Carotenoids and Polyphenols in Breast Milk Composition: Effects on Infant Health
Yıl 2025,
Cilt: 10 Sayı: 2, 309 - 314, 14.06.2025
Zeyneb Yıldırım
,
Kadriye Toprak
Öz
Breast milk is the most ideal food for infants in the first months of life, fulfilling all their needs on its own. In addition to the nutritional components in breast milk, the bioactive components contained in breast milk are of great importance for ensuring optimal growth and development of infants. Phytochemicals are also important bioactive components in the composition of breast milk. They are defined as secondary plant metabolites that offer health benefits, such as protection against oxidative stress and inflammation. These compounds are absorbed into the body through the diet of the nursing mother and are excreted in breast milk. Among these metabolites, polyphenols and carotenoids are particularly important phytochemical components found in breast milk. This review evaluates the carotenoid and polyphenol content of breast milk and the potential benefits of these phytochemicals for infants. The study encompasses a review of the literature regarding the presence of polyphenols and carotenoids in breast milk, the nutrients associated with these bioactive components, and their effects on infant health. Further research is needed to better understand the role that phytochemicals can play in infant health and to enhance knowledge about the unique composition of breast milk. In this context, conducting comprehensive studies is essential.
Kaynakça
-
who.int [Internet]. World Health Organisation; 2024 [cited 2023 May 10]. Available from: https://www.who.int/health-topics/breastfeeding#tab=tab_1.
-
Zou L, Pande G, Akoh CC. Infant formula fat analogs and human milk fat: new focus on infant developmental needs. Annu Rev Food Sci Technol. 2016;7:139-65. DOI: 10.1146/annurev-food-041715-033120.
-
Xue Y, Campos-Giménez E, Redeuil KM, Lévèques A, Actis-Goretta L, Vinyes-Pares G, et al. Concentrations of carotenoids and tocopherols in breast milk from urban Chinese mothers and their associations with maternal characteristics: a cross-sectional study. Nutrients. 2017;9(11):1229. DOI: 10.3390/nu9111229.
-
Tsopmo A. Phytochemicals in human milk and their potential antioxidative protection. Antioxidants. 2018;7(2):32. DOI: 10.3390/antiox7020032.
-
Zheng Y, Correa-Silva S, Palmeira P, Carneiro-Sampaio M. Maternal vaccination as an additional approach to improve the protection of the nursling: Anti-infective properties of breast milk. Clinics. 2022;77:100093. DOI: 10.1016/j.clinsp.2022.100093
-
Trend S, Strunk T, Lloyd ML, Kok CH, Metcalfe J, Geddes DT, et al. Levels of innate immune factors in preterm and term mothers’ breast milk during the 1st month postpartum. Br J Nutr. 2016;115(7):1178-93. DOI: 10.1017/S0007114516000234.
-
Zielińska MA, Wesołowska A, Pawlus B, Hamułka J. Health effects of carotenoids during pregnancy and lactation. Nutrients. 2017;9(8):838. DOI: 10.3390/nu9080838
-
Gidrewicz DA, Fenton TR. A systematic review and meta-analysis of the nutrient content of preterm and term breast milk. BMC pediatr. 2014;14:1-14. DOI: 10.1186/1471-2431-14-216.
-
Fares S, Sethom MM, Kacem S, Ksibi I, Feki M, Jebnoun S, et al. Retinol and alpha-tocopherol in the colostrum of lactating Tunisian women delivering prematurely: Associations with maternal characteristics. Pediatr Neonatol. 2016;57(2):120-6. DOI: 10.1016/j.pedneo.2015.06.003.
-
de Azeredo VB, Trugo NM. Retinol, carotenoids, and tocopherols in the milk of lactating adolescents and relationships with plasma concentrations. Nutrition. 2008;24(2):133-9. DOI: 10.1016/j.nut.2007.10.011.
-
Prell C, Koletzko B. Breastfeeding and complementary feeding: recommendations on infant nutrition. Dtsch Arztebl Int. 2016;113(25):435. DOI: 10.3238/arztebl.2016.0435.
-
Zielinska MA, Hamulka J, Wesolowska A. Carotenoid content in breastmilk in the 3rd and 6th month of lactation and its associations with maternal dietary intake and anthropometric characteristics. Nutrients. 2019;11(1):193. DOI: 10.3390/nu11010193.
-
Song BJ, Jouni ZE, Ferruzzi MG. Assessment of phytochemical content in human milk during different stages of lactation. Nutrition. 2013;29(1):195-202. DOI: 10.1016/j.nut.2012.07.015.
-
Khymenets O, Rabassa M, Rodríguez-Palmero M, Rivero-Urgell M, Urpi-Sarda M, Tulipani S, et al. Dietary epicatechin is available to breastfed infants through human breast milk in the form of host and microbial metabolites. J Agric Food Chem. 2016;64(26):5354-60. DOI: 10.1021/acs.jafc.6b01947.
-
Ifrim-Chen F, Dragos D, Moga M, Barbilian A, Mircea L, Oproiu AM, et al. "Ectopic" Gustative And Olfactory Receptors In The Brain-New Targets For Neurodegeneration Therapy? Farmacia. 2019;67(1). DOI: 10.31925/farmacia.2019.1.5.
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Soares S, Silva MS, Garcia-Estevez I, Groβmann P, Bras N, Brandao E, et al. Human bitter taste receptors are activated by different classes of polyphenols. J Agric Food Chem. 2018;66(33):8814-23. DOI: 10.1021/acs.jafc.8b03569.
-
Ríos J, Valero-Jara V, Thomas-Valdés S. Phytochemicals in breast milk and their benefits for infants. Crit Rev Food Sci Nutr. 2022;62(25):6821-36. DOI: 10.1080/10408398.2021.1906627.
-
Poniedziałek B, Rzymski P, Pięt M, Gąsecka M, Stroińska A, Niedzielski P, et al. Relation between polyphenols, malondialdehyde, antioxidant capacity, lactate dehydrogenase and toxic elements in human colostrum milk. Chemosphere. 2018;191:548-54. DOI: 10.1016/j.chemosphere.2017.10.098.
-
Sherry CL, Oliver JS, Renzi LM, Marriage BJ. Lutein supplementation increases breast milk and plasma lutein concentrations in lactating women and infant plasma concentrations but does not affect other carotenoids. J Nutr. 2014;144(8):1256-63. DOI: 10.3945/jn.114.192914.
-
Xu X, Zhao X, Berde Y, Low YL, Kuchan MJ. Milk and plasma lutein and zeaxanthin concentrations in Chinese breast-feeding mother–infant dyads with healthy maternal fruit and vegetable intake. J Am Coll Nutr. 2019;38(2):179-84. DOI: 10.1080/07315724.2018.1490934.
-
Saini RK, Nile SH, Park SW. Carotenoids from fruits and vegetables: Chemistry, analysis, occurrence, bioavailability and biological activities. Food Res Int. 2015;76:735-50. DOI: 10.1016/j.foodres.2015.07.047.
-
Ermakov IV, Ermakova MR, Bernstein PS, Chan GM, Gellermann W. Resonance Raman based skin carotenoid measurements in newborns and infants. J Biophotonics. 2013;6(10):793-802. DOI: 10.1002/jbio.201200195.
-
Zupo R, Castellana F, De Nucci S, Sila A, Aresta S, Buscemi C, et al. Role of dietary carotenoids in frailty syndrome: A systematic review. Biomedicines. 2022;10(3):632. DOI: 10.3390/biomedicines10030632.
-
Moran NE, Mohn ES, Hason N, Erdman Jr JW, Johnson EJ. Intrinsic and extrinsic factors impacting absorption, metabolism, and health effects of dietary carotenoids. Adv Nutr. 2018;9(4):465-92. DOI: 10.1093/advances/nmy025.
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Şengün P. Goji Berry (lycium barabrum l.) meyvelerinin olgunlaşma evreleri ve kurutulma sürecinde karotenoid kompozisyonundaki değişim [master’s thesis]. [Denizli]: Pamukkale Üniversitesi; 2021.
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Xavier AA, Díaz-Salido E, Arenilla-Vélez I, Aguayo-Maldonado J, Garrido-Fernández J, Fontecha J, et al. Carotenoid content in human colostrum is associated to preterm/full-term birth condition. Nutrients. 2018;10(11):1654. DOI: 10.3390/nu10111654.
-
Lipkie TE, Morrow AL, Jouni ZE, McMahon RJ, Ferruzzi MG. Longitudinal survey of carotenoids in human milk from urban cohorts in China, Mexico, and the USA. PloS One. 2015;10(6):e0127729. DOI: 10.1371/journal.pone.0127729.
-
Sun H, Wu T, Mao Y, Tian F, Cai X, Kuchan MJ, Chen, J. Carotenoid profile in breast milk and maternal and cord plasma: a longitudinal study in Southwest China. Br J Nutr. 2021;126(9),1281-1287. DOI: 10.1017/S0007114521000027.
-
Sun A, Tian L, Xiong X, Kuchan M, Dai X, Sun H, Wang H, Li X, Zhang L, Zhao YR, Chen J, Mao Y, Li X. Carotenoids in maternal and cord blood, breast milk, and their association with maternal dietary intake: a longitudinal study in Shanghai, China. Br J Nutr. 2023;1–36. DOI: 10.1017/s000711452300257x.
-
Tian L, Wang L, Li F, Sun A, Ni M, Sun H, Wang H, Li X, Zhao Y, Zhang L, Li X, Kuchan MJ, Mao Y, Chen J. Carotenoids profile in maternal and cord plasma and its trends in breast milk along lactation: A comparative study among three cities in northern China. Food Funct. 2025;16(3):1000-1015. DOI: 10.1039/d4fo05112b.
-
Zhou L, Chan YT, Lo K, Zhao D, Wong V WS, Ng YF Ho, WW, Li L, Lee H, Wong MS, Li SY. Carotenoids and Vitamin A in Breastmilk of Hong Kong Lactating Mothers and Their Relationships with Maternal Diet. Nutrients. 2022;14(10),2031. DOI: 10.3390/nu14102031.
-
Zhang Y, Yang J, Huang N, Xiao L, Lin H, Luo J, et al. Changes in breast milk lutein concentrations and their associations with dietary lutein intake: a 12-week prospective analytical study. Br J Nutr. 2019;122(9):1033-9. DOI: 10.1017/S0007114519001727.
-
Bernstein PS, Sharifzadeh M, Liu A, Ermakov I, Nelson K, Sheng X, et al. Blue-light reflectance imaging of macular pigment in infants and children. Invest Ophthalmol Vis Sci. 2013;54(6):4034-40. DOI: 10.1167/iovs.13-11891.
-
Cena H, Castellazzi AM, Pietri A, Roggi C, Turconi G. Lutein concentration in human milk during early lactation and its relationship with dietary lutein intake. Public Health Nutr. 2009;12(10):1878-84. DOI: 10.1017/S1368980009004807.
-
Alhujaily M, Dhifi W, Mnif W. An Overview of the Potential of Medicinal Plants Used in the Development of Nutraceuticals for the Management of Diabetes Mellitus: Proposed Biological Mechanisms. Processes. 2022;10(10):2044. DOI: 10.3390/pr10102044.
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Faggio C, Sureda A, Morabito S, Sanches-Silva A, Mocan A, Nabavi SF, et al. Flavonoids and platelet aggregation: A brief review. Eur J Pharmacol. 2017;807:91-101. DOI: 10.1016/j.ejphar.2017.04.009.
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Anne Sütü Bileşimindeki Karotenoidler ve Polifenoller: Bebek Sağlığı Üzerine Etkileri
Yıl 2025,
Cilt: 10 Sayı: 2, 309 - 314, 14.06.2025
Zeyneb Yıldırım
,
Kadriye Toprak
Öz
Anne sütü yaşamın ilk aylarında bebeğin ihtiyaçlarını tek başına karşılayan, bebek için en ideal besindir. Bebeklerin optimal büyüme ve gelişmesini sağlamak için anne sütündeki besleyici özellikte bileşenlerin yanı sıra anne sütünün içerdiği biyoaktif bileşenler de büyük önem arz etmektedir. Fitokimyasallar da anne sütünün bileşiminde bulunan önemli biyoaktif bileşenlerdendir. Fitokimyasallar, oksidatif strese ve inflamasyona karşı koruma gibi sağlık yararları olan ikincil bitki metabolitleri olarak tanımlanmakta, emziren annenin diyeti ile vücuda alınarak, anne sütüne geçişi olmaktadır. Bu metabolitler arasında özellikle polifenoller ve karotenoidler, anne sütünde bulunan önemli fitokimyasal bileşenlerdendir. Bu derlemede anne sütünün karotenoid ve polifenol içeriği ve anne sütünde bulunan bu fitokimyasalların bebekler için olası faydaları değerlendirilmektedir. Araştırma kapsamında anne sütündeki polifenol ve karotenoid içerik, bu biyoaktif bileşenlerin hangi besinlerde olduğu ve bebeğin sağlığı üzerindeki etkisini içeren literatür taranmıştır. Fitokimyasalların bebek sağlığında oynayabileceği rolü daha iyi anlamak ve anne sütünün benzersiz bileşimi hakkındaki bilgileri geliştirmek için daha fazla araştırmaya ihtiyaç vardır.
Kaynakça
-
who.int [Internet]. World Health Organisation; 2024 [cited 2023 May 10]. Available from: https://www.who.int/health-topics/breastfeeding#tab=tab_1.
-
Zou L, Pande G, Akoh CC. Infant formula fat analogs and human milk fat: new focus on infant developmental needs. Annu Rev Food Sci Technol. 2016;7:139-65. DOI: 10.1146/annurev-food-041715-033120.
-
Xue Y, Campos-Giménez E, Redeuil KM, Lévèques A, Actis-Goretta L, Vinyes-Pares G, et al. Concentrations of carotenoids and tocopherols in breast milk from urban Chinese mothers and their associations with maternal characteristics: a cross-sectional study. Nutrients. 2017;9(11):1229. DOI: 10.3390/nu9111229.
-
Tsopmo A. Phytochemicals in human milk and their potential antioxidative protection. Antioxidants. 2018;7(2):32. DOI: 10.3390/antiox7020032.
-
Zheng Y, Correa-Silva S, Palmeira P, Carneiro-Sampaio M. Maternal vaccination as an additional approach to improve the protection of the nursling: Anti-infective properties of breast milk. Clinics. 2022;77:100093. DOI: 10.1016/j.clinsp.2022.100093
-
Trend S, Strunk T, Lloyd ML, Kok CH, Metcalfe J, Geddes DT, et al. Levels of innate immune factors in preterm and term mothers’ breast milk during the 1st month postpartum. Br J Nutr. 2016;115(7):1178-93. DOI: 10.1017/S0007114516000234.
-
Zielińska MA, Wesołowska A, Pawlus B, Hamułka J. Health effects of carotenoids during pregnancy and lactation. Nutrients. 2017;9(8):838. DOI: 10.3390/nu9080838
-
Gidrewicz DA, Fenton TR. A systematic review and meta-analysis of the nutrient content of preterm and term breast milk. BMC pediatr. 2014;14:1-14. DOI: 10.1186/1471-2431-14-216.
-
Fares S, Sethom MM, Kacem S, Ksibi I, Feki M, Jebnoun S, et al. Retinol and alpha-tocopherol in the colostrum of lactating Tunisian women delivering prematurely: Associations with maternal characteristics. Pediatr Neonatol. 2016;57(2):120-6. DOI: 10.1016/j.pedneo.2015.06.003.
-
de Azeredo VB, Trugo NM. Retinol, carotenoids, and tocopherols in the milk of lactating adolescents and relationships with plasma concentrations. Nutrition. 2008;24(2):133-9. DOI: 10.1016/j.nut.2007.10.011.
-
Prell C, Koletzko B. Breastfeeding and complementary feeding: recommendations on infant nutrition. Dtsch Arztebl Int. 2016;113(25):435. DOI: 10.3238/arztebl.2016.0435.
-
Zielinska MA, Hamulka J, Wesolowska A. Carotenoid content in breastmilk in the 3rd and 6th month of lactation and its associations with maternal dietary intake and anthropometric characteristics. Nutrients. 2019;11(1):193. DOI: 10.3390/nu11010193.
-
Song BJ, Jouni ZE, Ferruzzi MG. Assessment of phytochemical content in human milk during different stages of lactation. Nutrition. 2013;29(1):195-202. DOI: 10.1016/j.nut.2012.07.015.
-
Khymenets O, Rabassa M, Rodríguez-Palmero M, Rivero-Urgell M, Urpi-Sarda M, Tulipani S, et al. Dietary epicatechin is available to breastfed infants through human breast milk in the form of host and microbial metabolites. J Agric Food Chem. 2016;64(26):5354-60. DOI: 10.1021/acs.jafc.6b01947.
-
Ifrim-Chen F, Dragos D, Moga M, Barbilian A, Mircea L, Oproiu AM, et al. "Ectopic" Gustative And Olfactory Receptors In The Brain-New Targets For Neurodegeneration Therapy? Farmacia. 2019;67(1). DOI: 10.31925/farmacia.2019.1.5.
-
Soares S, Silva MS, Garcia-Estevez I, Groβmann P, Bras N, Brandao E, et al. Human bitter taste receptors are activated by different classes of polyphenols. J Agric Food Chem. 2018;66(33):8814-23. DOI: 10.1021/acs.jafc.8b03569.
-
Ríos J, Valero-Jara V, Thomas-Valdés S. Phytochemicals in breast milk and their benefits for infants. Crit Rev Food Sci Nutr. 2022;62(25):6821-36. DOI: 10.1080/10408398.2021.1906627.
-
Poniedziałek B, Rzymski P, Pięt M, Gąsecka M, Stroińska A, Niedzielski P, et al. Relation between polyphenols, malondialdehyde, antioxidant capacity, lactate dehydrogenase and toxic elements in human colostrum milk. Chemosphere. 2018;191:548-54. DOI: 10.1016/j.chemosphere.2017.10.098.
-
Sherry CL, Oliver JS, Renzi LM, Marriage BJ. Lutein supplementation increases breast milk and plasma lutein concentrations in lactating women and infant plasma concentrations but does not affect other carotenoids. J Nutr. 2014;144(8):1256-63. DOI: 10.3945/jn.114.192914.
-
Xu X, Zhao X, Berde Y, Low YL, Kuchan MJ. Milk and plasma lutein and zeaxanthin concentrations in Chinese breast-feeding mother–infant dyads with healthy maternal fruit and vegetable intake. J Am Coll Nutr. 2019;38(2):179-84. DOI: 10.1080/07315724.2018.1490934.
-
Saini RK, Nile SH, Park SW. Carotenoids from fruits and vegetables: Chemistry, analysis, occurrence, bioavailability and biological activities. Food Res Int. 2015;76:735-50. DOI: 10.1016/j.foodres.2015.07.047.
-
Ermakov IV, Ermakova MR, Bernstein PS, Chan GM, Gellermann W. Resonance Raman based skin carotenoid measurements in newborns and infants. J Biophotonics. 2013;6(10):793-802. DOI: 10.1002/jbio.201200195.
-
Zupo R, Castellana F, De Nucci S, Sila A, Aresta S, Buscemi C, et al. Role of dietary carotenoids in frailty syndrome: A systematic review. Biomedicines. 2022;10(3):632. DOI: 10.3390/biomedicines10030632.
-
Moran NE, Mohn ES, Hason N, Erdman Jr JW, Johnson EJ. Intrinsic and extrinsic factors impacting absorption, metabolism, and health effects of dietary carotenoids. Adv Nutr. 2018;9(4):465-92. DOI: 10.1093/advances/nmy025.
-
Şengün P. Goji Berry (lycium barabrum l.) meyvelerinin olgunlaşma evreleri ve kurutulma sürecinde karotenoid kompozisyonundaki değişim [master’s thesis]. [Denizli]: Pamukkale Üniversitesi; 2021.
-
Xavier AA, Díaz-Salido E, Arenilla-Vélez I, Aguayo-Maldonado J, Garrido-Fernández J, Fontecha J, et al. Carotenoid content in human colostrum is associated to preterm/full-term birth condition. Nutrients. 2018;10(11):1654. DOI: 10.3390/nu10111654.
-
Lipkie TE, Morrow AL, Jouni ZE, McMahon RJ, Ferruzzi MG. Longitudinal survey of carotenoids in human milk from urban cohorts in China, Mexico, and the USA. PloS One. 2015;10(6):e0127729. DOI: 10.1371/journal.pone.0127729.
-
Sun H, Wu T, Mao Y, Tian F, Cai X, Kuchan MJ, Chen, J. Carotenoid profile in breast milk and maternal and cord plasma: a longitudinal study in Southwest China. Br J Nutr. 2021;126(9),1281-1287. DOI: 10.1017/S0007114521000027.
-
Sun A, Tian L, Xiong X, Kuchan M, Dai X, Sun H, Wang H, Li X, Zhang L, Zhao YR, Chen J, Mao Y, Li X. Carotenoids in maternal and cord blood, breast milk, and their association with maternal dietary intake: a longitudinal study in Shanghai, China. Br J Nutr. 2023;1–36. DOI: 10.1017/s000711452300257x.
-
Tian L, Wang L, Li F, Sun A, Ni M, Sun H, Wang H, Li X, Zhao Y, Zhang L, Li X, Kuchan MJ, Mao Y, Chen J. Carotenoids profile in maternal and cord plasma and its trends in breast milk along lactation: A comparative study among three cities in northern China. Food Funct. 2025;16(3):1000-1015. DOI: 10.1039/d4fo05112b.
-
Zhou L, Chan YT, Lo K, Zhao D, Wong V WS, Ng YF Ho, WW, Li L, Lee H, Wong MS, Li SY. Carotenoids and Vitamin A in Breastmilk of Hong Kong Lactating Mothers and Their Relationships with Maternal Diet. Nutrients. 2022;14(10),2031. DOI: 10.3390/nu14102031.
-
Zhang Y, Yang J, Huang N, Xiao L, Lin H, Luo J, et al. Changes in breast milk lutein concentrations and their associations with dietary lutein intake: a 12-week prospective analytical study. Br J Nutr. 2019;122(9):1033-9. DOI: 10.1017/S0007114519001727.
-
Bernstein PS, Sharifzadeh M, Liu A, Ermakov I, Nelson K, Sheng X, et al. Blue-light reflectance imaging of macular pigment in infants and children. Invest Ophthalmol Vis Sci. 2013;54(6):4034-40. DOI: 10.1167/iovs.13-11891.
-
Cena H, Castellazzi AM, Pietri A, Roggi C, Turconi G. Lutein concentration in human milk during early lactation and its relationship with dietary lutein intake. Public Health Nutr. 2009;12(10):1878-84. DOI: 10.1017/S1368980009004807.
-
Alhujaily M, Dhifi W, Mnif W. An Overview of the Potential of Medicinal Plants Used in the Development of Nutraceuticals for the Management of Diabetes Mellitus: Proposed Biological Mechanisms. Processes. 2022;10(10):2044. DOI: 10.3390/pr10102044.
-
Faggio C, Sureda A, Morabito S, Sanches-Silva A, Mocan A, Nabavi SF, et al. Flavonoids and platelet aggregation: A brief review. Eur J Pharmacol. 2017;807:91-101. DOI: 10.1016/j.ejphar.2017.04.009.
-
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