Nerve Guidance Conduits for Spinal Cord Injury

Öz

Every year, between 250,000 and 500,000 people become spinal cord injured worldwide. Since no effective therapeutic plan, injuries result in life-long disability and a broad range of secondary complications. The spinal cord as a part of the central nervous system (CNS) has a limited regeneration capacity compared with that of the peripheral nervous system. CNS axons do not regenerate appreciably in their native environment because of an impermeable glial scar formation and blocked synaptic target. The current therapeutic approach to SCI patients mainly aims at eliminating further damage to the spinal cord. Much of the research effort in this area has focused on nerve guidance conduits to enhance regeneration across nerve gaps. Nerve guidance conduits are predominantly fabricated as hollow tubes or as porous foam rods because of the ease in the manufacturing of these devices. Recently, multi-channeled conduit is very promising because of its guidance capacity and mimicking natural tissue. A combination of multi-channel structure with nanofibrous matrix was also shown that the physical structure of the basement membrane of the neural matrix and nanofibrous structure of the nerve conduit has facilitated the differentiation of NSCs into neurons. However, very attractive innovative technologies were adapted in the nerve guidance conduits production, significant improvements are still required for the advancement of therapeutic strategy to clinical practice.

Anahtar Kelimeler

• nerve tissue engineering
• multi-channel conduit
• nanofibrous matrix

Kaynakça

1. 1. Anon. n.d. ‘Spinal Cord Injury - Symptoms and Causes’. Mayo Clinic. Retrieved 15 October 2020 (https://www.mayoclinic.org/diseases-conditions/spinal-cord-injury/symptoms-causes/syc- 20377890).
2. 2. Chen, Yuying, Ying Tang, Lawrence C. Vogel, and Michael J. Devivo. ‘Causes of Spinal Cord Injury’. Topics in Spinal Cord Injury Rehabilitation, 19 (2013) pp.1–8.
3. 3. Courtine, Grégoire, and Michael V. Sofroniew. ‘Spinal Cord Repair: Advances in Biology and Technology’. Nature Medicine, 25 (2019) pp.898–908.
4. 4. Huang, Yi-Cheng, and Yi-You Huang. ‘Biomaterials and Strategies for Nerve Regeneration’. Artificial Organs, 30 (2006) pp.514–22.
5. 5. Koffler, Jacob, Wei Zhu, Xin Qu, Oleksandr Platoshyn, Jennifer N. Dulin, John Brock, Lori Graham, et al. ‘Biomimetic 3D-Printed Scaffolds for Spinal Cord Injury Repair’. Nature Medicine, 25 (2019) pp.263–69.
6. 6. Li, Jun, and Guilherme Lepski. ‘Cell Transplantation for Spinal Cord Injury: A Systematic Review’. BioMed Research International, 2013 (2013) pp. 786475.
7. 7. Liu, Ting, John D. Houle, Jinye Xu, Barbara P. Chan, and Sing Yian Chew. ‘Nanofibrous Collagen Nerve Conduits for Spinal Cord Repair’. Tissue Engineering. Part A, 18 (2012) pp.1057–66.
8. 8. Manoukian, Ohan S., Jiana T. Baker, Swetha Rudraiah, Michael R. Arul, Anthony T. Vella, Abraham J. Domb, and Sangamesh G. Kumbar. ‘Functional Polymeric Nerve Guidance Conduits and Drug Delivery Strategies for Peripheral Nerve Repair and Regeneration’. Journal of Controlled Release: Official Journal of the Controlled Release Society, 317 (2020) pp.78–95.

9. 9. Mothe, Andrea J., and Charles H. Tator. ‘Advances in Stem Cell Therapy for Spinal Cord Injury’. The Journal of Clinical Investigation, 122 (2012) pp.3824–34.
10. 10. Nectow, Alexander R., Kacey G. Marra, and David L. Kaplan. ‘Biomaterials for the Development of Peripheral Nerve Guidance Conduits’. Tissue Engineering. Part B, Reviews, 18 (2012) pp.40–50.
11. 11. Straley, Karin S., Cheryl Wong Po Foo, and Sarah C. Heilshorn. ‘Biomaterial Design Strategies for the Treatment of Spinal Cord Injuries’. Journal of Neurotrauma, 27 (2010) pp.1–19.
12. 12. Sun, Xiumin, Ying Bai, Hong Zhai, Sheng Liu, Chi Zhang, Yiwei Xu, Jianlong Zou, et al. ‘Devising Micro/Nano-Architectures in Multi-Channel Nerve Conduits towards a pro-Regenerative Matrix for the Repair of Spinal Cord Injury’. Acta Biomaterialia, 86 (2019) pp.194–206.
13. 13. Tang-Schomer, Min D., James D. White, Lee W. Tien, L. Ian Schmitt, Thomas M. Valentin, Daniel J. Graziano, Amy M. Hopkins, Fiorenzo G. Omenetto, Philip G. Haydon, and David L. Kaplan. ‘Bioengineered Functional Brain-like Cortical Tissue’. Proceedings of the National Academy of Sciences, 111 (2014) pp.13811–16.
14. 14. Thomas, Aline M., Matthew B. Kubilius, Samantha J. Holland, Stephanie K. Seidlits, Ryan M. Boehler, Aileen J. Anderson, Brian J. Cummings, and Lonnie D. Shea. ‘Channel Density and Porosity of Degradable Bridging Scaffolds on Axon Growth after Spinal Injury’. Biomaterials 34 (2013) pp.2213–20.
15. 15.Tsintou, Magdalini, Kyriakos Dalamagkas, and Alexander Marcus Seifalian. ‘Advances in Regenerative Therapies for Spinal Cord Injury: A Biomaterials Approach’. Neural Regeneration Research, 10 (2015) pp.726–42.
16. 16. You, Renchuan, Qiang Zhang, Xiufang Li, Shuqin Yan, Zuwei Luo, Jing Qu, and Mingzhong Li. ‘Multichannel Bioactive Silk Nanofiber Conduits Direct and Enhance Axonal Regeneration after Spinal Cord Injury’. ACS Biomaterials Science & Engineering, 6 (2020) pp.4677–86.
17. 17. Zeng, Chen-guang, Yi Xiong, Gaoyi Xie, Peng Dong, and Daping Quan. ‘Fabrication and Evaluation of PLLA Multichannel Conduits with Nanofibrous Microstructure for the Differentiation of NSCs In Vitro’. Tissue Engineering. Part A, 20 (2014) pp.1038.