SAĞLIK SEKTÖRÜNDE ÜÇ BOYUTLU YAZICI UYGULAMALARI: GÜNCEL DURUMU VE GELECEĞİ

Öz

Üç boyutlu yazıcılar günümüzde birçok yerde kullanılan hızla gelişen bir teknolojidir. Bu araştırmada, günümüzde sıklıkla kullanılan üç boyutlu yazıcıların sağlık alanındaki gelişmelerini inceledik. Üç boyutlu (3D) bioprint, doku anatomi, biyoloji ve fizyolojiyi canlandırmak için canlı hücreler, nükleik asitler, ilaç partikülleri, proteinler ve büyüme faktörleri dahil, biyolojik materyallerin tasarımı ve tam yerleşimi için güçlü bir araç haline gelmiştir.

Bioprinting son on yılda önemli ölçüde gelişmiştir ve gelecekte canlı doku üretiminde yaygın olarak kullanılacaktır. Çoğu hasta, gelişen teknoloji sayesinde doku hasarı ve organ nakli sorunlarının, özelleştirilmiş modeller ile üç boyutlu biyo-baskılarla çözüleceğini düşünmektedir. Bu çalışmada üç boyutlu biyo-yazıcı teknolojisi tanıtıldı, doku mühendisliği, rejeneratif tıp vb. Sağlık alanında uygulamalar ve kullanımları incelenmiştir.

Anahtar Kelimeler

• Biyoprinter,Doku Mühendisliği

THREE DIMENSIONAL PRINTER APPLICATIONS IN THE HEALTH SECTOR: CURRENT SITUATION AND FUTURE

Öz

Three-dimensional printers are a rapidly developing technology that is used in many places today. In this research, we have examined the developments in the field of health of the three dimensional printers which are frequently used today. Three-dimensional (3D) bioprint has become a powerful tool for the design and full placement of biological materials, including living cells, nucleic acids, drug particles, proteins and growth factors, to revitalize tissue anatomy, biology and physiology.

Bioprinting has evolved significantly over the last decade and will be used extensively in future live tissue production. Most patients think that by means of developing technology, tissue damage and organ transplantation problems will be solved with three-dimensional bioprinteres with customized models. In this study, three-dimensional bio-printer technology is introduced, tissue engineering, regenerative medicine and so on. applications and uses in the field of health have been examined.

Anahtar Kelimeler

• Biyoprinter,Tissue Engineering

Kaynakça

1. Kaushik A., Kant S., Kalra P. Rapid Prototyping Technologies and Applications in Modern Engineering -A Review, March 2015
2. Aydın L., Küçük S. Üç Boyutlu Yazıcı ve Tarayıcı ile Hastaya Özel Medikal Ortez Tasarımı ve Geliştirilmesi, Journal of Polytechnic, 2017: 20 (1) 1-8
3. Gibson I., Rosen D.W., Stucker B. Additive Manufacturing Technologies - Rapid Prototyping. New York, NY,10013: Springer Science+Business Media. London 2010.s.30
4. You Can Now See the First Ever 3D Printer -- Invented by Chuck Hull - In the National Inventors Hall of Fame. The Voice of 3D Printing / Additive Manufacturing https://3dprint.com/72171/first-3d-printer-chuck-hul/ Accessed January 12, 2018.
5. Matias E., Rao B. 3D Printing: On Its Historical Evolution and the Implications for Business, 2015 Proceedings of PICMET '15: Management of the Technology Age USA,2015 ,1-8
6. Reprap 3d (3 boyutlu ) yazıcı:Elektronik hobi.http://elektronikhobi.net/reprap-3-d-3-boyutlu-yazici/ Accessed February 20,2018
7. Mellor S., Hao L., Zhang D. Additive Manufacturing: A Framework for Implementation, 2014: 194–201
8. Gaoa W., Zhanga Y.,Ramanujana D., Ramani K., Chenc Y., Williams C.B., Wang C.C.L., Shina Y.C., Zhang S.,Zavattieri P.D. The status, challenges, and future of additive manufacturing in engineering, Computer-Aided Design , Elsevier Journal Finder 2015,65-89

9. Kietzmann J., Pitt L., Berthon P. Disruptions, decisions, and destinations: Enter the age of 3-D printing and additive manufacturing, Business Horizons Journal, 2015, 209-215
10. Murphy V.S., Atala A. 3D bioprinting of tissues and organs, Nature biotechnology review, 2014:1-13
11. Peng, J., The Future of Medicine: 3D-Printed Organs , Berkeley Scientific Journal, 2016:14-16
12. Kusaka M., Sugimoto M., Fukami N., Sasaki H., Takenaka M., Anraku T., Ito T., Kenmochi T., Shiroki R., and Hoshinaga K. Initial Experience With a Tailor-made Simulation and Navigation Program Using a 3-D Printer Model of Kidney Transplantation Surgery, Elsevier Journal Finder 2015:596-599
13. Niikura T, Sugimoto M, Lee SY, et al. Tactile surgical navigation system for complex acetabular fracture surgery, Orthopedics, Tip&Techniques 2014:237-242
14. Klammert U., Gbureck U., Vorndran E., Rödıger J., Meyer-Marcotty P., Kübler A. C., 3D printed calcium phosphate implants for reconstruction of cranial and maxillofacial defects, Journal of Cranio-Maxillo-Facial Surgery (2010):1-6
15. Kim D., Lim J.Y, Shim K.W., Han J.W.,Yi S., Yoon D.H., Kim K.N., Ha Y., Ji G.Y., Shin D.A.,Sacral Reconstruction with a 3D-Printed Implant after Hemisacrectomy in a Patient with Sacral Osteosarcoma: 1-Year Follow-Up Result , Yonsei Med 2017;58(2):453-457.
16. Forrestal DP, Klein TJ, Woodruff MA. Challenges in engineering large customized bone const-ructs. Biotechnol Bioeng. 2017;114: 1129–1139
17. Yılgör H.P. , 3D Baskı Teknolojileri Uluslararası Sempozyumu (3B-BTS2017), 3D Biyobaskı İle Anatomik Şekilli Kemik Dokusu Üretimi,2017:59-61
18. Temple JP, Hutton DL, Hung BP, Yilgor H.P, Cook CA, Kondragunta R, Jia X, Grayson WL. “Engineering Anatomically-Shaped Vascularized Bone Grafts with hASCs and 3D-Printed PCL Scaffolds”, Journal Biomedical Materials Research, A 2014; 102A: 4317-4325
19. Rejeneratif Tıp, Liv Medcell http://www.livkokhucre.com/kok-hucre-ve-rejeneratif-tip/rejeneratif-tip/ Accessed 18,2018
20. HASIRCI V. , Yüklenim Dergisi, Rejeneratif Tıp, Doku Mühendisliği. Nanoteknoloji: Yapay Nefes Borusu, 2015: 92-93
21. Chana S. , 3D Organ Printing, The Science Journal of the Lander College of Arts and Sciences 2016; 10(1), 66-72
22. Takahiro N. ,Maki S. , Sang Yang L. , Yoshitada S. , Kotaro N. , Ryosuke K. , Masahiro K Tactile Surgical Navigation System for Complex Acetabular Fracture Surgery , 2014:237-242