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Bibliometric Evaluation of the Relationship between Selenium and Breast Cancer: A Synopsis

Yıl 2025, Sayı: 26, 686 - 696, 31.08.2025
https://doi.org/10.38079/igusabder.1749163

Öz

Aim: To discover the relationship between breast cancer and selenium via bibliometric analysis, identify their current status in literature, and investigate the international research activity based on breast cancer and selenium publications.
Method: The Web of Science Core Collection (WoS) database was used to retrieve the data. The keywords (“breast cancer”) and (“selenium”) were utilized in “topic” selection mode for the search. Bibliometric analysis was employed to evaluate the papers, and correlation analysis was performed to identify the associations between the number of publications and citation counts.
Results: A total of 731 outputs were produced between 1980 and 2025. The USA was reported as the most productive and most cited country. The most productive journal, publisher, and institution were reported as “Biological Trace Element Research”, “Elsevier”, and “Harvard University”, respectively. The most cited journal was “Cancer Research and Treatment”, the most active funding institution was “National Institutes of Health NIH,” and “breast cancer” was the most common keyword.
Conclusion: The analysis highlights a growing interest in the potential role of selenium in breast cancer prevention, diagnosis, and treatment. The findings also reveal emerging themes and knowledge gaps that warrant further investigation, particularly regarding selenium’s biological mechanisms and clinical applications. Overall, this analysis serves as a guide for future research directions and promote evidence-based advancements in breast cancer management related to selenium.

Kaynakça

  • 1. World Health Organization. Breast cancer. World Health Organization. https://www.who.int/news-room/fact-sheets/detail/breast-cancer. Published August 2025. Accessed February 21, 2025.
  • 2. Harris RJ, Lippman ME, Veronesi U, Willett, W. Breast cancer. New England Journal of Medicine. 1992;327:473–480. doi: 10.1056/NEJM199208133270706
  • 3. Mahata J, Basu A, Ghoshal S, et al. Chromosomal aberrations and sister chromatid exchanges in individuals exposed to arsenic through drinking water in West Bengal, India. Mutation Research. 2003;534(1–2):133–143. doi: 10.1016/s1383-5718(02)00255-3.
  • 4. Waks AG, Winer EP. Breast cancer treatment: A review. JAMA. 2019;321(3):288–300.
  • 5. Veronesi U, Boyle P, Goldhirsch A, Orecchia R, Viale G. Breast cancer. The Lancet. 2005;365(9472):1727–1741. doi: 10.1016/S0140-6736(05)66546-4.
  • 6. Collaborative Group on Hormonal Factors in Breast Cancer. Familial breast cancer: Collaborative reanalysis of individual data from 52 epidemiological studies including 58 209 women with breast cancer and 101 986 women without the disease. The Lancet. 2001;358(9291).1389–1399. doi: 10.1016/S0140-6736(01)06524-2.
  • 7. Allison KH. Molecular pathology of breast cancer: What a pathologist needs to know. American Journal of Clinical Pathology. 2012;138(6):770–780.
  • 8. Hulka BS. Epidemiology of susceptibility to breast cancer. Progress in Clinical and Biological Research. 1996;395:159–174.
  • 9. Feng Y, Spezia M, Huang S, et al. Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis. Genes & Diseases. 2018;5(2):77–106. doi: 10.1016/j.gendis.2018.05.001.
  • 10. Zou XN, Taylor PR, Mark SD, et al. Seasonal variation of food consumption and selected nutrient intake in Linxian, a high risk area for esophageal cancer in China. International Journal for Vitamin and Nutrition Research. 2002;72(6):375–382.
  • 11. Evans SO, Khairuddin PF, Jameson MB. Optimising selenium for modulation of cancer treatments. Anticancer Research. 2017;37:6497–6509.
  • 12. Fairweather-Tait SJ, Bao Y, Broadley MR, et al. Selenium in human health and disease: An overview. Antioxidants & Redox Signaling. 2011;14:3–26.
  • 13. Rayman MP. Selenium and human health. The Lancet. 2012;379:1256–1268.
  • 14. Lu J, Holmgren A. Selenoproteins. Journal of Biological Chemistry. 2009;284(2):723–727.
  • 15. Papp LV, Lu J, Holmgren A, Khanna KK. From selenium to selenoproteins: Synthesis, identity, and their role in human health. Antioxidants & Redox Signaling. 2007;9(7):775–806. doi: 10.1089/ars.2007.1528.
  • 16. Callejón-Leblic B, Rodríguez-Moro G, Arias-Borrego A, et al. Absolute quantification of selenoproteins and selenometabolites in lung cancer human serum by column switching coupled to triple quadrupole inductively coupled plasma mass spectrometry. Journal of Chromatography A. 2020;1619:460919.
  • 17. Jayachandran A, Shrestha R, Bridle KR, et al. Association between hereditary hemochromatosis and hepatocellular carcinoma: A comprehensive review. Hepatoma Research. 2020;6:8. doi: 10.20517/2394-5079.2019.35.
  • 18. Schomburg L. Selenium, selenoproteins and the thyroid gland: Interactions in health and disease. Nature Reviews Endocrinology. 2011;8(3):160–171.
  • 19. Combs GF. Selenium in cancer prevention: A review of the evidence and mechanism of action. Proceedings of the Nutrition Society. 2005;64(4):527–542.
  • 20. Donthu N, Kumar S, Mukherjee D, Pandey N, Lim WM. How to conduct a bibliometric analysis: An overview and guidelines. Journal of Business Research. 2021;133:285–296.
  • 21. Doulani AA. A bibliometric analysis and science mapping of scientific publications of Alzahra University during 1986–2019. Library Hi Tech. 2020;39:915–935.
  • 22. Hu W, Tu Y, Tan J, et al. Global research trends on endoplasmic reticulum stress in retinal diseases from 2000 to 2024. International Ophthalmology. 2025;45(1):1–21.
  • 23. Konar NM, Suner A. Altmetric, bibliometric, and visualized study of top 100 most cited papers in digital health. Bandırma Onyedi Eylül Üniversitesi Sağlık Bilimleri ve Araştırmaları Dergisi. 2024;6(2):262–275. doi: 10.46413/boneyusbad.1420103.
  • 24. Aylaz G, Konar NM. Current publication activity on nanoplastics & microplastics: A bibliometric analysis. Sustainable Water Resources Management. 2024;10(2):95.
  • 25. Ju L, Liu Y, Liu S, et al. Bibliometric analysis of global trends and characteristics of remote sensing for mineral exploration in the early 21st century. All Earth. 2024;36(1):1–17.
  • 26. Meng G, Xu H, Yang S, et al. Bibliometric analysis of worldwide research trends on breast cancer about inflammation. Frontiers in Oncology. 2023;13:1166690.
  • 27. Jiang S, Meng Q, Ji F, et al. A bibliometric analysis of metastatic breast cancer: Two-decade report (2002–2022). Frontiers in Oncology. 2023;13:1229222.
  • 28. Wu D, Pan C, Hu Y, et al. A bibliometric and visualization analysis of research trends and hotspots on targeted therapy for breast cancer from 2003 to 2022. Frontiers in Oncology. 2024;14:1366900.
  • 29. Wu Y, Cai T, Tao Y, et al. Emerging insights and global trends in the relationship between selenium and thyroid diseases: A bibliometric analysis. Endocrine, Metabolic & Immune Disorders - Drug Targets. 2024;24(7):808–819.
  • 30. Abejón R. A bibliometric analysis of research on selenium in drinking water during the 1990–2021 period: Treatment options for selenium removal. International Journal of Environmental Research and Public Health. 2022;19(10):5834.

Selenyum ile Meme Kanseri Arasındaki İlişkinin Bibliyometrik Değerlendirmesi

Yıl 2025, Sayı: 26, 686 - 696, 31.08.2025
https://doi.org/10.38079/igusabder.1749163

Öz

Amaç: Bu çalışmanın amacı, meme kanseri ile selenyum arasındaki ilişkiyi bibliyometrik analiz yoluyla ortaya koymak, literatürdeki mevcut durumu belirlemek ve meme kanseri ile selenyum konularında yapılan uluslararası araştırma faaliyetlerini incelemektir.
Yöntem: Veriler Web of Science Core Collection (WoS) veritabanından elde edildi. Arama için "konu" seçiminde "meme kanseri" ve "selenyum" anahtar kelimeleri kullanıldı. Yayınlar bibliyometrik analiz yöntemiyle değerlendirilmiş, yayın sayısı ile atıf sayısı arasındaki ilişkileri belirlemek amacıyla korelasyon analizi uygulanmıştır.
Bulgular: 1980 ile 2025 yılları arasında toplam 731 yayın üretilmiştir. En fazla yayın yapan ve en çok atıf alan ülke Amerika Birleşik Devletleri olmuştur. En üretken dergi “Biological Trace Element Research”, en üretken yayınevi “Elsevier” ve en üretken kurum ise “Harvard Üniversitesi” olarak belirlenmiştir. En çok atıf alan dergi “Cancer Research and Treatment” olurken, en aktif fon sağlayan kurum “National Institutes of Health (NIH)” olmuştur. En sık kullanılan anahtar kelime ise “meme kanseri” (breast cancer) olarak tespit edilmiştir.
Sonuç: Bu analiz, selenyumun meme kanserinin önlenmesi, tanısı ve tedavisindeki potansiyel rolüne yönelik artan ilgiyi ortaya koymaktadır. Bulgular, selenyumun biyolojik mekanizmaları ve klinik uygulamaları konusunda daha fazla araştırmaya ihtiyaç duyulduğunu ve bu alandaki bilgi boşluklarını göstermektedir. Genel olarak bu çalışma, gelecekteki araştırmalar için yol gösterici bir kaynak olmayı ve meme kanseri yönetiminde selenyumla ilişkili kanıta dayalı gelişmeleri teşvik etmeyi amaçlamaktadır.

Kaynakça

  • 1. World Health Organization. Breast cancer. World Health Organization. https://www.who.int/news-room/fact-sheets/detail/breast-cancer. Published August 2025. Accessed February 21, 2025.
  • 2. Harris RJ, Lippman ME, Veronesi U, Willett, W. Breast cancer. New England Journal of Medicine. 1992;327:473–480. doi: 10.1056/NEJM199208133270706
  • 3. Mahata J, Basu A, Ghoshal S, et al. Chromosomal aberrations and sister chromatid exchanges in individuals exposed to arsenic through drinking water in West Bengal, India. Mutation Research. 2003;534(1–2):133–143. doi: 10.1016/s1383-5718(02)00255-3.
  • 4. Waks AG, Winer EP. Breast cancer treatment: A review. JAMA. 2019;321(3):288–300.
  • 5. Veronesi U, Boyle P, Goldhirsch A, Orecchia R, Viale G. Breast cancer. The Lancet. 2005;365(9472):1727–1741. doi: 10.1016/S0140-6736(05)66546-4.
  • 6. Collaborative Group on Hormonal Factors in Breast Cancer. Familial breast cancer: Collaborative reanalysis of individual data from 52 epidemiological studies including 58 209 women with breast cancer and 101 986 women without the disease. The Lancet. 2001;358(9291).1389–1399. doi: 10.1016/S0140-6736(01)06524-2.
  • 7. Allison KH. Molecular pathology of breast cancer: What a pathologist needs to know. American Journal of Clinical Pathology. 2012;138(6):770–780.
  • 8. Hulka BS. Epidemiology of susceptibility to breast cancer. Progress in Clinical and Biological Research. 1996;395:159–174.
  • 9. Feng Y, Spezia M, Huang S, et al. Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis. Genes & Diseases. 2018;5(2):77–106. doi: 10.1016/j.gendis.2018.05.001.
  • 10. Zou XN, Taylor PR, Mark SD, et al. Seasonal variation of food consumption and selected nutrient intake in Linxian, a high risk area for esophageal cancer in China. International Journal for Vitamin and Nutrition Research. 2002;72(6):375–382.
  • 11. Evans SO, Khairuddin PF, Jameson MB. Optimising selenium for modulation of cancer treatments. Anticancer Research. 2017;37:6497–6509.
  • 12. Fairweather-Tait SJ, Bao Y, Broadley MR, et al. Selenium in human health and disease: An overview. Antioxidants & Redox Signaling. 2011;14:3–26.
  • 13. Rayman MP. Selenium and human health. The Lancet. 2012;379:1256–1268.
  • 14. Lu J, Holmgren A. Selenoproteins. Journal of Biological Chemistry. 2009;284(2):723–727.
  • 15. Papp LV, Lu J, Holmgren A, Khanna KK. From selenium to selenoproteins: Synthesis, identity, and their role in human health. Antioxidants & Redox Signaling. 2007;9(7):775–806. doi: 10.1089/ars.2007.1528.
  • 16. Callejón-Leblic B, Rodríguez-Moro G, Arias-Borrego A, et al. Absolute quantification of selenoproteins and selenometabolites in lung cancer human serum by column switching coupled to triple quadrupole inductively coupled plasma mass spectrometry. Journal of Chromatography A. 2020;1619:460919.
  • 17. Jayachandran A, Shrestha R, Bridle KR, et al. Association between hereditary hemochromatosis and hepatocellular carcinoma: A comprehensive review. Hepatoma Research. 2020;6:8. doi: 10.20517/2394-5079.2019.35.
  • 18. Schomburg L. Selenium, selenoproteins and the thyroid gland: Interactions in health and disease. Nature Reviews Endocrinology. 2011;8(3):160–171.
  • 19. Combs GF. Selenium in cancer prevention: A review of the evidence and mechanism of action. Proceedings of the Nutrition Society. 2005;64(4):527–542.
  • 20. Donthu N, Kumar S, Mukherjee D, Pandey N, Lim WM. How to conduct a bibliometric analysis: An overview and guidelines. Journal of Business Research. 2021;133:285–296.
  • 21. Doulani AA. A bibliometric analysis and science mapping of scientific publications of Alzahra University during 1986–2019. Library Hi Tech. 2020;39:915–935.
  • 22. Hu W, Tu Y, Tan J, et al. Global research trends on endoplasmic reticulum stress in retinal diseases from 2000 to 2024. International Ophthalmology. 2025;45(1):1–21.
  • 23. Konar NM, Suner A. Altmetric, bibliometric, and visualized study of top 100 most cited papers in digital health. Bandırma Onyedi Eylül Üniversitesi Sağlık Bilimleri ve Araştırmaları Dergisi. 2024;6(2):262–275. doi: 10.46413/boneyusbad.1420103.
  • 24. Aylaz G, Konar NM. Current publication activity on nanoplastics & microplastics: A bibliometric analysis. Sustainable Water Resources Management. 2024;10(2):95.
  • 25. Ju L, Liu Y, Liu S, et al. Bibliometric analysis of global trends and characteristics of remote sensing for mineral exploration in the early 21st century. All Earth. 2024;36(1):1–17.
  • 26. Meng G, Xu H, Yang S, et al. Bibliometric analysis of worldwide research trends on breast cancer about inflammation. Frontiers in Oncology. 2023;13:1166690.
  • 27. Jiang S, Meng Q, Ji F, et al. A bibliometric analysis of metastatic breast cancer: Two-decade report (2002–2022). Frontiers in Oncology. 2023;13:1229222.
  • 28. Wu D, Pan C, Hu Y, et al. A bibliometric and visualization analysis of research trends and hotspots on targeted therapy for breast cancer from 2003 to 2022. Frontiers in Oncology. 2024;14:1366900.
  • 29. Wu Y, Cai T, Tao Y, et al. Emerging insights and global trends in the relationship between selenium and thyroid diseases: A bibliometric analysis. Endocrine, Metabolic & Immune Disorders - Drug Targets. 2024;24(7):808–819.
  • 30. Abejón R. A bibliometric analysis of research on selenium in drinking water during the 1990–2021 period: Treatment options for selenium removal. International Journal of Environmental Research and Public Health. 2022;19(10):5834.
Toplam 30 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Onkoloji, Tıp Fiziği
Bölüm Makaleler
Yazarlar

Selim Öğüt 0000-0001-9126-6477

Erken Görünüm Tarihi 30 Ağustos 2025
Yayımlanma Tarihi 31 Ağustos 2025
Gönderilme Tarihi 23 Temmuz 2025
Kabul Tarihi 21 Ağustos 2025
Yayımlandığı Sayı Yıl 2025 Sayı: 26

Kaynak Göster

JAMA Öğüt S. Bibliometric Evaluation of the Relationship between Selenium and Breast Cancer: A Synopsis. IGUSABDER. 2025;:686–696.

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