Lenfödemde Konservatif ve Cerrahi Tedavi Yöntemleri: Geleneksel Derleme ve Bibliyometrik Analiz

Öz

Lenfödem, lenfatik drenajın bozulması sonucunda proteinden zengin interstisyel sıvının subkutanöz alanda birikmesi ile karakterize kronik ve ilerleyici bir hastalıktır. Lenfatik sistemin konjenital malformasyonu sonucunda primer ya da enfeksiyon, travma, cerrahi gibi nedenlerle edinilmiş tıkanıklık veya sistem bütünlüğünün bozulması sonucunda sekonder olarak açığa çıkabilir. Hastalık, şişlik ve zamanla ülserasyona kadar ilerleyen cilt değişiklikleri ile günlük yaşam aktivitelerinde problemlere yol açarak yaşam kalitesini olumsuz etkiler. Lenfödem tedavisinde erken teşhis ve müdahale önemlidir. Tanı öncelikle hikâye ve klinik bulgulara dayanmakla birlikte, görüntüleme yöntemleri de kullanılabilir. Lenfödem tedavisinde konservatif ve cerrahi yöntemler kullanılır. Konservatif tedaviler aynı zamanda cerrahi tedaviyi tamamlayıcı bir rol üstlenir. Tedavi başarısı, erken teşhis, doğru tedavi yönteminin doğru zamanda uygulanması ve disiplinler arası iş birliği ile ilişkilidir. Bu literatür taraması, periferik lenfödem ve güncel tedavi yöntemleri hakkında bir bakış açısı sunmayı amaçlamaktadır. Ayrıca, lenfödemde konservatif ve cerrahi tedavi yöntemleri hakkında bibliyometrik veri sunarak araştırmacılara katkıda bulunmayı hedeflemektedir.

Anahtar Kelimeler

• lenfödem
• konservatif tedavi
• cerrahi tedavi

Conservative and Surgical Treatment Methods in Lymphedema: Traditional Review and Bibliometric Analysis

Öz

Lymphedema is a chronic and progressive disease characterized by the accumulation of protein-rich interstitial fluid in the subcutaneous area as a result of impaired lymphatic drainage. It may occur primary as a result of congenital malformation of the lymphatic system, or secondary as a result of obstruction, or disruption of system integrity due to reasons such as infection, trauma, surgery. The disease negatively affects the quality of life by causing problems in daily living activities with swelling, and skin changes that progress to ulceration over time. Early diagnosis and intervention are important in the treatment of lymphedema. Diagnosis primarily relies on history and clinical findings, but imaging methods can also be used. Conservative and surgical methods are used in the treatment of lymphedema. Conservative treatments also play a complementary role to surgical treatment. Treatment success is associated with early diagnosis, the correct application of the appropriate treatment method at the right time and multidisciplinary collaboration. This literature review aims to provide an overview of peripheral lymphedema and current treatment methods. Additionally, it aims to contribute to researchers by presenting bibliometric data on conservative and surgical treatment methods in lymphedema.

Anahtar Kelimeler

• lymphedema
• conservative treatment
• surgical treatment

Kaynakça

1. Moore Jr JE, Bertram CD. Lymphatic system flows. Annual review of fluid mechanics. 2018;50:459-82.
2. Azhar SH, Lim HY, Tan B-K, Angeli V. The unresolved pathophysiology of lymphedema. Frontiers in physiology. 2020;11:137.
3. Grada AA, Phillips TJ. Lymphedema: Pathophysiology and clinical manifestations. JAAD. 2017;77(6):1009-20.
4. Finnane A, Hayes SC, Obermair A, Janda M. Quality of life of women with lower-limb lymphedema following gynecological cancer. Expert Rev Pharmacoecon Outcomes Res. 2011;11(3):287-97.
5. Taghian NR, Miller CL, Jammallo LS, O’Toole J, Skolny MN. Lymphedema following breast cancer treatment and impact on quality of life: A review. Crit Rev Oncol Hematol. 2014;92(3):227-34.
6. Farzaliyev F, Hamacher R, Steinau Professor HU, Bertram S, Podleska LE. Secondary angiosarcoma: a fatal complication of chronic lymphedema. J Surg Oncol (Tallinn). 2020;121(1):85-90.
7. Knackstedt R, Chen WF. Current Concepts in Surgical Management of Lymphedema. Physical Medicine and Rehabilitation Clinics. 2022;33(4):885-99.
8. Sleigh BC, Manna B. Lymphedema. 2023. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. Available from: https://www. ncbi.nlm.nih.gov/books/NBK537239/.

9. Finkelstein ER, Ha M, Hanwright P, Ngaage LM, Yoon JS, Liang F, et al. A review of American insurance coverage and criteria for the conservative management of lymphedema. J Vasc Surg Venous Lymphat Disord. 2022;10(4):929-36.
10. Senger J-LB, Kadle RL, Skoracki RJ. Current Concepts in the Management of Primary Lymphedema. Medicina. 2023;59(5):894.
11. O'Donnell Jr TF, Allison GM, Iafrati MD. A systematic review of guidelines for lymphedema and the need for contemporary intersocietal guidelines for the management of lymphedema. J Vasc Surg Venous Lymphat Disord. 2020;8(4):676-84.
12. Executive Committee. The diagnosis and treatment of peripheral lymphedema: 2020 Consensus Document of the International Society of Lymphology. Lymphology. 2020;53(1):3-19.
13. Oropallo A, Donis-Garcia M, Ahn S, Rao A. Current Concepts in the Diagnosis and Management of Lymphedema. Advances in Skin & Wound Care. 2020;33(11):570-80.
14. Hahn RG, Dull RO, Zdolsek J. The Extended Starling principle needs clinical validation. Acta Anaesthesiologica Scandinavica. 2020;64(7):884-7.
15. Shinaoka A, Suami H. Anatomy of the lymphatic system and structural changes in lymphedema of the extremities. Multimodal Management of Upper and Lower Extremity Lymphedema: Springer; 2022. p. 7-14.
16. Grada AA, Phillips TJ. Lymphedema: Pathophysiology and clinical manifestations. Journal of the American Academy of Dermatology. 2017;77(6):1009-20.
17. Földi M, Földi E, Strößenreuther C, Kubik S. Földi's textbook of lymphology: for physicians and lymphedema therapists: Elsevier Health Sciences; 2012. 224 p.
18. Donahue MJ, Donahue PC, Rane S, Thompson CR, Strother MK, Scott AO, et al. Assessment of lymphatic impairment and interstitial protein accumulation in patients with breast cancer treatment-related lymphedema using CEST MRI. Magn Reson Med. 2016;75(1):345-55.
19. Zuther JE, Norton S. Lymphedema Management: The Comprehensive Guide for Practitioners. Thieme; 2012. p. 49-50.
20. Sarıkaya S, Uysa HB, Gemalmaz A, Sönmez HM. A Rare Case of Idiopathic Lymphedema. ANATOL J FM. 2021;4(2):182-6.
21. Bolletta A, Di Taranto G, Chen S, Elia R, Amorosi V, Chan JC, et al. Surgical treatment of Milroy disease. Journal of surgical oncology. 2020;121(1):175-81.
22. Hanson SE, Chang EI, Schaverien MV, Chu C, Selber JC, Hanasono MM. Controversies in surgical management of lymphedema. Plastic and Reconstructive Surgery Global Open. 2020;8(3):2671.
23. Greene AK, Goss JA. Diagnosis and Staging of Lymphedema. Semin Plast Surg. 2018;32(1):12-6.
24. Grada AA, Phillips TJ. Lymphedema: diagnostic workup and management. Journal of the American Academy of Dermatology. 2017;77(6):995-1006.
25. Axelsson R, Holstensson M, Estenberg U. 21 Lymphoscintigraphy. Handbook of Nuclear Medicine and Molecular Imaging for Physicists: Radiopharmaceuticals and Clinical Applications, Volume III 2022. p. 313.
26. Tartaglione G, Pagan M, Ieria FP, Visconti G, Tartaglione T. Imaging the Lymphatic System. In: Gholamrezanezhad A, Assadi M, Jadvar H, editors. Radiology‐Nuclear Medicine Diagnostic Imaging: A Correlative Approach2023. p. 747-71.
27. Pluetrattanabha N, Direksunthorn T. Recent Advances in Ultrasound of Soft Tissue Lesions. International Journal of General Medicine. 2023;30:1163-70.
28. Johansson K, Ochalek K, Hayes S. Prevention of arm lymphedema through the use of compression sleeves following breast cancer: results from a targeted literature review. Physical Therapy Reviews. 2020;25(4):213-8.
29. Venchiarutti RL, Templeton S, Mathers L, Charters E, Clark JR. Treatment approaches and outcomes of a head and neck lymphedema service at an Australian comprehensive cancer center. Head & Neck. 2023;45(6):1539-48.
30. Pateva I, Greene AK, Snyder KM. How we approach lymphedema in the pediatric population. Pediatric blood & cancer. 2022;69:29908.
31. Nikolovska L, Bogdanovska H. Efficiency of decongestive physiotherapy methods in patients with lymphedema. KNOWLEDGE-International Journal. 2021;47(4):693-7.
32. Kablan N, Alaca N, Tatar Y. Comparison of the immediate effect of petrissage massage and manual lymph drainage following exercise on biomechanical and viscoelastic properties of the rectus femoris muscle in women. Journal of sport rehabilitation. 2021;30(5):725-30.
33. Grosu-Bularda A, Lita FF, Serban A, Hodea FV, Stoian A, Lascar I, et al. Therapeutic Management of Breast Cancer Related Upper Limb Lymphedema. Modern Medicine. 2021;28(4):367-82.
34. Ezzo J, Manheimer E, McNeely ML, Howell DM, Weiss R, Johansson KI, et al. Manual lymphatic drainage for lymphedema following breast cancer treatment. Cochrane Database of Systematic Reviews. 2015(5):CD003475.
35. Provencher A-M, Giguere-Lemieux E, Croteau É, Ruchat S-M, Corbin-Berrigan L-A. The use of manual lymphatic drainage on clinical presentation of musculoskeletal injuries: A systematic review. Complementary Therapies in Clinical Practice. 2021;45:101469.
36. Cesiro J. Physical Therapy Associated With Lymphatic System Disorders. 2017. In: Cardiovascular and Pulmonary Physical Therapy: An Evidence-Based Approach, 3e [Internet]. New York, NY: McGraw- Hill Education. Available from: accessphysiotherapy.mhmedical.com/ content.aspx?aid=1148788017.
37. Hettrick H, Aviles F. Tearing Down the Silos of Lymphedema Care in the Wound Clinic 2017; 11(10). Available from: https://www. todayswoundclinic.com/articles/tearing-down-silos-lymphedema-care-wound-clinic.
38. Cheville AL, Andrews K, Kollasch J, Schmidt K, Basford J. Adapting lymphedema treatment to the palliative setting. Am J Hosp Palliat. 2014;31(1):38-44.
39. Dissemond J, Assenheimer B, Bültemann A, Gerber V, Gretener S, Kohler‐von Siebenthal E, et al. Compression therapy in patients with venous leg ulcers. J Dtsch Dermatol Ges. 2016;14(11):1072-87.
40. Bakar Y, Tuğral A. Lower extremity lymphedema management after gynecologic cancer surgery: a review of current management strategies. Annals of Vascular Surgery. 2017;44:442-50.
41. Davies C, Levenhagen K, Ryans K, Perdomo M, Gilchrist L. Interventions for Breast Cancer–Related Lymphedema: Clinical Practice Guideline From the Academy of Oncologic Physical Therapy of APTA. Physical Therapy. 2020;100(7):1163-79.
42. Viviano SL, Neligan PC. Updates on Excisional Procedures for Lymphedema. Adv Wound Care (New Rochelle). 2022;11(8):419-27.
43. Chang DW, Suami H, Skoracki R. A prospective analysis of 100 consecutive lymphovenous bypass cases for treatment of extremity lymphedema. Plastic and reconstructive surgery. 2013;132(5):1305-14.
44. Park KE, Allam O, Chandler L, Mozzafari MA, Ly C, Lu X, et al. Surgical management of lymphedema: a review of current literature. Gland Surgery. 2020;9(2):503.
45. Scaglioni MF, Meroni M, Fritsche E. Combining superficial and deep lymphovenous anastomosis for lymphedema treatment: Preliminary results. Microsurgery. 2022;42(1):22-31.
46. Schaverien MV, Munnoch DA, Brorson H. Liposuction Treatment of Lymphedema. Semin Plast Surg. 2018;32(1):42-7.
47. Hassan K, Chang DW. The Charles procedure as part of the modern armamentarium against lymphedema. Ann Plast Surg. 2020;85(6):37-43.
48. Granzow JW. Lymphedema surgery: the current state of the art. Clin Exp Metastasis. 2018;35:553-8.
49. Hanson SE, Chang EI, Schaverien MV, Chu C, Selber JC, Hanasono MM. Controversies in Surgical Management of Lymphedema. Plast Reconstr Surg Glob Open. 2020;8(3):e2671.
50. Yamamoto T, Narushima M, Yoshimatsu H, Seki Y, Yamamoto N, Oka A, et al. Minimally invasive lymphatic supermicrosurgery (MILS): indocyanine green lymphography-guided simultaneous multisite lymphaticovenular anastomoses via millimeter skin incisions. Ann Plast Surg. 2014;72(1):67-70.
51. Jørgensen MG, Toyserkani NM, Sørensen JA. The effect of prophylactic lymphovenous anastomosis and shunts for preventing cancer‐related lymphedema: A systematic review and meta‐analysis. Microsurgery. 2018;38(5):576-85.
52. Cheng M-H, Huang J-J, Wu C-W, Yang C-Y, Lin C-Y, Henry SL, et al. The mechanism of vascularized lymph node transfer for lymphedema: natural lymphaticovenous drainage. Plast Reconst Surg. 2014;133(2):192-8.
53. Kareh AM, Xu KY. Surgical management of lymphedema. Missouri medicine. 2020;117(2):143.
54. Schaverien MV, Badash I, Patel KM, Selber JC, Cheng MH. Vascularized Lymph Node Transfer for Lymphedema. Semin Plast Surg. 2018;32(1):28-35.
55. Ito R, Suami H. Overview of lymph node transfer for lymphedema treatment. Plast Reconstr Surg. 2014;134(3):548-56.
56. Scaglioni MF, Arvanitakis M, Chen YC, Giovanoli P, Chia-Shen Yang J, Chang EI. Comprehensive review of vascularized lymph node transfers for lymphedema: Outcomes and complications. Microsurgery. 2018;38(2):222-9.
57. Klernäs P, Johnsson A, Boyages J, Brorson H, Munnoch A, Johansson K. Quality of life improvements in patients with lymphedema after surgical or nonsurgical interventions with 1-year follow-up. Lymphat Res Biol. 2020;18(4):340-50.
58. Hoffner M, Peterson P, Månsson S, Brorson H. Lymphedema leads to fat deposition in muscle and decreased muscle/water volume after liposuction: a magnetic resonance imaging study. Lymphat Res Biol. 2018;16(2):174-81.
59. Yoshida S, Imai H, Roh S, Mese T, Koshima I. Comparison of the Effectiveness of Liposuction for Lower Limb versus Upper Limb Lymphedema. J Clin Med. 2023;12(5):1727.
60. Kung TA, Champaneria MC, Maki JH, Neligan PC. Current Concepts in the Surgical Management of Lymphedema. Plast Reconstr Surg. 2017;139(4):1003-13.
61. Hassan K, Chang DW. The Charles Procedure as Part of the Modern Armamentarium Against Lymphedema. Ann Plast Surg. 2020;85(6):e37-e43.
62. Petrek JA, Pressman PI, Smith RA. Lymphedema: current issues in research and management. CA Cancer J Clin. 2000;50(5):292-307.
63. Kenzō K, Stockheimer KR. Kinesio taping for lymphoedema and chronic swelling. Albuquerque N.M: Kinesi USA, LLC; 2006.
64. Smykla A, Walewicz K, Trybulski R, Halski T, Kucharzewski M, Kucio C, et al. Effect of kinesiology taping on breast cancer-related lymphedema: a randomized single-blind controlled pilot study. Biomed Res Int. 2013;2013:767106.
65. Kasawara KT, Mapa JMR, Ferreira V, Added MAN, Shiwa SR, Carvas Jr N, et al. Effects of Kinesio Taping on breast cancer-related lymphedema: A meta-analysis in clinical trials. Physiother Theory Pract. 2018;34(5):337-45.
66. Gatt M, Willis S, Leuschner S. A meta‐analysis of the effectiveness and safety of kinesiology taping in the management of cancer‐related lymphoedema. European journal of cancer care. 2017;26(5):12510.
67. Tran K, Argáez C. Intermittent pneumatic compression devices for the management of lymphedema: a review of clinical effectiveness and guidelines. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health [Internet]. 2018. Available from: https://europepmc.org/article/ NBK/nbk487690#free-full-text.
68. Desai SS, Shao M, Collaborative VO. Superior clinical, quality of life, functional, and health economic outcomes with pneumatic compression therapy for lymphedema. Ann Vasc Surg. 2020;63:298-306.
69. Soran A, Toktas O, Grassi A, Sezgin E. Adding pneumatic compression therapy in lower extremity lymphedema increases compliance of treatment, while decreasing the infection rate. Lymphat Res Biol. 2022;20(3):315-8.
70. Sanal-Toprak C, Ozsoy-Unubol T, Bahar-Ozdemir Y, Akyuz G. The efficacy of intermittent pneumatic compression as a substitute for manual lymphatic drainage in complete decongestive therapy in the treatment of breast cancer related lymphedema. Lymphology. 2019;52(2):82-91.
71. Kim Y, Kim S, Lim JY, Hwang CM, Ko M-H, Hwang JH. Home-Based Intermittent Pneumatic Compression Therapy: The Impact in Chronic Leg Lymphedema in Patients Treated for Gynecologic Cancer. Healthcare [Internet]. 2022; 10(4):[638 p.]. Available from: https://doi.org/10.3390/ healthcare10040638.
72. Dunn N, Williams EM, Dolan G, Davies JH. Intermittent Pneumatic Compression for the Treatment of Lower Limb Lymphedema: A Pilot Trial of Sequencing to Mimic Manual Lymphatic Drainage Versus Traditional Graduated Sequential Compression. Lymphat Res Biol. 2022;20(5):514-21.
73. Uzkeser H, Karatay S, Erdemci B, Koc M, Senel K. Efficacy of manual lymphatic drainage and intermittent pneumatic compression pump use in the treatment of lymphedema after mastectomy: a randomized controlled trial. Breast Cancer. 2015;22:300-7.
74. Boris M, Weindorf S, Lasinski B. The risk of genital edema after external pump compression for lower limb lymphedema. Lymphology. 1998;31(1):15-20.
75. Phillips JJ, Gordon SJ. Intermittent pneumatic compression dosage for adults and children with lymphedema: a systematic review. Lymphat Res Biol. 2019;17(1):2-18.
76. Wang Y, Ge Y, Xing W, Liu J, Wu J, Lin H, et al. The effectiveness and safety of low-level laser therapy on breast cancer–related lymphedema: An overview and update of systematic reviews. Lasers Med Sci. 2022;37(3):1389–413.
77. Baxter GD, Liu L, Petrich S, Gisselman AS, Chapple C, Anders JJ, et al. Low level laser therapy (Photobiomodulation therapy) for breast cancer-related lymphedema: a systematic review. BMC cancer. 2017;17(1):1-13.
78. Omar MTA, Shaheen AAM, Zafar H. A systematic review of the effect of low-level laser therapy in the management of breast cancer-related lymphedema. Supportive Care in Cancer. 2012;20:2977-84.
79. Kilmartin L, Denham T, Fu MR, Yu G, Kuo T-T, Axelrod D, et al. Complementary low-level laser therapy for breast cancer-related lymphedema: a pilot, double-blind, randomized, placebo-controlled study. Lasers Med Sci. 2020;35:95-105.
80. Jang D-H, Song D-H, Chang E-J, Jeon JY. Anti-inflammatory and lymphangiogenetic effects of low-level laser therapy on lymphedema in an experimental mouse tail model. Lasers Med Sci. 2016;31:289-96.
81. Mahmood D, Ahmad A, Sharif F, Arslan SA. Clinical application of low-level laser therapy (Photo-biomodulation therapy) in the management of breast cancer-related lymphedema: a systematic review. BMC cancer. 2022;22(1):937.
82. Donahue PM, MacKenzie A, Filipovic A, Koelmeyer L. Advances in the prevention and treatment of breast cancer-related lymphedema. Breast Cancer Res Treat. 2023;200(1):1-14.
83. Donthu N, Kumar S, Mukherjee D, Pandey N, Lim WM. How to conduct a bibliometric analysis: An overview and guidelines. J Bus Res. 2021;133:285-96.