USAGE OF 3D PRINTER MATERIALS IN RADIOTHERAPY: DOSIMETRIC EVALUATION

Öz

In radiotherapy, tissue-equivalent materials called 'bolus' are used in patient applications or tissue-equivalent phantoms are used in device calibration before patient treatments. However, these commercial materials are manufactured and sold in standard sizes, they cannot meet diverse design needs. In recent years, 3D printers play an important role in meeting the production needs of different designs. In this study, it was aimed to dosimetrically evaluate the response of PLA (Polylactic Acid), TPU (Thermoplastic Polyurethane), and Nylon (Polyamide) materials produced for use in 3D (3D) printers, which are increasingly used. Hounsfield Unit (HU) values were determined on the CT simulator device. Dosimetric measurements were made using the 6 MV nominal photon energy obtained in the Varian DHX linear accelerator. Percent depth dose (%DD) and dose profile measurements were made with water phantom, and transmittance measurements were made with solid phantom. The average HU densities of the materials vary between -8.61 and -441.08. The PLA material gave the closest results to the HU value of water, with an average value of -24.72 HU. % depth and penumbra values were found as within 2% and ±2 mm. When the permeability measurements of all materials were evaluated, it was observed that the change with the RW3 plate was 0.2% maximum. The dosimetric parameters of the materials printed in the 3D printer give similar results, but it seems appropriate to evaluate the material to be used dosimetrically due to the printing properties and material variability before using it as a patient personalization materials.

Anahtar Kelimeler

• 3D printer
• Dosimetry
• Radiotherapy

Proje Numarası

121F335

3B YAZICI MALZEMELERİNİN RADYOTERAPİDE KULLANIMI: DOZİMETRİK DEĞERLENDİRME

Öz

Radyoterapide hasta uygulamalarında ‘bolus’ olarak isimlendirilen doku eşdeğeri malzemeler ya da hasta tedavileri öncesi cihaz kalibrasyonunda doku eşdeğeri fantomlar kullanılmaktadır. Ancak ticari olarak satılan bu malzemeler standart boyutlarda üretilerek satışı yapılmakta; farklı dizaynlara duyulan ihtiyacı karşılamamaktadır. Son yıllarda farklı dizaynlarda üretim ihtiyacını karşılamada 3 boyutlu (3B) yazıcılar önemli bir rol üstlenmektedir. Bu çalışmada kullanımı giderek artan 3B yazıcılarda kullanım için üretilmiş PLA (Poliaktik Asit), TPU (Termoplastik Poliüretan) ve Naylon (Polyamide) malzemelerinin radyasyona verdikleri cevabın dozimetrik olarak değerlendirilmesi hedeflenmiştir. BT simülatör cihazında Hounsfiel Unit (HU) değerleri belirlendi. Dozimetrik ölçümler Varian DHX lineer hızlandırıcısında elde edilen 6 MV nominal foton enerjisi kullanılarak yapılmıştır. Yüzde derin doz (%DD) ve doz profili ölçümleri su fantomunda, ışın geçirgenlik ölçümleri katı fantomda yapılmıştır. Malzemelerin ortalama HU yoğunlukları -8.61 ile -441.08 arasında değişmektedir. PLA malzemesi ort. -24.72 ile suyun HU değeri (0)’ ne en yakın sonuçları vermiştir. % derin doz ve penumbra değerleri %2 ve ±2 mm içerisinde bulunmuştur. Tüm malzemelere ait geçirgenlik ölçümleri değerlendirildiğinde RW3 katı su fantomu plakası ile değişimin maksimum % 0.2 olduğu görülmüştür. 3B yazıcıda basılan malzemelerin dozimetrik parametrelerinin birbirlerine benzer sonuçlar verdiği ancak hastada kişisel malzeme olarak kullanılmadan önce basım özellikleri ve malzeme değişkenlikleri sebebiyle kullanılacak malzemenin dozimetrik olarak değerlendirilmesi uygun gözükmektedir.

Anahtar Kelimeler

• 3B yazıcı
• Dozimetri
• Radyoterapi

Destekleyen Kurum

TÜRKİYE BİLİMSEL VE TEKNOLOJİK ARAŞTIRMA KURUMU

Proje Numarası

121F335

Teşekkür

Bu çalışma TÜBİTAK ARDEB 1001 - Bilimsel ve Teknolojik Araştırma Projelerini Destekleme Programı kapsamında desteklenerek gerçekleştirilmiştir.

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