Derleme
BibTex RIS Kaynak Göster

Traditional Use, Therapeutic Properties and Antioxidant Activity of Honey

Yıl 2022, Cilt: 2 Sayı: 2, 42 - 55, 30.09.2022

Öz

Honey is a naturally sweet substance produced by honey bees (Apis mellifera) from the nectar of flowers, the secretions of plants or the secretions of sucking insects on plants. This sweet substance has a different chemical composition according to the plant flora from which it is obtained, and contains sugars, small amounts of protein, enzymes, amino acids, minerals, trace elements, vitamins, aroma compounds, various flavonoids and phenolic compounds. Due to these properties, honey has been used as a food since ancient times, as well as burns, cataracts, ulcers, diabetes, wound healing, etc. It has been used as a medicine by folk physicians for ailments. It has been used as a medicine by folk physicians for ailments. These use cases have been scientifically supported by subsequent studies. It was concluded that honey is effective as a therapeutic agent and it has been widely used in alternative medicine. In this study, the chemical composition of honey, its antioxidant properties and important therapeutic properties against some diseases were tried to be emphasized.

Kaynakça

  • Abuharfeil, N., Al-Oran, R., Abo-Shehada, M. 1999. The effect of bee honey on the proliferative activity of human B-and T-lymphocytes and the activity of phagocytes. Food and agricultural Immunology, 11 (2), 169-177.
  • Adebiyi, F. M., Akpan, I., Obiajunwa, E. I., Olaniyi, H. B. 2004. Chemical/physical characterization of Nigerian honey. Pakistan journal of Nutrition, 3( 5), 278-281.
  • Aggad, H., Guemour, D. 2014. Honey antibacterial activity. Med Aromat Plants, 3 (152), 2167-0142.
  • Ahmad, A., Khan, R. A., Mesaik, M. A. 2009. Anti inflammatory effect of natural honey on bovine thrombin‐induced oxidative burst in phagocytes. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 23 (6), 801-808.
  • Alam, F., Islam, M. D., Gan, S. H., Khalil, M. 2014. Honey: a potential therapeutic agent for managing diabetic wounds. Evidence-Based Complementary and Alternative Medicine, 2014.
  • Ali, A. M., Hendawy, A. O. 2021. Bee honey in combination with exercise-better physical performance and less fatigue for a more active lifestyle during the COVID-19 era. Sports Med. Health Sci.
  • Ali, A. M., Kunugi, H. 2020. Intermittent fasting, dietary modifications, and exercise for the control of gestational diabetes and maternal mood dysregulation: A review and a case report. International journal of environmental research and public health, 17 (24), 9379.
  • Ali, A. M., Kunugi, H. 2019. Bee honey protects astrocytes against oxidative stress: A preliminary in vitro investigation. Neuropsychopharmacology Reports, 39 (4), 312-314.
  • Ali, A. T., Chowdhury, M. N., Al Humayyd, M. S. 1991. Inhibitory effect of natural honey on Helicobacter pylori. Tropical gastroenterology: official journal of the Digestive Diseases Foundation, 12 (3), 139-143.
  • Al-Jabri, A. A. 2005. Honey, milk and antibiotics. African Journal of Biotechnology, 4 (13).
  • Allsop, K. A., Miller, J. B. 1996. Honey revisited: a reappraisal of honey in pre-industrial diets. British Journal of Nutrition, 75(4), 513-520.
  • Al-Mamary, M., Al-Meeri, A., Al-Habori, M. 2002. Antioxidant activities and total phenolics of different types of honey. Nutrition research, 22 (9), 1041-1047.
  • Almasaudi, S. B., Al-Nahari, A. A., El Sayed, M., Barbour, E., Al Muhayawi, S. M., Al-Jaouni, S., Harakeh, S. 2017. Antimicrobial effect of different types of honey on Staphylococcus aureus. Saudi journal of biological sciences, 24 (6), 1255-1261.
  • Alnaqdy, A., Al-Jabri, A., Al Mahrooqi, Z., Nzeako, B., Nsanze, H. 2005. Inhibition effect of honey on the adherence of Salmonella to intestinal epithelial cells in vitro. International journal of food microbiology, 103 (3), 347-351.
  • Alvarez-Suarez, J. M., Tulipani, S., Romandini, S., Bertoli, E., Battino, M. 2010. Contribution of honey in nutrition and human health: a review. Mediterranean Journal of Nutrition and Metabolism, 3 (1), 15-23.
  • Alvarez-Suarez, J. M., Gasparrini, M., Forbes-Hernández, T. Y., Mazzoni, L., Giampieri, F. 2014. The composition and biological activity of honey: a focus on Manuka honey. Foods, 3 (3), 420-432.
  • Alves, A., Ramos, A., Gonçalves, M. M., Bernardo, M., Mendes, B. 2013. Antioxidant activity, quality parameters and mineral content of Portuguese monofloral honeys. Journal of Food Composition and Analysis, 30(2), 130-138.
  • Al-Waili, N. S., Al-Waili, T. N., Al-Waili, A. N., Saloom, K. S. 2006. Influence of natural honey on biochemical and hematological variables in AIDS: a case study. The Scientific World Journal, 6, 1985-1989.
  • Al-Waili, N. S. 2004. Natural honey lowers plasma glucose, C-reactive protein, homocysteine, and blood lipids in healthy, diabetic, and hyperlipidemic subjects: comparison with dextrose and sucrose. Journal of medicinal food, 7 (1), 100-107.
  • Al-Waili, N. S., Haq, A. 2004. Effect of honey on antibody production against thymus-dependent and thymus-independent antigens in primary and secondary immune responses. Journal of medicinal food, 7(4), 491-494.
  • Al-Waili, N. S., Boni, N. S. 2003. Natural honey lowers plasma prostaglandin concentrations in normal individuals. Journal of medicinal food, 6 (2), 129-133.
  • American Diabetes Association (ADA), 2004. Diagnosis and classification of diabetes mellitus. Diabetes Care, 27(Supplement 1):S5-S10. Anonymous, 1994. Ayurveda Aushadha Sangrahaya. Part 2. Vol. 1. Sri Lanka: Maharagama.
  • Asadi-Pooya, A. A., Pnjehshahin, M. R., Beheshti, S. 2003. The antimycobacterial effect of honey: an in vitro study. Rivista di biologia, 96 (3), 491-495.
  • Attanzio, A., Tesoriere, L., Allegra, M., Livrea, M. A. 2016. Monofloral honeys by Sicilian black honeybee (Apis mellifera ssp. sicula) have high reducing power and antioxidant capacity. Heliyon, 2(11), e00193.
  • Bansal, V., Medhi, B., Pandhi, P. 2005. Honey--a remedy rediscovered and its therapeutic utility. Kathmandu University medical journal (KUMJ), 3 (3), 305-309.
  • Becerril-Sánchez, A. L., Quintero-Salazar, B., Dublán-García, O., Escalona-Buendía, H. B. 2021. Phenolic compounds in honey and their relationship with antioxidant activity, botanical origin, and color. Antioxidants, 10 (11), 1700.
  • Bendich, A. 2010. Nutrition and health: Bioactive Compounds and Cancer. Humanna Press, Totowa.
  • Beretta, G., Granata, P., Ferrero, M., Orioli, M., Facino, R. M. 2005. Standardization of antioxidant properties of honey by a combination of spectrophotometric/fluorimetric assays and chemometrics. Analytica Chimica Acta, 533 (2), 185-191.
  • Berger, M. M. 2005. Can oxidative damage be treated nutritionally?. Clinical nutrition, 24 (2), 172-183.
  • Bilsel, Y., Bugra, D., Yamaner, S., Bulut, T., Cevikbas, U., Turkoglu, U. J. D. S. 2002. Could honey have a place in colitis therapy? Effects of honey, prednisolone, and disulfiram on inflammation, nitric oxide, and free radical formation. Digestive Surgery, 19 (4), 306-312.
  • Bogdanov, S., Jurendic, T., Sieber, R., Gallmann, P. 2008. Honey for nutrition and health: a review. Journal of the American college of Nutrition, 27 (6), 677-689.
  • Burlando, B., Cornara, L. 2013. Honey in dermatology and skin care: A review. Journal of Cosmetic Dermatology, 12(4):306-313.
  • Carter, D. A., Blair, S. E., Cokcetin, N. N., Bouzo, D., Brooks, P., Schothauer, R., Harry, E. J. 2016. Therapeutic manuka honey: no longer so alternative. Frontiers in microbiology, 7, 569.
  • Carter, D. A., Blair, S.E., Irish, J. 2010. An Investigation into the Therapeutic Properties of Honey: Rural Industries Research and Development Corporation, Sydney.
  • Chib, A., Gupta, N., Bhat, A., Anjum, N., Yadav, G. 2020. Role of antioxidants in food. Int. J. Chem. Stud, 8, 2354-2361.
  • Chowdhury, M. M. 1999. Honey: is it worth rubbing it in?. Journal of the Royal Society of Medicine, 92(12), 663-663.
  • Cornara, L., M. Biagi, Xiao, J., Burlando, B. 2017. Therapeutic properties of bioactive compounds from different honeybee products. Frontiers in Pharmacology, 8: 412.
  • Coronado, M., Vega y León, S., Gutiérrez, R., Vázquez, M., Radilla, C. 2015). Antioxidantes: perspectiva actual para la salud humana. Revista chilena de nutrición, 42 (2), 206-212.
  • Creus, E. G. 2004. Compuestos fenólicos. Offarm, 23 (6), 80-84.
  • Dżugan, M., Tomczyk, M., Sowa, P., Grabek-Lejko, D. 2018. Antioxidant activity as biomarker of honey variety. Molecules, 23 (8), 2069.
  • Emsen, I. M. 2007. A different and safe method of split thickness skin graft fixation: medical honey application. Burns, 33 (6), 782-787.
  • Erejuwa, O. O., Sulaiman, S. A., Ab Wahab, M. S. 2012. Honey-a novel antidiabetic agent. International journal of biological sciences, 8 (6), 913.
  • Eteraf-Oskouei, T., Najafi, M. 2013. Traditional and modern uses of natural honey in human diseases: a review. Iranian journal of basic medical sciences, 16 (6), 731.
  • Etzold, E., Lichtenberg-Kraag, B. 2008. Determination of the botanical origin of honey by Fourier-transformed infrared spectroscopy: an approach for routine analysis. European Food Research and Technology, 227(2), 579-586.
  • Ezz El-Arab, A. M., Girgis, S. M., Hegazy, E. M., El-Khalek, A., Azzat, B. 2006. Effect of dietary honey on intestinal microflora and toxicity of mycotoxins in mice. BMC Complementary and Alternative Medicine, 6 (1), 1-13.
  • Fahim, H., Dasti, J. I., Ali, I., Ahmed, S., Nadeem, M. 2014. Physico-chemical analysis and antimicrobial potential of A pis dorsata, A pis mellifera and Z iziphus jujube honey samples from Pakistan. Asian Pacific journal of tropical biomedicine, 4 (8), 633-641.
  • Fauzi, A. N., Norazmi, M. N., Yaacob, N. S. 2011. Tualang honey induces apoptosis and disrupts the mitochondrial membrane potential of human breast and cervical cancer cell lines. Food and Chemical Toxicology, 49 (4), 871-878.
  • Ferreira, R. D. S., Mendonca, L. A. B. M., Ribeiro, C. F. A., Calcas, N. C., Guimaraes, R. D. C. A., Nascimento, V. A. D., Franco, O. L. 2022. Relationship between intestinal microbiota, diet and biological systems: an integrated view. Critical Reviews in Food Science and Nutrition, 62 (5), 1166-1186.
  • Frankel, S., Robinson, G. E., Berenbaum, M. R. 1998. Antioxidant capacity and correlated characteristics of 14 unifloral honeys. Journal of Apicultural Research, 37 (1), 27-31.
  • Fresco, P., Borges, F. Diniz, C. 2006. Marques, M New insights on the anticancer properties of dietary polyphenols. Med Res Rev, 26: 747-766.
  • Gethin, G. T., Cowman, S., Conroy, R. M. 2008. The impact of Manuka honey dressings on the surface pH of chronic wounds. Int Wound J, 5: 185-194.
  • Gheldof, N., Wang, X. H., Engeseth, N. J. 2002. Identification and quantification of antioxidant components of honeys from various floral sources. Journal of agricultural and food chemistry, 50 (21), 5870-5877.
  • Gutıérrez-Grıjalva, E. P. Castıllo, R. 2016. Review: Dietary phenolic compounds, health benefits and bioaccessibility Review: dietary phenolic compounds, health benefits and bioaccessibility. v. 66, p.
  • Güleç, M. 2007.Türkiye'nin Doğu Anadolu Bölgesi'ndeki Bazı İllerden Toplanan Bal Örneklerinde Metal Düzeylerinin Belirlenmesi. Doktora Tezi. Ankara Üniversitesi Sağlık Bilimleri Enstitüsü, Farmakoloji ve Toksikoloji Anabilim Dalı, Ankara-Türkiye.
  • Hadjmohammadi, M.R., Nazari, S.S. 2010. Separation optimization of quercetin, hesperetin and chrysin in honey by micellar liquid chromatography and experimental design. J. Sep Sci 33: 3144-3151.
  • Hashemipour, M. A., Tavakolineghad, Z., Arabzadeh, S. A., Iranmanesh, Z., Nassab, S. A. 2014. Antiviral Activities of Honey, Royal Jelly, and Acyclovir Against HSV-1. Wounds: a compendium of clinical research and practice, 26 (2), 47-54.
  • Hassanein, S. M., Gebreel, H. M., Hassan, A. A. 2010. Honey Compared with Some Antibiotics against Bacteria Isolated From Burn-wound Infections of Patients in Ain Shams University Hospital. Journal of American Science, 6: 301-320.
  • Hegazi, A. G., El-Hady, A., Faten, K. 2009. Influence of honey on the suppression of human low density lipoprotein (LDL) peroxidation (in vitro). Evidence-Based Complementary and Alternative Medicine, 6 (1), 113-121.
  • Israili, Z. H. 2014. Antimicrobial properties of honey. American Journal of Therapeutics, 21(4): 304-323.
  • Jaganathan, S. K. 2009. Honey constituents and their apoptotic effect in colon cancer cells. Journal of ApiProduct and ApiMedical Science, 1(2):29-36.
  • Jeffrey, A. E., Echazarreta, C. M. 1996. Medical uses of honey. Rev Biomed, 7 (1), 43-49.
  • Julianti, E., Rajah, K. K., Fidrianny, I. 2017. Antibacterial activity of ethanolic extract of cinnamon bark, honey, and their combination effects against acne-causing bacteria. Scientia Pharmaceutica, 85 (2): 19.
  • Kahraman, T., Buyukunal, S. K., Vural, A., Altunatmaz, S. S. 2010. Physico-chemical properties in honey from different regions of Turkey. Food chemistry, 123 (1), 41-44.
  • Khalil, M., Sulaiman, S., Boukraa, L. 2010. Antioxidant Properties of Honey and Its Role in Preventing Health Disorder. The Open Nutraceuticals Journal 3: 6-16.
  • Khan, R. U., Naz, S., Abudabos, A. M. 2017. Towards a better understanding of the therapeutic applications and corresponding mechanisms of action of honey. Environmental Science and Pollution Research, 24 (36), 27755-27766.
  • Kim, S., Hong, I., Woo, S., Jang, H., Pak, S., Han, S. 2017. Isolation of abscisic acid from Korean acacia honey with anti-Helicobacter pylori activity. Pharmacognosy Magazine, 13 (Suppl 2), S170.
  • Krell, R. 1996. Value added products from beekeeping. Rome: FAO.
  • Krpan, M., Marković, K., Šarić, G., Skoko, B., Hruškar, M., Vahčić, N. 2009. Antioxidant activities and total phenolics of acacia honey. Czech journal of food sciences, 27(Special Issue 1), Antioxidant-Activities.
  • Küçük, M., Kolaylı, S., Karaoğlu, Ş., Ulusoy, E., Baltacı, C., Candan, F. 2007. Biological activities and chemical composition of three honeys of different types from Anatolia. Food chemistry, 100 (2), 526-534.
  • Lee, Y. J., Kuo, H. C., Chu, C. Y., Wang, C. J., Lin, W. C., Tseng, T. H. 2003. Involvement of tumor suppressor protein p53 and p38 MAPK in caffeic acid phenethyl ester-induced apoptosis of C6 glioma cells. Biochemical pharmacology, 66(12), 2281-2289.
  • Liyanage, D., Mawatha, B. 2017. Health benefits and traditional uses of honey: A review. J. Apith, 2 (1), 9-14.
  • Majtan, J., 2014. Honey: An immunomodulator in wound healing. Wound Repair and Regeneration, 22 (2):187-192.
  • Medhi, B., Puri, A., Upadhyay, S., Kaman, L. 2008. Topical application of honey in the treatment of wound healing: a metaanalysis. JK Sci, 10 (4), 166-169.
  • Mesaik, M. A., Dastagir, N., Uddin, N., Rehman, K., Azim, M. K. 2015. Characterization of immunomodulatory activities of honey glycoproteins and glycopeptides. Journal of agricultural and food chemistry, 63 (1), 177-184.
  • Minatel, I. O., Borges, C. V., Ferreira, M. I., Gomez, H. A. G., Chen, C. Y. O., Lima, G. P. P. 2017. Phenolic compounds: Functional properties, impact of processing and bioavailability. Phenolic Compd. Biol. Act, 8, 1-24.
  • Mirzoeva, O. K., Calder, P. C. 1996. The effect of propolis and its components on eicosanoid production during the inflammatory response. Prostaglandins Leukot Fatty Acids, 55:441-449.
  • Mohammed, H. A., Al-Lenjawi, B., Mendoza, D. 2018. Seborrheic dermatitis treatment with natural honey. Wounds, 5 (2).
  • Mohapatra, D. P., Thakur, V., Brar, S. K. 2011. Antibacterial efficacy of raw and processed honey. Biotechnology Research International, 1-6. Molan, P. C. 1998. A brief review of the use of honey as a clinical dressing. Aust J Wound Mange, 6:148–158.
  • Molan, P. C. 1999. Why honey is effective as a medicine. 1. Its use in modern medicine. Bee World, 80:80–92.
  • Molan, P., Rhodes, T. 2015. Honey: A biologic wound dressing. Wounds-A Compendium of Clinical Research and Practice, 27 (6): 141-151.
  • Nasuti, C., Gabbianelli, R., Falcioni, G., Cantalamessa, F. 2006. Antioxidative and gastroprotective activities of anti-inflammatory formulations derived from chestnut honey in rats. Nutrition Research, 26(3), 130-137.
  • Nugent, K. 2019. Oxidative Stress. Southwest Respir. Crit. Care Chron., 7, 1-3.
  • Nweze, A. J., Olovo, C. V., Nweze, E. I., John, O. O., Paul, C. 2020. Therapeutic properties of honey. Honey Anal. New Adv. Chall, 332, 1-21.
  • Nweze, J. A., Okafor, J. I., Nweze, E. I., Nweze, J. E. 2016. Comparison of antimicrobial potential of honey samples from Apis mellifera and two stingless bees from Nsukka, Nigeria. Journal of Pharmacognosy and Natural Products, 2 (4), 1-7.
  • Nzeako, B. C., Al-Namaani, F. 2006. The antibacterial activity of honey on helicobacter pylori. Sultan Qaboos University Medical Journal, 6 (2): 71-76.
  • Oryan, A., Alemzadeh, E., Moshiri, A. 2016. Biological properties and therapeutic activities of honey in wound healing: A narrative review and meta-analysis. Journal of tissue viability, 25 (2), 98-118.
  • Osato, M. S., Reddy, S. G., Graham, D. Y. 1999. Osmotic effect of honey on growth and viability of Helicobacterpylori. Digestive diseases and sciences, 44 (3), 462-464.
  • Palma, J. M., Seiquer, I. 2020. To be or not to be… an antioxidant? That is the question. Antioxidants, 9 (12), 1234.
  • Pauliuc, D., Dranca, F., Oroian, M. 2020. Antioxidant activity, total phenolic content, individual phenolics and physicochemical parameters suitability for Romanian honey authentication. Foods, 9 (3), 306.
  • Peñarrieta, J. M., Tejeda, L., Mollinedo, P., Vila, J. L., Bravo, J. A. 2014. Compuestos fenólicos y su presencia en alimentos. Revista Boliviana de Química, 31 (2), 68-81.
  • Pentoś, K., Łuczycka, D., Oszmiański, J., Lachowicz, S., Pasternak, G. 2020. Polish honey as a source of antioxidants–a comparison with Manuka honey. Journal of Apicultural Research, 59 (5), 939-945.
  • Pichichero, E., Cicconi, R., Mattei, M., Muzi, M. G., Canini, A. 2010. Acacia honey and chrysin reduce proliferation of melanoma cells through alterations in cell cycle progression. International journal of oncology, 37 (4), 973-981.
  • Ransome, H. M. 1937. "The Sacred Bee in Ancient Times and Folklore". London: George Allen & Unwin, 19-41 pp.
  • Rao, P. V., Krishnan, K. T., Salleh, N., Gan, S. H. 2016. Biological and therapeutic effects of honey produced by honey bees and stingless bees: a comparative review. Revista Brasileira de Farmacognosia, 26, 657-664.
  • Rindt, I. K., Niculae, M., Brudașcă, F. 2007. Antibacterial activity of honey and propolis Mellifera against Staphylococcus aureus. Lucr Stiint: Univ Stiint Agric a Banat Timisoara Med Vet.
  • Samarghandian, S., Farkhondeh, T., Samini, F. 2017. Honey and health: A review of recent clinical research. Pharmacognosy Research, 9 (2):121-127.
  • Semprini, A., Singer, J., Braithwaite, I., Shortt, N., Thayabaran, D., McConnell, M., Beasley, R. 2019. Kanuka honey versus aciclovir for the topical treatment of herpes simplex labialis: a randomised controlled trial. BMJ open, 9(5), e026201.
  • Simon, A., Traynor, K., Santos, K., Blaser, G., Bode, U., Molan, P. 2009. Medical honey for wound care-still the ‘latest resort’?. Evidence-based complementary and alternative medicine, 6 (2), 165-173.
  • Šimúth, J., Bíliková, K., Kováčová, E., Kuzmová, Z., Schroder, W. 2004. Immunochemical approach to detection of adulteration in honey: physiologically active royal jelly protein stimulating TNF-α release is a regular component of honey. Journal of agricultural and food chemistry, 52 (8), 2154-2158.
  • Storz, G., Imlay, J. A. 1999. Oxidative stress. Cur Opin Microbiol, 2:188–194.
  • Subrahmanyam, M. 1991. Topical application of honey in treatment of burns. Br. J. Surg, 78: 497-498.
  • Swellam, T., Miyanaga, N., Onozawa, M., Hattori, K., Kawai, K., Shimazui, T., Akaza, H. 2003. Antineoplastic activity of honey in an experimental bladder cancer implantation model: in vivo and in vitro studies. International journal of urology, 10 (4), 213-219.
  • Tang, J. S., Compton, B. J., Marshall, A., Anderson, R., Li, Y., van der Woude, H., Gasser, O. 2020. Mānuka honey-derived methylglyoxal enhances microbial sensing by mucosal-associated invariant T cells. Food & function, 11 (7), 5782-5787.
  • Tantawy, M. 2020. Efficacy of Natural Honey Treatment in Patients With Novel Coronavirus. ClinicalTrials. gov.
  • Telles, S., Puthige, R., Visweswaraiah, N. K. 2007. An Ayurvedic basis for using honey to treat herpes. Med Sci Monit, 13:LE, 17-17.
  • Thomsen, S. F. 2014. Atopic dermatitis: Natural history, diagnosis, and treatment. ISRN Allergy, 1-7.
  • Tomasin, R., Cintra Gomes-Marcondes, M. C. 2011. Oral administration of Aloe vera and honey reduces walker tumour growth by decreasing cell proliferation and increasing apoptosis in tumour tissue. Phytotherapy Research, 25 (4):619-623.
  • Tonks, A. J., Cooper, R. A., Jones, K. P., Blair, S., Parton, J., Tonks, A. 2003. Honey stimulates inflammatory cytokine production from monocytes. Cytokine, 21 (5), 242-247.
  • Tonks, A., Cooper, R. A., Price, A. J., Molan, P. C., Jones, K. P. 2001. Stimulation of TNF-α release in monocytes by honey. Cytokine, 14 (4), 240-242.
  • Tosi, E., Martinet, R., Ortega, M., Lucero, H. A., Ré, E. 2008. Honey diastase activity modified by heating. Food chemistry, 106(3), 883-887.
  • Tsiapara, A. V., Jaakkola, M., Chinou, I., Graikou, K., Tolonen, T., Virtanen, V., Moutsatsou, P. 2009. Bioactivity of Greek honey extracts on breast cancer (MCF-7), prostate cancer (PC-3) and endometrial cancer (Ishikawa) cells: Profile analysis of extracts. Food Chemistry, 116 (3), 702-708.
  • Turkmen, N., Sari, F., Poyrazoglu, E. S., Velioglu, Y. S. 2006. Effects of prolonged heating on antioxidant activity and colour of honey. Food Chemistry, 95 (4), 653-657.
  • Türk Gıda Kodeksi Bal Tebliği, 2020. https://www.resmigazete.gov.tr/eskiler/2020/04/20200422-13. Erişim Tarihi:15.02.2022
  • Ulubelen, A., Topcu, G., Tan, N., Ölçal, S., Johansson, C., Üçer, M., Tamer, Ş. 1995. Biological activities of a Turkish medicinal plant, Prangos platychlaena. Journal of ethnopharmacology, 45 (3), 193-197.
  • Valko, M., Rhodes, C. J. B., Moncol, J., Izakovic, M. M., Mazur, M. 2006. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chemico-biological interactions, 160 (1), 1-40.
  • Viuda‐Martos, M., Ruiz‐Navajas, Y., Fernández‐López, J., Pérez‐Álvarez, J. A. 2008. Functional properties of honey, propolis, and royal jelly. Journal of food science, 73 (9), R117-R124.
  • Yusuf, W. N. W., Mohammad, W. M. Z. W., Gan, S. H., Mustafa, M., Abd Aziz, C. B., Sulaiman, S. A. 2019. Tualang honey ameliorates viral load, CD4 counts and improves quality of life in asymptomatic human immunodeficiency virus infected patients. Journal of traditional and complementary medicine, 9 (4), 249-256.
  • White, J. W. 1979. Composition of honey. In: Crane E, editor. Honey: A Comprehensive Survey, London: Heinemann. 157–192 p.
  • White, J.W. 1975. The hive and the honeybee. Dadant & Sons Inc., Illinois.
  • Woo, K. J., Jeong, Y. J., Inoue, H., Park, J. W., Kwon, T. K. 2005. Chrysin suppresses lipopolysacherideinduced cyclooxygenase-2 expression through inhibition of nuclear factor for IL-6 (NF-IL6) DNA-binding activity. FEBS Lett 579: 705-711.
  • Yan, X., Murphy, B. T., Hammond, G. B., Vinson, J. A., & Neto, C. C. (2002). Antioxidant activities and antitumor screening of extracts from cranberry fruit (Vaccinium macrocarpon). Journal of agricultural and food chemistry, 50 (21), 5844-5849.
  • Zumla, A., Lulat, A. 1989. Honey-a remedy rediscovered. Journal of the Royal Society of Medicine, 82 (7), 384-385.

Balın Geleneksel Kullanımı, Terapötik Özellikleri ve Antioksidan Aktivitesi

Yıl 2022, Cilt: 2 Sayı: 2, 42 - 55, 30.09.2022

Öz

Bal, bal arıları (Apis mellifera) tarafından çiçek nektarlarından bitkilerin salgılarından veya bitkiler üzerindeki emici böceklerin salgılarından üretilen doğal tatlı bir maddedir. Bu tatlı madde elde edildiği bitki florasına göre farklı kimyasal bileşime sahip olup içeriğinde şekerler, az miktarda protein, enzimler, amino asitler, mineraller, eser elementler, vitaminler, aroma bileşikleri çeşitli flavonoidler ve fenolik bileşikleri barındırmaktadır. Bu özellikleri nedeniyle antik çağlardan bu yana bal, gıda maddesi olarak kullanılmasının yanı sıra yanıklar, kataraktlar, ülserler, diyabet, yara iyileşmesi vb. rahatsızlıklar için halk hekimleri tarafından ilaç olarak kullanılmıştır. Daha sonraları yapılan çalışmalarla bu kullanım durumları bilimsel olarak da desteklenmiştir. Balın terapötik bir ajan olarak etkili olduğu sonucuna varılmış ve alternatif tıpta yaygın bir şekilde kullanım alanı bulmuştur. Bu çalışmada balın kimyasal bileşimi, antioksidan özellikleri ve bazı hastalıklara karşı önemli terapötik özellikleri vurgulanmaya çalışılmıştır.

Kaynakça

  • Abuharfeil, N., Al-Oran, R., Abo-Shehada, M. 1999. The effect of bee honey on the proliferative activity of human B-and T-lymphocytes and the activity of phagocytes. Food and agricultural Immunology, 11 (2), 169-177.
  • Adebiyi, F. M., Akpan, I., Obiajunwa, E. I., Olaniyi, H. B. 2004. Chemical/physical characterization of Nigerian honey. Pakistan journal of Nutrition, 3( 5), 278-281.
  • Aggad, H., Guemour, D. 2014. Honey antibacterial activity. Med Aromat Plants, 3 (152), 2167-0142.
  • Ahmad, A., Khan, R. A., Mesaik, M. A. 2009. Anti inflammatory effect of natural honey on bovine thrombin‐induced oxidative burst in phagocytes. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 23 (6), 801-808.
  • Alam, F., Islam, M. D., Gan, S. H., Khalil, M. 2014. Honey: a potential therapeutic agent for managing diabetic wounds. Evidence-Based Complementary and Alternative Medicine, 2014.
  • Ali, A. M., Hendawy, A. O. 2021. Bee honey in combination with exercise-better physical performance and less fatigue for a more active lifestyle during the COVID-19 era. Sports Med. Health Sci.
  • Ali, A. M., Kunugi, H. 2020. Intermittent fasting, dietary modifications, and exercise for the control of gestational diabetes and maternal mood dysregulation: A review and a case report. International journal of environmental research and public health, 17 (24), 9379.
  • Ali, A. M., Kunugi, H. 2019. Bee honey protects astrocytes against oxidative stress: A preliminary in vitro investigation. Neuropsychopharmacology Reports, 39 (4), 312-314.
  • Ali, A. T., Chowdhury, M. N., Al Humayyd, M. S. 1991. Inhibitory effect of natural honey on Helicobacter pylori. Tropical gastroenterology: official journal of the Digestive Diseases Foundation, 12 (3), 139-143.
  • Al-Jabri, A. A. 2005. Honey, milk and antibiotics. African Journal of Biotechnology, 4 (13).
  • Allsop, K. A., Miller, J. B. 1996. Honey revisited: a reappraisal of honey in pre-industrial diets. British Journal of Nutrition, 75(4), 513-520.
  • Al-Mamary, M., Al-Meeri, A., Al-Habori, M. 2002. Antioxidant activities and total phenolics of different types of honey. Nutrition research, 22 (9), 1041-1047.
  • Almasaudi, S. B., Al-Nahari, A. A., El Sayed, M., Barbour, E., Al Muhayawi, S. M., Al-Jaouni, S., Harakeh, S. 2017. Antimicrobial effect of different types of honey on Staphylococcus aureus. Saudi journal of biological sciences, 24 (6), 1255-1261.
  • Alnaqdy, A., Al-Jabri, A., Al Mahrooqi, Z., Nzeako, B., Nsanze, H. 2005. Inhibition effect of honey on the adherence of Salmonella to intestinal epithelial cells in vitro. International journal of food microbiology, 103 (3), 347-351.
  • Alvarez-Suarez, J. M., Tulipani, S., Romandini, S., Bertoli, E., Battino, M. 2010. Contribution of honey in nutrition and human health: a review. Mediterranean Journal of Nutrition and Metabolism, 3 (1), 15-23.
  • Alvarez-Suarez, J. M., Gasparrini, M., Forbes-Hernández, T. Y., Mazzoni, L., Giampieri, F. 2014. The composition and biological activity of honey: a focus on Manuka honey. Foods, 3 (3), 420-432.
  • Alves, A., Ramos, A., Gonçalves, M. M., Bernardo, M., Mendes, B. 2013. Antioxidant activity, quality parameters and mineral content of Portuguese monofloral honeys. Journal of Food Composition and Analysis, 30(2), 130-138.
  • Al-Waili, N. S., Al-Waili, T. N., Al-Waili, A. N., Saloom, K. S. 2006. Influence of natural honey on biochemical and hematological variables in AIDS: a case study. The Scientific World Journal, 6, 1985-1989.
  • Al-Waili, N. S. 2004. Natural honey lowers plasma glucose, C-reactive protein, homocysteine, and blood lipids in healthy, diabetic, and hyperlipidemic subjects: comparison with dextrose and sucrose. Journal of medicinal food, 7 (1), 100-107.
  • Al-Waili, N. S., Haq, A. 2004. Effect of honey on antibody production against thymus-dependent and thymus-independent antigens in primary and secondary immune responses. Journal of medicinal food, 7(4), 491-494.
  • Al-Waili, N. S., Boni, N. S. 2003. Natural honey lowers plasma prostaglandin concentrations in normal individuals. Journal of medicinal food, 6 (2), 129-133.
  • American Diabetes Association (ADA), 2004. Diagnosis and classification of diabetes mellitus. Diabetes Care, 27(Supplement 1):S5-S10. Anonymous, 1994. Ayurveda Aushadha Sangrahaya. Part 2. Vol. 1. Sri Lanka: Maharagama.
  • Asadi-Pooya, A. A., Pnjehshahin, M. R., Beheshti, S. 2003. The antimycobacterial effect of honey: an in vitro study. Rivista di biologia, 96 (3), 491-495.
  • Attanzio, A., Tesoriere, L., Allegra, M., Livrea, M. A. 2016. Monofloral honeys by Sicilian black honeybee (Apis mellifera ssp. sicula) have high reducing power and antioxidant capacity. Heliyon, 2(11), e00193.
  • Bansal, V., Medhi, B., Pandhi, P. 2005. Honey--a remedy rediscovered and its therapeutic utility. Kathmandu University medical journal (KUMJ), 3 (3), 305-309.
  • Becerril-Sánchez, A. L., Quintero-Salazar, B., Dublán-García, O., Escalona-Buendía, H. B. 2021. Phenolic compounds in honey and their relationship with antioxidant activity, botanical origin, and color. Antioxidants, 10 (11), 1700.
  • Bendich, A. 2010. Nutrition and health: Bioactive Compounds and Cancer. Humanna Press, Totowa.
  • Beretta, G., Granata, P., Ferrero, M., Orioli, M., Facino, R. M. 2005. Standardization of antioxidant properties of honey by a combination of spectrophotometric/fluorimetric assays and chemometrics. Analytica Chimica Acta, 533 (2), 185-191.
  • Berger, M. M. 2005. Can oxidative damage be treated nutritionally?. Clinical nutrition, 24 (2), 172-183.
  • Bilsel, Y., Bugra, D., Yamaner, S., Bulut, T., Cevikbas, U., Turkoglu, U. J. D. S. 2002. Could honey have a place in colitis therapy? Effects of honey, prednisolone, and disulfiram on inflammation, nitric oxide, and free radical formation. Digestive Surgery, 19 (4), 306-312.
  • Bogdanov, S., Jurendic, T., Sieber, R., Gallmann, P. 2008. Honey for nutrition and health: a review. Journal of the American college of Nutrition, 27 (6), 677-689.
  • Burlando, B., Cornara, L. 2013. Honey in dermatology and skin care: A review. Journal of Cosmetic Dermatology, 12(4):306-313.
  • Carter, D. A., Blair, S. E., Cokcetin, N. N., Bouzo, D., Brooks, P., Schothauer, R., Harry, E. J. 2016. Therapeutic manuka honey: no longer so alternative. Frontiers in microbiology, 7, 569.
  • Carter, D. A., Blair, S.E., Irish, J. 2010. An Investigation into the Therapeutic Properties of Honey: Rural Industries Research and Development Corporation, Sydney.
  • Chib, A., Gupta, N., Bhat, A., Anjum, N., Yadav, G. 2020. Role of antioxidants in food. Int. J. Chem. Stud, 8, 2354-2361.
  • Chowdhury, M. M. 1999. Honey: is it worth rubbing it in?. Journal of the Royal Society of Medicine, 92(12), 663-663.
  • Cornara, L., M. Biagi, Xiao, J., Burlando, B. 2017. Therapeutic properties of bioactive compounds from different honeybee products. Frontiers in Pharmacology, 8: 412.
  • Coronado, M., Vega y León, S., Gutiérrez, R., Vázquez, M., Radilla, C. 2015). Antioxidantes: perspectiva actual para la salud humana. Revista chilena de nutrición, 42 (2), 206-212.
  • Creus, E. G. 2004. Compuestos fenólicos. Offarm, 23 (6), 80-84.
  • Dżugan, M., Tomczyk, M., Sowa, P., Grabek-Lejko, D. 2018. Antioxidant activity as biomarker of honey variety. Molecules, 23 (8), 2069.
  • Emsen, I. M. 2007. A different and safe method of split thickness skin graft fixation: medical honey application. Burns, 33 (6), 782-787.
  • Erejuwa, O. O., Sulaiman, S. A., Ab Wahab, M. S. 2012. Honey-a novel antidiabetic agent. International journal of biological sciences, 8 (6), 913.
  • Eteraf-Oskouei, T., Najafi, M. 2013. Traditional and modern uses of natural honey in human diseases: a review. Iranian journal of basic medical sciences, 16 (6), 731.
  • Etzold, E., Lichtenberg-Kraag, B. 2008. Determination of the botanical origin of honey by Fourier-transformed infrared spectroscopy: an approach for routine analysis. European Food Research and Technology, 227(2), 579-586.
  • Ezz El-Arab, A. M., Girgis, S. M., Hegazy, E. M., El-Khalek, A., Azzat, B. 2006. Effect of dietary honey on intestinal microflora and toxicity of mycotoxins in mice. BMC Complementary and Alternative Medicine, 6 (1), 1-13.
  • Fahim, H., Dasti, J. I., Ali, I., Ahmed, S., Nadeem, M. 2014. Physico-chemical analysis and antimicrobial potential of A pis dorsata, A pis mellifera and Z iziphus jujube honey samples from Pakistan. Asian Pacific journal of tropical biomedicine, 4 (8), 633-641.
  • Fauzi, A. N., Norazmi, M. N., Yaacob, N. S. 2011. Tualang honey induces apoptosis and disrupts the mitochondrial membrane potential of human breast and cervical cancer cell lines. Food and Chemical Toxicology, 49 (4), 871-878.
  • Ferreira, R. D. S., Mendonca, L. A. B. M., Ribeiro, C. F. A., Calcas, N. C., Guimaraes, R. D. C. A., Nascimento, V. A. D., Franco, O. L. 2022. Relationship between intestinal microbiota, diet and biological systems: an integrated view. Critical Reviews in Food Science and Nutrition, 62 (5), 1166-1186.
  • Frankel, S., Robinson, G. E., Berenbaum, M. R. 1998. Antioxidant capacity and correlated characteristics of 14 unifloral honeys. Journal of Apicultural Research, 37 (1), 27-31.
  • Fresco, P., Borges, F. Diniz, C. 2006. Marques, M New insights on the anticancer properties of dietary polyphenols. Med Res Rev, 26: 747-766.
  • Gethin, G. T., Cowman, S., Conroy, R. M. 2008. The impact of Manuka honey dressings on the surface pH of chronic wounds. Int Wound J, 5: 185-194.
  • Gheldof, N., Wang, X. H., Engeseth, N. J. 2002. Identification and quantification of antioxidant components of honeys from various floral sources. Journal of agricultural and food chemistry, 50 (21), 5870-5877.
  • Gutıérrez-Grıjalva, E. P. Castıllo, R. 2016. Review: Dietary phenolic compounds, health benefits and bioaccessibility Review: dietary phenolic compounds, health benefits and bioaccessibility. v. 66, p.
  • Güleç, M. 2007.Türkiye'nin Doğu Anadolu Bölgesi'ndeki Bazı İllerden Toplanan Bal Örneklerinde Metal Düzeylerinin Belirlenmesi. Doktora Tezi. Ankara Üniversitesi Sağlık Bilimleri Enstitüsü, Farmakoloji ve Toksikoloji Anabilim Dalı, Ankara-Türkiye.
  • Hadjmohammadi, M.R., Nazari, S.S. 2010. Separation optimization of quercetin, hesperetin and chrysin in honey by micellar liquid chromatography and experimental design. J. Sep Sci 33: 3144-3151.
  • Hashemipour, M. A., Tavakolineghad, Z., Arabzadeh, S. A., Iranmanesh, Z., Nassab, S. A. 2014. Antiviral Activities of Honey, Royal Jelly, and Acyclovir Against HSV-1. Wounds: a compendium of clinical research and practice, 26 (2), 47-54.
  • Hassanein, S. M., Gebreel, H. M., Hassan, A. A. 2010. Honey Compared with Some Antibiotics against Bacteria Isolated From Burn-wound Infections of Patients in Ain Shams University Hospital. Journal of American Science, 6: 301-320.
  • Hegazi, A. G., El-Hady, A., Faten, K. 2009. Influence of honey on the suppression of human low density lipoprotein (LDL) peroxidation (in vitro). Evidence-Based Complementary and Alternative Medicine, 6 (1), 113-121.
  • Israili, Z. H. 2014. Antimicrobial properties of honey. American Journal of Therapeutics, 21(4): 304-323.
  • Jaganathan, S. K. 2009. Honey constituents and their apoptotic effect in colon cancer cells. Journal of ApiProduct and ApiMedical Science, 1(2):29-36.
  • Jeffrey, A. E., Echazarreta, C. M. 1996. Medical uses of honey. Rev Biomed, 7 (1), 43-49.
  • Julianti, E., Rajah, K. K., Fidrianny, I. 2017. Antibacterial activity of ethanolic extract of cinnamon bark, honey, and their combination effects against acne-causing bacteria. Scientia Pharmaceutica, 85 (2): 19.
  • Kahraman, T., Buyukunal, S. K., Vural, A., Altunatmaz, S. S. 2010. Physico-chemical properties in honey from different regions of Turkey. Food chemistry, 123 (1), 41-44.
  • Khalil, M., Sulaiman, S., Boukraa, L. 2010. Antioxidant Properties of Honey and Its Role in Preventing Health Disorder. The Open Nutraceuticals Journal 3: 6-16.
  • Khan, R. U., Naz, S., Abudabos, A. M. 2017. Towards a better understanding of the therapeutic applications and corresponding mechanisms of action of honey. Environmental Science and Pollution Research, 24 (36), 27755-27766.
  • Kim, S., Hong, I., Woo, S., Jang, H., Pak, S., Han, S. 2017. Isolation of abscisic acid from Korean acacia honey with anti-Helicobacter pylori activity. Pharmacognosy Magazine, 13 (Suppl 2), S170.
  • Krell, R. 1996. Value added products from beekeeping. Rome: FAO.
  • Krpan, M., Marković, K., Šarić, G., Skoko, B., Hruškar, M., Vahčić, N. 2009. Antioxidant activities and total phenolics of acacia honey. Czech journal of food sciences, 27(Special Issue 1), Antioxidant-Activities.
  • Küçük, M., Kolaylı, S., Karaoğlu, Ş., Ulusoy, E., Baltacı, C., Candan, F. 2007. Biological activities and chemical composition of three honeys of different types from Anatolia. Food chemistry, 100 (2), 526-534.
  • Lee, Y. J., Kuo, H. C., Chu, C. Y., Wang, C. J., Lin, W. C., Tseng, T. H. 2003. Involvement of tumor suppressor protein p53 and p38 MAPK in caffeic acid phenethyl ester-induced apoptosis of C6 glioma cells. Biochemical pharmacology, 66(12), 2281-2289.
  • Liyanage, D., Mawatha, B. 2017. Health benefits and traditional uses of honey: A review. J. Apith, 2 (1), 9-14.
  • Majtan, J., 2014. Honey: An immunomodulator in wound healing. Wound Repair and Regeneration, 22 (2):187-192.
  • Medhi, B., Puri, A., Upadhyay, S., Kaman, L. 2008. Topical application of honey in the treatment of wound healing: a metaanalysis. JK Sci, 10 (4), 166-169.
  • Mesaik, M. A., Dastagir, N., Uddin, N., Rehman, K., Azim, M. K. 2015. Characterization of immunomodulatory activities of honey glycoproteins and glycopeptides. Journal of agricultural and food chemistry, 63 (1), 177-184.
  • Minatel, I. O., Borges, C. V., Ferreira, M. I., Gomez, H. A. G., Chen, C. Y. O., Lima, G. P. P. 2017. Phenolic compounds: Functional properties, impact of processing and bioavailability. Phenolic Compd. Biol. Act, 8, 1-24.
  • Mirzoeva, O. K., Calder, P. C. 1996. The effect of propolis and its components on eicosanoid production during the inflammatory response. Prostaglandins Leukot Fatty Acids, 55:441-449.
  • Mohammed, H. A., Al-Lenjawi, B., Mendoza, D. 2018. Seborrheic dermatitis treatment with natural honey. Wounds, 5 (2).
  • Mohapatra, D. P., Thakur, V., Brar, S. K. 2011. Antibacterial efficacy of raw and processed honey. Biotechnology Research International, 1-6. Molan, P. C. 1998. A brief review of the use of honey as a clinical dressing. Aust J Wound Mange, 6:148–158.
  • Molan, P. C. 1999. Why honey is effective as a medicine. 1. Its use in modern medicine. Bee World, 80:80–92.
  • Molan, P., Rhodes, T. 2015. Honey: A biologic wound dressing. Wounds-A Compendium of Clinical Research and Practice, 27 (6): 141-151.
  • Nasuti, C., Gabbianelli, R., Falcioni, G., Cantalamessa, F. 2006. Antioxidative and gastroprotective activities of anti-inflammatory formulations derived from chestnut honey in rats. Nutrition Research, 26(3), 130-137.
  • Nugent, K. 2019. Oxidative Stress. Southwest Respir. Crit. Care Chron., 7, 1-3.
  • Nweze, A. J., Olovo, C. V., Nweze, E. I., John, O. O., Paul, C. 2020. Therapeutic properties of honey. Honey Anal. New Adv. Chall, 332, 1-21.
  • Nweze, J. A., Okafor, J. I., Nweze, E. I., Nweze, J. E. 2016. Comparison of antimicrobial potential of honey samples from Apis mellifera and two stingless bees from Nsukka, Nigeria. Journal of Pharmacognosy and Natural Products, 2 (4), 1-7.
  • Nzeako, B. C., Al-Namaani, F. 2006. The antibacterial activity of honey on helicobacter pylori. Sultan Qaboos University Medical Journal, 6 (2): 71-76.
  • Oryan, A., Alemzadeh, E., Moshiri, A. 2016. Biological properties and therapeutic activities of honey in wound healing: A narrative review and meta-analysis. Journal of tissue viability, 25 (2), 98-118.
  • Osato, M. S., Reddy, S. G., Graham, D. Y. 1999. Osmotic effect of honey on growth and viability of Helicobacterpylori. Digestive diseases and sciences, 44 (3), 462-464.
  • Palma, J. M., Seiquer, I. 2020. To be or not to be… an antioxidant? That is the question. Antioxidants, 9 (12), 1234.
  • Pauliuc, D., Dranca, F., Oroian, M. 2020. Antioxidant activity, total phenolic content, individual phenolics and physicochemical parameters suitability for Romanian honey authentication. Foods, 9 (3), 306.
  • Peñarrieta, J. M., Tejeda, L., Mollinedo, P., Vila, J. L., Bravo, J. A. 2014. Compuestos fenólicos y su presencia en alimentos. Revista Boliviana de Química, 31 (2), 68-81.
  • Pentoś, K., Łuczycka, D., Oszmiański, J., Lachowicz, S., Pasternak, G. 2020. Polish honey as a source of antioxidants–a comparison with Manuka honey. Journal of Apicultural Research, 59 (5), 939-945.
  • Pichichero, E., Cicconi, R., Mattei, M., Muzi, M. G., Canini, A. 2010. Acacia honey and chrysin reduce proliferation of melanoma cells through alterations in cell cycle progression. International journal of oncology, 37 (4), 973-981.
  • Ransome, H. M. 1937. "The Sacred Bee in Ancient Times and Folklore". London: George Allen & Unwin, 19-41 pp.
  • Rao, P. V., Krishnan, K. T., Salleh, N., Gan, S. H. 2016. Biological and therapeutic effects of honey produced by honey bees and stingless bees: a comparative review. Revista Brasileira de Farmacognosia, 26, 657-664.
  • Rindt, I. K., Niculae, M., Brudașcă, F. 2007. Antibacterial activity of honey and propolis Mellifera against Staphylococcus aureus. Lucr Stiint: Univ Stiint Agric a Banat Timisoara Med Vet.
  • Samarghandian, S., Farkhondeh, T., Samini, F. 2017. Honey and health: A review of recent clinical research. Pharmacognosy Research, 9 (2):121-127.
  • Semprini, A., Singer, J., Braithwaite, I., Shortt, N., Thayabaran, D., McConnell, M., Beasley, R. 2019. Kanuka honey versus aciclovir for the topical treatment of herpes simplex labialis: a randomised controlled trial. BMJ open, 9(5), e026201.
  • Simon, A., Traynor, K., Santos, K., Blaser, G., Bode, U., Molan, P. 2009. Medical honey for wound care-still the ‘latest resort’?. Evidence-based complementary and alternative medicine, 6 (2), 165-173.
  • Šimúth, J., Bíliková, K., Kováčová, E., Kuzmová, Z., Schroder, W. 2004. Immunochemical approach to detection of adulteration in honey: physiologically active royal jelly protein stimulating TNF-α release is a regular component of honey. Journal of agricultural and food chemistry, 52 (8), 2154-2158.
  • Storz, G., Imlay, J. A. 1999. Oxidative stress. Cur Opin Microbiol, 2:188–194.
  • Subrahmanyam, M. 1991. Topical application of honey in treatment of burns. Br. J. Surg, 78: 497-498.
  • Swellam, T., Miyanaga, N., Onozawa, M., Hattori, K., Kawai, K., Shimazui, T., Akaza, H. 2003. Antineoplastic activity of honey in an experimental bladder cancer implantation model: in vivo and in vitro studies. International journal of urology, 10 (4), 213-219.
  • Tang, J. S., Compton, B. J., Marshall, A., Anderson, R., Li, Y., van der Woude, H., Gasser, O. 2020. Mānuka honey-derived methylglyoxal enhances microbial sensing by mucosal-associated invariant T cells. Food & function, 11 (7), 5782-5787.
  • Tantawy, M. 2020. Efficacy of Natural Honey Treatment in Patients With Novel Coronavirus. ClinicalTrials. gov.
  • Telles, S., Puthige, R., Visweswaraiah, N. K. 2007. An Ayurvedic basis for using honey to treat herpes. Med Sci Monit, 13:LE, 17-17.
  • Thomsen, S. F. 2014. Atopic dermatitis: Natural history, diagnosis, and treatment. ISRN Allergy, 1-7.
  • Tomasin, R., Cintra Gomes-Marcondes, M. C. 2011. Oral administration of Aloe vera and honey reduces walker tumour growth by decreasing cell proliferation and increasing apoptosis in tumour tissue. Phytotherapy Research, 25 (4):619-623.
  • Tonks, A. J., Cooper, R. A., Jones, K. P., Blair, S., Parton, J., Tonks, A. 2003. Honey stimulates inflammatory cytokine production from monocytes. Cytokine, 21 (5), 242-247.
  • Tonks, A., Cooper, R. A., Price, A. J., Molan, P. C., Jones, K. P. 2001. Stimulation of TNF-α release in monocytes by honey. Cytokine, 14 (4), 240-242.
  • Tosi, E., Martinet, R., Ortega, M., Lucero, H. A., Ré, E. 2008. Honey diastase activity modified by heating. Food chemistry, 106(3), 883-887.
  • Tsiapara, A. V., Jaakkola, M., Chinou, I., Graikou, K., Tolonen, T., Virtanen, V., Moutsatsou, P. 2009. Bioactivity of Greek honey extracts on breast cancer (MCF-7), prostate cancer (PC-3) and endometrial cancer (Ishikawa) cells: Profile analysis of extracts. Food Chemistry, 116 (3), 702-708.
  • Turkmen, N., Sari, F., Poyrazoglu, E. S., Velioglu, Y. S. 2006. Effects of prolonged heating on antioxidant activity and colour of honey. Food Chemistry, 95 (4), 653-657.
  • Türk Gıda Kodeksi Bal Tebliği, 2020. https://www.resmigazete.gov.tr/eskiler/2020/04/20200422-13. Erişim Tarihi:15.02.2022
  • Ulubelen, A., Topcu, G., Tan, N., Ölçal, S., Johansson, C., Üçer, M., Tamer, Ş. 1995. Biological activities of a Turkish medicinal plant, Prangos platychlaena. Journal of ethnopharmacology, 45 (3), 193-197.
  • Valko, M., Rhodes, C. J. B., Moncol, J., Izakovic, M. M., Mazur, M. 2006. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chemico-biological interactions, 160 (1), 1-40.
  • Viuda‐Martos, M., Ruiz‐Navajas, Y., Fernández‐López, J., Pérez‐Álvarez, J. A. 2008. Functional properties of honey, propolis, and royal jelly. Journal of food science, 73 (9), R117-R124.
  • Yusuf, W. N. W., Mohammad, W. M. Z. W., Gan, S. H., Mustafa, M., Abd Aziz, C. B., Sulaiman, S. A. 2019. Tualang honey ameliorates viral load, CD4 counts and improves quality of life in asymptomatic human immunodeficiency virus infected patients. Journal of traditional and complementary medicine, 9 (4), 249-256.
  • White, J. W. 1979. Composition of honey. In: Crane E, editor. Honey: A Comprehensive Survey, London: Heinemann. 157–192 p.
  • White, J.W. 1975. The hive and the honeybee. Dadant & Sons Inc., Illinois.
  • Woo, K. J., Jeong, Y. J., Inoue, H., Park, J. W., Kwon, T. K. 2005. Chrysin suppresses lipopolysacherideinduced cyclooxygenase-2 expression through inhibition of nuclear factor for IL-6 (NF-IL6) DNA-binding activity. FEBS Lett 579: 705-711.
  • Yan, X., Murphy, B. T., Hammond, G. B., Vinson, J. A., & Neto, C. C. (2002). Antioxidant activities and antitumor screening of extracts from cranberry fruit (Vaccinium macrocarpon). Journal of agricultural and food chemistry, 50 (21), 5844-5849.
  • Zumla, A., Lulat, A. 1989. Honey-a remedy rediscovered. Journal of the Royal Society of Medicine, 82 (7), 384-385.
Toplam 122 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Derlemeler
Yazarlar

Pınar Coşkun Bu kişi benim 0000-0002-9170-5799

Yayımlanma Tarihi 30 Eylül 2022
Gönderilme Tarihi 14 Mart 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 2 Sayı: 2

Kaynak Göster

APA Coşkun, P. (2022). Balın Geleneksel Kullanımı, Terapötik Özellikleri ve Antioksidan Aktivitesi. Uluslararası Gıda Tarım Ve Hayvan Bilimleri Dergisi, 2(2), 42-55.