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Hemodiyalize Bağlı Gelişen Kardiyovasküler Disfonksiyona Yönelik Egzersiz Yaklaşımları

Yıl 2025, Cilt: 8 Sayı: 1, 25 - 37, 30.05.2025
https://doi.org/10.52538/iduhes.1587695

Öz

Hemodiyaliz, böbrek fonksiyonlarının yetersiz olduğu durumlarda, kanın yapay bir böbrek cihazı aracılığıyla temizlenmesini sağlayan bir tedavi yöntemidir. Bu süreçte, hastanın kanı vücut dışına alınarak diyaliz membranından geçirilir; bu sayede toksinler, fazla sıvı ve elektrolitler uzaklaştırılır. Hemodiyaliz kronik böbrek yetmezliği yaşayan hastalar için hayat kurtarıcı bir tedavi yöntemi olmasına rağmen, beraberinde kardiyovasküler disfonksiyon gibi sağlık sorunlarını da getirebilmektedir. Bu sebeple bu derlemede hemodiyalize bağlı olarak ortaya çıkan kardiyak disfonksiyon ve bu duruma yönelik uygulanan egzersiz yaklaşımlarını incelemeyi amaçladık. Eylül 2024 ve Kasım 2024 tarihleri arasında ‘‘böbrek diyalizi, böbrek yetmezliği, egzersiz, rehabilitasyon’’ anahtar kelimeleri kullanılarak PubMed, Google Akademik ve Scopus üzerinden elektronik veri tabanları tarandı. 2014-2024 yılları arasında toplamda 28 çalışmaya ulaşıldı. Konuyla ilgili 13 makale çalışmaya dahil edildi. Hemodiyaliz sırasında gelişen kardiyovasküler disfonksiyon, genellikle sıvı dengesizliği, elektrolit değişiklikleri ve oksidatif stres gibi faktörlerden kaynaklanmaktadır. Bu komplikasyonlar hastalarda kalp yetmezliği, aritmi ve koroner arter hastalığı gibi ciddi durumlara yol açarak yaşam kalitesini olumsuz etkilemektedir. Bu problemlerin yönetimi kapsamında çeşitli egzersiz yaklaşımları uygulanmaktadır. Bu egzersiz programları içerisinde aerobik egzersizler (bisiklet ergometresinde sürekli tipte), ev programları şeklinde uygulanan egzersizler ve hastanın durumuna göre de elastik bant veya ağırlık kaldırma şeklinde uygulanan dirençli egzersiz eğitimleri yer almaktadır. Literatürdeki çalışmalar, hemodiyalize giren bireylerde özellikle aerobik egzersizlerin kardiyovasküler komplikasyonları azaltmada etkili olduğunu göstermektedir. Egzersiz eğitimi sonrasında kalp atım hızı regüle olur, kan akışı iyileşir ve kardiyovasküler endurans artar. Böylece bu bireylerde kardiyovasküler disfonksiyon gelişme riski azalabilmektedir. Ayrıca, bireylerde elektrolit dengesizlikleri kontrol altına alınabilir, hipertansiyon yönetimi ve insülin duyarlılığı artar. Dolayısıyla bireylerin glisemik kontrolünün sağlanmasına da katkı sağlanabilir. Sonuç olarak, hemodiyaliz alınan günler dışında ve hemodiyaliz sırasında uygulanan egzersiz eğitimleri güvenlidir ve kardiyovasküler disfonksiyonun önlenmesinde faydalıdır. Bu nedenle hemodiyalize bağlanan bireylerin tedavisine düzenli uygulanan egzersiz programlarının entegrasyonuyla sağlıklarını desteklemek ve yaşam kalitelerini artırmak mümkündür.

Kaynakça

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Exercise Approaches for Cardiovascular Dysfunction Due to Hemodialysis

Yıl 2025, Cilt: 8 Sayı: 1, 25 - 37, 30.05.2025
https://doi.org/10.52538/iduhes.1587695

Öz

Hemodialysis is a treatment method that cleanses the blood through an artificial kidney device when kidney function is insufficient. In this process, the patients blood is taken outside the body and passed through a dialysis membrane, which removes toxins, excess fluid and electrolytes. Although hemodialysis is a life-saving treatment for patients with chronic renal failure, it can also bring health problems such as cardiovascular dysfunction. Therefore, in this review, we aimed to examine cardiac dysfunction associated with hemodialysis and exercise approaches to address this condition. Between September 2024 and November 2024, electronic databases were scanned through PubMed, Google Scholar and Scopus using the keywords “exercise, rehabilitation, renal dialysis, renal insufficiency”. A total of 28 studies were found between 2014-2024. Related 13 articles were included in the study. Cardiovascular dysfunction during hemodialysis is usually caused by factors such as fluid imbalance, electrolyte changes and oxidative stress. These complications lead to serious conditions such as heart failure, arrhythmia and coronary artery disease in patients, negatively affecting quality of life. Various exercise approaches are applied in the management of these problems. These exercise programs include aerobic exercises (continuous type on bicycle ergometer), exercises applied in the form of home programs and resistance exercise training applied in the form of elastic band or weight lifting according to the patient's condition. Studies in the literature show that especially aerobic exercises are effective in reducing cardiovascular complications in individuals undergoing hemodialysis. After exercise training, heart rate is regulated, blood flow improves and cardiovascular endurance increases. Thus, the risk of developing cardiovascular dysfunction may be reduced in these individuals. In addition, electrolyte imbalances can be controlled, hypertension management and insulin sensitivity can be improved. Therefore, it may also contribute to the glycemic control of individuals. In conclusion, exercise training outside the days of hemodialysis and during hemodialysis is safe and beneficial in preventing cardiovascular dysfunction. Therefore, it is possible to support their health and improve their quality of life by integrating regular exercise programs into the treatment of individuals on hemodialysis.

Kaynakça

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  • Greenberg, K. I. ve Choi, M. J. (2021). Hemodialysis Emergencies: Core Curriculum 2021. American Journal of Kidney Diseases, 77(5), 796–809. https://doi.org/10.1053/j.ajkd.2020.11.024
  • Han, B. G., Lee, J. Y., Choi, S. O., Yang, J. W. ve Kim, J. S. (2020). Relative overhydration is independently associated with left ventricular hypertrophy in dialysis naïve patients with stage 5 chronic kidney disease. Scientific reports, 10(1), 15924, 1-11. https://doi.org/10.1038/s41598-020-73038-8
  • Huang, M., Lv, A., Wang, J., Zhang, B., Xu, N., Zhai, Z., Gao, J., Wang, Y., Li, T. ve Ni, C. (2020). The effect of intradialytic combined exercise on hemodialysis efficiency in end-stage renal disease patients: a randomized-controlled trial. International urology and nephrology, 52(5), 969–976. https://doi.org/10.1007/s11255-020-02459-1
  • Ikizler, T. A., Burrowes, J. D., Byham-Gray, L. D., Campbell, K. L., Carrero, J. J., Chan, W., Fouque, D., Friedman, A. N., Ghaddar, S., Goldstein-Fuchs, D. J., Kaysen, G. A., Kopple, J. D., Teta, D., Yee-Moon Wang, A. ve Cuppari, L. (2020). KDOQI Clinical Practice Guideline for Nutrition in CKD: 2020 Update. American journal of kidney diseases : the official journal of the National Kidney Foundation, 76(3 Suppl 1), 1–107. https://doi.org/10.1053/j.ajkd.2020.05.006
  • Joki, N., Hase, H., Nakamura, R. ve Yamaguchi, T. (1997). Onset of coronary artery disease prior to initiation of haemodialysis in patients with end-stage renal disease. Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, 12(4), 718–723. https://doi.org/ 10.1093/ndt/12.4.718
  • Kaur, J., Young, B. E. ve Fadel, P. J. (2017). Sympathetic Overactivity in Chronic Kidney Disease: Consequences and Mechanisms. International Journal of Molecular Sciences, 18(8), 1-18. https://doi.org/ 10.3390/ijms18081682
  • Kim, I. S., Kim, S., Yoo, T. H. ve Kim, J. K. (2023). Diagnosis and treatment of hypertension in dialysis patients: a systematic review. Clinical Hypertension 2023 29:1, 29(1), 1–12. https://doi.org/10.1186/S40885-023-00240-x
  • Korsheed, S., Eldehni, M. T., John, S. G., Fluck, R. J. ve McIntyre, C. W. (2011). Effects of arteriovenous fistula formation on arterial stiffness and cardiovascular performance and function. Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, 26(10), 3296–3302. https://doi.org/10.1093/ndt/gfq851
  • Liu, Y., Luo, X., Deng, S., Chen, J., Zhang, L., Huang, Y. ve Hu, H. (2023). Combined aerobic and resistance exercise in maintenance hemodialysis patients: A meta-analysis. Seminars in Dialysis, 36(4), 278–293. https://doi.org/10.1111/sdi.13162
  • Locatelli, F., Martin-Malo, A., Hannedouche, T., Loureiro, A., Papadimitriou, M., Wizemann, V., Jacobson, S. H., Czekalski, S., Ronco, C., Vanholder, R. ve Membrane Permeability Outcome (MPO) Study Group (2009). Effect of membrane permeability on survival of hemodialysis patients. Journal of the American Society of Nephrology : JASN, 20(3), 645–654. https://doi.org/10.1681/ASN.2008060590
  • London, G. M., Guérin, A. P., Marchais, S. J., Métivier, F., Pannier, B. ve Adda, H. (2003). Arterial media calcification in end-stage renal disease: impact on all-cause and cardiovascular mortality. Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, 18(9), 1731–1740. https://doi.org/10.1093/ndt/gfg414
  • Maufrais, C., Josse, M., Patrier, L., Grandperrin, A., Isnard, M., Turc-Baron, C., Nottin, S., Mandigout, S., Cristol, J. P. ve Obert, P. (2024). Cardioprotective effect of intradialytic exercise on left atrial mechanics. American journal of physiology. Renal physiology, 326(5), 694–703. https://doi.org/10.1152/ajprenal.00380.2023
  • McIntyre, C. W. ve Rosansky, S. J. (2012). Starting dialysis is dangerous: how do we balance the risk? Kidney International, 82(4), 382–387. https://doi.org/10.1038/ki.2012.133
  • Momeni, A., Nematolahi, A. ve Nasr, M. (2014). Effect of intradialytic exercise on echocardiographic findings in hemodialysis patients. Iranian Journal of Kidney Diseases, 8(3), 207–211.
  • Nakamura, S., Ishibashi-Ueda, H., Niizuma, S., Yoshihara, F., Horio, T. ve Kawano, Y. (2009). Coronary calcification in patients with chronic kidney disease and coronary artery disease. Clinical Journal of the American Society of Nephrology : CJASN, 4(12), 1892–1900. https://doi.org/10.2215/cjn.04320709
  • Olano CG, Akram SM, Hashmi MF. Uremic Encephalopathy. [Updated 2024 Jul 6]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/nbk564327/
  • Oliveira E Silva, V. R., Stringuetta Belik, F., Hueb, J. C., de Souza Gonçalves, R., Costa Teixeira Caramori, J., Perez Vogt, B., Barretti, P., Zanati Bazan, S. G., De Stefano, G. M. M. F., Martin, L. C. ve da Silva Franco, R. J. (2019). Aerobic Exercise Training and Nontraditional Cardiovascular Risk Factors in Hemodialysis Patients: Results from a Prospective Randomized Trial. Cardiorenal medicine, 9(6), 391–399. https://doi.org/10.1159/000501589
  • Otto, C. M., Kuusisto, J., Reichenbach, D. D., Gown, A. M. ve O’Brien, K. D. (1994). Characterization of the early lesion of “degenerative” valvular aortic stenosis. Histological and immunohistochemical studies. Circulation, 90(2), 844–853. https://doi.org/10.1161/01.cir.90.2.844
  • Parfrey, P. S., Foley, R. N., Harnett, J. D., Kent, G. M., Murray, D. ve Barre, P. E. (1996). Outcome and risk factors of ischemic heart disease in chronic uremia. Kidney International, 49(5), 1428–1434. https://doi.org/10.1038/ki.1996.201
  • Preka, E. ve Shroff, R. (2023). Hemodialysis. Evidence-Based Nephrology, Second Edition: Volumes 1,2, 2, 412–425. https://doi.org/10.1002/9781119105954.ch66
  • Rafaqat, S., Rafaqat, S., Khurshid, H. ve Rafaqat, S. (2022). Electrolyte’s imbalance role in atrial fibrillation: Pharmacological management. International Journal of Arrhythmia 2022 23:1, 23(1), 1–10. https://doi.org/10.1186/s42444-022-00065-z
  • Raggi, P., Boulay, A., Chasan-Taber, S., Amin, N., Dillon, M., Burke, S. K. ve Chertow, G. M. (2002). Cardiac calcification in adult hemodialysis patients: A link between end-stage renal disease and cardiovascular disease? Journal of the American College of Cardiology, 39(4), 695–701. https://doi.org/10.1016/s0735-1097(01)01781-8
  • Raharjo, Y., Zainol Abidin, M. N., Ismail, A. F., Fahmi, M. Z., Saiful, Elma, M., Santoso, D., Haula', H. ve Habibi, A. R. (2022). Dialysis Membranes for Acute Kidney Injury. Membranes, 12(3), 325, 1-15. https://doi.org/10.3390/membranes12030325
  • Rangaswami, J., Bhalla, V., Blair, J. E. A., Chang, T. I., Costa, S., Lentine, K. L., Lerma, E. V., Mezue, K., Molitch, M., Mullens, W., Ronco, C., Tang, W. H. W., McCullough, P. A. ve American Heart Association Council on the Kidney in Cardiovascular Disease and Council on Clinical Cardiology (2019). Cardiorenal Syndrome: Classification, Pathophysiology, Diagnosis, and Treatment Strategies: A Scientific Statement From the American Heart Association. Circulation, 139(16), 840–878. https://doi.org/10.1161/cir.0000000000000664
  • Reddy, Y. N. V., Obokata, M., Dean, P. G., Melenovsky, V., Nath, K. A. ve Borlaug, B. A. (2017). Long-term cardiovascular changes following creation of arteriovenous fistula in patients with end stage renal disease. European Heart Journal, 38(24), 1913–1923. https://doi.org/10.1093/eurheartj/ehx045
  • Sabe, M. A., Claggett, B., Burdmann, E. A., Desai, A. S., Ivanovich, P., Kewalramani, R., Lewis, E. F., McMurray, J. J., Olson, K. A., Parfrey, P., Solomon, S. D. ve Pfeffer, M. A. (2016). Coronary Artery Disease Is a Predictor of Progression to Dialysis in Patients With Chronic Kidney Disease, Type 2 Diabetes Mellitus, and Anemia: An Analysis of the Trial to Reduce Cardiovascular Events With Aranesp Therapy (TREAT). Journal of the American Heart Association, 5(4), e002850. https://doi.org/10.1161/jaha.115.002850
  • Salusky, I. B. ve Goodman, W. G. (2002). Cardiovascular calcification in end-stage renal disease. Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, 17(2), 336–339. https://doi.org/10.1093/ndt/17.2.336
  • Schreiber, B. D. (2003). Congestive heart failure in patients with chronic kidney disease and on dialysis. The American Journal of the Medical Sciences, 325(4), 179–193. https://doi.org/10.1097/00000441-200304000-00004
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  • Shang, F., Wang, S. C., Hsu, C. Y., Miao, Y., Martin, M., Yin, Y., Wu, C. C., Wang, Y. T., Wu, G., Chien, S., Huang, H. D., Tarng, D. C., Shiu, Y. T., Cheung, A. K., Huang, P. H., Chen, Z. ve Shyy, J. Y. (2017). MicroRNA-92a Mediates Endothelial Dysfunction in CKD. Journal of the American Society of Nephrology : JASN, 28(11), 3251–3261. https://doi.org/10.1681/asn.2016111215
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  • Van Craenenbroeck, A. H., Van Craenenbroeck, E. M., Van Ackeren, K., Vrints, C. J., Conraads, V. M., Verpooten, G. A., Kouidi, E. ve Couttenye, M. M. (2015). Effect of Moderate Aerobic Exercise Training on Endothelial Function and Arterial Stiffness in CKD Stages 3-4: A Randomized Controlled Trial. American journal of kidney diseases : the official journal of the National Kidney Foundation, 66(2), 285–296. https://doi.org/10.1053/j.ajkd.2015.03.015
  • Verrelli, D., Sharma, A., Alexiuk, J., Tays, Q., Rossum, K., Sharma, M., Ford, E., Iansavitchene, A., Al-Jaishi, A. A., Whitlock, R., McIntyre, C. W., Garg, A. X. ve Bohm, C. (2024). Effect of Intradialytic Exercise on Cardiovascular Outcomes in Maintenance Hemodialysis: A Systematic Review and Meta-Analysis. Kidney360, 5(3), 390–413. https://doi.org/10.34067/kid.0000000000000361
  • Watanabe, R. (2020). Hyperkalemia in chronic kidney disease. Revista Da Associação Médica Brasileira, 66(1), 31–36. https://doi.org/10.1590/1806-9282.66.S1.31
  • Yang, J. ve He, W. (2019). Chronic Kidney Disease: Diagnosis and Treatment. Chronic Kidney Disease: Diagnosis and Treatment, 1–253. https://doi.org/10.1007/978-981-32-9131-7/cover
  • Zang, W., Fang, M., He, H., Mu, L., Zheng, X., Shu, H., Ge, N. ve Wang, S. (2022). Comparative efficacy of exercise modalities for cardiopulmonary function in hemodialysis patients: A systematic review and network meta-analysis. Frontiers in public health, 10, 1040704. https://doi.org/10.3389/fpubh.2022.1040704
Toplam 53 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Hizmetleri ve Sistemleri (Diğer)
Bölüm Makaleler
Yazarlar

Cansu Özdemir 0009-0000-8908-5941

Gülşah Barğı 0000-0002-5243-3997

Erken Görünüm Tarihi 28 Mayıs 2025
Yayımlanma Tarihi 30 Mayıs 2025
Gönderilme Tarihi 19 Kasım 2024
Kabul Tarihi 12 Nisan 2025
Yayımlandığı Sayı Yıl 2025 Cilt: 8 Sayı: 1

Kaynak Göster

APA Özdemir, C., & Barğı, G. (2025). Hemodiyalize Bağlı Gelişen Kardiyovasküler Disfonksiyona Yönelik Egzersiz Yaklaşımları. Izmir Democracy University Health Sciences Journal, 8(1), 25-37. https://doi.org/10.52538/iduhes.1587695

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19952  19958  20682 

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