Organosülfür Bileşikleri ve Sağlık: Kapsamlı Bir Bakış

Öz

Organosülfür bileşikleri, yapılarında kükürt atomu bulunan ve başta antikanserojen olmak üzere antioksidan, antiinflamatuar, antimikrobiyal, kardiyoprotektif, antiobezite ve antidiyabetik etkiler gösteren biyoaktif moleküllerdir. Bu derlemenin amacı, organosülfür bileşiklerinin kimyasal özelliklerini, biyolojik aktivitelerini ve sağlık üzerindeki etkilerini güncel literatür doğrultusunda kapsamlı bir şekilde değerlendirmektir. Bu bileşiklerin hücre döngüsünün düzenlemesi, metastazın önlenmesi, apoptozun indüklemesi ve anjiyogenezin inhibe edilmesi gibi kanser karşıtı mekanizmalar üzerinde etkili olduğu gösterilmiştir. Ayrıca, oksidatif strese karşı mücadele, hücresel detoksifikasyon süreçlerinin desteklenmesi, bağışıklık sisteminin güçlendirilmesi ve kardiyovasküler hastalık riskinin azaltılması gibi çeşitli fizyolojik süreçlerde de önemli roller üstlendikleri çeşitli çalışmalarla ortaya konmuştur. Özellikle sarımsak, soğan, pırasa, brokoli, lahana ve karnabahar gibi sebzelerde yüksek miktarda bulunmakla birlikte biyoyararlanımları; besinlerin kesilmesi, ezilmesi, çiğnenmesi veya pişirilmesi gibi işleme yöntemlerinden önemli ölçüde etkilenmektedir. Bu nedenle, ilgili bileşiklerin biyoyararlanımlarını artırmaya yönelik uygun hazırlama ve pişirme yöntemlerinin belirlenmesi ve sağlık üzerindeki etkilerinin daha kapsamlı bir şekilde anlaşılması için ileri düzey klinik araştırmalara ihtiyaç duyulmaktadır.

Anahtar Kelimeler

• alil sülfür bileşikleri
• allisin
• biyolojik aktiviteler
• glukosinolatlar
• Organosülfür bileşikleri

Organosulfur Compounds and Health: A Comprehensive Overview

Öz

Organosulfur compounds are bioactive molecules containing sulphur atoms in their structures and showing antioxidant, anti-inflammatory, antimicrobial, cardioprotective, antidiabetic, antiobesity and neuroprotective, especially anticarcinogenic effects. The aim of this review is to comprehensively evaluate the chemical properties, biological activities, health effects, and bioavailability of organosulfur compounds in line with the current literature. These compounds have been shown to influence anti-cancer mechanisms such as regulation of the cell cycle, prevention of metastasis, induction of apoptosis, and inhibition of angiogenesis. In addition, various studies have shown that they play important roles in various physiological processes, such as combating oxidative stress, supporting cellular detoxification processes, strengthening the immune system, and reducing the risk of cardiovascular disease. Although organosulfur compounds are particularly high in vegetables such as garlic, onion, leek, broccoli, cabbage, and cauliflower, their bioavailability is significantly affected by processing methods such as cutting, crushing, chewing, or cooking. Therefore, further clinical research is needed to determine appropriate preparation and cooking methods to enhance the bioavailability of the relevant compounds and to better understand their health effects.

Anahtar Kelimeler

• allyl sulphur compounds
• allicin
• biological activities
• glucosinolates
• Organosulfur compounds

Kaynakça

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