Çölyak hastalarında non-alkolik yağlı karaciğer hastalığı yaygınlığı artmıyor: Kesitsel çalışma

Öz

Amaç: Çölyak Hastalığı (CH), karaciğer hastalıklarıyla ilişkilidir. Her iki hastalıkta; bağırsak mikrobiyotasında değişiklik ve bağırsak geçirgenliği gibi aynı etiyopatogenetik risk faktörlerine sahip olması nedeniyle alkolik olmayan yağlı karaciğer hastalığı (AOYKH) ile ilişkilendirilebilir. Bu hastalıkların bu yakın lişkisine rağmen, bu konuda çok az çalışma yapılmıştır. Bu nedenle, biz çalışmamızda ÇH olan hastalarda AOYKH yaygınlığını belirlemeyi amaçladık. Gereç ve Yöntem: Kesitsel nitelikte çalışmamız; üçüncü basamak bir sağlık merkezinde gerçekleştirildi. Çalışmanın ilk amacı, en az 6 ay boyunca glutensiz diyet ile tedavi edilen ÇH AOYKH sıklığını belirlemektir. İkincil olarak da; en az 6 ay boyunca glütensiz diyet ile tedavi edilen ÇH AOYKH’nın göreceli riskini değerlendirmektir. Tanısı konulmuş ÇH ve en az 6 ay önce glutensiz diyet başlatılmış hastalar çalışmaya Grup A olarak alındı. Kontrol grubu (Grup B), polikliniğimize dispepsi ile başvuran ayaktan hastalar arasından seçildi. Hepatosteatoz, ultrasonografik inceleme ile teşhis edildi. Bulgular: Grup A ve Grup B, yaş, cinsiyet, vücut kitle indeksi (VKİ) ve diabetes mellitus (DM) varlığı açısından benzerdi. Alkolik olmayan yağlı karaciğer hastalığı sıklığı Grup A'da %22,7 iken, Grup B'de %28,1 idi (P = 0,35). İleri yaş, yüksek VKİ, yüksek kan şekeri, DM varlığı AOYKH için bir risk faktörüydü. Sonuç: Çölyak hastalığı olan bireyler, genel popülasyona kıyasla alkolik olmayan yağlı karaciğer hastalığı açısından artmış risk altında değildir.

Anahtar Kelimeler

• Ultrasonografi
• alkolik olmayan yağlı karaciğer hastalığı
• çölyak hastalığı

Prevalence of non-alcoholic fatty liver disease is not increased in patients with celiac disease: a cross-sectional study

Öz

Objective: Celiac disease (CD) is associated with liver diseases and could be associated Non-alcoholic fatty liver disease (NAFLD) due both diseases have same etiopathogenetic risk factors such as altered gut microbiota and intestinal permeability. Despite this tight association of these disease, there are few studies on this subject. Therefore, we aimed to determine the prevalence of NAFLD in patients with celiac disease. Material and Methods: This cross sectional, was carried out in a tertiary health center. The aim of the study is to determine the frequency of NAFLD in CD patients treated with a gluten-free diet (GFD) for at least 6 months. The secondary aim was to assess the relative risk of NAFLD in CD patients treated with a GFD for at least 6 months. Patients with diagnosed CD and a GFD was initiated at least 6 months before were included the study as a group A. The control group (group B) was selected from the outpatients who applied to our polyclinic with dyspepsia. Hepatosteatosis was diagnosed by ultrasonographic examination. Results: Group A and Group B were similar in terms of age, gender frequency, body mass index (BMI) and presence of diabetes mellitus. The frequency of NAFLD was 22.7% in Group A and 28.1 in Group B (P = 0.35). Advanced age, high BMI, high blood sugar, presence of DM was a risk factor for NAFLD. Conclusion: Individuals with celiac disease are not at increased risk of nonalcoholic fatty liver disease compared to the general population.

Anahtar Kelimeler

• Ultrasonography
• non-alcoholic fatty liver disease
• celiac disease

Kaynakça

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