas R. Gods, gains, and genes. In: Voland E, Schiefenhövel W, editors. The biological evolution of religious mind and behavior. 1st ed. Berlin: Springer-Verlag Berlin Heidelberg; 2009. p. 25-49. 8. Shih JC, Chen K, Ridd MJ. Role of MAO A and B in neurotransmitter metabolism and behavior. Pol J Pharmacol 1999;51:25-9. 9. Brunner HG, Nelen M, Breakefield XO, Ropers HH, van Oost BA. Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A. Science 1993;262:578-80. 10. Lalanne L, Ayranci G, Kieffer BL, Lutz PE. The kappa opioid receptor: from addiction to depression, and back. Front Psychiatry 2014;5:170. 11. Di Chiara G, Imperato A. Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proc Natl Acad Sci U S A 1988;85:5274-8. 12. Zaliauskiene L, Kang S, Brouillette CG, Lebowitz J, Arani RB, Collawn JF. Down-regulation of cell surface receptors is modulated by polar residues within the transmembrane domain. Mol Biol Cell 2000;11:2643-55. 13. Nestler EJ. Epigenetic mechanisms of drug addiction. Neuropharmacology 2014;76:259-68.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Bölüm | Derleme |
| Yazarlar | |
| Yayımlanma Tarihi | 4 Nisan 2019 |
| Yayımlandığı Sayı | Yıl 2019 Cilt: 5 Sayı: 1 |
