Kemik Sağlığında Bağırsak Mikrobiyotasının Etkisi: Güncel Yaklaşımlar

Öz

Osteoporozun görülme sıklığı günden güne artış göstermektedir. Özellikle ilerleyen yaş, cinsiyet, D vitamini seviyeleri risk faktörlerinden bazıları olarak karşımıza çıkmaktadır. Son yıllarda ise, bağırsak mikrobiyotasının kemik sağlığı üzerinde etkileri olduğu düşünülmektedir. Osteoporozun oluşmasında hiperparatiroidizm malabsorpsiyon, hipertiroidizm, anoreksiya nervoza, kronik böbrek yetmezliği, uzun sürekli fiziksel aktivite azlığı ve Cushing sendromu gibi farklı hastalıkların da etkili olabileceği bilinmektedir. Bağırsak mikrobiyotasında disbiyoz, kemik iyileşmesini zorlaştıran faktörlerden biridir. Mikrobiyotanın kemik iyileşmesi ve kemik sağlığı üzerinde lipopolisakkaritler, safra asidi, kısa zincirli yağ asitleri, mikrobiyotanın hormonlar üzerinde olan dolaylı etkileri ve mikrobiyotanın bağışıklık sistemi üzerinde olan dolaylı etkileri aracılığıyla rol oynayabileceği görünmektedir. Bu derlemenin amacı bağırsak mikrobiyotasının kemik sağlığı üzerindeki etkilerini güncel yaklaşımlarla değerlendirilmesidir.

Anahtar Kelimeler

• Mikrobiyota
• kemik sağlığı
• osteoporoz

The Effect of Gut Microbiota on Bone Health: Current Approaches

Öz

The incidence of osteoporosis is increasing day by day. Especially advancing age, gender, vitamin D levels are some of the risk factors. In recent years, it is thought that the gut microbiota has effects on bone health. It is known that different diseases such as hyperparathyroidism, malabsorption, hyperthyroidism, anorexia nervosa, chronic kidney failure, long-term lack of physical activity, and Cushing's syndrome may also be effective in the formation of osteoporosis. Dysbiosis in the gut microbiota is one of the factors that complicates bone healing. It seems that microbiota may play a role in bone healing and bone health through lipopolysaccharides, bile acid, short-chain fatty acids, indirect effects of microbiota on hormones, and indirect effects of microbiota on the immune system. The aim of this review is to evaluate the effects of gut microbiota on bone health with current approaches.

Anahtar Kelimeler

• Microbiota
• bone health
• osteoporosis

Kaynakça

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