Kendiliğinden Montajlı Peptidler ve Kullanım Alanları

Yıl 2020, Cilt: 3 Sayı: 3, 361 - 385, 15.12.2020

Şeyma Aydın Zülal Kesmen

https://doi.org/10.38001/ijlsb.683994

Öz

Moleküler kendiliğinden montaj, moleküllerin kovalent olmayan etkileşimler yoluyla biraraya gelerek supramoleküler yapılar oluşturduğu doğal bir mekanizmadır. Doğada mevcut olan nano ve mikro yapıdaki kendiliğinden montaj mekanizmalarının taklit edilmesiyle, istenilen özellikte çeşitli materyallerin tasarlanması mümkündür. Bu nanoyapılar, karbonhidrat, nükleik asitler ve peptidler gibi yapı taşlarının kendiliğinden montajıyla oluşmakla birlikte bunlar arasında kendiliğinden montajlı peptidler biyouyumluluk, biyobozunurluk ve kimyasal çeşitlilik yönünden en umut verici olanıdır. Peptitlerin kendi kendine montaj özelliklerinden yararlanılarak, nanotüpler, nano lifler, nano küreler, nano kapsüller ve hidrojeller gibi çok sayıda nanoyapı elde edilmiştir. Kendiliğinden montajlı peptid nanoyapılarının işlevi, uygun peptid bloklarının tasarımı ile ayarlanırken stabilite ve aktivitesi sıcaklık, pH, ışık ve elektriksel kuvvet gibi dış uyarıcılar kullanılarak değiştirilebilmektedir. Bugüne kadar peptidlerin kendiliğinden montaj mekanizması kullanılarak çok sayıda işlevsel materyal tasarlanmış ve bu materyaller birçok alanda uygulama imkanı bulmuştur. Bunlar arasında en çok öne çıkanlar, ilaç salınımı ve doku mühendisliği uygulamalarıdır. Bu derlemede, kendiliğinden montajlı peptid yapı blokları, kendiliğinden montaj mekanizması ve kendiliğinden montajlı peptid nanoyapıların uygulama alanları üzerinde durulmuştur.

Anahtar Kelimeler

Kendiliğinden montajlı peptidler, ilaç salınımı, enkapsülasyon, doku mühendisliği, antimikrobiyal uygulamalar

Self-Assembled Peptides and Their Applications

Öz

Molecular self-assembly is a natural mechanism by which molecules come together through non-covalent interactions to form supramolecular structures. It is possible to design various materials with the desired properties by mimicking the self-assembling mechanisms in the nano and micro structures present in nature. Although these nanostructures are formed by self-assembly of building blocks such as carbohydrates, nucleic acids and peptides, self-assembled peptides are the most promising in terms of biocompatibility, biodegradability and chemical diversity. By utilizing the self-assembly properties of peptides, many nanostructures such as nanotubes, nanofibers, nanospheres, nanocapsules and hydrogels have been produced. The function of the self-assembled peptide nanostructures can be adjusted by the design of suitable peptide blocks, while the stability and activity can be altered using external stimulants such as temperature, pH, light and electrical force. To date, a large number of functional materials have been designed using the self-assembly mechanism for peptides and they have been applied in many areas. The most prominent of these are drug release and tissue engineering applications. In this review, self-assembled peptide building blocks, the self-assembly mechanism and the application areas of self-assembled peptide nanostructures have been discussed.

Anahtar Kelimeler

Self-assembled peptides, drug release, tissue engineering, encapsulation, antimicrobial applications

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