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The Relation of Preterm Birth and Microbiota

Yıl 2018, Sayı: 4, 383 - 392, 20.04.2018

Öz

One hundred trillion of symbiotic bacterial cells in every
human being make up the human microbiota. Microbiota protects tissues from
antigens and pathogens by increasing mucosal barrier resistance. In pregnancy
there are changes in the female body, especially in the vaginal microbial. In
studies, it has been reported that this alteration inhibits pathogenesis by the
secretion of antibacterial bacteriocins such as lactic acid, which can maintain
acid pH. The impaired vaginal environment is associated with pregnancy
complications, especially with the risk of preterm birth. This study discusses
the relationship between preterm birth and microbiota.

Kaynakça

  • Romero R, Dey SK, Fisher SJ. Preterm labor: One syndrome, many causes. Science. 2014;345(6198):760–765. doi: 10.1126/science.1251816.
  • Forsgren M, Isolauri E, Salminen S, Rautava S. Late preterm birth has direct and indirect effects on infant gut microbiota development during the first six months of life. Acta Paediatrica. 2017;106(7):1103-1109. doi: 10.1111/apa.13837.
  • Grier A, Qiu X, Bandyopadhyay S, et al. Impact of prematurity and nutrition on the developing gut microbiome and preterm infant growth. Microbiome. 2017;5(1):158. https://doi.org/10.1186/s40168-017-0377-0.
  • Romero R, Hassan SS, Gajer P, et al. The composition and stability of the vaginal microbiota of normal pregnant women is different from that of non-pregnant women. Microbiome. 2014;2(1):4. doi: 10.1186/2049-2618-2-4.
  • Goldenberg RL, Culhane JF, Iams JD, Romero R. Epidemiology and causes of preterm birth. Lancet. 2008;371(9606):75–84. doi: 10.1016/S0140-6736(08)60074-4.
  • Payne MS, Ireland DJ, Watts R, et al. Ureaplasma parvum genotype, combined vaginal colonisation with Candida albicans, and spontaneous preterm birth in an Australian cohort of pregnant women. BMC Pregnancy Childbirth. 2016;16(1):312. http://dx.doi.org/10.1186/s12884-016-1110-x.
  • Nuriel-Ohayon M, Neuman H, Koren O. Microbial changes during pregnancy, birth, and infancy. Front Microbiol. 2016;7:1031. doi: 10.3389/fmicb.2016.01031.
  • Soma-Pillay P, Nelson-Piercy C, Tolppanen H, Mebazaa A. Physiological changes in pregnancy. Cardiovasc J Afr. 2016;27(2):89–94. doi: 10.5830/CVJA-2016-021.
  • Koren O, Goodrich JK, Cullender TC, et al. Host remodeling of the gut microbiome and metabolic changes during pregnancy. Cell. 2012;150(3):470–480. doi: 10.1016/j.cell.2012.07.008.
  • Parnell LA, Briggs CM, Cao B, et al. Microbial communities in placentas from term normal pregnancy exhibits patially variable profiles. Sci Rep. 2017;7:11200. doi: 10.1038/s41598-017-11514-4.
  • Uslu Yuvacı H, Cevrıoğlu AS. Kadın üreme sistemi mikrobiyotası. Journal of Biotechnology and Strategic Health Research. 2017;1:95-103.
  • Ravel J, Gajer P, Abdo Z, et al. Vaginal microbiome of reproductive-age women. Proc Natl Acad Sci USA. 2011;108(suppl 1):4680-4687. doi: 10.1073/pnas.1002611107.
  • Klebanoff SJ, Hillier SL, Eschenbach DA, Waltersdorph AM. Control of the microbial flora of the vagina by H2O2-generating lactobacilli. J Infect Dis. 1991;164(1):94-100. https://doi.org/10.1093/infdis/164.1.94.
  • Dunlop AL, Mulle JG, Ferranti EP, et al. Maternal microbiome and pregnancy outcomes that impact infant health: are view. Adv Neonatal Care. 2015;15(6):377-385. doi: 10.1097/ANC.0000000000000218.
  • Cao B, Stout MJ, Lee I, Mysorekar IU. Placental microbiome and its role in preterm birth. Neoreviews. 2014;15(12):e537–e545. doi: 10.1542/neo.15-12-e537.
  • Brotman RM. Vaginal microbiome and sexually transmitted infections: an epidemiologic perspective. J Clin Invest. 2011;121(12):4610–4617. doi: 10.1172/JCI57172.
  • Haque MM, Merchant M, Kumar PN, Dutta A, Mande SS. First-trimester vaginal microbiome diversity: A potential indicator of preterm delivery risk. Scientific Reports. 2017;7(1):16145. doi:10.1038/s41598-017-16352-y.
  • Nelson DB, Hanlon A, Nachamkin I, et al. Early pregnancy changes in bacterial vaginosis-associated bacteria and preterm delivery. Paediatric and Perinatal Epidemiology. 2014;28(2):88-96. doi: 10.1111/ppe.12106.
  • MacIntyre DA, Chandiramani M, Lee YS, et al. The vaginal microbiome during pregnancy and the postpartum period in a European population. Sci Rep. 2015;5:8988. doi: 10.1038/srep08988.
  • Parnell LA, Briggs CM, Mysorekar IU. Maternal microbiomes in preterm birth: Recent progress and analytical pipelines. Seminars in perinatology. 2017;41(7);392-400. doi: https://doi.org/10.1053/j.semperi.2017.07.010.
  • Kindinger LM, Bennett PR, Lee YS, et al. The interaction between vaginal microbiota, cervical length, and vaginal progesterone treatment for preterm birth risk. Microbiome. 2017;5:6. doi: 10.1186/s40168-016-0223-9.
  • Ghartey J, Bastek JA, Brown AG, Anglim L, Elovitz MA. Women with preterm birth have a distinct cervicovaginal metabolome. Am J Obstet Gynecol. 2015;212(6):776.e1-776.e12. doi: 10.1016/j.ajog.2015.03.052.
  • Romero R, Hassan SS, Gajer P, et al. The vaginal microbiota of pregnant women who subsequently have spontaneous preterm labor and delivery and those with a normal delivery at term. Microbiome. 2014;2:18. doi: 10.1186/2049-2618-2-18.
  • Verstraelen H, Vilchez-Vargas R, Desimpel F, et al. Characterisation of the human uterine microbiome in non-pregnant women through deep sequencing of the V1-2 region of the 16S rRNA gene. Peer J. 2016;4:e1602. doi: 10.7717/peerj.1602.
  • Pelzer E, Gomez – Arango LF, Barrett HL, Nitert MD. Review: Maternal health and the placental microbiome. Placenta. 2016;54:30-37. doi: 10.1016/j.placenta.2016.12.003.
  • Aagaard K, Ma J, Antony KM, et al. The placenta harbors a unique microbiome. Sci Transl Med. 2014;6(237):237ra65. doi: 10.1126/scitranslmed.3008599.
  • Prince AL, Ma J, Kannan PS, et al. The placental membrane microbiome is altered among subjects with spontaneous preterm birth with and without chorioamnionitis. Am J Obstet Gynecol. 2016;214(5):627.e1-627.e16. doi: 10.1016/j.ajog.2016.01.193.
  • Cao B, Macones C, Mysorekar IU. ATG16L1 governs placental infection risk and preterm birth in mice and women. JCI Insight. 2016;1(21):e86654. doi: 10.1172/jci.insight.86654.
  • Cao B, Camden AJ, Parnell LA, Mysorekar IU. Autophagy regulation of physiological and pathological processes in the female reproductive tract. Am J Reprod Immunol. 2017;77(5):e12650. doi: 10.1111/aji.12650.

Erken Doğum ve Mikrobiyota İlişkisi

Yıl 2018, Sayı: 4, 383 - 392, 20.04.2018

Öz

Her insanda bulunan yüz trilyon simbiyotik bakteri hücresi
insan mikrobiyotasını oluşturmaktadır. Mikrobiyota, mukozal bariyer direncini
artırarak dokuları antijen ve patojenlerden korumaktadır. Gebelikte kadın
vücudunda, özellikle de vajinal mikrobiyumda değişimler olmaktadır.  Çalışmalarda bu değişikliğin, asit pH'ını
koruyabilen laktik asit gibi antibakteriyel bakteriyosinlerin salgılanması
yoluyla patojen gelişimini inhibe ettiği bildirilmektedir. Bozulmuş vajinal ortam
gebelik komplikasyonlarıyla özellikle erken doğum riski ile ilişkilendirilmektedir.
Bu çalışmada erken doğum ve mikrobiyata ilişkisi tartışılmaktadır.

Kaynakça

  • Romero R, Dey SK, Fisher SJ. Preterm labor: One syndrome, many causes. Science. 2014;345(6198):760–765. doi: 10.1126/science.1251816.
  • Forsgren M, Isolauri E, Salminen S, Rautava S. Late preterm birth has direct and indirect effects on infant gut microbiota development during the first six months of life. Acta Paediatrica. 2017;106(7):1103-1109. doi: 10.1111/apa.13837.
  • Grier A, Qiu X, Bandyopadhyay S, et al. Impact of prematurity and nutrition on the developing gut microbiome and preterm infant growth. Microbiome. 2017;5(1):158. https://doi.org/10.1186/s40168-017-0377-0.
  • Romero R, Hassan SS, Gajer P, et al. The composition and stability of the vaginal microbiota of normal pregnant women is different from that of non-pregnant women. Microbiome. 2014;2(1):4. doi: 10.1186/2049-2618-2-4.
  • Goldenberg RL, Culhane JF, Iams JD, Romero R. Epidemiology and causes of preterm birth. Lancet. 2008;371(9606):75–84. doi: 10.1016/S0140-6736(08)60074-4.
  • Payne MS, Ireland DJ, Watts R, et al. Ureaplasma parvum genotype, combined vaginal colonisation with Candida albicans, and spontaneous preterm birth in an Australian cohort of pregnant women. BMC Pregnancy Childbirth. 2016;16(1):312. http://dx.doi.org/10.1186/s12884-016-1110-x.
  • Nuriel-Ohayon M, Neuman H, Koren O. Microbial changes during pregnancy, birth, and infancy. Front Microbiol. 2016;7:1031. doi: 10.3389/fmicb.2016.01031.
  • Soma-Pillay P, Nelson-Piercy C, Tolppanen H, Mebazaa A. Physiological changes in pregnancy. Cardiovasc J Afr. 2016;27(2):89–94. doi: 10.5830/CVJA-2016-021.
  • Koren O, Goodrich JK, Cullender TC, et al. Host remodeling of the gut microbiome and metabolic changes during pregnancy. Cell. 2012;150(3):470–480. doi: 10.1016/j.cell.2012.07.008.
  • Parnell LA, Briggs CM, Cao B, et al. Microbial communities in placentas from term normal pregnancy exhibits patially variable profiles. Sci Rep. 2017;7:11200. doi: 10.1038/s41598-017-11514-4.
  • Uslu Yuvacı H, Cevrıoğlu AS. Kadın üreme sistemi mikrobiyotası. Journal of Biotechnology and Strategic Health Research. 2017;1:95-103.
  • Ravel J, Gajer P, Abdo Z, et al. Vaginal microbiome of reproductive-age women. Proc Natl Acad Sci USA. 2011;108(suppl 1):4680-4687. doi: 10.1073/pnas.1002611107.
  • Klebanoff SJ, Hillier SL, Eschenbach DA, Waltersdorph AM. Control of the microbial flora of the vagina by H2O2-generating lactobacilli. J Infect Dis. 1991;164(1):94-100. https://doi.org/10.1093/infdis/164.1.94.
  • Dunlop AL, Mulle JG, Ferranti EP, et al. Maternal microbiome and pregnancy outcomes that impact infant health: are view. Adv Neonatal Care. 2015;15(6):377-385. doi: 10.1097/ANC.0000000000000218.
  • Cao B, Stout MJ, Lee I, Mysorekar IU. Placental microbiome and its role in preterm birth. Neoreviews. 2014;15(12):e537–e545. doi: 10.1542/neo.15-12-e537.
  • Brotman RM. Vaginal microbiome and sexually transmitted infections: an epidemiologic perspective. J Clin Invest. 2011;121(12):4610–4617. doi: 10.1172/JCI57172.
  • Haque MM, Merchant M, Kumar PN, Dutta A, Mande SS. First-trimester vaginal microbiome diversity: A potential indicator of preterm delivery risk. Scientific Reports. 2017;7(1):16145. doi:10.1038/s41598-017-16352-y.
  • Nelson DB, Hanlon A, Nachamkin I, et al. Early pregnancy changes in bacterial vaginosis-associated bacteria and preterm delivery. Paediatric and Perinatal Epidemiology. 2014;28(2):88-96. doi: 10.1111/ppe.12106.
  • MacIntyre DA, Chandiramani M, Lee YS, et al. The vaginal microbiome during pregnancy and the postpartum period in a European population. Sci Rep. 2015;5:8988. doi: 10.1038/srep08988.
  • Parnell LA, Briggs CM, Mysorekar IU. Maternal microbiomes in preterm birth: Recent progress and analytical pipelines. Seminars in perinatology. 2017;41(7);392-400. doi: https://doi.org/10.1053/j.semperi.2017.07.010.
  • Kindinger LM, Bennett PR, Lee YS, et al. The interaction between vaginal microbiota, cervical length, and vaginal progesterone treatment for preterm birth risk. Microbiome. 2017;5:6. doi: 10.1186/s40168-016-0223-9.
  • Ghartey J, Bastek JA, Brown AG, Anglim L, Elovitz MA. Women with preterm birth have a distinct cervicovaginal metabolome. Am J Obstet Gynecol. 2015;212(6):776.e1-776.e12. doi: 10.1016/j.ajog.2015.03.052.
  • Romero R, Hassan SS, Gajer P, et al. The vaginal microbiota of pregnant women who subsequently have spontaneous preterm labor and delivery and those with a normal delivery at term. Microbiome. 2014;2:18. doi: 10.1186/2049-2618-2-18.
  • Verstraelen H, Vilchez-Vargas R, Desimpel F, et al. Characterisation of the human uterine microbiome in non-pregnant women through deep sequencing of the V1-2 region of the 16S rRNA gene. Peer J. 2016;4:e1602. doi: 10.7717/peerj.1602.
  • Pelzer E, Gomez – Arango LF, Barrett HL, Nitert MD. Review: Maternal health and the placental microbiome. Placenta. 2016;54:30-37. doi: 10.1016/j.placenta.2016.12.003.
  • Aagaard K, Ma J, Antony KM, et al. The placenta harbors a unique microbiome. Sci Transl Med. 2014;6(237):237ra65. doi: 10.1126/scitranslmed.3008599.
  • Prince AL, Ma J, Kannan PS, et al. The placental membrane microbiome is altered among subjects with spontaneous preterm birth with and without chorioamnionitis. Am J Obstet Gynecol. 2016;214(5):627.e1-627.e16. doi: 10.1016/j.ajog.2016.01.193.
  • Cao B, Macones C, Mysorekar IU. ATG16L1 governs placental infection risk and preterm birth in mice and women. JCI Insight. 2016;1(21):e86654. doi: 10.1172/jci.insight.86654.
  • Cao B, Camden AJ, Parnell LA, Mysorekar IU. Autophagy regulation of physiological and pathological processes in the female reproductive tract. Am J Reprod Immunol. 2017;77(5):e12650. doi: 10.1111/aji.12650.
Toplam 29 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Klinik Tıp Bilimleri
Bölüm Makaleler
Yazarlar

Canan Örüklü

Nevin Hotun Şahin

Yayımlanma Tarihi 20 Nisan 2018
Kabul Tarihi 22 Şubat 2018
Yayımlandığı Sayı Yıl 2018 Sayı: 4

Kaynak Göster

JAMA Örüklü C, Hotun Şahin N. Erken Doğum ve Mikrobiyota İlişkisi. IGUSABDER. 2018;:383–392.

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