The frequency of cholelithiasis in inflammatory bowel disease

Öz

Introduction: The results of studies on the frequency of cholelithiasis (CL) in patients with İnflammatory Bowel Disease (IBD) are controversial. We evaluated the frequency of CL in patients with IBD followed in our clinic. Materials and Methods: Patients with IBD followed between April 1, 2016 and December 1, 2022 were evaluated retrospectively. Results: 195 patients with IBD, 84 patients with Ulcerative Colitis (UC) and 111 with patients Crohn's Disease (CD), were included in the study. The frequency of CL increased statistically significantly compared to healthy control (HC) in the IBD group and in the UC group, but although it seemed to be more common than HC in the CD group, it was not statistically significant. Patients with CL in both the IBD group and the HC group were older, but there was no gender difference (p 0.04 and 0.01 for age, 1 and 0.7 for gender, respectively). Conclusion: CL is a common EIM in patients with IBD. In this study, the frequency of CL was found to be increased in IBD compared to HCs.

Anahtar Kelimeler

• Inflammatory Bowel Disease
• Cholelithiasis
• Ulcerative Colitis
• Crohn

İnflamatuvar barsak hastalığında kolelitiazis sıklığı

Öz

Giriş ve Amaç: İnflamatuvar Barsak Hastalığı’nda (İBH) ekstraintestinal bulgulardan (EİM) safra kesesi taşı sıklığı ile ilgili çalışmaların sonuçları tartışmalıdır. Kliniğimizde takip edilen inflamatuvar barsak hastalarında kolelitiazis (KL) sıklığını değerlendirdik. Gereç ve Yöntem: 1 Nisan 2016 ile 1 Aralık 2022 arasında takip edilen hastalar retrospektif olarak değerlendirildi. Bulgular: Çalışmaya 84’ü Ülseratif Kolit (ÜK), 111’i Crohn Hastalığı (CH) olmak üzere 195 İBH tanılı hasta dahil edilmiştir. KL sıklığına bakıldığında tüm İBH grubunda ve ÜK grubunda SK’ye göre KL sıklığı istatistiksel olarak anlamlı artmıştı ancak CH grubunda SK’ye göre daha sık gibi görünse de istatistiksel olarak anlamlı değildi. Hem İBH grubunda hem de SK grubunda KL olan hastalar daha ileri yaşlı idi ancak cinsiyet farkı yoktu (p sırasıyla yaş için 0,04 ve 0,01, cinsiyet için 1 ve 0,7). Sonuç: İBH’de KL sık EIM’dir. Bu çalışmada da sağlıklı kontrollere göre İBH’de KL sıklığı artmış olarak bulunmuştur.

Anahtar Kelimeler

• İnflamuvar barsak hastalığı
• kolelitiazis
• ultrasonografi

Kaynakça

1. 1. Konduk BT, Hülagü S. İnflamatuvar bağırsak hastalıklarında tanı. Turkiye Klinik J Int Med Sci 2005; 1: 16-53.
2. 2.Karlinger K, Györke T, Makö E, Mester A, Tarján Z. The epidemiology and the pathogenesis of inflammatory bowel disease. Eur J Radiol. 2000;35(3):154-67.
3. 3. Agrawal D, Rukkannagari S, Kethu S. Pathogenesis and clinical approach to extraintestinal manifestations of inflammatory bowel disease. Minerva Gastroenterol Dietol. 2007;53(3):233-48.
4. 4.Das KM. Relationship of extraintestinal involvements in inflammatory bowel disease: new insights into autoimmune pathogenesis. Dig Dis Sci. 1999;(1):1-13.
5. 5.Bargiggia S, Maconi G, Elli M, Molteni P, Ardizzone S, Parente F, et al. Sonographic prevalence of liver steatosis and biliary tract stones in patients with inflammatory bowel disease: study of 511 subjects at a single center. J Clin Gastroenterol. 2003; 36(5):417-20.
6. 6. Fraquelli M, Losco A, Visentin S, Cesana BM, Pometta R, Colli A, et al. Gallstone disease and related risk factors in patients with Crohn disease: analysis of 330 consecutive cases. Arch Intern Med. 2001; 161(18):2201-4.
7. 7.Lorusso D, Leo S, Mossa A, Misciagna G, Guerra V. Cholelithiasis in inflammatory bowel disease. A case-control study. Dis Colon Rectum. 1990;33(9):791-4.
8. 8.Kangas E, Lehmusto P, Matikainen M. Gallstones in Crohn’s disease. Hepatogastroenterology 1990; 37: 83-84

9. 9.Chen CH, Lin CL, Kao CH. Association between inflammatory bowel disease and cholelithiasis: a nationwide population-based cohort study. Int J Environ Res Public Health. 2018;15(3):513.
10. 10.Zhang FM, Xu CF, Shan GD, Chen HT, Xu GQ. Is gallstone disease associated with inflammatory bowel diseases? A meta-analysis. J Dig Dis. 2015;16(11):634-641.
11. 11.Zhang FM, Xu CF, Shan GD, Chen HT, Xu GQ. Is gallstone disease associated with inflammatory bowel diseases? A meta-analysis. J Dig Dis. 2015;16(11):634–41.
12. 12. Hutchinson R, Tyrrell PN, Kumar D, Dunn JA, Li JK, Allan RN. Pathogenesis of gall stones in Crohn’s disease: an alternative explanation. Gut. 1994;35(1):94–7.
13. 13.Kratzer W, Haenle MM, Mason RA, von Tirpitz C, Kaechele V. Prevalence of cholelithiasis in patients with chronic inflammatory bowel disease. World J Gastroenterol. 2005;11(39):6170–5.
14. 14.Schölmerich J, Braun G, Volk BA, Spamer C, Hoppe-Seyler P, Gerok W. Detection of extraintestinal and intestinal abnormalities in inflammatory bowel disease by ultrasound. Dig Surg 1987: 82-87.
15. 15.Parente F, Pastore L, Bargiggia S, Cucino C, Greco S, Molteni M, et al. Incidence and risk factors for gallstones in patients with inflammatory bowel disease: a large case-control study. Hepatology. 2007;45(5):1267–74.